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Q9WTW5

- S22A3_MOUSE

UniProt

Q9WTW5 - S22A3_MOUSE

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Protein

Solute carrier family 22 member 3

Gene

Slc22a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.1 PublicationCurated

GO - Molecular functioni

  1. dopamine transmembrane transporter activity Source: Ensembl
  2. organic cation transmembrane transporter activity Source: MGI
  3. quaternary ammonium group transmembrane transporter activity Source: MGI
  4. toxin transporter activity Source: Ensembl

GO - Biological processi

  1. dopamine transport Source: Ensembl
  2. histamine transport Source: MGI
  3. histamine uptake Source: MGI
  4. monoamine transport Source: MGI
  5. organic cation transport Source: MGI
  6. quaternary ammonium group transport Source: MGI
  7. regulation of appetite Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_196555. Abacavir transmembrane transport.
REACT_198610. Organic cation transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 3
Alternative name(s):
Organic cation transporter 3
Gene namesi
Name:Slc22a3
Synonyms:Oct3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1333817. Slc22a3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Solute carrier family 22 member 3PRO_0000220504Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9WTW5.
PRIDEiQ9WTW5.

PTM databases

PhosphoSiteiQ9WTW5.

Expressioni

Tissue specificityi

Highly expressed in placenta and in kidney cortex, but not in medulla. Low levels found in brain. In the kidney, expressed specifically in the proximal and distal convoluted tubules and within Bowman capsule, but not in the glomerulus.2 PublicationsCurated

Developmental stagei

Levels are high during gestation, but decrease greatly towards the end of gestation.1 PublicationCurated

Gene expression databases

BgeeiQ9WTW5.
ExpressionAtlasiQ9WTW5. baseline and differential.
GenevestigatoriQ9WTW5.

Structurei

3D structure databases

ProteinModelPortaliQ9WTW5.
SMRiQ9WTW5. Positions 148-530.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121HelicalSequence AnalysisAdd
BLAST
Transmembranei177 – 19721HelicalSequence AnalysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence AnalysisAdd
BLAST
Transmembranei264 – 28421HelicalSequence AnalysisAdd
BLAST
Transmembranei376 – 39621HelicalSequence AnalysisAdd
BLAST
Transmembranei464 – 48421HelicalSequence AnalysisAdd
BLAST
Transmembranei493 – 51321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234568.
HOVERGENiHBG061545.
InParanoidiQ9WTW5.
KOiK08200.
OMAiWCRGPSA.
OrthoDBiEOG78PV8N.
PhylomeDBiQ9WTW5.
TreeFamiTF315847.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WTW5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPTFDQALRK AGEFGRFQRR VFLLLCLTGV TFAFLFVGVV FLGSQPDYYW
60 70 80 90 100
CRGPRATALA ERCAWSPEEE WNLTTPELHV PAERRGQGHC HRYLLEATNT
110 120 130 140 150
SSELSCDPLT AFPNRSAPLV SCSGDWRYVE THSTIVSQFD LVCSNAWMLD
160 170 180 190 200
LTQAILNLGF LAGAFTLGYA ADRYGRLIIY LISCFGVGIT GVVVAFAPNF
210 220 230 240 250
SVFVIFRFLQ GVFGKGAWMT CFVIVTEIVG SKQRRIVGIV IQMFFTLGII
260 270 280 290 300
ILPGIAYFTP SWQGIQLAIS LPSFLFLLYY WVVPESPRWL ITRKQGEKAL
310 320 330 340 350
QILRRVAKCN GKHLSSNYSE ITVTDEEVSN PSCLDLVRTP QMRKCTLILM
360 370 380 390 400
FAWFTSAVVY QGLVMRLGLI GGNLYIDFFI SGLVELPGAL LILLTIERLG
410 420 430 440 450
RRLPFAASNI VAGVSCLVTA FLPEGIPWLR TTVATLGRLG ITMAFEIVYL
460 470 480 490 500
VNSELYPTTL RNFGVSLCSG LCDFGGIIAP FLLFRLAAIW LELPLIIFGI
510 520 530 540 550
LASVCGGLVM LLPETKGIAL PETVEDVEKL GSSQLHQCGR KKKTQVSTSD

V
Length:551
Mass (Da):61,053
Last modified:November 1, 1999 - v1
Checksum:iC4D66AAC2EFCFBDB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF078750 mRNA. Translation: AAD20978.1.
AF078748 Genomic DNA. Translation: AAD20238.1.
AF082566 mRNA. Translation: AAD53007.1.
CCDSiCCDS28391.1.
RefSeqiNP_035525.1. NM_011395.2.
UniGeneiMm.99252.

Genome annotation databases

EnsembliENSMUST00000024595; ENSMUSP00000024595; ENSMUSG00000023828.
GeneIDi20519.
KEGGimmu:20519.
UCSCiuc008aku.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF078750 mRNA. Translation: AAD20978.1 .
AF078748 Genomic DNA. Translation: AAD20238.1 .
AF082566 mRNA. Translation: AAD53007.1 .
CCDSi CCDS28391.1.
RefSeqi NP_035525.1. NM_011395.2.
UniGenei Mm.99252.

3D structure databases

ProteinModelPortali Q9WTW5.
SMRi Q9WTW5. Positions 148-530.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2073684.

PTM databases

PhosphoSitei Q9WTW5.

Proteomic databases

PaxDbi Q9WTW5.
PRIDEi Q9WTW5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000024595 ; ENSMUSP00000024595 ; ENSMUSG00000023828 .
GeneIDi 20519.
KEGGi mmu:20519.
UCSCi uc008aku.1. mouse.

Organism-specific databases

CTDi 6581.
MGIi MGI:1333817. Slc22a3.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00760000118852.
HOGENOMi HOG000234568.
HOVERGENi HBG061545.
InParanoidi Q9WTW5.
KOi K08200.
OMAi WCRGPSA.
OrthoDBi EOG78PV8N.
PhylomeDBi Q9WTW5.
TreeFami TF315847.

Enzyme and pathway databases

Reactomei REACT_196555. Abacavir transmembrane transport.
REACT_198610. Organic cation transport.

Miscellaneous databases

ChiTaRSi SLC22A3. mouse.
NextBioi 298739.
PROi Q9WTW5.
SOURCEi Search...

Gene expression databases

Bgeei Q9WTW5.
ExpressionAtlasi Q9WTW5. baseline and differential.
Genevestigatori Q9WTW5.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
TIGRFAMsi TIGR00898. 2A0119. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27."
    Verhaagh S., Schweifer N., Barlow D.P., Zwart R.
    Genomics 55:209-218(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: CD-1.
    Tissue: Placenta.
  2. "Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney."
    Wu X., Huang W., Ganapathy M.E., Wang H., Kekuda R., Conway S.J., Leibach F.H., Ganapathy V.
    Am. J. Physiol. 279:F449-F458(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE, FUNCTION, TISSUE SPECIFICITY.
    Tissue: Kidney.

Entry informationi

Entry nameiS22A3_MOUSE
AccessioniPrimary (citable) accession number: Q9WTW5
Secondary accession number(s): Q9R209
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3