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Q9WTW5 (S22A3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 22 member 3
Alternative name(s):
Organic cation transporter 3
Gene names
Name:Slc22a3
Synonyms:Oct3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length551 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain. Ref.2

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Highly expressed in placenta and in kidney cortex, but not in medulla. Low levels found in brain. In the kidney, expressed specifically in the proximal and distal convoluted tubules and within Bowman capsule, but not in the glomerulus. Ref.1 Ref.2

Developmental stage

Levels are high during gestation, but decrease greatly towards the end of gestation. Ref.1

Sequence similarities

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 551551Solute carrier family 22 member 3
PRO_0000220504

Regions

Transmembrane21 – 4121Helical; Potential
Transmembrane177 – 19721Helical; Potential
Transmembrane236 – 25621Helical; Potential
Transmembrane264 – 28421Helical; Potential
Transmembrane376 – 39621Helical; Potential
Transmembrane464 – 48421Helical; Potential
Transmembrane493 – 51321Helical; Potential

Amino acid modifications

Glycosylation721N-linked (GlcNAc...) Potential
Glycosylation991N-linked (GlcNAc...) Potential
Glycosylation1141N-linked (GlcNAc...) Potential
Glycosylation1991N-linked (GlcNAc...) Potential
Glycosylation3171N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9WTW5 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: C4D66AAC2EFCFBDB

FASTA55161,053
        10         20         30         40         50         60 
MPTFDQALRK AGEFGRFQRR VFLLLCLTGV TFAFLFVGVV FLGSQPDYYW CRGPRATALA 

        70         80         90        100        110        120 
ERCAWSPEEE WNLTTPELHV PAERRGQGHC HRYLLEATNT SSELSCDPLT AFPNRSAPLV 

       130        140        150        160        170        180 
SCSGDWRYVE THSTIVSQFD LVCSNAWMLD LTQAILNLGF LAGAFTLGYA ADRYGRLIIY 

       190        200        210        220        230        240 
LISCFGVGIT GVVVAFAPNF SVFVIFRFLQ GVFGKGAWMT CFVIVTEIVG SKQRRIVGIV 

       250        260        270        280        290        300 
IQMFFTLGII ILPGIAYFTP SWQGIQLAIS LPSFLFLLYY WVVPESPRWL ITRKQGEKAL 

       310        320        330        340        350        360 
QILRRVAKCN GKHLSSNYSE ITVTDEEVSN PSCLDLVRTP QMRKCTLILM FAWFTSAVVY 

       370        380        390        400        410        420 
QGLVMRLGLI GGNLYIDFFI SGLVELPGAL LILLTIERLG RRLPFAASNI VAGVSCLVTA 

       430        440        450        460        470        480 
FLPEGIPWLR TTVATLGRLG ITMAFEIVYL VNSELYPTTL RNFGVSLCSG LCDFGGIIAP 

       490        500        510        520        530        540 
FLLFRLAAIW LELPLIIFGI LASVCGGLVM LLPETKGIAL PETVEDVEKL GSSQLHQCGR 

       550 
KKKTQVSTSD V 

« Hide

References

[1]"Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27."
Verhaagh S., Schweifer N., Barlow D.P., Zwart R.
Genomics 55:209-218(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Strain: CD-1.
Tissue: Placenta.
[2]"Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney."
Wu X., Huang W., Ganapathy M.E., Wang H., Kekuda R., Conway S.J., Leibach F.H., Ganapathy V.
Am. J. Physiol. 279:F449-F458(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE, FUNCTION, TISSUE SPECIFICITY.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF078750 mRNA. Translation: AAD20978.1.
AF078748 Genomic DNA. Translation: AAD20238.1.
AF082566 mRNA. Translation: AAD53007.1.
RefSeqNP_035525.1. NM_011395.2.
UniGeneMm.99252.

3D structure databases

ProteinModelPortalQ9WTW5.
SMRQ9WTW5. Positions 158-530.
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL2073684.

PTM databases

PhosphoSiteQ9WTW5.

Proteomic databases

PaxDbQ9WTW5.
PRIDEQ9WTW5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000024595; ENSMUSP00000024595; ENSMUSG00000023828.
GeneID20519.
KEGGmmu:20519.
UCSCuc008aku.1. mouse.

Organism-specific databases

CTD6581.
MGIMGI:1333817. Slc22a3.

Phylogenomic databases

eggNOGCOG0477.
GeneTreeENSGT00730000110561.
HOGENOMHOG000234568.
HOVERGENHBG061545.
InParanoidQ9WTW5.
KOK08200.
OMAWCRGPSA.
OrthoDBEOG78PV8N.
PhylomeDBQ9WTW5.
TreeFamTF315847.

Gene expression databases

ArrayExpressQ9WTW5.
BgeeQ9WTW5.
GenevestigatorQ9WTW5.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 1 hit.
TIGRFAMsTIGR00898. 2A0119. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC22A3. mouse.
NextBio298739.
PROQ9WTW5.
SOURCESearch...

Entry information

Entry nameS22A3_MOUSE
AccessionPrimary (citable) accession number: Q9WTW5
Secondary accession number(s): Q9R209
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot