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Protein

Solute carrier family 23 member 1

Gene

Slc23a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-RNO-196836. Vitamin C (ascorbate) metabolism.

Protein family/group databases

TCDBi2.A.40.6.1. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 23 member 1
Alternative name(s):
Na(+)/L-ascorbic acid transporter 1
Sodium-dependent vitamin C transporter 1
Gene namesi
Name:Slc23a1
Synonyms:Svct1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi619875. Slc23a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5959CytoplasmicSequence analysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence analysisAdd
BLAST
Topological domaini81 – 888ExtracellularSequence analysis
Transmembranei89 – 10921HelicalSequence analysisAdd
BLAST
Topological domaini110 – 1101CytoplasmicSequence analysis
Transmembranei111 – 13121HelicalSequence analysisAdd
BLAST
Topological domaini132 – 16635ExtracellularSequence analysisAdd
BLAST
Transmembranei167 – 18721HelicalSequence analysisAdd
BLAST
Topological domaini188 – 21427CytoplasmicSequence analysisAdd
BLAST
Transmembranei215 – 23218HelicalSequence analysisAdd
BLAST
Topological domaini233 – 2364ExtracellularSequence analysis
Intramembranei237 – 25014HelicalSequence analysisAdd
BLAST
Topological domaini251 – 2577ExtracellularSequence analysis
Transmembranei258 – 27821HelicalSequence analysisAdd
BLAST
Topological domaini279 – 31941CytoplasmicSequence analysisAdd
BLAST
Transmembranei320 – 34021HelicalSequence analysisAdd
BLAST
Topological domaini341 – 36525ExtracellularSequence analysisAdd
BLAST
Transmembranei366 – 38621HelicalSequence analysisAdd
BLAST
Topological domaini387 – 40923CytoplasmicSequence analysisAdd
BLAST
Transmembranei410 – 43021HelicalSequence analysisAdd
BLAST
Topological domaini431 – 4333ExtracellularSequence analysis
Transmembranei434 – 45421HelicalSequence analysisAdd
BLAST
Topological domaini455 – 46410CytoplasmicSequence analysis
Transmembranei465 – 48521HelicalSequence analysisAdd
BLAST
Topological domaini486 – 49712ExtracellularSequence analysisAdd
BLAST
Transmembranei498 – 51821HelicalSequence analysisAdd
BLAST
Topological domaini519 – 60486CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • basal plasma membrane Source: UniProtKB
  • brush border Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • integral component of plasma membrane Source: RGD
  • intracellular organelle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 604604Solute carrier family 23 member 1PRO_0000165977Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence analysis
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence analysis
Modified residuei597 – 5971PhosphothreonineBy similarity
Modified residuei599 – 5991PhosphoserineBy similarity
Modified residuei602 – 6021PhosphothreonineBy similarity

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9WTW7.
PRIDEiQ9WTW7.

Expressioni

Tissue specificityi

Highly expressed in the straight segment of proximal tubules in the kidney, in intestine and liver. Detected in epithelial cells of the bronchiole and epididymis.

Gene expression databases

GenevisibleiQ9WTW7. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027048.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1292. Eukaryota.
COG2233. LUCA.
GeneTreeiENSGT00390000015686.
HOGENOMiHOG000038201.
HOVERGENiHBG056256.
InParanoidiQ9WTW7.
KOiK14611.
OMAiAHDKAKV.
OrthoDBiEOG7R56RZ.
PhylomeDBiQ9WTW7.
TreeFamiTF313272.

Family and domain databases

InterProiIPR029954. SLC23A1.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PTHR11119:SF21. PTHR11119:SF21. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WTW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAQEDPGSS KQHECPDSAG TSTRDQQAPL PAEPKFDMLY KIEDVPPWYL
60 70 80 90 100
CILLGFQHYL TCFSGTIAVP FLLAEALCVG RDQHMISQLI GTIFTCVGIT
110 120 130 140 150
TLIQTTVGIR LPLFQASAFA FLVPAKAILA LERWKCPPEE EIYGNWSMPL
160 170 180 190 200
NTSHIWHPRI REVQGAIMVS SVVEVVIGLL GLPGALLSYI GPLTVTPTVS
210 220 230 240 250
LIGLSVFQAA GDRAGSHWGI SACSILLIVL FSQYLRNLTF LLPVYRWGKG
260 270 280 290 300
LTLFRIQIFK MFPIVLAIMT VWLLCYVLTL TDVLPADPTV YGFQARTDAR
310 320 330 340 350
GDIMAISPWI RIPYPCQWGL PTVTVAAVLG MFSATLAGII ESIGDYYACA
360 370 380 390 400
RLAGAPPPPV HAINRGIFTE GVCCIIAGLL GTGNGSTSSS PNIGVLGITK
410 420 430 440 450
VGSRRVVQYG AGIMLILGAI GKFTALFASL PDPILGGMFC TLFGMITAVG
460 470 480 490 500
LSNLQFVDMN SSRNLFVLGF SMFFGLTLPN YLDSNPGAIN TGVPEVDQIL
510 520 530 540 550
TVLLTTEMFV GGCLAFILDN TVPGSPEERG LIQWKAGAHA NSETLASLKS
560 570 580 590 600
YDFPFGMGMV KRTTFFRYIP ICPVFRGFSK TENQPAVLED APDNTETGSV

CTKV
Length:604
Mass (Da):65,263
Last modified:November 1, 1999 - v1
Checksum:iC436A68100B713FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080452 mRNA. Translation: AAD30367.1.
BC078851 mRNA. Translation: AAH78851.1.
RefSeqiNP_059011.1. NM_017315.2.
UniGeneiRn.144579.

Genome annotation databases

EnsembliENSRNOT00000084372; ENSRNOP00000072205; ENSRNOG00000061695.
GeneIDi50621.
KEGGirno:50621.
UCSCiRGD:619875. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080452 mRNA. Translation: AAD30367.1.
BC078851 mRNA. Translation: AAH78851.1.
RefSeqiNP_059011.1. NM_017315.2.
UniGeneiRn.144579.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027048.

Protein family/group databases

TCDBi2.A.40.6.1. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

Proteomic databases

PaxDbiQ9WTW7.
PRIDEiQ9WTW7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000084372; ENSRNOP00000072205; ENSRNOG00000061695.
GeneIDi50621.
KEGGirno:50621.
UCSCiRGD:619875. rat.

Organism-specific databases

CTDi9963.
RGDi619875. Slc23a1.

Phylogenomic databases

eggNOGiKOG1292. Eukaryota.
COG2233. LUCA.
GeneTreeiENSGT00390000015686.
HOGENOMiHOG000038201.
HOVERGENiHBG056256.
InParanoidiQ9WTW7.
KOiK14611.
OMAiAHDKAKV.
OrthoDBiEOG7R56RZ.
PhylomeDBiQ9WTW7.
TreeFamiTF313272.

Enzyme and pathway databases

ReactomeiR-RNO-196836. Vitamin C (ascorbate) metabolism.

Miscellaneous databases

NextBioi610446.
PROiQ9WTW7.

Gene expression databases

GenevisibleiQ9WTW7. RN.

Family and domain databases

InterProiIPR029954. SLC23A1.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PTHR11119:SF21. PTHR11119:SF21. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A family of mammalian Na+-dependent L-ascorbic acid transporters."
    Tsukaguchi H., Tokui T., Mackenzie B., Berger U.V., Chen X.-Z., Wang Y., Brubaker R.F., Hediger M.A.
    Nature 399:70-75(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiS23A1_RAT
AccessioniPrimary (citable) accession number: Q9WTW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.