Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9WTZ0 (UXT_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein UXT
Alternative name(s):
Ubiquitously expressed transcript protein
Gene names
Name:Uxt
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length157 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor (AR) transcription. AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM. Together with URI1, associates with chromatin to the NKX3-1 promoter region By similarity.

Subunit structure

Homohexamer. Interacts with LRPPRC. Interacts with AR N-terminus. In the nucleus interacts specifically with RELA and forms a dynamic complex with NF-kappa-B and is recruited to the NF-kappa-B enhanceosome upon stimulation. Interacts with MECOM and URI1 By similarity.

Subcellular location

Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the UXT family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 157157Protein UXT
PRO_0000065752

Sequences

Sequence LengthMass (Da)Tools
Q9WTZ0 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: FDB8DEF32730BA87

FASTA15718,191
        10         20         30         40         50         60 
MATPPKRRAL DTVGEKVLRY ETFISDVLQR DLQKVLDHRD KVYEQLSVYL QLRNVIERLQ 

        70         80         90        100        110        120 
ETNHSELYMQ VDLGCNFFVD TVVPDTSRIY VALGYGFFLE LTLAEALKFI DRKSSLLTEL 

       130        140        150 
SDSLTKDSMN IKAHIHMMLE GLRELQGLQN FPEPSTH 

« Hide

References

[1]"Cloning and characterization of UXT, a novel gene in human Xp11, which is widely and abundantly expressed in tumor tissue."
Schroer A., Schneider S., Ropers H.-H., Nothwang H.G.
Genomics 56:340-343(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF092738 mRNA. Translation: AAD28699.1.
CCDSCCDS30049.1.
UniGeneMm.34779.

3D structure databases

ProteinModelPortalQ9WTZ0.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9WTZ0.

Proteomic databases

MaxQBQ9WTZ0.
PaxDbQ9WTZ0.
PRIDEQ9WTZ0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc009suf.1. mouse.

Organism-specific databases

MGIMGI:1277988. Uxt.

Phylogenomic databases

eggNOGNOG263764.
HOGENOMHOG000005748.
HOVERGENHBG001087.
InParanoidQ9WTZ0.
PhylomeDBQ9WTZ0.

Gene expression databases

CleanExMM_UXT.
GenevestigatorQ9WTZ0.

Family and domain databases

Gene3D1.10.287.370. 1 hit.
InterProIPR003994. PFD_UXT.
IPR009053. Prefoldin.
IPR004127. Prefoldin_subunit_alpha.
[Graphical view]
PfamPF02996. Prefoldin. 1 hit.
[Graphical view]
PRINTSPR01502. UXTPROTEIN.
SUPFAMSSF46579. SSF46579. 1 hit.
ProtoNetSearch...

Other

PROQ9WTZ0.
SOURCESearch...

Entry information

Entry nameUXT_MOUSE
AccessionPrimary (citable) accession number: Q9WTZ0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot