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Protein

Solute carrier family 23 member 2

Gene

Slc23a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate.

GO - Molecular functioni

  • L-ascorbate:sodium symporter activity Source: RGD
  • L-ascorbic acid transporter activity Source: UniProtKB
  • sodium-dependent L-ascorbate transmembrane transporter activity Source: Ensembl
  • transporter activity Source: RGD

GO - Biological processi

  • carboxylic acid transmembrane transport Source: GOC
  • L-ascorbic acid metabolic process Source: RGD
  • L-ascorbic acid transport Source: UniProtKB
  • response to oxidative stress Source: RGD
  • transepithelial L-ascorbic acid transport Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-RNO-196836. Vitamin C (ascorbate) metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 23 member 2
Alternative name(s):
Na(+)/L-ascorbic acid transporter 2
Sodium-dependent vitamin C transporter 2
Gene namesi
Name:Slc23a2
Synonyms:Svct2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi619876. Slc23a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini8 – 109102CytoplasmicSequence analysisAdd
BLAST
Transmembranei110 – 13021HelicalSequence analysisAdd
BLAST
Topological domaini131 – 1388ExtracellularSequence analysis
Transmembranei139 – 15921HelicalSequence analysisAdd
BLAST
Topological domaini160 – 1601CytoplasmicSequence analysis
Transmembranei161 – 18121HelicalSequence analysisAdd
BLAST
Topological domaini182 – 21534ExtracellularSequence analysisAdd
BLAST
Transmembranei216 – 23621HelicalSequence analysisAdd
BLAST
Topological domaini237 – 26327CytoplasmicSequence analysisAdd
BLAST
Transmembranei264 – 28118HelicalSequence analysisAdd
BLAST
Topological domaini282 – 2854ExtracellularSequence analysis
Intramembranei286 – 29914HelicalSequence analysisAdd
BLAST
Topological domaini300 – 3067ExtracellularSequence analysis
Transmembranei307 – 32721HelicalSequence analysisAdd
BLAST
Topological domaini328 – 36841CytoplasmicSequence analysisAdd
BLAST
Transmembranei369 – 38921HelicalSequence analysisAdd
BLAST
Topological domaini390 – 41425ExtracellularSequence analysisAdd
BLAST
Transmembranei415 – 43521HelicalSequence analysisAdd
BLAST
Topological domaini436 – 45823CytoplasmicSequence analysisAdd
BLAST
Transmembranei459 – 47921HelicalSequence analysisAdd
BLAST
Topological domaini480 – 4823ExtracellularSequence analysis
Transmembranei483 – 50321HelicalSequence analysisAdd
BLAST
Topological domaini504 – 51310CytoplasmicSequence analysis
Transmembranei514 – 53421HelicalSequence analysisAdd
BLAST
Topological domaini535 – 54410ExtracellularSequence analysis
Transmembranei545 – 56521HelicalSequence analysisAdd
BLAST
Topological domaini566 – 64782CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: Ensembl
  • basal plasma membrane Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • integral component of plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 647647Solute carrier family 23 member 2PRO_0000165980Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei69 – 691PhosphoserineBy similarity
Modified residuei74 – 741PhosphothreonineCombined sources
Modified residuei77 – 771PhosphoserineBy similarity
Modified residuei78 – 781PhosphothreonineBy similarity
Modified residuei80 – 801PhosphoserineCombined sources
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence analysis
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence analysis
Modified residuei646 – 6461PhosphothreonineBy similarity

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9WTW8.
PRIDEiQ9WTW8.

PTM databases

iPTMnetiQ9WTW8.
SwissPalmiQ9WTW8.

Expressioni

Tissue specificityi

Highly expressed in neural, neuroendocrine, exocrine and endothelial tissues and in osteoblasts. Detected in neurons throughout the central nervous system, in meninges and choroid plexus, in the anterior pituitary, the intermediate lobe, in pancreas, adrenal cortex, gastric glands, and in the inner nuclear layer of the retina.

Gene expression databases

GenevisibleiQ9WTW8. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028885.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1292. Eukaryota.
COG2233. LUCA.
GeneTreeiENSGT00390000015686.
HOGENOMiHOG000038201.
HOVERGENiHBG056256.
InParanoidiQ9WTW8.
KOiK14611.
OMAiPSEKRIN.
OrthoDBiEOG7R56RZ.
PhylomeDBiQ9WTW8.
TreeFamiTF313272.

