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Q9WTY4

- AQP5_MOUSE

UniProt

Q9WTY4 - AQP5_MOUSE

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Protein

Aquaporin-5

Gene

Aqp5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions.

GO - Molecular functioni

  1. water channel activity Source: MGI

GO - Biological processi

  1. camera-type eye morphogenesis Source: MGI
  2. carbon dioxide transport Source: Ensembl
  3. odontogenesis Source: Ensembl
  4. pancreatic juice secretion Source: Ensembl
  5. saliva secretion Source: MGI
  6. water transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-5
Short name:
AQP-5
Gene namesi
Name:Aqp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:106215. Aqp5.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: MGI
  2. basal plasma membrane Source: MGI
  3. endoplasmic reticulum Source: MGI
  4. extracellular vesicular exosome Source: Ensembl
  5. integral component of plasma membrane Source: MGI
  6. microvillus Source: MGI
  7. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Aquaporin-5PRO_0000063952Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9WTY4.
PRIDEiQ9WTY4.

PTM databases

PhosphoSiteiQ9WTY4.

Expressioni

Gene expression databases

BgeeiQ9WTY4.
CleanExiMM_AQP5.
GenevestigatoriQ9WTY4.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048739.

Structurei

3D structure databases

ProteinModelPortaliQ9WTY4.
SMRiQ9WTY4. Positions 2-245.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini34 – 363ExtracellularSequence Analysis
Topological domaini58 – 8730CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini109 – 12618ExtracellularSequence AnalysisAdd
BLAST
Topological domaini148 – 16114CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini183 – 20523ExtracellularSequence AnalysisAdd
BLAST
Topological domaini227 – 26539CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence AnalysisAdd
BLAST
Transmembranei37 – 5721HelicalSequence AnalysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence AnalysisAdd
BLAST
Transmembranei127 – 14721HelicalSequence AnalysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence AnalysisAdd
BLAST
Transmembranei206 – 22621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi69 – 713NPA 1
Motifi185 – 1873NPA 2

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0580.
GeneTreeiENSGT00760000119223.
HOGENOMiHOG000288286.
HOVERGENiHBG000312.
InParanoidiQ9WTY4.
KOiK09867.
OMAiMNRFSPS.
OrthoDBiEOG7N8ZWD.
PhylomeDBiQ9WTY4.
TreeFamiTF312940.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023276. Aquaporin_5.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02017. AQUAPORIN5.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WTY4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKEVCSVAF FKAVFAEFLA TLIFVFFGLG SALKWPSALP TILQISIAFG
60 70 80 90 100
LAIGTLAQAL GPVSGGHINP AITLALLIGN QISLLRAIFY VAAQLVGAIA
110 120 130 140 150
GAGILYWLAP GNARGNLAVN ALSNNTTPGK AVVVELILTF QLALCIFSST
160 170 180 190 200
DSRRTSPVGS PALSIGLSVT LGHLVGIYFT GCSMNPARSF GPAVVMNRFS
210 220 230 240 250
PSHWVFWVGP IVGAVLAAIL YFYLLFPSSL SLHDRVAVVK GTYEPEEDWE
260
DHREERKKTI ELTAH
Length:265
Mass (Da):28,274
Last modified:November 1, 1999 - v1
Checksum:i917DF4A0C0A4C620
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF087654 mRNA. Translation: AAD32491.1.
AK009302 mRNA. Translation: BAB26203.1.
CCDSiCCDS27823.1.
RefSeqiNP_033831.1. NM_009701.4.
UniGeneiMm.45580.

Genome annotation databases

EnsembliENSMUST00000088200; ENSMUSP00000085530; ENSMUSG00000044217.
ENSMUST00000169082; ENSMUSP00000127611; ENSMUSG00000044217.
GeneIDi11830.
KEGGimmu:11830.
UCSCiuc007xpt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF087654 mRNA. Translation: AAD32491.1 .
AK009302 mRNA. Translation: BAB26203.1 .
CCDSi CCDS27823.1.
RefSeqi NP_033831.1. NM_009701.4.
UniGenei Mm.45580.

3D structure databases

ProteinModelPortali Q9WTY4.
SMRi Q9WTY4. Positions 2-245.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000048739.

PTM databases

PhosphoSitei Q9WTY4.

Proteomic databases

PaxDbi Q9WTY4.
PRIDEi Q9WTY4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000088200 ; ENSMUSP00000085530 ; ENSMUSG00000044217 .
ENSMUST00000169082 ; ENSMUSP00000127611 ; ENSMUSG00000044217 .
GeneIDi 11830.
KEGGi mmu:11830.
UCSCi uc007xpt.1. mouse.

Organism-specific databases

CTDi 362.
MGIi MGI:106215. Aqp5.

Phylogenomic databases

eggNOGi COG0580.
GeneTreei ENSGT00760000119223.
HOGENOMi HOG000288286.
HOVERGENi HBG000312.
InParanoidi Q9WTY4.
KOi K09867.
OMAi MNRFSPS.
OrthoDBi EOG7N8ZWD.
PhylomeDBi Q9WTY4.
TreeFami TF312940.

Miscellaneous databases

NextBioi 279743.
PROi Q9WTY4.
SOURCEi Search...

Gene expression databases

Bgeei Q9WTY4.
CleanExi MM_AQP5.
Genevestigatori Q9WTY4.

Family and domain databases

Gene3Di 1.20.1080.10. 1 hit.
InterProi IPR023271. Aquaporin-like.
IPR023276. Aquaporin_5.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view ]
PANTHERi PTHR19139. PTHR19139. 1 hit.
Pfami PF00230. MIP. 1 hit.
[Graphical view ]
PRINTSi PR02017. AQUAPORIN5.
PR00783. MINTRINSICP.
SUPFAMi SSF81338. SSF81338. 1 hit.
TIGRFAMsi TIGR00861. MIP. 1 hit.
PROSITEi PS00221. MIP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of murine Aqp5: evidence for a conserved aquaporin gene cluster."
    Krane C.M., Towne J.E., Menon A.G.
    Mamm. Genome 10:498-505(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: FEBN.
    Tissue: Lung.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung and Tongue.

Entry informationi

Entry nameiAQP5_MOUSE
AccessioniPrimary (citable) accession number: Q9WTY4
Secondary accession number(s): Q545H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3