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Protein

Solute carrier family 23 member 2

Gene

Slc23a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate.

GO - Molecular functioni

  • L-ascorbate:sodium symporter activity Source: RGD
  • L-ascorbic acid transporter activity Source: UniProtKB
  • sodium-dependent L-ascorbate transmembrane transporter activity Source: Ensembl
  • transporter activity Source: RGD

GO - Biological processi

  • L-ascorbic acid metabolic process Source: RGD
  • L-ascorbic acid transport Source: UniProtKB
  • response to oxidative stress Source: RGD
  • transepithelial L-ascorbic acid transport Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-RNO-196836. Vitamin C (ascorbate) metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 23 member 2
Alternative name(s):
Na(+)/L-ascorbic acid transporter 2
Sodium-dependent vitamin C transporter 2
Gene namesi
Name:Slc23a2
Synonyms:Svct2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi619876. Slc23a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini8 – 109CytoplasmicSequence analysisAdd BLAST102
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Topological domaini131 – 138ExtracellularSequence analysis8
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160CytoplasmicSequence analysis1
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 215ExtracellularSequence analysisAdd BLAST34
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
Topological domaini237 – 263CytoplasmicSequence analysisAdd BLAST27
Transmembranei264 – 281HelicalSequence analysisAdd BLAST18
Topological domaini282 – 285ExtracellularSequence analysis4
Intramembranei286 – 299HelicalSequence analysisAdd BLAST14
Topological domaini300 – 306ExtracellularSequence analysis7
Transmembranei307 – 327HelicalSequence analysisAdd BLAST21
Topological domaini328 – 368CytoplasmicSequence analysisAdd BLAST41
Transmembranei369 – 389HelicalSequence analysisAdd BLAST21
Topological domaini390 – 414ExtracellularSequence analysisAdd BLAST25
Transmembranei415 – 435HelicalSequence analysisAdd BLAST21
Topological domaini436 – 458CytoplasmicSequence analysisAdd BLAST23
Transmembranei459 – 479HelicalSequence analysisAdd BLAST21
Topological domaini480 – 482ExtracellularSequence analysis3
Transmembranei483 – 503HelicalSequence analysisAdd BLAST21
Topological domaini504 – 513CytoplasmicSequence analysis10
Transmembranei514 – 534HelicalSequence analysisAdd BLAST21
Topological domaini535 – 544ExtracellularSequence analysis10
Transmembranei545 – 565HelicalSequence analysisAdd BLAST21
Topological domaini566 – 647CytoplasmicSequence analysisAdd BLAST82

GO - Cellular componenti

  • apical plasma membrane Source: Ensembl
  • basal plasma membrane Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • integral component of plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001659801 – 647Solute carrier family 23 member 2Add BLAST647

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69PhosphoserineBy similarity1
Modified residuei74PhosphothreonineCombined sources1
Modified residuei77PhosphoserineBy similarity1
Modified residuei78PhosphothreonineBy similarity1
Modified residuei80PhosphoserineCombined sources1
Glycosylationi187N-linked (GlcNAc...)Sequence analysis1
Glycosylationi195N-linked (GlcNAc...)Sequence analysis1
Modified residuei646PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9WTW8.
PRIDEiQ9WTW8.

PTM databases

iPTMnetiQ9WTW8.
PhosphoSitePlusiQ9WTW8.
SwissPalmiQ9WTW8.

Expressioni

Tissue specificityi

Highly expressed in neural, neuroendocrine, exocrine and endothelial tissues and in osteoblasts. Detected in neurons throughout the central nervous system, in meninges and choroid plexus, in the anterior pituitary, the intermediate lobe, in pancreas, adrenal cortex, gastric glands, and in the inner nuclear layer of the retina.

Gene expression databases

BgeeiENSRNOG00000021262.
GenevisibleiQ9WTW8. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028885.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1292. Eukaryota.
COG2233. LUCA.
GeneTreeiENSGT00390000015686.
HOGENOMiHOG000038201.
HOVERGENiHBG056256.
InParanoidiQ9WTW8.
KOiK14611.
OMAiIGMEGLM.
OrthoDBiEOG091G063Y.
PhylomeDBiQ9WTW8.
TreeFamiTF313272.

