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Q9WTW3

- KCNE4_MOUSE

UniProt

Q9WTW3 - KCNE4_MOUSE

Protein

Potassium voltage-gated channel subfamily E member 4

Gene

Kcne4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNQ1/KVLTQ1 inhibits potassium current By similarity.By similarity

    GO - Molecular functioni

    1. potassium channel activity Source: MGI
    2. voltage-gated potassium channel activity Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Protein family/group databases

    TCDBi8.A.10.4.1. the slow voltage-gated k+) channel accessory protein (mink) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily E member 4
    Alternative name(s):
    MinK-related peptide 3
    Minimum potassium ion channel-related peptide 3
    Potassium channel subunit beta MiRP3
    Gene namesi
    Name:Kcne4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1891125. Kcne4.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. voltage-gated potassium channel complex Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 170170Potassium voltage-gated channel subfamily E member 4PRO_0000144293Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9WTW3.

    Expressioni

    Gene expression databases

    BgeeiQ9WTW3.
    GenevestigatoriQ9WTW3.

    Interactioni

    Subunit structurei

    Associates with KCNQ1/KVLQT1.Curated

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WTW3.
    SMRiQ9WTW3. Positions 4-87.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini57 – 170114CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the potassium channel KCNE family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42046.
    GeneTreeiENSGT00390000013776.
    HOGENOMiHOG000237340.
    HOVERGENiHBG052229.
    InParanoidiQ9WTW3.
    KOiK04898.
    OMAiLWGEAMK.
    OrthoDBiEOG74XS89.
    PhylomeDBiQ9WTW3.
    TreeFamiTF333025.

    Family and domain databases

    InterProiIPR000369. K_chnl_volt-dep_bsu_KCNE.
    [Graphical view]
    PfamiPF02060. ISK_Channel. 1 hit.
    [Graphical view]
    PRINTSiPR00168. KCNECHANNEL.

    Sequencei

    Sequence statusi: Complete.

    Q9WTW3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRMEPLNST YPSAAASSSP LESHVPSNSS GNGNEYFYIL VVMSFYGVFL    50
    IGIMLGYMKS KRREKKSSLL LLYKDEERLW GEAMKPLPMM SGLRSGQVPM 100
    MLNMLQESVA PALSCTLCSM EGDSVSSESS SPDVHLPIQE EGADDELEET 150
    SETPLNDSSE GSSENIHQNS 170
    Length:170
    Mass (Da):18,639
    Last modified:November 1, 1999 - v1
    Checksum:i3B6B9D73EAE351CA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF076533 mRNA. Translation: AAD28091.1.
    BC032920 mRNA. Translation: AAH32920.1.
    CCDSiCCDS15088.1.
    RefSeqiNP_067317.1. NM_021342.1.
    UniGeneiMm.24386.

    Genome annotation databases

    EnsembliENSMUST00000057262; ENSMUSP00000055415; ENSMUSG00000047330.
    GeneIDi57814.
    KEGGimmu:57814.
    UCSCiuc007bqq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF076533 mRNA. Translation: AAD28091.1 .
    BC032920 mRNA. Translation: AAH32920.1 .
    CCDSi CCDS15088.1.
    RefSeqi NP_067317.1. NM_021342.1.
    UniGenei Mm.24386.

    3D structure databases

    ProteinModelPortali Q9WTW3.
    SMRi Q9WTW3. Positions 4-87.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 8.A.10.4.1. the slow voltage-gated k+) channel accessory protein (mink) family.

    Proteomic databases

    PRIDEi Q9WTW3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000057262 ; ENSMUSP00000055415 ; ENSMUSG00000047330 .
    GeneIDi 57814.
    KEGGi mmu:57814.
    UCSCi uc007bqq.1. mouse.

    Organism-specific databases

    CTDi 23704.
    MGIi MGI:1891125. Kcne4.

    Phylogenomic databases

    eggNOGi NOG42046.
    GeneTreei ENSGT00390000013776.
    HOGENOMi HOG000237340.
    HOVERGENi HBG052229.
    InParanoidi Q9WTW3.
    KOi K04898.
    OMAi LWGEAMK.
    OrthoDBi EOG74XS89.
    PhylomeDBi Q9WTW3.
    TreeFami TF333025.

    Miscellaneous databases

    NextBioi 314002.
    PROi Q9WTW3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9WTW3.
    Genevestigatori Q9WTW3.

    Family and domain databases

    InterProi IPR000369. K_chnl_volt-dep_bsu_KCNE.
    [Graphical view ]
    Pfami PF02060. ISK_Channel. 1 hit.
    [Graphical view ]
    PRINTSi PR00168. KCNECHANNEL.
    ProtoNeti Search...

    Publicationsi

    1. Abbott G.W., Sesti F., Buck M.E., Goldstein S.A.N.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Thymus.

    Entry informationi

    Entry nameiKCNE4_MOUSE
    AccessioniPrimary (citable) accession number: Q9WTW3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3