Family and domain databases

InterProiIPR029956. SlC23A2.
IPR006042. Xan_ur_permease.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PTHR11119:SF33. PTHR11119:SF33. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
PROSITEiPS01116. XANTH_URACIL_PERMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WTW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGVGKNTSK SVEVGGSTEG KYEEEAKRPD FFTLPVVING GATSSGEQDN
60 70 80 90 100
EDTELMAIYT TENGIAEKSS LAETLDSTGS LDPQRSDMIY TIEDVPPWYL
110 120 130 140 150
CIFLGLQHYL TCFSGTIAVP FLLADAMCVG DDQWATSQLI GTIFFCVGIT
160 170 180 190 200
TLLQTTFGCR LPLFQASAFA FLAPARAILS LDKWKCNTTE ITVANGTAEL
210 220 230 240 250
LEHIWHPRIQ EIQGAIIMSS LIEVVIGLLG LPGALLRYIG PLTITPTVAL
260 270 280 290 300
IGLSGFQAAG ERAGKHWGIA MLTIFLVLLF SQYARNVKFP LPIYKSKKGW
310 320 330 340 350
TAYKLQLFKM FPIILAILVS WLLCFIFTVT DVFPSNSTDY GYYARTDARK
360 370 380 390 400
GVLLVAPWFK VPYPFQWGMP TVSAAGVIGM LSAVVASIIE SIGDYYACAR
410 420 430 440 450
LSCAPPPPIH AINRGIFVEG LSCVLDGVFG TGNGSTSSSP NIGVLGITKV
460 470 480 490 500
GSRRVIQYGA ALMLGLGMIG KFSALFASLP DPVLGALFCT LFGMITAVGL
510 520 530 540 550
SNLQFIDLNS SRNLFVLGFS IFFGLVLPSY LRQNPLVTGI TGIDQVLNVL
560 570 580 590 600
LTTAMFVGGC VAFILDNTIP GTPEERGIKK WKKGVSKGNK SLDGMESYNL
610 620 630 640
PFGMNIIKKY RCFSYLPISP TFAGYTWKGF GKSENRRSSD KDSQATV
Length:647
Mass (Da):70,070
Last modified:September 22, 2009 - v2
Checksum:i623AF185769F135E
GO

Sequence cautioni

The sequence AAD30368.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080453 mRNA. Translation: AAD30368.1. Different initiation.
RefSeqiNP_059012.2. NM_017316.2.
XP_006235129.1. XM_006235067.2.
XP_006235130.1. XM_006235068.2.
UniGeneiRn.11963.

Genome annotation databases

EnsembliENSRNOT00000028885; ENSRNOP00000028885; ENSRNOG00000021262.
GeneIDi50622.
KEGGirno:50622.
UCSCiRGD:619876. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080453 mRNA. Translation: AAD30368.1. Different initiation.
RefSeqiNP_059012.2. NM_017316.2.
XP_006235129.1. XM_006235067.2.
XP_006235130.1. XM_006235068.2.
UniGeneiRn.11963.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028885.

PTM databases

iPTMnetiQ9WTW8.
SwissPalmiQ9WTW8.

Proteomic databases

PaxDbiQ9WTW8.
PRIDEiQ9WTW8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028885; ENSRNOP00000028885; ENSRNOG00000021262.
GeneIDi50622.
KEGGirno:50622.
UCSCiRGD:619876. rat.

Organism-specific databases

CTDi9962.
RGDi619876. Slc23a2.

Phylogenomic databases

eggNOGiKOG1292. Eukaryota.
COG2233. LUCA.
GeneTreeiENSGT00390000015686.
HOGENOMiHOG000038201.
HOVERGENiHBG056256.
InParanoidiQ9WTW8.
KOiK14611.
OMAiPSEKRIN.
OrthoDBiEOG7R56RZ.
PhylomeDBiQ9WTW8.
TreeFamiTF313272.

Enzyme and pathway databases

ReactomeiR-RNO-196836. Vitamin C (ascorbate) metabolism.

Miscellaneous databases

NextBioi610450.
PROiQ9WTW8.

Gene expression databases

GenevisibleiQ9WTW8. RN.

Family and domain databases

InterProiIPR029956. SlC23A2.
IPR006042. Xan_ur_permease.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PTHR11119:SF33. PTHR11119:SF33. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
PROSITEiPS01116. XANTH_URACIL_PERMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A family of mammalian Na+-dependent L-ascorbic acid transporters."
    Tsukaguchi H., Tokui T., Mackenzie B., Berger U.V., Chen X.-Z., Wang Y., Brubaker R.F., Hediger M.A.
    Nature 399:70-75(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-74 AND SER-80, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS23A2_RAT
AccessioniPrimary (citable) accession number: Q9WTW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: September 22, 2009
Last modified: May 11, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.