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Q9WTW3 (KCNE4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily E member 4
Alternative name(s):
MinK-related peptide 3
Minimum potassium ion channel-related peptide 3
Potassium channel subunit beta MiRP3
Gene names
Name:Kcne4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length170 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNQ1/KVLTQ1 inhibits potassium current By similarity.

Subunit structure

Associates with KCNQ1/KVLQT1 Probable.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the potassium channel KCNE family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 170170Potassium voltage-gated channel subfamily E member 4
PRO_0000144293

Regions

Transmembrane36 – 5621Helical; Potential
Topological domain57 – 170114Cytoplasmic Potential

Amino acid modifications

Glycosylation81N-linked (GlcNAc...) Potential
Glycosylation281N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9WTW3 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 3B6B9D73EAE351CA

FASTA17018,639
        10         20         30         40         50         60 
MLRMEPLNST YPSAAASSSP LESHVPSNSS GNGNEYFYIL VVMSFYGVFL IGIMLGYMKS 

        70         80         90        100        110        120 
KRREKKSSLL LLYKDEERLW GEAMKPLPMM SGLRSGQVPM MLNMLQESVA PALSCTLCSM 

       130        140        150        160        170 
EGDSVSSESS SPDVHLPIQE EGADDELEET SETPLNDSSE GSSENIHQNS 

« Hide

References

« Hide 'large scale' references
[1]Abbott G.W., Sesti F., Buck M.E., Goldstein S.A.N.
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Thymus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF076533 mRNA. Translation: AAD28091.1.
BC032920 mRNA. Translation: AAH32920.1.
RefSeqNP_067317.1. NM_021342.1.
UniGeneMm.24386.

3D structure databases

ProteinModelPortalQ9WTW3.
SMRQ9WTW3. Positions 4-87.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

TCDB8.A.10.4.1. the slow voltage-gated k+) channel accessory protein (mink) family.

Proteomic databases

PRIDEQ9WTW3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000057262; ENSMUSP00000055415; ENSMUSG00000047330.
GeneID57814.
KEGGmmu:57814.
UCSCuc007bqq.1. mouse.

Organism-specific databases

CTD23704.
MGIMGI:1891125. Kcne4.

Phylogenomic databases

eggNOGNOG42046.
GeneTreeENSGT00390000013776.
HOGENOMHOG000237340.
HOVERGENHBG052229.
InParanoidQ9WTW3.
KOK04898.
OMALWGEAMK.
OrthoDBEOG74XS89.
PhylomeDBQ9WTW3.
TreeFamTF333025.

Gene expression databases

BgeeQ9WTW3.
GenevestigatorQ9WTW3.

Family and domain databases

InterProIPR000369. K_chnl_volt-dep_bsu_KCNE.
[Graphical view]
PfamPF02060. ISK_Channel. 1 hit.
[Graphical view]
PRINTSPR00168. KCNECHANNEL.
ProtoNetSearch...

Other

NextBio314002.
PROQ9WTW3.
SOURCESearch...

Entry information

Entry nameKCNE4_MOUSE
AccessionPrimary (citable) accession number: Q9WTW3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot