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Protein

Solute carrier family 22 member 3

Gene

Slc22a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.Curated1 Publication

GO - Molecular functioni

  1. dopamine transmembrane transporter activity Source: Ensembl
  2. organic cation transmembrane transporter activity Source: MGI
  3. quaternary ammonium group transmembrane transporter activity Source: MGI
  4. toxin transporter activity Source: Ensembl

GO - Biological processi

  1. dopamine transport Source: Ensembl
  2. histamine transport Source: MGI
  3. histamine uptake Source: MGI
  4. monoamine transport Source: MGI
  5. organic cation transport Source: MGI
  6. quaternary ammonium group transport Source: MGI
  7. regulation of appetite Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_196555. Abacavir transmembrane transport.
REACT_198610. Organic cation transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 3
Alternative name(s):
Organic cation transporter 3
Gene namesi
Name:Slc22a3
Synonyms:Oct3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1333817. Slc22a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121HelicalSequence AnalysisAdd
BLAST
Transmembranei177 – 19721HelicalSequence AnalysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence AnalysisAdd
BLAST
Transmembranei264 – 28421HelicalSequence AnalysisAdd
BLAST
Transmembranei376 – 39621HelicalSequence AnalysisAdd
BLAST
Transmembranei464 – 48421HelicalSequence AnalysisAdd
BLAST
Transmembranei493 – 51321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Solute carrier family 22 member 3PRO_0000220504Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9WTW5.
PRIDEiQ9WTW5.

PTM databases

PhosphoSiteiQ9WTW5.

Expressioni

Tissue specificityi

Highly expressed in placenta and in kidney cortex, but not in medulla. Low levels found in brain. In the kidney, expressed specifically in the proximal and distal convoluted tubules and within Bowman capsule, but not in the glomerulus.Curated2 Publications

Developmental stagei

Levels are high during gestation, but decrease greatly towards the end of gestation.Curated1 Publication

Gene expression databases

BgeeiQ9WTW5.
ExpressionAtlasiQ9WTW5. baseline and differential.
GenevestigatoriQ9WTW5.

Structurei

3D structure databases

ProteinModelPortaliQ9WTW5.
SMRiQ9WTW5. Positions 148-530.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234568.
HOVERGENiHBG061545.
InParanoidiQ9WTW5.
KOiK08200.
OMAiWCRGPSA.
OrthoDBiEOG78PV8N.
PhylomeDBiQ9WTW5.
TreeFamiTF315847.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WTW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTFDQALRK AGEFGRFQRR VFLLLCLTGV TFAFLFVGVV FLGSQPDYYW
60 70 80 90 100
CRGPRATALA ERCAWSPEEE WNLTTPELHV PAERRGQGHC HRYLLEATNT
110 120 130 140 150
SSELSCDPLT AFPNRSAPLV SCSGDWRYVE THSTIVSQFD LVCSNAWMLD
160 170 180 190 200
LTQAILNLGF LAGAFTLGYA ADRYGRLIIY LISCFGVGIT GVVVAFAPNF
210 220 230 240 250
SVFVIFRFLQ GVFGKGAWMT CFVIVTEIVG SKQRRIVGIV IQMFFTLGII
260 270 280 290 300
ILPGIAYFTP SWQGIQLAIS LPSFLFLLYY WVVPESPRWL ITRKQGEKAL
310 320 330 340 350
QILRRVAKCN GKHLSSNYSE ITVTDEEVSN PSCLDLVRTP QMRKCTLILM
360 370 380 390 400
FAWFTSAVVY QGLVMRLGLI GGNLYIDFFI SGLVELPGAL LILLTIERLG
410 420 430 440 450
RRLPFAASNI VAGVSCLVTA FLPEGIPWLR TTVATLGRLG ITMAFEIVYL
460 470 480 490 500
VNSELYPTTL RNFGVSLCSG LCDFGGIIAP FLLFRLAAIW LELPLIIFGI
510 520 530 540 550
LASVCGGLVM LLPETKGIAL PETVEDVEKL GSSQLHQCGR KKKTQVSTSD

V
Length:551
Mass (Da):61,053
Last modified:November 1, 1999 - v1
Checksum:iC4D66AAC2EFCFBDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078750 mRNA. Translation: AAD20978.1.
AF078748 Genomic DNA. Translation: AAD20238.1.
AF082566 mRNA. Translation: AAD53007.1.
CCDSiCCDS28391.1.
RefSeqiNP_035525.1. NM_011395.2.
UniGeneiMm.99252.

Genome annotation databases

EnsembliENSMUST00000024595; ENSMUSP00000024595; ENSMUSG00000023828.
GeneIDi20519.
KEGGimmu:20519.
UCSCiuc008aku.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078750 mRNA. Translation: AAD20978.1.
AF078748 Genomic DNA. Translation: AAD20238.1.
AF082566 mRNA. Translation: AAD53007.1.
CCDSiCCDS28391.1.
RefSeqiNP_035525.1. NM_011395.2.
UniGeneiMm.99252.

3D structure databases

ProteinModelPortaliQ9WTW5.
SMRiQ9WTW5. Positions 148-530.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

ChEMBLiCHEMBL2073684.

PTM databases

PhosphoSiteiQ9WTW5.

Proteomic databases

PaxDbiQ9WTW5.
PRIDEiQ9WTW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024595; ENSMUSP00000024595; ENSMUSG00000023828.
GeneIDi20519.
KEGGimmu:20519.
UCSCiuc008aku.1. mouse.

Organism-specific databases

CTDi6581.
MGIiMGI:1333817. Slc22a3.

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234568.
HOVERGENiHBG061545.
InParanoidiQ9WTW5.
KOiK08200.
OMAiWCRGPSA.
OrthoDBiEOG78PV8N.
PhylomeDBiQ9WTW5.
TreeFamiTF315847.

Enzyme and pathway databases

ReactomeiREACT_196555. Abacavir transmembrane transport.
REACT_198610. Organic cation transport.

Miscellaneous databases

ChiTaRSiSlc22a3. mouse.
NextBioi298739.
PROiQ9WTW5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WTW5.
ExpressionAtlasiQ9WTW5. baseline and differential.
GenevestigatoriQ9WTW5.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27."
    Verhaagh S., Schweifer N., Barlow D.P., Zwart R.
    Genomics 55:209-218(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: CD-1.
    Tissue: Placenta.
  2. "Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney."
    Wu X., Huang W., Ganapathy M.E., Wang H., Kekuda R., Conway S.J., Leibach F.H., Ganapathy V.
    Am. J. Physiol. 279:F449-F458(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE, FUNCTION, TISSUE SPECIFICITY.
    Tissue: Kidney.

Entry informationi

Entry nameiS22A3_MOUSE
AccessioniPrimary (citable) accession number: Q9WTW5
Secondary accession number(s): Q9R209
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1999
Last modified: January 7, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.