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Protein

Aquaporin-5

Gene

Aqp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity (PubMed:16571723). Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723).1 Publication

GO - Molecular functioni

GO - Biological processi

  • camera-type eye morphogenesis Source: MGI
  • carbon dioxide transport Source: MGI
  • cellular water homeostasis Source: GO_Central
  • ion transmembrane transport Source: GO_Central
  • odontogenesis Source: Ensembl
  • pancreatic juice secretion Source: Ensembl
  • saliva secretion Source: MGI
  • water transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-432047. Passive transport by Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-5
Short name:
AQP-5
Gene namesi
Name:Aqp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:106215. Aqp5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212CytoplasmicSequence analysisAdd
BLAST
Transmembranei13 – 3321HelicalSequence analysisAdd
BLAST
Topological domaini34 – 363ExtracellularSequence analysis
Transmembranei37 – 5721HelicalSequence analysisAdd
BLAST
Topological domaini58 – 8730CytoplasmicSequence analysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence analysisAdd
BLAST
Topological domaini109 – 12618ExtracellularSequence analysisAdd
BLAST
Transmembranei127 – 14721HelicalSequence analysisAdd
BLAST
Topological domaini148 – 16114CytoplasmicSequence analysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence analysisAdd
BLAST
Topological domaini183 – 20523ExtracellularSequence analysisAdd
BLAST
Transmembranei206 – 22621HelicalSequence analysisAdd
BLAST
Topological domaini227 – 26539CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • basal plasma membrane Source: MGI
  • endoplasmic reticulum Source: MGI
  • extracellular exosome Source: MGI
  • integral component of plasma membrane Source: MGI
  • microvillus Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Reduced Ca2+ entry and loss of regulatory volume decrease in response to hypotonicity in acinar cells. HTS-stimulated Ca2+ entry is significantly decreased in submandibular gland acini and almost completely abolished in parotid acini.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Aquaporin-5PRO_0000063952Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9WTY4.
PaxDbiQ9WTY4.
PRIDEiQ9WTY4.

PTM databases

iPTMnetiQ9WTY4.
PhosphoSiteiQ9WTY4.

Expressioni

Tissue specificityi

Expressed in salivary glands (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000044217.
CleanExiMM_AQP5.
GenevisibleiQ9WTY4. MM.

Interactioni

Subunit structurei

Interacts with TRPV4; the interaction is probably indirect and regulates TRPV4 activation by hypotonicity.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085530.

Structurei

3D structure databases

ProteinModelPortaliQ9WTY4.
SMRiQ9WTY4. Positions 2-245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi69 – 713NPA 1
Motifi185 – 1873NPA 2

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00760000119223.
HOGENOMiHOG000288286.
HOVERGENiHBG000312.
InParanoidiQ9WTY4.
KOiK09867.
OMAiNISGCHV.
OrthoDBiEOG091G166T.
PhylomeDBiQ9WTY4.
TreeFamiTF312940.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023276. Aquaporin_5.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02017. AQUAPORIN5.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WTY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKEVCSVAF FKAVFAEFLA TLIFVFFGLG SALKWPSALP TILQISIAFG
60 70 80 90 100
LAIGTLAQAL GPVSGGHINP AITLALLIGN QISLLRAIFY VAAQLVGAIA
110 120 130 140 150
GAGILYWLAP GNARGNLAVN ALSNNTTPGK AVVVELILTF QLALCIFSST
160 170 180 190 200
DSRRTSPVGS PALSIGLSVT LGHLVGIYFT GCSMNPARSF GPAVVMNRFS
210 220 230 240 250
PSHWVFWVGP IVGAVLAAIL YFYLLFPSSL SLHDRVAVVK GTYEPEEDWE
260
DHREERKKTI ELTAH
Length:265
Mass (Da):28,274
Last modified:November 1, 1999 - v1
Checksum:i917DF4A0C0A4C620
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087654 mRNA. Translation: AAD32491.1.
AK009302 mRNA. Translation: BAB26203.1.
CCDSiCCDS27823.1.
RefSeqiNP_033831.1. NM_009701.4.
UniGeneiMm.45580.

Genome annotation databases

EnsembliENSMUST00000088200; ENSMUSP00000085530; ENSMUSG00000044217.
ENSMUST00000169082; ENSMUSP00000127611; ENSMUSG00000044217.
GeneIDi11830.
KEGGimmu:11830.
UCSCiuc007xpt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087654 mRNA. Translation: AAD32491.1.
AK009302 mRNA. Translation: BAB26203.1.
CCDSiCCDS27823.1.
RefSeqiNP_033831.1. NM_009701.4.
UniGeneiMm.45580.

3D structure databases

ProteinModelPortaliQ9WTY4.
SMRiQ9WTY4. Positions 2-245.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085530.

PTM databases

iPTMnetiQ9WTY4.
PhosphoSiteiQ9WTY4.

Proteomic databases

MaxQBiQ9WTY4.
PaxDbiQ9WTY4.
PRIDEiQ9WTY4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088200; ENSMUSP00000085530; ENSMUSG00000044217.
ENSMUST00000169082; ENSMUSP00000127611; ENSMUSG00000044217.
GeneIDi11830.
KEGGimmu:11830.
UCSCiuc007xpt.1. mouse.

Organism-specific databases

CTDi362.
MGIiMGI:106215. Aqp5.

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00760000119223.
HOGENOMiHOG000288286.
HOVERGENiHBG000312.
InParanoidiQ9WTY4.
KOiK09867.
OMAiNISGCHV.
OrthoDBiEOG091G166T.
PhylomeDBiQ9WTY4.
TreeFamiTF312940.

Enzyme and pathway databases

ReactomeiR-MMU-432047. Passive transport by Aquaporins.

Miscellaneous databases

PROiQ9WTY4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044217.
CleanExiMM_AQP5.
GenevisibleiQ9WTY4. MM.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023276. Aquaporin_5.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02017. AQUAPORIN5.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAQP5_MOUSE
AccessioniPrimary (citable) accession number: Q9WTY4
Secondary accession number(s): Q545H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.