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Q9WTY4 (AQP5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aquaporin-5

Short name=AQP-5
Gene names
Name:Aqp5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions.

Subcellular location

Membrane; Multi-pass membrane protein.

Domain

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similarities

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Aquaporin-5
PRO_0000063952

Regions

Topological domain1 – 1212Cytoplasmic Potential
Transmembrane13 – 3321Helical; Potential
Topological domain34 – 363Extracellular Potential
Transmembrane37 – 5721Helical; Potential
Topological domain58 – 8730Cytoplasmic Potential
Transmembrane88 – 10821Helical; Potential
Topological domain109 – 12618Extracellular Potential
Transmembrane127 – 14721Helical; Potential
Topological domain148 – 16114Cytoplasmic Potential
Transmembrane162 – 18221Helical; Potential
Topological domain183 – 20523Extracellular Potential
Transmembrane206 – 22621Helical; Potential
Topological domain227 – 26539Cytoplasmic Potential
Motif69 – 713NPA 1
Motif185 – 1873NPA 2

Amino acid modifications

Glycosylation1241N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9WTY4 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 917DF4A0C0A4C620

FASTA26528,274
        10         20         30         40         50         60 
MKKEVCSVAF FKAVFAEFLA TLIFVFFGLG SALKWPSALP TILQISIAFG LAIGTLAQAL 

        70         80         90        100        110        120 
GPVSGGHINP AITLALLIGN QISLLRAIFY VAAQLVGAIA GAGILYWLAP GNARGNLAVN 

       130        140        150        160        170        180 
ALSNNTTPGK AVVVELILTF QLALCIFSST DSRRTSPVGS PALSIGLSVT LGHLVGIYFT 

       190        200        210        220        230        240 
GCSMNPARSF GPAVVMNRFS PSHWVFWVGP IVGAVLAAIL YFYLLFPSSL SLHDRVAVVK 

       250        260 
GTYEPEEDWE DHREERKKTI ELTAH 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of murine Aqp5: evidence for a conserved aquaporin gene cluster."
Krane C.M., Towne J.E., Menon A.G.
Mamm. Genome 10:498-505(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: FEBN.
Tissue: Lung.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Lung and Tongue.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF087654 mRNA. Translation: AAD32491.1.
AK009302 mRNA. Translation: BAB26203.1.
RefSeqNP_033831.1. NM_009701.4.
UniGeneMm.45580.

3D structure databases

ProteinModelPortalQ9WTY4.
SMRQ9WTY4. Positions 2-245.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000048739.

PTM databases

PhosphoSiteQ9WTY4.

Proteomic databases

PaxDbQ9WTY4.
PRIDEQ9WTY4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000088200; ENSMUSP00000085530; ENSMUSG00000044217.
ENSMUST00000169082; ENSMUSP00000127611; ENSMUSG00000044217.
GeneID11830.
KEGGmmu:11830.
UCSCuc007xpt.1. mouse.

Organism-specific databases

CTD362.
MGIMGI:106215. Aqp5.

Phylogenomic databases

eggNOGCOG0580.
GeneTreeENSGT00740000115105.
HOGENOMHOG000288286.
HOVERGENHBG000312.
InParanoidQ9WTY4.
KOK09867.
OMAHQLVIRA.
OrthoDBEOG7N8ZWD.
PhylomeDBQ9WTY4.
TreeFamTF312940.

Gene expression databases

BgeeQ9WTY4.
CleanExMM_AQP5.
GenevestigatorQ9WTY4.

Family and domain databases

Gene3D1.20.1080.10. 1 hit.
InterProIPR023271. Aquaporin-like.
IPR023276. Aquaporin_5.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERPTHR19139. PTHR19139. 1 hit.
PfamPF00230. MIP. 1 hit.
[Graphical view]
PRINTSPR02017. AQUAPORIN5.
PR00783. MINTRINSICP.
SUPFAMSSF81338. SSF81338. 1 hit.
TIGRFAMsTIGR00861. MIP. 1 hit.
PROSITEPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio279743.
PROQ9WTY4.
SOURCESearch...

Entry information

Entry nameAQP5_MOUSE
AccessionPrimary (citable) accession number: Q9WTY4
Secondary accession number(s): Q545H1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot