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Protein

Potassium voltage-gated channel subfamily E member 4

Gene

Kcne4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNQ1/KVLTQ1 inhibits potassium current (By similarity).By similarity

GO - Molecular functioni

  • ion channel binding Source: MGI
  • potassium channel activity Source: MGI
  • voltage-gated potassium channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Protein family/group databases

TCDBi8.A.10.4.1. the slow voltage-gated k+) channel accessory protein (mink) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily E member 4
Alternative name(s):
MinK-related peptide 3
Minimum potassium ion channel-related peptide 3
Potassium channel subunit beta MiRP3
Gene namesi
Name:Kcne4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1891125. Kcne4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Topological domaini57 – 170CytoplasmicSequence analysisAdd BLAST114

GO - Cellular componenti

  • apical plasma membrane Source: Ensembl
  • voltage-gated potassium channel complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001442931 – 170Potassium voltage-gated channel subfamily E member 4Add BLAST170

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1
Glycosylationi28N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9WTW3.
PRIDEiQ9WTW3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000047330.
ExpressionAtlasiQ9WTW3. baseline and differential.
GenevisibleiQ9WTW3. MM.

Interactioni

Subunit structurei

Interacts with KCNQ1; impairs KCNQ1 localization in lipid rafts and inhibits voltage-gated potassium channel activity.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055415.

Structurei

3D structure databases

ProteinModelPortaliQ9WTW3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the potassium channel KCNE family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWSX. Eukaryota.
ENOG41129VY. LUCA.
GeneTreeiENSGT00390000013776.
HOGENOMiHOG000237340.
HOVERGENiHBG052229.
InParanoidiQ9WTW3.
KOiK04898.
OMAiLWGEAMK.
OrthoDBiEOG091G0QZW.
PhylomeDBiQ9WTW3.
TreeFamiTF333025.

Family and domain databases

InterProiIPR000369. K_chnl_KCNE.
[Graphical view]
PfamiPF02060. ISK_Channel. 1 hit.
[Graphical view]
PRINTSiPR00168. KCNECHANNEL.

Sequencei

Sequence statusi: Complete.

Q9WTW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRMEPLNST YPSAAASSSP LESHVPSNSS GNGNEYFYIL VVMSFYGVFL
60 70 80 90 100
IGIMLGYMKS KRREKKSSLL LLYKDEERLW GEAMKPLPMM SGLRSGQVPM
110 120 130 140 150
MLNMLQESVA PALSCTLCSM EGDSVSSESS SPDVHLPIQE EGADDELEET
160 170
SETPLNDSSE GSSENIHQNS
Length:170
Mass (Da):18,639
Last modified:November 1, 1999 - v1
Checksum:i3B6B9D73EAE351CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076533 mRNA. Translation: AAD28091.1.
BC032920 mRNA. Translation: AAH32920.1.
CCDSiCCDS15088.1.
RefSeqiNP_067317.1. NM_021342.1.
UniGeneiMm.24386.

Genome annotation databases

EnsembliENSMUST00000057262; ENSMUSP00000055415; ENSMUSG00000047330.
GeneIDi57814.
KEGGimmu:57814.
UCSCiuc007bqq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076533 mRNA. Translation: AAD28091.1.
BC032920 mRNA. Translation: AAH32920.1.
CCDSiCCDS15088.1.
RefSeqiNP_067317.1. NM_021342.1.
UniGeneiMm.24386.

3D structure databases

ProteinModelPortaliQ9WTW3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055415.

Protein family/group databases

TCDBi8.A.10.4.1. the slow voltage-gated k+) channel accessory protein (mink) family.

Proteomic databases

PaxDbiQ9WTW3.
PRIDEiQ9WTW3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057262; ENSMUSP00000055415; ENSMUSG00000047330.
GeneIDi57814.
KEGGimmu:57814.
UCSCiuc007bqq.1. mouse.

Organism-specific databases

CTDi23704.
MGIiMGI:1891125. Kcne4.

Phylogenomic databases

eggNOGiENOG410IWSX. Eukaryota.
ENOG41129VY. LUCA.
GeneTreeiENSGT00390000013776.
HOGENOMiHOG000237340.
HOVERGENiHBG052229.
InParanoidiQ9WTW3.
KOiK04898.
OMAiLWGEAMK.
OrthoDBiEOG091G0QZW.
PhylomeDBiQ9WTW3.
TreeFamiTF333025.

Miscellaneous databases

PROiQ9WTW3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047330.
ExpressionAtlasiQ9WTW3. baseline and differential.
GenevisibleiQ9WTW3. MM.

Family and domain databases

InterProiIPR000369. K_chnl_KCNE.
[Graphical view]
PfamiPF02060. ISK_Channel. 1 hit.
[Graphical view]
PRINTSiPR00168. KCNECHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNE4_MOUSE
AccessioniPrimary (citable) accession number: Q9WTW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.