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Q9WTX4 (NRG4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pro-neuregulin-4, membrane-bound isoform

Short name=Pro-NRG4

Cleaved into the following chain:

  1. Neuregulin-4
    Short name=NRG-4
Gene names
Name:Nrg4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length115 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors. Ref.1

Subunit structure

Interacts with ERBB4. Ref.1

Subcellular location

Pro-neuregulin-4, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein By similarity. Note: Does not seem to be active By similarity.

Neuregulin-4: Secreted By similarity.

Tissue specificity

Highly expressed in pancreas; weakly expressed in muscle.

Domain

The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization By similarity.

ERBB receptor binding is elicited entirely by the EGF-like domain By similarity.

Post-translational modification

Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form By similarity.

Extensive glycosylation precedes the proteolytic cleavage By similarity.

Sequence similarities

Belongs to the neuregulin family.

Contains 1 EGF-like domain.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
Secreted
   Coding sequence diversityAlternative splicing
   DomainEGF-like domain
Transmembrane
Transmembrane helix
   Molecular functionGrowth factor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: At least 3 isoforms may be produced.
Isoform 1 (identifier: Q9WTX4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 115115Pro-neuregulin-4, membrane-bound isoform
PRO_0000019487
Chain1 – 6161Neuregulin-4
PRO_0000019488

Regions

Topological domain1 – 6262Extracellular Potential
Transmembrane63 – 8321Helical; Note=Internal signal sequence; Potential
Topological domain84 – 11532Cytoplasmic Potential
Domain5 – 4642EGF-like

Amino acid modifications

Glycosylation391N-linked (GlcNAc...) Potential
Glycosylation601N-linked (GlcNAc...) Potential
Disulfide bond9 ↔ 23 By similarity
Disulfide bond17 ↔ 34 By similarity
Disulfide bond36 ↔ 45 By similarity

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 989A1E376F857B49

FASTA11512,744
        10         20         30         40         50         60 
MPTDHEQPCG PRHRSFCLNG GICYVIPTIP SPFCRCIENY TGARCEEVFL PSSSIPSESN 

        70         80         90        100        110 
LSAAFVVLAV LLTLTIAALC FLCRKGHLQR ASSVQCEISL VETNNTRTRH SHREH 

« Hide

References

[1]"Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase."
Harari D., Tzahar E., Romano J., Shelly M., Pierce J.H., Andrews G.C., Yarden Y.
Oncogene 18:2681-2689(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH ERBB4.
Strain: C57BL/6J.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF083067 mRNA. Translation: AAD21874.1.
CCDSCCDS52801.1. [Q9WTX4-1]
RefSeqNP_114391.1. NM_032002.2. [Q9WTX4-1]
XP_006511631.1. XM_006511568.1. [Q9WTX4-1]
XP_006511632.1. XM_006511569.1. [Q9WTX4-1]
XP_006511633.1. XM_006511570.1. [Q9WTX4-1]
UniGeneMm.443874.

3D structure databases

ProteinModelPortalQ9WTX4.
SMRQ9WTX4. Positions 16-46.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000079037.

Proteomic databases

PRIDEQ9WTX4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000130158; ENSMUSP00000115247; ENSMUSG00000032311. [Q9WTX4-1]
ENSMUST00000164721; ENSMUSP00000130929; ENSMUSG00000032311. [Q9WTX4-1]
GeneID83961.
KEGGmmu:83961.
UCSCuc009psf.2. mouse. [Q9WTX4-1]

Organism-specific databases

CTD145957.
MGIMGI:1933833. Nrg4.

Phylogenomic databases

eggNOGNOG42904.
GeneTreeENSGT00390000014815.
HOGENOMHOG000113853.
HOVERGENHBG006533.
InParanoidQ9WTX4.
KOK05458.
OMANGGICYM.
PhylomeDBQ9WTX4.

Gene expression databases

ArrayExpressQ9WTX4.
BgeeQ9WTX4.
CleanExMM_NRG4.
GenevestigatorQ9WTX4.

Family and domain databases

InterProIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
[Graphical view]
SMARTSM00181. EGF. 1 hit.
[Graphical view]
PROSITEPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio350830.
PROQ9WTX4.
SOURCESearch...

Entry information

Entry nameNRG4_MOUSE
AccessionPrimary (citable) accession number: Q9WTX4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot