Q9WTY0 (AQP6_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aquaporin-6
Short name=AQP-6

Gene names

Name:

Aqp6

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism.
Subcellular location	Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Tissue specificity	Kidney.
Domain	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence similarities	Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]

Ontologies

Keywords
Biological process	Transport
Cellular component	Cytoplasmic vesicle Membrane
Domain	Repeat Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	water transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW transport vesicle membrane Traceable author statement. Source: Reactome
Molecular function	nitrate transmembrane transporter activity Inferred from mutant phenotype. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Aquaporin-6		PRO_0000063957
Regions
	Topological domain	1 – 27	27	Cytoplasmic Potential
	Transmembrane	28 – 45	18	Helical; Potential
	Topological domain	46 – 51	6	Extracellular Potential
	Transmembrane	52 – 70	19	Helical; Potential
	Topological domain	71 – 96	26	Cytoplasmic Potential
	Transmembrane	97 – 118	22	Helical; Potential
	Topological domain	119 – 138	20	Extracellular Potential
	Transmembrane	139 – 159	21	Helical; Potential
	Topological domain	160 – 165	6	Cytoplasmic Potential
	Transmembrane	166 – 185	20	Helical; Potential
	Topological domain	186 – 211	26	Extracellular Potential
	Transmembrane	212 – 233	22	Helical; Potential
	Topological domain	234 – 276	43	Cytoplasmic Potential
	Motif	79 – 81	3	NPA 1
	Motif	193 – 195	3	NPA 2
Amino acid modifications
	Glycosylation	134	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9WTY0 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: A0B724FF81A4C492	FASTA	276	28,860
	10 20 30 40 50 60 MEPGLCNRAY LLVGGLWTAI SKALFAEFLA TGLYVFFGVG SVLPWPVALP SVLQVAITFN 70 80 90 100 110 120 LATATAVQIS WKTSGAHANP AVTLAYLVGS HISLPRAVAY IAAQLAGATV GAALLYGVTP 130 140 150 160 170 180 GGVRETLGVN VVHNSTSTGQ AVAVELVLTL QLVLCVFASM DSRQTLGSPA AMIGTSVALG 190 200 210 220 230 240 HLIGIYFTGC SMNPARSFGP AVIVGKFAVH WIFWVGPLTG AVLASLIYNF ILFPDTKTVA 250 260 270 QRLAILVGTT KVEKVVDLEP QKKESQTNSE DTEVSV

References

[1]	"Aquaporin-6: an intracellular vesicle water channel protein in renal epithelia." Yasui M., Kwon T.H., Knepper M.A., Nielsen S., Agre P. Proc. Natl. Acad. Sci. U.S.A. 96:5808-5813(1999) [PubMed: 10318966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF083879 mRNA. Translation: AAD29856.1.
IPI	IPI00203480.
RefSeq	NP_071517.1. NM_022181.1.
UniGene	Rn.48667.
3D structure databases
ProteinModelPortal	Q9WTY0.
SMR	Q9WTY0. Positions 20-248.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9WTY0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000000323; ENSRNOP00000000323; ENSRNOG00000000296.
GeneID	29170.
KEGG	rno:29170.
UCSC	NM_022181. rat.
Organism-specific databases
CTD	363.
RGD	71100. Aqp6.
Phylogenomic databases
eggNOG	roNOG16633.
GeneTree	ENSGT00550000074347.
HOVERGEN	HBG000312.
InParanoid	Q9WTY0.
OMA	VHWVFWV.
OrthoDB	EOG4FJ89M.
PhylomeDB	Q9WTY0.
Enzyme and pathway databases
Reactome	REACT_32223. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	Q9WTY0.
Genevestigator	Q9WTY0.
GermOnline	ENSRNOG00000000296. Rattus norvegicus.
Family and domain databases
InterPro	IPR012269. Aquaporin. IPR023271. Aquaporin-like. IPR023254. Aquaporin_6. IPR000425. MIP. IPR022357. MIP_CS. [Graphical view]
Gene3D	G3DSA:1.20.1080.10. MIP. 1 hit.
KO	K09868.
PANTHER	PTHR19139:SF36. Aquaporin_6. 1 hit. PTHR19139. MIP. 1 hit.
Pfam	PF00230. MIP. 1 hit. [Graphical view]
PRINTS	PR02018. AQUAPORIN6. PR00783. MINTRINSICP.
SUPFAM	SSF81338. MIP. 1 hit.
TIGRFAMs	TIGR00861. MIP. 1 hit.
PROSITE	PS00221. MIP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	608228.

Entry information

Entry name

AQP6_RAT

Accession

Primary (citable) accession number: Q9WTY0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	November 1, 1999
Last modified:	November 16, 2011
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program