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Q9WTX7

- FHL5_MOUSE

UniProt

Q9WTX7 - FHL5_MOUSE

Protein

Four and a half LIM domains protein 5

Gene

Fhl5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri8 – 3225C4-typeSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. transcription coactivator activity Source: MGI
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    2. transcription, DNA-templated Source: MGI

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Four and a half LIM domains protein 5
    Short name:
    FHL-5
    Alternative name(s):
    Activator of cAMP-responsive element modulator in testis
    Short name:
    Activator of CREM in testis
    Gene namesi
    Name:Fhl5
    Synonyms:Act
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1913192. Fhl5.

    Subcellular locationi

    Nucleus 1 Publication
    Note: Nuclei of round and elongated spermatids.

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 284284Four and a half LIM domains protein 5PRO_0000075743Add
    BLAST

    Proteomic databases

    PaxDbiQ9WTX7.
    PRIDEiQ9WTX7.

    PTM databases

    PhosphoSiteiQ9WTX7.

    Expressioni

    Tissue specificityi

    Testis-specific, temporal expression is coordinated with CREM.1 Publication

    Gene expression databases

    BgeeiQ9WTX7.
    CleanExiMM_FHL5.
    GenevestigatoriQ9WTX7.

    Interactioni

    Subunit structurei

    Interacts with CREM via the third LIM domain.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Spag8B9EKF15EBI-7530396,EBI-7981981

    Protein-protein interaction databases

    BioGridi208318. 1 interaction.
    IntActiQ9WTX7. 2 interactions.
    MINTiMINT-1341882.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WTX7.
    SMRiQ9WTX7. Positions 3-283.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini39 – 10062LIM zinc-binding 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini101 – 16060LIM zinc-binding 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini161 – 22060LIM zinc-binding 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 3 LIM zinc-binding domains.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri8 – 3225C4-typeSequence AnalysisAdd
    BLAST

    Keywords - Domaini

    LIM domain, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG314122.
    GeneTreeiENSGT00740000115334.
    HOGENOMiHOG000231075.
    HOVERGENiHBG074526.
    InParanoidiQ9WTX7.
    OMAiYCVSCYD.
    OrthoDBiEOG7P8P7M.
    PhylomeDBiQ9WTX7.
    TreeFamiTF314113.

    Family and domain databases

    Gene3Di2.10.110.10. 5 hits.
    InterProiIPR001781. Znf_LIM.
    [Graphical view]
    PfamiPF00412. LIM. 4 hits.
    [Graphical view]
    SMARTiSM00132. LIM. 4 hits.
    [Graphical view]
    PROSITEiPS00478. LIM_DOMAIN_1. 4 hits.
    PS50023. LIM_DOMAIN_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9WTX7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSSQFDCQY CTSSLIGKKY VLKDDNLYCI SCYDRIFSNY CEQCKEPIES    50
    DSKDLCYKNR HWHEGCFRCN KCHHSLVEKP FVAKDDRLLC TDCYSNECSS 100
    KCFHCKRTIM PGSRKMEFKG NYWHETCFVC EHCRQPIGTK PLISKESGNY 150
    CVPCFEKEFA HYCNFCKKVI TSGGITFRDQ IWHKECFLCS GCRKELYEEA 200
    FMSKDDFPFC LDCYNHLYAK KCAACTKPIT GLRGAKFICF QDRQWHSECF 250
    NCGKCSVSLV GEGFLTHNME ILCRKCGSGA DTDA 284
    Length:284
    Mass (Da):32,907
    Last modified:November 1, 1999 - v1
    Checksum:i0537543FC0B222E4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF083394 mRNA. Translation: AAD23916.1.
    AK006414 mRNA. Translation: BAB24576.1.
    BC048473 mRNA. Translation: AAH48473.1.
    CCDSiCCDS18009.1.
    RefSeqiNP_067293.1. NM_021318.3.
    UniGeneiMm.87325.

    Genome annotation databases

    EnsembliENSMUST00000029922; ENSMUSP00000029922; ENSMUSG00000028259.
    ENSMUST00000108204; ENSMUSP00000103839; ENSMUSG00000028259.
    GeneIDi57756.
    KEGGimmu:57756.
    UCSCiuc008sef.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF083394 mRNA. Translation: AAD23916.1 .
    AK006414 mRNA. Translation: BAB24576.1 .
    BC048473 mRNA. Translation: AAH48473.1 .
    CCDSi CCDS18009.1.
    RefSeqi NP_067293.1. NM_021318.3.
    UniGenei Mm.87325.

    3D structure databases

    ProteinModelPortali Q9WTX7.
    SMRi Q9WTX7. Positions 3-283.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 208318. 1 interaction.
    IntActi Q9WTX7. 2 interactions.
    MINTi MINT-1341882.

    PTM databases

    PhosphoSitei Q9WTX7.

    Proteomic databases

    PaxDbi Q9WTX7.
    PRIDEi Q9WTX7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029922 ; ENSMUSP00000029922 ; ENSMUSG00000028259 .
    ENSMUST00000108204 ; ENSMUSP00000103839 ; ENSMUSG00000028259 .
    GeneIDi 57756.
    KEGGi mmu:57756.
    UCSCi uc008sef.1. mouse.

    Organism-specific databases

    CTDi 9457.
    MGIi MGI:1913192. Fhl5.

    Phylogenomic databases

    eggNOGi NOG314122.
    GeneTreei ENSGT00740000115334.
    HOGENOMi HOG000231075.
    HOVERGENi HBG074526.
    InParanoidi Q9WTX7.
    OMAi YCVSCYD.
    OrthoDBi EOG7P8P7M.
    PhylomeDBi Q9WTX7.
    TreeFami TF314113.

    Miscellaneous databases

    ChiTaRSi FHL5. mouse.
    NextBioi 313924.
    PROi Q9WTX7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9WTX7.
    CleanExi MM_FHL5.
    Genevestigatori Q9WTX7.

    Family and domain databases

    Gene3Di 2.10.110.10. 5 hits.
    InterProi IPR001781. Znf_LIM.
    [Graphical view ]
    Pfami PF00412. LIM. 4 hits.
    [Graphical view ]
    SMARTi SM00132. LIM. 4 hits.
    [Graphical view ]
    PROSITEi PS00478. LIM_DOMAIN_1. 4 hits.
    PS50023. LIM_DOMAIN_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CBP-independent activation of CREM and CREB by the LIM-only protein ACT."
      Fimia G.M., De Cesare D., Sassone-Corsi P.
      Nature 398:165-169(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH CREM.
      Tissue: Testis.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiFHL5_MOUSE
    AccessioniPrimary (citable) accession number: Q9WTX7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3