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Protein

Solute carrier family 23 member 1

Gene

Slc23a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-RNO-196836. Vitamin C (ascorbate) metabolism.

Protein family/group databases

TCDBi2.A.40.6.1. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 23 member 1
Alternative name(s):
Na(+)/L-ascorbic acid transporter 1
Sodium-dependent vitamin C transporter 1
Gene namesi
Name:Slc23a1
Synonyms:Svct1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi619875. Slc23a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 59CytoplasmicSequence analysisAdd BLAST59
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 88ExtracellularSequence analysis8
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110CytoplasmicSequence analysis1
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 166ExtracellularSequence analysisAdd BLAST35
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 214CytoplasmicSequence analysisAdd BLAST27
Transmembranei215 – 232HelicalSequence analysisAdd BLAST18
Topological domaini233 – 236ExtracellularSequence analysis4
Intramembranei237 – 250HelicalSequence analysisAdd BLAST14
Topological domaini251 – 257ExtracellularSequence analysis7
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Topological domaini279 – 319CytoplasmicSequence analysisAdd BLAST41
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Topological domaini341 – 365ExtracellularSequence analysisAdd BLAST25
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Topological domaini387 – 409CytoplasmicSequence analysisAdd BLAST23
Transmembranei410 – 430HelicalSequence analysisAdd BLAST21
Topological domaini431 – 433ExtracellularSequence analysis3
Transmembranei434 – 454HelicalSequence analysisAdd BLAST21
Topological domaini455 – 464CytoplasmicSequence analysis10
Transmembranei465 – 485HelicalSequence analysisAdd BLAST21
Topological domaini486 – 497ExtracellularSequence analysisAdd BLAST12
Transmembranei498 – 518HelicalSequence analysisAdd BLAST21
Topological domaini519 – 604CytoplasmicSequence analysisAdd BLAST86

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • basal plasma membrane Source: UniProtKB
  • brush border Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • integral component of plasma membrane Source: RGD
  • intracellular organelle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001659771 – 604Solute carrier family 23 member 1Add BLAST604

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi145N-linked (GlcNAc...)Sequence analysis1
Glycosylationi151N-linked (GlcNAc...)Sequence analysis1
Modified residuei597PhosphothreonineBy similarity1
Modified residuei599PhosphoserineBy similarity1
Modified residuei602PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9WTW7.
PRIDEiQ9WTW7.

PTM databases

iPTMnetiQ9WTW7.
PhosphoSitePlusiQ9WTW7.

Expressioni

Tissue specificityi

Highly expressed in the straight segment of proximal tubules in the kidney, in intestine and liver. Detected in epithelial cells of the bronchiole and epididymis.

Gene expression databases

BgeeiENSRNOG00000019938.
GenevisibleiQ9WTW7. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027048.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1292. Eukaryota.
COG2233. LUCA.
GeneTreeiENSGT00390000015686.
HOGENOMiHOG000038201.
HOVERGENiHBG056256.
InParanoidiQ9WTW7.
KOiK14611.
PhylomeDBiQ9WTW7.
TreeFamiTF313272.

Family and domain databases

InterProiIPR029954. SLC23A1.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PTHR11119:SF21. PTHR11119:SF21. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WTW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAQEDPGSS KQHECPDSAG TSTRDQQAPL PAEPKFDMLY KIEDVPPWYL
60 70 80 90 100
CILLGFQHYL TCFSGTIAVP FLLAEALCVG RDQHMISQLI GTIFTCVGIT
110 120 130 140 150
TLIQTTVGIR LPLFQASAFA FLVPAKAILA LERWKCPPEE EIYGNWSMPL
160 170 180 190 200
NTSHIWHPRI REVQGAIMVS SVVEVVIGLL GLPGALLSYI GPLTVTPTVS
210 220 230 240 250
LIGLSVFQAA GDRAGSHWGI SACSILLIVL FSQYLRNLTF LLPVYRWGKG
260 270 280 290 300
LTLFRIQIFK MFPIVLAIMT VWLLCYVLTL TDVLPADPTV YGFQARTDAR
310 320 330 340 350
GDIMAISPWI RIPYPCQWGL PTVTVAAVLG MFSATLAGII ESIGDYYACA
360 370 380 390 400
RLAGAPPPPV HAINRGIFTE GVCCIIAGLL GTGNGSTSSS PNIGVLGITK
410 420 430 440 450
VGSRRVVQYG AGIMLILGAI GKFTALFASL PDPILGGMFC TLFGMITAVG
460 470 480 490 500
LSNLQFVDMN SSRNLFVLGF SMFFGLTLPN YLDSNPGAIN TGVPEVDQIL
510 520 530 540 550
TVLLTTEMFV GGCLAFILDN TVPGSPEERG LIQWKAGAHA NSETLASLKS
560 570 580 590 600
YDFPFGMGMV KRTTFFRYIP ICPVFRGFSK TENQPAVLED APDNTETGSV

CTKV
Length:604
Mass (Da):65,263
Last modified:November 1, 1999 - v1
Checksum:iC436A68100B713FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080452 mRNA. Translation: AAD30367.1.
BC078851 mRNA. Translation: AAH78851.1.
RefSeqiNP_059011.1. NM_017315.2.
UniGeneiRn.144579.

Genome annotation databases

EnsembliENSRNOT00000084372; ENSRNOP00000072205; ENSRNOG00000061695.
GeneIDi50621.
KEGGirno:50621.
UCSCiRGD:619875. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080452 mRNA. Translation: AAD30367.1.
BC078851 mRNA. Translation: AAH78851.1.
RefSeqiNP_059011.1. NM_017315.2.
UniGeneiRn.144579.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027048.

Protein family/group databases

TCDBi2.A.40.6.1. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

PTM databases

iPTMnetiQ9WTW7.
PhosphoSitePlusiQ9WTW7.

Proteomic databases

PaxDbiQ9WTW7.
PRIDEiQ9WTW7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000084372; ENSRNOP00000072205; ENSRNOG00000061695.
GeneIDi50621.
KEGGirno:50621.
UCSCiRGD:619875. rat.

Organism-specific databases

CTDi9963.
RGDi619875. Slc23a1.

Phylogenomic databases

eggNOGiKOG1292. Eukaryota.
COG2233. LUCA.
GeneTreeiENSGT00390000015686.
HOGENOMiHOG000038201.
HOVERGENiHBG056256.
InParanoidiQ9WTW7.
KOiK14611.
PhylomeDBiQ9WTW7.
TreeFamiTF313272.

Enzyme and pathway databases

ReactomeiR-RNO-196836. Vitamin C (ascorbate) metabolism.

Miscellaneous databases

PROiQ9WTW7.

Gene expression databases

BgeeiENSRNOG00000019938.
GenevisibleiQ9WTW7. RN.

Family and domain databases

InterProiIPR029954. SLC23A1.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PTHR11119:SF21. PTHR11119:SF21. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS23A1_RAT
AccessioniPrimary (citable) accession number: Q9WTW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.