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Protein

Aquaporin-6

Gene

Aqp6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism.

GO - Molecular functioni

  • anion channel activity Source: Reactome
  • glycerol channel activity Source: GO_Central
  • nitrate transmembrane transporter activity Source: RGD
  • water channel activity Source: GO_Central

GO - Biological processi

  • cellular water homeostasis Source: GO_Central
  • nitrate transport Source: RGD
  • odontogenesis Source: Ensembl
  • water transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-RNO-432047. Passive transport by Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-6
Short name:
AQP-6
Gene namesi
Name:Aqp6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi71100. Aqp6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27CytoplasmicSequence analysisAdd BLAST27
Transmembranei28 – 45HelicalSequence analysisAdd BLAST18
Topological domaini46 – 51ExtracellularSequence analysis6
Transmembranei52 – 70HelicalSequence analysisAdd BLAST19
Topological domaini71 – 96CytoplasmicSequence analysisAdd BLAST26
Transmembranei97 – 118HelicalSequence analysisAdd BLAST22
Topological domaini119 – 138ExtracellularSequence analysisAdd BLAST20
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 165CytoplasmicSequence analysis6
Transmembranei166 – 185HelicalSequence analysisAdd BLAST20
Topological domaini186 – 211ExtracellularSequence analysisAdd BLAST26
Transmembranei212 – 233HelicalSequence analysisAdd BLAST22
Topological domaini234 – 276CytoplasmicSequence analysisAdd BLAST43

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639571 – 276Aquaporin-6Add BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9WTY0.

Expressioni

Tissue specificityi

Kidney.

Gene expression databases

BgeeiENSRNOG00000000296.
GenevisibleiQ9WTY0. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000323.

Structurei

3D structure databases

ProteinModelPortaliQ9WTY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi79 – 81NPA 13
Motifi193 – 195NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00760000119223.
HOGENOMiHOG000288286.
HOVERGENiHBG000312.
InParanoidiQ9WTY0.
KOiK09868.
OMAiNSVSIGQ.
OrthoDBiEOG091G166T.
PhylomeDBiQ9WTY0.
TreeFamiTF312940.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023254. Aquaporin_6.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02018. AQUAPORIN6.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WTY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGLCNRAY LLVGGLWTAI SKALFAEFLA TGLYVFFGVG SVLPWPVALP
60 70 80 90 100
SVLQVAITFN LATATAVQIS WKTSGAHANP AVTLAYLVGS HISLPRAVAY
110 120 130 140 150
IAAQLAGATV GAALLYGVTP GGVRETLGVN VVHNSTSTGQ AVAVELVLTL
160 170 180 190 200
QLVLCVFASM DSRQTLGSPA AMIGTSVALG HLIGIYFTGC SMNPARSFGP
210 220 230 240 250
AVIVGKFAVH WIFWVGPLTG AVLASLIYNF ILFPDTKTVA QRLAILVGTT
260 270
KVEKVVDLEP QKKESQTNSE DTEVSV
Length:276
Mass (Da):28,860
Last modified:November 1, 1999 - v1
Checksum:iA0B724FF81A4C492
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083879 mRNA. Translation: AAD29856.1.
RefSeqiNP_071517.1. NM_022181.1.
UniGeneiRn.48667.

Genome annotation databases

EnsembliENSRNOT00000083570; ENSRNOP00000071627; ENSRNOG00000053181.
GeneIDi29170.
KEGGirno:29170.
UCSCiRGD:71100. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083879 mRNA. Translation: AAD29856.1.
RefSeqiNP_071517.1. NM_022181.1.
UniGeneiRn.48667.

3D structure databases

ProteinModelPortaliQ9WTY0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000323.

Proteomic databases

PaxDbiQ9WTY0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000083570; ENSRNOP00000071627; ENSRNOG00000053181.
GeneIDi29170.
KEGGirno:29170.
UCSCiRGD:71100. rat.

Organism-specific databases

CTDi363.
RGDi71100. Aqp6.

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00760000119223.
HOGENOMiHOG000288286.
HOVERGENiHBG000312.
InParanoidiQ9WTY0.
KOiK09868.
OMAiNSVSIGQ.
OrthoDBiEOG091G166T.
PhylomeDBiQ9WTY0.
TreeFamiTF312940.

Enzyme and pathway databases

ReactomeiR-RNO-432047. Passive transport by Aquaporins.

Miscellaneous databases

PROiQ9WTY0.

Gene expression databases

BgeeiENSRNOG00000000296.
GenevisibleiQ9WTY0. RN.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023254. Aquaporin_6.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02018. AQUAPORIN6.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAQP6_RAT
AccessioniPrimary (citable) accession number: Q9WTY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: November 1, 1999
Last modified: October 5, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.