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Q9WTY4

- AQP5_MOUSE

UniProt

Q9WTY4 - AQP5_MOUSE

Protein

Aquaporin-5

Gene

Aqp5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions.

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. water channel activity Source: MGI

    GO - Biological processi

    1. camera-type eye morphogenesis Source: MGI
    2. carbon dioxide transport Source: Ensembl
    3. odontogenesis Source: Ensembl
    4. pancreatic juice secretion Source: Ensembl
    5. saliva secretion Source: MGI
    6. water transport Source: MGI

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aquaporin-5
    Short name:
    AQP-5
    Gene namesi
    Name:Aqp5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:106215. Aqp5.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: MGI
    2. basal plasma membrane Source: MGI
    3. endoplasmic reticulum Source: MGI
    4. integral component of plasma membrane Source: MGI
    5. microvillus Source: MGI
    6. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 265265Aquaporin-5PRO_0000063952Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9WTY4.
    PRIDEiQ9WTY4.

    PTM databases

    PhosphoSiteiQ9WTY4.

    Expressioni

    Gene expression databases

    BgeeiQ9WTY4.
    CleanExiMM_AQP5.
    GenevestigatoriQ9WTY4.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000048739.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WTY4.
    SMRiQ9WTY4. Positions 2-245.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1212CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini34 – 363ExtracellularSequence Analysis
    Topological domaini58 – 8730CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini109 – 12618ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini148 – 16114CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini183 – 20523ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini227 – 26539CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei37 – 5721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei88 – 10821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei162 – 18221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei206 – 22621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi69 – 713NPA 1
    Motifi185 – 1873NPA 2

    Domaini

    Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0580.
    GeneTreeiENSGT00740000115105.
    HOGENOMiHOG000288286.
    HOVERGENiHBG000312.
    InParanoidiQ9WTY4.
    KOiK09867.
    OMAiMNRFSPS.
    OrthoDBiEOG7N8ZWD.
    PhylomeDBiQ9WTY4.
    TreeFamiTF312940.

    Family and domain databases

    Gene3Di1.20.1080.10. 1 hit.
    InterProiIPR023271. Aquaporin-like.
    IPR023276. Aquaporin_5.
    IPR000425. MIP.
    IPR022357. MIP_CS.
    [Graphical view]
    PANTHERiPTHR19139. PTHR19139. 1 hit.
    PfamiPF00230. MIP. 1 hit.
    [Graphical view]
    PRINTSiPR02017. AQUAPORIN5.
    PR00783. MINTRINSICP.
    SUPFAMiSSF81338. SSF81338. 1 hit.
    TIGRFAMsiTIGR00861. MIP. 1 hit.
    PROSITEiPS00221. MIP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9WTY4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKEVCSVAF FKAVFAEFLA TLIFVFFGLG SALKWPSALP TILQISIAFG    50
    LAIGTLAQAL GPVSGGHINP AITLALLIGN QISLLRAIFY VAAQLVGAIA 100
    GAGILYWLAP GNARGNLAVN ALSNNTTPGK AVVVELILTF QLALCIFSST 150
    DSRRTSPVGS PALSIGLSVT LGHLVGIYFT GCSMNPARSF GPAVVMNRFS 200
    PSHWVFWVGP IVGAVLAAIL YFYLLFPSSL SLHDRVAVVK GTYEPEEDWE 250
    DHREERKKTI ELTAH 265
    Length:265
    Mass (Da):28,274
    Last modified:November 1, 1999 - v1
    Checksum:i917DF4A0C0A4C620
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF087654 mRNA. Translation: AAD32491.1.
    AK009302 mRNA. Translation: BAB26203.1.
    CCDSiCCDS27823.1.
    RefSeqiNP_033831.1. NM_009701.4.
    UniGeneiMm.45580.

    Genome annotation databases

    EnsembliENSMUST00000088200; ENSMUSP00000085530; ENSMUSG00000044217.
    ENSMUST00000169082; ENSMUSP00000127611; ENSMUSG00000044217.
    GeneIDi11830.
    KEGGimmu:11830.
    UCSCiuc007xpt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF087654 mRNA. Translation: AAD32491.1 .
    AK009302 mRNA. Translation: BAB26203.1 .
    CCDSi CCDS27823.1.
    RefSeqi NP_033831.1. NM_009701.4.
    UniGenei Mm.45580.

    3D structure databases

    ProteinModelPortali Q9WTY4.
    SMRi Q9WTY4. Positions 2-245.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000048739.

    PTM databases

    PhosphoSitei Q9WTY4.

    Proteomic databases

    PaxDbi Q9WTY4.
    PRIDEi Q9WTY4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000088200 ; ENSMUSP00000085530 ; ENSMUSG00000044217 .
    ENSMUST00000169082 ; ENSMUSP00000127611 ; ENSMUSG00000044217 .
    GeneIDi 11830.
    KEGGi mmu:11830.
    UCSCi uc007xpt.1. mouse.

    Organism-specific databases

    CTDi 362.
    MGIi MGI:106215. Aqp5.

    Phylogenomic databases

    eggNOGi COG0580.
    GeneTreei ENSGT00740000115105.
    HOGENOMi HOG000288286.
    HOVERGENi HBG000312.
    InParanoidi Q9WTY4.
    KOi K09867.
    OMAi MNRFSPS.
    OrthoDBi EOG7N8ZWD.
    PhylomeDBi Q9WTY4.
    TreeFami TF312940.

    Miscellaneous databases

    NextBioi 279743.
    PROi Q9WTY4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9WTY4.
    CleanExi MM_AQP5.
    Genevestigatori Q9WTY4.

    Family and domain databases

    Gene3Di 1.20.1080.10. 1 hit.
    InterProi IPR023271. Aquaporin-like.
    IPR023276. Aquaporin_5.
    IPR000425. MIP.
    IPR022357. MIP_CS.
    [Graphical view ]
    PANTHERi PTHR19139. PTHR19139. 1 hit.
    Pfami PF00230. MIP. 1 hit.
    [Graphical view ]
    PRINTSi PR02017. AQUAPORIN5.
    PR00783. MINTRINSICP.
    SUPFAMi SSF81338. SSF81338. 1 hit.
    TIGRFAMsi TIGR00861. MIP. 1 hit.
    PROSITEi PS00221. MIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of murine Aqp5: evidence for a conserved aquaporin gene cluster."
      Krane C.M., Towne J.E., Menon A.G.
      Mamm. Genome 10:498-505(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: FEBN.
      Tissue: Lung.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Lung and Tongue.

    Entry informationi

    Entry nameiAQP5_MOUSE
    AccessioniPrimary (citable) accession number: Q9WTY4
    Secondary accession number(s): Q545H1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3