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Q9WTX7

- FHL5_MOUSE

UniProt

Q9WTX7 - FHL5_MOUSE

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Protein

Four and a half LIM domains protein 5

Gene
Fhl5, Act
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri8 – 3225C4-type Reviewed predictionAdd
BLAST

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. transcription coactivator activity Source: MGI
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  2. transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Four and a half LIM domains protein 5
Short name:
FHL-5
Alternative name(s):
Activator of cAMP-responsive element modulator in testis
Short name:
Activator of CREM in testis
Gene namesi
Name:Fhl5
Synonyms:Act
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1913192. Fhl5.

Subcellular locationi

Nucleus
Note: Nuclei of round and elongated spermatids.1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Four and a half LIM domains protein 5PRO_0000075743Add
BLAST

Proteomic databases

PaxDbiQ9WTX7.
PRIDEiQ9WTX7.

PTM databases

PhosphoSiteiQ9WTX7.

Expressioni

Tissue specificityi

Testis-specific, temporal expression is coordinated with CREM.1 Publication

Gene expression databases

BgeeiQ9WTX7.
CleanExiMM_FHL5.
GenevestigatoriQ9WTX7.

Interactioni

Subunit structurei

Interacts with CREM via the third LIM domain.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Spag8B9EKF15EBI-7530396,EBI-7981981

Protein-protein interaction databases

BioGridi208318. 1 interaction.
IntActiQ9WTX7. 2 interactions.
MINTiMINT-1341882.

Structurei

3D structure databases

ProteinModelPortaliQ9WTX7.
SMRiQ9WTX7. Positions 3-283.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 10062LIM zinc-binding 1Add
BLAST
Domaini101 – 16060LIM zinc-binding 2Add
BLAST
Domaini161 – 22060LIM zinc-binding 3Add
BLAST

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri8 – 3225C4-type Reviewed predictionAdd
BLAST

Keywords - Domaini

LIM domain, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG314122.
GeneTreeiENSGT00740000115334.
HOGENOMiHOG000231075.
HOVERGENiHBG074526.
InParanoidiQ9WTX7.
OMAiYCVSCYD.
OrthoDBiEOG7P8P7M.
PhylomeDBiQ9WTX7.
TreeFamiTF314113.

Family and domain databases

Gene3Di2.10.110.10. 5 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 4 hits.
[Graphical view]
SMARTiSM00132. LIM. 4 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WTX7-1 [UniParc]FASTAAdd to Basket

« Hide

MTSSQFDCQY CTSSLIGKKY VLKDDNLYCI SCYDRIFSNY CEQCKEPIES    50
DSKDLCYKNR HWHEGCFRCN KCHHSLVEKP FVAKDDRLLC TDCYSNECSS 100
KCFHCKRTIM PGSRKMEFKG NYWHETCFVC EHCRQPIGTK PLISKESGNY 150
CVPCFEKEFA HYCNFCKKVI TSGGITFRDQ IWHKECFLCS GCRKELYEEA 200
FMSKDDFPFC LDCYNHLYAK KCAACTKPIT GLRGAKFICF QDRQWHSECF 250
NCGKCSVSLV GEGFLTHNME ILCRKCGSGA DTDA 284
Length:284
Mass (Da):32,907
Last modified:November 1, 1999 - v1
Checksum:i0537543FC0B222E4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF083394 mRNA. Translation: AAD23916.1.
AK006414 mRNA. Translation: BAB24576.1.
BC048473 mRNA. Translation: AAH48473.1.
CCDSiCCDS18009.1.
RefSeqiNP_067293.1. NM_021318.3.
UniGeneiMm.87325.

Genome annotation databases

EnsembliENSMUST00000029922; ENSMUSP00000029922; ENSMUSG00000028259.
ENSMUST00000108204; ENSMUSP00000103839; ENSMUSG00000028259.
GeneIDi57756.
KEGGimmu:57756.
UCSCiuc008sef.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF083394 mRNA. Translation: AAD23916.1 .
AK006414 mRNA. Translation: BAB24576.1 .
BC048473 mRNA. Translation: AAH48473.1 .
CCDSi CCDS18009.1.
RefSeqi NP_067293.1. NM_021318.3.
UniGenei Mm.87325.

3D structure databases

ProteinModelPortali Q9WTX7.
SMRi Q9WTX7. Positions 3-283.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 208318. 1 interaction.
IntActi Q9WTX7. 2 interactions.
MINTi MINT-1341882.

PTM databases

PhosphoSitei Q9WTX7.

Proteomic databases

PaxDbi Q9WTX7.
PRIDEi Q9WTX7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029922 ; ENSMUSP00000029922 ; ENSMUSG00000028259 .
ENSMUST00000108204 ; ENSMUSP00000103839 ; ENSMUSG00000028259 .
GeneIDi 57756.
KEGGi mmu:57756.
UCSCi uc008sef.1. mouse.

Organism-specific databases

CTDi 9457.
MGIi MGI:1913192. Fhl5.

Phylogenomic databases

eggNOGi NOG314122.
GeneTreei ENSGT00740000115334.
HOGENOMi HOG000231075.
HOVERGENi HBG074526.
InParanoidi Q9WTX7.
OMAi YCVSCYD.
OrthoDBi EOG7P8P7M.
PhylomeDBi Q9WTX7.
TreeFami TF314113.

Miscellaneous databases

ChiTaRSi FHL5. mouse.
NextBioi 313924.
PROi Q9WTX7.
SOURCEi Search...

Gene expression databases

Bgeei Q9WTX7.
CleanExi MM_FHL5.
Genevestigatori Q9WTX7.

Family and domain databases

Gene3Di 2.10.110.10. 5 hits.
InterProi IPR001781. Znf_LIM.
[Graphical view ]
Pfami PF00412. LIM. 4 hits.
[Graphical view ]
SMARTi SM00132. LIM. 4 hits.
[Graphical view ]
PROSITEi PS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CBP-independent activation of CREM and CREB by the LIM-only protein ACT."
    Fimia G.M., De Cesare D., Sassone-Corsi P.
    Nature 398:165-169(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH CREM.
    Tissue: Testis.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiFHL5_MOUSE
AccessioniPrimary (citable) accession number: Q9WTX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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