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Q9WTW5

- S22A3_MOUSE

UniProt

Q9WTW5 - S22A3_MOUSE

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Protein
Solute carrier family 22 member 3
Gene
Slc22a3, Oct3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.1 Publication

GO - Molecular functioni

  1. dopamine transmembrane transporter activity Source: Ensembl
  2. organic cation transmembrane transporter activity Source: MGI
  3. quaternary ammonium group transmembrane transporter activity Source: MGI
  4. toxin transporter activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. dopamine transport Source: Ensembl
  2. histamine transport Source: MGI
  3. histamine uptake Source: MGI
  4. monoamine transport Source: MGI
  5. organic cation transport Source: MGI
  6. quaternary ammonium group transport Source: MGI
  7. regulation of appetite Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_196555. Abacavir transmembrane transport.
REACT_198610. Organic cation transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 3
Alternative name(s):
Organic cation transporter 3
Gene namesi
Name:Slc22a3
Synonyms:Oct3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1333817. Slc22a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121Helical; Reviewed prediction
Add
BLAST
Transmembranei177 – 19721Helical; Reviewed prediction
Add
BLAST
Transmembranei236 – 25621Helical; Reviewed prediction
Add
BLAST
Transmembranei264 – 28421Helical; Reviewed prediction
Add
BLAST
Transmembranei376 – 39621Helical; Reviewed prediction
Add
BLAST
Transmembranei464 – 48421Helical; Reviewed prediction
Add
BLAST
Transmembranei493 – 51321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Solute carrier family 22 member 3
PRO_0000220504Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi99 – 991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi114 – 1141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi199 – 1991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi317 – 3171N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9WTW5.
PRIDEiQ9WTW5.

PTM databases

PhosphoSiteiQ9WTW5.

Expressioni

Tissue specificityi

Highly expressed in placenta and in kidney cortex, but not in medulla. Low levels found in brain. In the kidney, expressed specifically in the proximal and distal convoluted tubules and within Bowman capsule, but not in the glomerulus.2 Publications

Developmental stagei

Levels are high during gestation, but decrease greatly towards the end of gestation.1 Publication

Gene expression databases

ArrayExpressiQ9WTW5.
BgeeiQ9WTW5.
GenevestigatoriQ9WTW5.

Structurei

3D structure databases

ProteinModelPortaliQ9WTW5.
SMRiQ9WTW5. Positions 157-530.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00730000110561.
HOGENOMiHOG000234568.
HOVERGENiHBG061545.
InParanoidiQ9WTW5.
KOiK08200.
OMAiWCRGPSA.
OrthoDBiEOG78PV8N.
PhylomeDBiQ9WTW5.
TreeFamiTF315847.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WTW5-1 [UniParc]FASTAAdd to Basket

« Hide

MPTFDQALRK AGEFGRFQRR VFLLLCLTGV TFAFLFVGVV FLGSQPDYYW    50
CRGPRATALA ERCAWSPEEE WNLTTPELHV PAERRGQGHC HRYLLEATNT 100
SSELSCDPLT AFPNRSAPLV SCSGDWRYVE THSTIVSQFD LVCSNAWMLD 150
LTQAILNLGF LAGAFTLGYA ADRYGRLIIY LISCFGVGIT GVVVAFAPNF 200
SVFVIFRFLQ GVFGKGAWMT CFVIVTEIVG SKQRRIVGIV IQMFFTLGII 250
ILPGIAYFTP SWQGIQLAIS LPSFLFLLYY WVVPESPRWL ITRKQGEKAL 300
QILRRVAKCN GKHLSSNYSE ITVTDEEVSN PSCLDLVRTP QMRKCTLILM 350
FAWFTSAVVY QGLVMRLGLI GGNLYIDFFI SGLVELPGAL LILLTIERLG 400
RRLPFAASNI VAGVSCLVTA FLPEGIPWLR TTVATLGRLG ITMAFEIVYL 450
VNSELYPTTL RNFGVSLCSG LCDFGGIIAP FLLFRLAAIW LELPLIIFGI 500
LASVCGGLVM LLPETKGIAL PETVEDVEKL GSSQLHQCGR KKKTQVSTSD 550
V 551
Length:551
Mass (Da):61,053
Last modified:November 1, 1999 - v1
Checksum:iC4D66AAC2EFCFBDB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF078750 mRNA. Translation: AAD20978.1.
AF078748 Genomic DNA. Translation: AAD20238.1.
AF082566 mRNA. Translation: AAD53007.1.
CCDSiCCDS28391.1.
RefSeqiNP_035525.1. NM_011395.2.
UniGeneiMm.99252.

Genome annotation databases

EnsembliENSMUST00000024595; ENSMUSP00000024595; ENSMUSG00000023828.
GeneIDi20519.
KEGGimmu:20519.
UCSCiuc008aku.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF078750 mRNA. Translation: AAD20978.1 .
AF078748 Genomic DNA. Translation: AAD20238.1 .
AF082566 mRNA. Translation: AAD53007.1 .
CCDSi CCDS28391.1.
RefSeqi NP_035525.1. NM_011395.2.
UniGenei Mm.99252.

3D structure databases

ProteinModelPortali Q9WTW5.
SMRi Q9WTW5. Positions 157-530.
ModBasei Search...

Chemistry

ChEMBLi CHEMBL2073684.

PTM databases

PhosphoSitei Q9WTW5.

Proteomic databases

PaxDbi Q9WTW5.
PRIDEi Q9WTW5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000024595 ; ENSMUSP00000024595 ; ENSMUSG00000023828 .
GeneIDi 20519.
KEGGi mmu:20519.
UCSCi uc008aku.1. mouse.

Organism-specific databases

CTDi 6581.
MGIi MGI:1333817. Slc22a3.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00730000110561.
HOGENOMi HOG000234568.
HOVERGENi HBG061545.
InParanoidi Q9WTW5.
KOi K08200.
OMAi WCRGPSA.
OrthoDBi EOG78PV8N.
PhylomeDBi Q9WTW5.
TreeFami TF315847.

Enzyme and pathway databases

Reactomei REACT_196555. Abacavir transmembrane transport.
REACT_198610. Organic cation transport.

Miscellaneous databases

ChiTaRSi SLC22A3. mouse.
NextBioi 298739.
PROi Q9WTW5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9WTW5.
Bgeei Q9WTW5.
Genevestigatori Q9WTW5.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
TIGRFAMsi TIGR00898. 2A0119. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27."
    Verhaagh S., Schweifer N., Barlow D.P., Zwart R.
    Genomics 55:209-218(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: CD-1.
    Tissue: Placenta.
  2. "Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney."
    Wu X., Huang W., Ganapathy M.E., Wang H., Kekuda R., Conway S.J., Leibach F.H., Ganapathy V.
    Am. J. Physiol. 279:F449-F458(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE, FUNCTION, TISSUE SPECIFICITY.
    Tissue: Kidney.

Entry informationi

Entry nameiS22A3_MOUSE
AccessioniPrimary (citable) accession number: Q9WTW5
Secondary accession number(s): Q9R209
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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