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Q9WTW5

- S22A3_MOUSE

UniProt

Q9WTW5 - S22A3_MOUSE

Protein

Solute carrier family 22 member 3

Gene

Slc22a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.1 PublicationCurated

    GO - Molecular functioni

    1. dopamine transmembrane transporter activity Source: Ensembl
    2. organic cation transmembrane transporter activity Source: MGI
    3. quaternary ammonium group transmembrane transporter activity Source: MGI
    4. toxin transporter activity Source: Ensembl

    GO - Biological processi

    1. dopamine transport Source: Ensembl
    2. histamine transport Source: MGI
    3. histamine uptake Source: MGI
    4. monoamine transport Source: MGI
    5. organic cation transport Source: MGI
    6. quaternary ammonium group transport Source: MGI
    7. regulation of appetite Source: MGI

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_196555. Abacavir transmembrane transport.
    REACT_198610. Organic cation transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 22 member 3
    Alternative name(s):
    Organic cation transporter 3
    Gene namesi
    Name:Slc22a3
    Synonyms:Oct3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1333817. Slc22a3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 551551Solute carrier family 22 member 3PRO_0000220504Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9WTW5.
    PRIDEiQ9WTW5.

    PTM databases

    PhosphoSiteiQ9WTW5.

    Expressioni

    Tissue specificityi

    Highly expressed in placenta and in kidney cortex, but not in medulla. Low levels found in brain. In the kidney, expressed specifically in the proximal and distal convoluted tubules and within Bowman capsule, but not in the glomerulus.2 PublicationsCurated

    Developmental stagei

    Levels are high during gestation, but decrease greatly towards the end of gestation.1 PublicationCurated

    Gene expression databases

    ArrayExpressiQ9WTW5.
    BgeeiQ9WTW5.
    GenevestigatoriQ9WTW5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WTW5.
    SMRiQ9WTW5. Positions 157-530.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei177 – 19721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei236 – 25621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei264 – 28421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei376 – 39621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei464 – 48421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei493 – 51321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00730000110561.
    HOGENOMiHOG000234568.
    HOVERGENiHBG061545.
    InParanoidiQ9WTW5.
    KOiK08200.
    OMAiWCRGPSA.
    OrthoDBiEOG78PV8N.
    PhylomeDBiQ9WTW5.
    TreeFamiTF315847.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004749. Orgcat_transp.
    IPR005828. Sub_transporter.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00898. 2A0119. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9WTW5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPTFDQALRK AGEFGRFQRR VFLLLCLTGV TFAFLFVGVV FLGSQPDYYW    50
    CRGPRATALA ERCAWSPEEE WNLTTPELHV PAERRGQGHC HRYLLEATNT 100
    SSELSCDPLT AFPNRSAPLV SCSGDWRYVE THSTIVSQFD LVCSNAWMLD 150
    LTQAILNLGF LAGAFTLGYA ADRYGRLIIY LISCFGVGIT GVVVAFAPNF 200
    SVFVIFRFLQ GVFGKGAWMT CFVIVTEIVG SKQRRIVGIV IQMFFTLGII 250
    ILPGIAYFTP SWQGIQLAIS LPSFLFLLYY WVVPESPRWL ITRKQGEKAL 300
    QILRRVAKCN GKHLSSNYSE ITVTDEEVSN PSCLDLVRTP QMRKCTLILM 350
    FAWFTSAVVY QGLVMRLGLI GGNLYIDFFI SGLVELPGAL LILLTIERLG 400
    RRLPFAASNI VAGVSCLVTA FLPEGIPWLR TTVATLGRLG ITMAFEIVYL 450
    VNSELYPTTL RNFGVSLCSG LCDFGGIIAP FLLFRLAAIW LELPLIIFGI 500
    LASVCGGLVM LLPETKGIAL PETVEDVEKL GSSQLHQCGR KKKTQVSTSD 550
    V 551
    Length:551
    Mass (Da):61,053
    Last modified:November 1, 1999 - v1
    Checksum:iC4D66AAC2EFCFBDB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF078750 mRNA. Translation: AAD20978.1.
    AF078748 Genomic DNA. Translation: AAD20238.1.
    AF082566 mRNA. Translation: AAD53007.1.
    CCDSiCCDS28391.1.
    RefSeqiNP_035525.1. NM_011395.2.
    UniGeneiMm.99252.

    Genome annotation databases

    EnsembliENSMUST00000024595; ENSMUSP00000024595; ENSMUSG00000023828.
    GeneIDi20519.
    KEGGimmu:20519.
    UCSCiuc008aku.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF078750 mRNA. Translation: AAD20978.1 .
    AF078748 Genomic DNA. Translation: AAD20238.1 .
    AF082566 mRNA. Translation: AAD53007.1 .
    CCDSi CCDS28391.1.
    RefSeqi NP_035525.1. NM_011395.2.
    UniGenei Mm.99252.

    3D structure databases

    ProteinModelPortali Q9WTW5.
    SMRi Q9WTW5. Positions 157-530.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL2073684.

    PTM databases

    PhosphoSitei Q9WTW5.

    Proteomic databases

    PaxDbi Q9WTW5.
    PRIDEi Q9WTW5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000024595 ; ENSMUSP00000024595 ; ENSMUSG00000023828 .
    GeneIDi 20519.
    KEGGi mmu:20519.
    UCSCi uc008aku.1. mouse.

    Organism-specific databases

    CTDi 6581.
    MGIi MGI:1333817. Slc22a3.

    Phylogenomic databases

    eggNOGi COG0477.
    GeneTreei ENSGT00730000110561.
    HOGENOMi HOG000234568.
    HOVERGENi HBG061545.
    InParanoidi Q9WTW5.
    KOi K08200.
    OMAi WCRGPSA.
    OrthoDBi EOG78PV8N.
    PhylomeDBi Q9WTW5.
    TreeFami TF315847.

    Enzyme and pathway databases

    Reactomei REACT_196555. Abacavir transmembrane transport.
    REACT_198610. Organic cation transport.

    Miscellaneous databases

    ChiTaRSi SLC22A3. mouse.
    NextBioi 298739.
    PROi Q9WTW5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9WTW5.
    Bgeei Q9WTW5.
    Genevestigatori Q9WTW5.

    Family and domain databases

    InterProi IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004749. Orgcat_transp.
    IPR005828. Sub_transporter.
    IPR005829. Sugar_transporter_CS.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    TIGRFAMsi TIGR00898. 2A0119. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27."
      Verhaagh S., Schweifer N., Barlow D.P., Zwart R.
      Genomics 55:209-218(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: CD-1.
      Tissue: Placenta.
    2. "Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney."
      Wu X., Huang W., Ganapathy M.E., Wang H., Kekuda R., Conway S.J., Leibach F.H., Ganapathy V.
      Am. J. Physiol. 279:F449-F458(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE, FUNCTION, TISSUE SPECIFICITY.
      Tissue: Kidney.

    Entry informationi

    Entry nameiS22A3_MOUSE
    AccessioniPrimary (citable) accession number: Q9WTW5
    Secondary accession number(s): Q9R209
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3