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Protein

Protein UXT

Gene

Uxt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor (AR) transcription. AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM. Together with URI1, associates with chromatin to the NKX3-1 promoter region (By similarity).By similarity

GO - Molecular functioni

  1. beta-tubulin binding Source: HGNC
  2. chromatin binding Source: UniProtKB
  3. RNA polymerase II transcription corepressor activity Source: UniProtKB

GO - Biological processi

  1. centrosome organization Source: HGNC
  2. microtubule cytoskeleton organization Source: HGNC
  3. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chaperone, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein UXT
Alternative name(s):
Ubiquitously expressed transcript protein
Gene namesi
Name:Uxt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1277988. Uxt.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Nucleus By similarity

GO - Cellular componenti

  1. centrosome Source: HGNC
  2. cytoplasm Source: UniProtKB
  3. cytoskeleton Source: HGNC
  4. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 157157Protein UXTPRO_0000065752Add
BLAST

Proteomic databases

MaxQBiQ9WTZ0.
PaxDbiQ9WTZ0.
PRIDEiQ9WTZ0.

PTM databases

PhosphoSiteiQ9WTZ0.

Expressioni

Gene expression databases

CleanExiMM_UXT.
GenevestigatoriQ9WTZ0.

Interactioni

Subunit structurei

Homohexamer. Interacts with LRPPRC. Interacts with AR N-terminus. In the nucleus interacts specifically with RELA and forms a dynamic complex with NF-kappa-B and is recruited to the NF-kappa-B enhanceosome upon stimulation. Interacts with MECOM and URI1 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9WTZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UXT family.Curated

Phylogenomic databases

eggNOGiNOG263764.
HOGENOMiHOG000005748.
HOVERGENiHBG001087.
InParanoidiQ9WTZ0.
PhylomeDBiQ9WTZ0.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR009053. Prefoldin.
IPR004127. Prefoldin_subunit_alpha.
IPR003994. UXT.
[Graphical view]
PfamiPF02996. Prefoldin. 1 hit.
[Graphical view]
PRINTSiPR01502. UXTPROTEIN.
SUPFAMiSSF46579. SSF46579. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WTZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPPKRRAL DTVGEKVLRY ETFISDVLQR DLQKVLDHRD KVYEQLSVYL
60 70 80 90 100
QLRNVIERLQ ETNHSELYMQ VDLGCNFFVD TVVPDTSRIY VALGYGFFLE
110 120 130 140 150
LTLAEALKFI DRKSSLLTEL SDSLTKDSMN IKAHIHMMLE GLRELQGLQN

FPEPSTH
Length:157
Mass (Da):18,191
Last modified:November 1, 1999 - v1
Checksum:iFDB8DEF32730BA87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092738 mRNA. Translation: AAD28699.1.
CCDSiCCDS30049.1.
UniGeneiMm.34779.

Genome annotation databases

UCSCiuc009suf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092738 mRNA. Translation: AAD28699.1.
CCDSiCCDS30049.1.
UniGeneiMm.34779.

3D structure databases

ProteinModelPortaliQ9WTZ0.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9WTZ0.

Proteomic databases

MaxQBiQ9WTZ0.
PaxDbiQ9WTZ0.
PRIDEiQ9WTZ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc009suf.1. mouse.

Organism-specific databases

MGIiMGI:1277988. Uxt.

Phylogenomic databases

eggNOGiNOG263764.
HOGENOMiHOG000005748.
HOVERGENiHBG001087.
InParanoidiQ9WTZ0.
PhylomeDBiQ9WTZ0.

Miscellaneous databases

PROiQ9WTZ0.
SOURCEiSearch...

Gene expression databases

CleanExiMM_UXT.
GenevestigatoriQ9WTZ0.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR009053. Prefoldin.
IPR004127. Prefoldin_subunit_alpha.
IPR003994. UXT.
[Graphical view]
PfamiPF02996. Prefoldin. 1 hit.
[Graphical view]
PRINTSiPR01502. UXTPROTEIN.
SUPFAMiSSF46579. SSF46579. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of UXT, a novel gene in human Xp11, which is widely and abundantly expressed in tumor tissue."
    Schroer A., Schneider S., Ropers H.-H., Nothwang H.G.
    Genomics 56:340-343(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiUXT_MOUSE
AccessioniPrimary (citable) accession number: Q9WTZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: March 4, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.