Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GTP-binding protein REM 2

Gene

Rem2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi122 – 129GTPBy similarity8
Nucleotide bindingi230 – 233GTPBy similarity4
Nucleotide bindingi261 – 262GTPBy similarity2

GO - Molecular functioni

  • GTPase activity Source: RGD
  • GTP binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein REM 2
Alternative name(s):
Rad and Gem-like GTP-binding protein 2
Gene namesi
Name:Rem2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi69081. Rem2.

Subcellular locationi

GO - Cellular componenti

  • intracellular Source: GOC
  • membrane Source: RGD
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224851 – 341GTP-binding protein REM 2Add BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphoserineCombined sources1
Modified residuei296PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9WTY2.
PRIDEiQ9WTY2.

PTM databases

iPTMnetiQ9WTY2.
PhosphoSitePlusiQ9WTY2.

Expressioni

Tissue specificityi

Expressed in brain and kidney.1 Publication

Gene expression databases

BgeeiENSRNOG00000011646.
GenevisibleiQ9WTY2. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016020.

Structurei

Secondary structure

1341
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi115 – 121Combined sources7
Helixi128 – 135Combined sources8
Beta strandi152 – 159Combined sources8
Beta strandi162 – 169Combined sources8
Helixi184 – 188Combined sources5
Beta strandi190 – 197Combined sources8
Helixi201 – 205Combined sources5
Helixi207 – 217Combined sources11
Beta strandi225 – 230Combined sources6
Helixi235 – 237Combined sources3
Helixi242 – 251Combined sources10
Beta strandi255 – 258Combined sources4
Turni261 – 264Combined sources4
Helixi267 – 280Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AIIX-ray2.66A/B113-283[»]
ProteinModelPortaliQ9WTY2.
SMRiQ9WTY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. RGK family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133672.
HOGENOMiHOG000246961.
HOVERGENiHBG104899.
InParanoidiQ9WTY2.
KOiK07848.
OMAiYERRITV.
OrthoDBiEOG091G0OCN.
PhylomeDBiQ9WTY2.
TreeFamiTF314379.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WTY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHTDLDTDMD ADTETVALCS SSSRQASPSG TPTPEADTTL LKQKPEKLLA
60 70 80 90 100
ELDRGGPPPA PGVPRRRGSM PVPYKHQLRR AQAVDELDWP PQASSSGSSD
110 120 130 140 150
SLGSGEAALA QKDGVFKVML LGESGVGKST LAGTFGGLQG DNAHEMENSE
160 170 180 190 200
DTYERRIMVD KEEVTLIVYD IWEQGDAGGW LQDHCLQTGD AFLIVFSVTD
210 220 230 240 250
RRSFSKVPET LLRLRAGRPH HDLPVILVGN KSDLARSREV SLEEGRHLAG
260 270 280 290 300
TLSCKHIETS AALHHNTREL FEGAVRQIRL RRGRGHAGGQ RPEPSSPDGP
310 320 330 340
APPTRRESLT KKAKRFLANL VPRNAKFFKQ RSRSCHDLSV L
Length:341
Mass (Da):37,275
Last modified:March 2, 2010 - v2
Checksum:i4CABA88C1925B97B
GO

Sequence cautioni

The sequence AAD34238 differs from that shown. Reason: Frameshift at position 26.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY916790 mRNA. Translation: AAX13958.1.
AF084464 mRNA. Translation: AAD34238.1. Frameshift.
RefSeqiNP_073176.2. NM_022685.2.
UniGeneiRn.48804.

Genome annotation databases

EnsembliENSRNOT00000016020; ENSRNOP00000016020; ENSRNOG00000011646.
GeneIDi64626.
KEGGirno:64626.
UCSCiRGD:69081. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY916790 mRNA. Translation: AAX13958.1.
AF084464 mRNA. Translation: AAD34238.1. Frameshift.
RefSeqiNP_073176.2. NM_022685.2.
UniGeneiRn.48804.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AIIX-ray2.66A/B113-283[»]
ProteinModelPortaliQ9WTY2.
SMRiQ9WTY2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016020.

PTM databases

iPTMnetiQ9WTY2.
PhosphoSitePlusiQ9WTY2.

Proteomic databases

PaxDbiQ9WTY2.
PRIDEiQ9WTY2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016020; ENSRNOP00000016020; ENSRNOG00000011646.
GeneIDi64626.
KEGGirno:64626.
UCSCiRGD:69081. rat.

Organism-specific databases

CTDi161253.
RGDi69081. Rem2.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133672.
HOGENOMiHOG000246961.
HOVERGENiHBG104899.
InParanoidiQ9WTY2.
KOiK07848.
OMAiYERRITV.
OrthoDBiEOG091G0OCN.
PhylomeDBiQ9WTY2.
TreeFamiTF314379.

Miscellaneous databases

PROiQ9WTY2.

Gene expression databases

BgeeiENSRNOG00000011646.
GenevisibleiQ9WTY2. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiREM2_RAT
AccessioniPrimary (citable) accession number: Q9WTY2
Secondary accession number(s): Q5D202
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 2, 2010
Last modified: November 30, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.