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Protein

Protein UXT

Gene

Uxt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription. Together with URI1, associates with chromatin to the NKX3-1 promoter region. Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm. May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM.By similarity
Isoform 1: Plays a role in protecting cells against TNF-alpha-induced apoptosis by preventing the recruitment of FADD and caspase 8 to the apoptotic complex I, composed of TRADD, TRAF2 and RIPK1/RIP.1 Publication

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • centrosome cycle Source: HGNC
  • microtubule cytoskeleton organization Source: HGNC
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Chaperone, Repressor
Biological processApoptosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein UXT
Alternative name(s):
Ubiquitously expressed transcript protein
Gene namesi
Name:Uxt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1277988 Uxt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000657521 – 157Protein UXTAdd BLAST157

Proteomic databases

EPDiQ9WTZ0
PaxDbiQ9WTZ0
PeptideAtlasiQ9WTZ0
PRIDEiQ9WTZ0

PTM databases

iPTMnetiQ9WTZ0
PhosphoSitePlusiQ9WTZ0

Expressioni

Gene expression databases

CleanExiMM_UXT

Interactioni

Subunit structurei

Homohexamer (By similarity). Interacts with LRPPRC (By similarity). Isoform 2 interacts with androgen receptor AR (via N-terminus) (By similarity). Interacts with estrogen receptor ESR1; the interaction relocalizes ESR1 to the cytoplasm (By similarity). In the nucleus, interacts specifically with RELA (via RHD domain) and forms a dynamic complex with NF-kappa-B and is recruited to the NF-kappa-B enhanceosome upon stimulation (By similarity). Interacts with MECOM (By similarity). Interacts with URI1 (By similarity). Isoform 1 is part of complex I composed of TNF-alpha receptor, TRADD, TRAF2 and RIPK1 (By similarity). Within the complex, interacts (via TPQE motif) with TRAF2; the interaction prevents the recruitment of FADD and CASP8/caspase 8 to complex I (PubMed:21307340).By similarity1 Publication

GO - Molecular functioni

  • beta-tubulin binding Source: HGNC

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000115342

Structurei

3D structure databases

ProteinModelPortaliQ9WTZ0
SMRiQ9WTZ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UXT family.Curated

Phylogenomic databases

eggNOGiKOG3047 Eukaryota
ENOG4111Q3P LUCA
GeneTreeiENSGT00390000018078
HOGENOMiHOG000005748
HOVERGENiHBG001087
InParanoidiQ9WTZ0
OMAiQVNIGSN
PhylomeDBiQ9WTZ0

Family and domain databases

Gene3Di1.10.287.370, 1 hit
InterProiView protein in InterPro
IPR009053 Prefoldin
IPR004127 Prefoldin_subunit_alpha
IPR003994 UXT
PfamiView protein in Pfam
PF02996 Prefoldin, 1 hit
PRINTSiPR01502 UXTPROTEIN

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q9WTZ0-1) [UniParc]FASTAAdd to basket
Also known as: UXT-V21 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATPPKRRAL DTVGEKVLRY ETFISDVLQR DLQKVLDHRD KVYEQLSVYL
60 70 80 90 100
QLRNVIERLQ ETNHSELYMQ VDLGCNFFVD TVVPDTSRIY VALGYGFFLE
110 120 130 140 150
LTLAEALKFI DRKSSLLTEL SDSLTKDSMN IKAHIHMMLE GLRELQGLQN

FPEPSPH
Length:157
Mass (Da):18,187
Last modified:September 27, 2017 - v2
Checksum:iFDBE1EF32730BA87
GO
Isoform 1 (identifier: Q9WTZ0-2)
Also known as: UXT-V11 Publication
Sequence is not available
Note: Derived from EST data. No initiation Met is found in the EST sequence upstream the Met for isoform 1.Curated
Length:
Mass (Da):

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156P → T in AAD28699 (PubMed:10087202).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092738 mRNA Translation: AAD28699.1
AK027917 mRNA Translation: BAC25665.1
AK163983 mRNA Translation: BAE37569.1
AL671853 Genomic DNA No translation available.
CH466625 Genomic DNA Translation: EDL00731.1
BC082294 mRNA Translation: AAH82294.1
CCDSiCCDS30049.1 [Q9WTZ0-1]
RefSeqiNP_038868.2, NM_013840.3 [Q9WTZ0-1]
UniGeneiMm.34779

Genome annotation databases

EnsembliENSMUST00000123836; ENSMUSP00000115342; ENSMUSG00000001134 [Q9WTZ0-1]
GeneIDi22294
KEGGimmu:22294
UCSCiuc009sue.1 mouse
uc009suf.1 mouse [Q9WTZ0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiUXT_MOUSE
AccessioniPrimary (citable) accession number: Q9WTZ0
Secondary accession number(s): Q8CEJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 27, 2017
Last modified: April 25, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health