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Q9WTZ0

- UXT_MOUSE

UniProt

Q9WTZ0 - UXT_MOUSE

Protein

Protein UXT

Gene

Uxt

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor (AR) transcription. AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM. Together with URI1, associates with chromatin to the NKX3-1 promoter region By similarity.By similarity

    GO - Molecular functioni

    1. beta-tubulin binding Source: HGNC
    2. chromatin binding Source: UniProtKB
    3. RNA polymerase II transcription corepressor activity Source: UniProtKB

    GO - Biological processi

    1. centrosome organization Source: HGNC
    2. microtubule cytoskeleton organization Source: HGNC
    3. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    4. protein folding Source: InterPro

    Keywords - Molecular functioni

    Activator, Chaperone, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein UXT
    Alternative name(s):
    Ubiquitously expressed transcript protein
    Gene namesi
    Name:Uxt
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1277988. Uxt.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. centrosome Source: HGNC
    2. cytoplasm Source: UniProtKB
    3. cytoskeleton Source: HGNC
    4. nucleus Source: UniProtKB
    5. prefoldin complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 157157Protein UXTPRO_0000065752Add
    BLAST

    Proteomic databases

    MaxQBiQ9WTZ0.
    PaxDbiQ9WTZ0.
    PRIDEiQ9WTZ0.

    PTM databases

    PhosphoSiteiQ9WTZ0.

    Expressioni

    Gene expression databases

    CleanExiMM_UXT.
    GenevestigatoriQ9WTZ0.

    Interactioni

    Subunit structurei

    Homohexamer. Interacts with LRPPRC. Interacts with AR N-terminus. In the nucleus interacts specifically with RELA and forms a dynamic complex with NF-kappa-B and is recruited to the NF-kappa-B enhanceosome upon stimulation. Interacts with MECOM and URI1 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WTZ0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UXT family.Curated

    Phylogenomic databases

    eggNOGiNOG263764.
    HOGENOMiHOG000005748.
    HOVERGENiHBG001087.
    InParanoidiQ9WTZ0.
    PhylomeDBiQ9WTZ0.

    Family and domain databases

    Gene3Di1.10.287.370. 1 hit.
    InterProiIPR003994. PFD_UXT.
    IPR009053. Prefoldin.
    IPR004127. Prefoldin_subunit_alpha.
    [Graphical view]
    PfamiPF02996. Prefoldin. 1 hit.
    [Graphical view]
    PRINTSiPR01502. UXTPROTEIN.
    SUPFAMiSSF46579. SSF46579. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9WTZ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATPPKRRAL DTVGEKVLRY ETFISDVLQR DLQKVLDHRD KVYEQLSVYL    50
    QLRNVIERLQ ETNHSELYMQ VDLGCNFFVD TVVPDTSRIY VALGYGFFLE 100
    LTLAEALKFI DRKSSLLTEL SDSLTKDSMN IKAHIHMMLE GLRELQGLQN 150
    FPEPSTH 157
    Length:157
    Mass (Da):18,191
    Last modified:November 1, 1999 - v1
    Checksum:iFDB8DEF32730BA87
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF092738 mRNA. Translation: AAD28699.1.
    CCDSiCCDS30049.1.
    UniGeneiMm.34779.

    Genome annotation databases

    UCSCiuc009suf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF092738 mRNA. Translation: AAD28699.1 .
    CCDSi CCDS30049.1.
    UniGenei Mm.34779.

    3D structure databases

    ProteinModelPortali Q9WTZ0.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9WTZ0.

    Proteomic databases

    MaxQBi Q9WTZ0.
    PaxDbi Q9WTZ0.
    PRIDEi Q9WTZ0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc009suf.1. mouse.

    Organism-specific databases

    MGIi MGI:1277988. Uxt.

    Phylogenomic databases

    eggNOGi NOG263764.
    HOGENOMi HOG000005748.
    HOVERGENi HBG001087.
    InParanoidi Q9WTZ0.
    PhylomeDBi Q9WTZ0.

    Miscellaneous databases

    PROi Q9WTZ0.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_UXT.
    Genevestigatori Q9WTZ0.

    Family and domain databases

    Gene3Di 1.10.287.370. 1 hit.
    InterProi IPR003994. PFD_UXT.
    IPR009053. Prefoldin.
    IPR004127. Prefoldin_subunit_alpha.
    [Graphical view ]
    Pfami PF02996. Prefoldin. 1 hit.
    [Graphical view ]
    PRINTSi PR01502. UXTPROTEIN.
    SUPFAMi SSF46579. SSF46579. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of UXT, a novel gene in human Xp11, which is widely and abundantly expressed in tumor tissue."
      Schroer A., Schneider S., Ropers H.-H., Nothwang H.G.
      Genomics 56:340-343(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiUXT_MOUSE
    AccessioniPrimary (citable) accession number: Q9WTZ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3