Q9WTZ0 (UXT_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified July 9, 2014. Version 79. History...
Names and origin
|Protein names||Recommended name:|
Ubiquitously expressed transcript protein
|Organism||Mus musculus (Mouse) [Reference proteome]|
|Taxonomic identifier||10090 [NCBI]|
|Sequence length||157 AA.|
|Protein existence||Evidence at transcript level|
General annotation (Comments)
Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor (AR) transcription. AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM. Together with URI1, associates with chromatin to the NKX3-1 promoter region By similarity.
Homohexamer. Interacts with LRPPRC. Interacts with AR N-terminus. In the nucleus interacts specifically with RELA and forms a dynamic complex with NF-kappa-B and is recruited to the NF-kappa-B enhanceosome upon stimulation. Interacts with MECOM and URI1 By similarity.
Belongs to the UXT family.
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Chain||1 – 157||157||Protein UXT||PRO_0000065752|
|||"Cloning and characterization of UXT, a novel gene in human Xp11, which is widely and abundantly expressed in tumor tissue."|
Schroer A., Schneider S., Ropers H.-H., Nothwang H.G.
Genomics 56:340-343(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
|+||Additional computationally mapped references.|
|AF092738 mRNA. Translation: AAD28699.1.|
3D structure databases
Protocols and materials databases
Genome annotation databases
|UCSC||uc009suf.1. mouse. |
|MGI||MGI:1277988. Uxt. |
Gene expression databases
Family and domain databases
|Gene3D||1.10.287.370. 1 hit. |
|InterPro||IPR003994. PFD_UXT. |
|Pfam||PF02996. Prefoldin. 1 hit. |
|PRINTS||PR01502. UXTPROTEIN. |
|SUPFAM||SSF46579. SSF46579. 1 hit. |
|Accession||Primary (citable) accession number: Q9WTZ0|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Chordata Protein Annotation Program|