Family and domain databases

InterProiIPR029956. SlC23A2.
IPR006042. Xan_ur_permease.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PTHR11119:SF33. PTHR11119:SF33. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
PROSITEiPS01116. XANTH_URACIL_PERMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WTW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGVGKNTSK SVEVGGSTEG KYEEEAKRPD FFTLPVVING GATSSGEQDN
60 70 80 90 100
EDTELMAIYT TENGIAEKSS LAETLDSTGS LDPQRSDMIY TIEDVPPWYL
110 120 130 140 150
CIFLGLQHYL TCFSGTIAVP FLLADAMCVG DDQWATSQLI GTIFFCVGIT
160 170 180 190 200
TLLQTTFGCR LPLFQASAFA FLAPARAILS LDKWKCNTTE ITVANGTAEL
210 220 230 240 250
LEHIWHPRIQ EIQGAIIMSS LIEVVIGLLG LPGALLRYIG PLTITPTVAL
260 270 280 290 300
IGLSGFQAAG ERAGKHWGIA MLTIFLVLLF SQYARNVKFP LPIYKSKKGW
310 320 330 340 350
TAYKLQLFKM FPIILAILVS WLLCFIFTVT DVFPSNSTDY GYYARTDARK
360 370 380 390 400
GVLLVAPWFK VPYPFQWGMP TVSAAGVIGM LSAVVASIIE SIGDYYACAR
410 420 430 440 450
LSCAPPPPIH AINRGIFVEG LSCVLDGVFG TGNGSTSSSP NIGVLGITKV
460 470 480 490 500
GSRRVIQYGA ALMLGLGMIG KFSALFASLP DPVLGALFCT LFGMITAVGL
510 520 530 540 550
SNLQFIDLNS SRNLFVLGFS IFFGLVLPSY LRQNPLVTGI TGIDQVLNVL
560 570 580 590 600
LTTAMFVGGC VAFILDNTIP GTPEERGIKK WKKGVSKGNK SLDGMESYNL
610 620 630 640
PFGMNIIKKY RCFSYLPISP TFAGYTWKGF GKSENRRSSD KDSQATV
Length:647
Mass (Da):70,070
Last modified:September 22, 2009 - v2
Checksum:i623AF185769F135E
GO

Sequence cautioni

The sequence AAD30368 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080453 mRNA. Translation: AAD30368.1. Different initiation.
RefSeqiNP_059012.2. NM_017316.2.
XP_006235129.1. XM_006235067.3.
XP_006235130.1. XM_006235068.3.
UniGeneiRn.11963.

Genome annotation databases

EnsembliENSRNOT00000028885; ENSRNOP00000028885; ENSRNOG00000021262.
GeneIDi50622.
KEGGirno:50622.
UCSCiRGD:619876. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080453 mRNA. Translation: AAD30368.1. Different initiation.
RefSeqiNP_059012.2. NM_017316.2.
XP_006235129.1. XM_006235067.3.
XP_006235130.1. XM_006235068.3.
UniGeneiRn.11963.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028885.

PTM databases

iPTMnetiQ9WTW8.
PhosphoSitePlusiQ9WTW8.
SwissPalmiQ9WTW8.

Proteomic databases

PaxDbiQ9WTW8.
PRIDEiQ9WTW8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028885; ENSRNOP00000028885; ENSRNOG00000021262.
GeneIDi50622.
KEGGirno:50622.
UCSCiRGD:619876. rat.

Organism-specific databases

CTDi9962.
RGDi619876. Slc23a2.

Phylogenomic databases

eggNOGiKOG1292. Eukaryota.
COG2233. LUCA.
GeneTreeiENSGT00390000015686.
HOGENOMiHOG000038201.
HOVERGENiHBG056256.
InParanoidiQ9WTW8.
KOiK14611.
OMAiIGMEGLM.
OrthoDBiEOG091G063Y.
PhylomeDBiQ9WTW8.
TreeFamiTF313272.

Enzyme and pathway databases

ReactomeiR-RNO-196836. Vitamin C (ascorbate) metabolism.

Miscellaneous databases

PROiQ9WTW8.

Gene expression databases

BgeeiENSRNOG00000021262.
GenevisibleiQ9WTW8. RN.

Family and domain databases

InterProiIPR029956. SlC23A2.
IPR006042. Xan_ur_permease.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PTHR11119:SF33. PTHR11119:SF33. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
PROSITEiPS01116. XANTH_URACIL_PERMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS23A2_RAT
AccessioniPrimary (citable) accession number: Q9WTW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: September 22, 2009
Last modified: November 2, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.