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Protein

Potassium voltage-gated channel subfamily E member 3

Gene

Kcne3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Protein family/group databases

TCDBi8.A.10.3.1. the slow voltage-gated k+) channel accessory protein (mink) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily E member 3
Alternative name(s):
MinK-related peptide 2
Minimum potassium ion channel-related peptide 2
Potassium channel subunit beta MiRP2
Gene namesi
Name:Kcne3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1891124. Kcne3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 103CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001442901 – 103Potassium voltage-gated channel subfamily E member 3Add BLAST103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi22N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9WTW2.
PRIDEiQ9WTW2.

PTM databases

iPTMnetiQ9WTW2.
PhosphoSitePlusiQ9WTW2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035165.
ExpressionAtlasiQ9WTW2. baseline and differential.
GenevisibleiQ9WTW2. MM.

Interactioni

Subunit structurei

Interacts with KCNB1. Interacts with KCNC2 (By similarity). Associates with KCNC4/Kv3.4 (By similarity). Interacts with KCNQ1; produces a current with nearly instantaneous activation with a linear current-voltage relationship and alters membrane raft localization (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039353.

Structurei

3D structure databases

ProteinModelPortaliQ9WTW2.
SMRiQ9WTW2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the potassium channel KCNE family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZ1X. Eukaryota.
ENOG410XU3Y. LUCA.
GeneTreeiENSGT00390000008537.
HOGENOMiHOG000113209.
HOVERGENiHBG052228.
InParanoidiQ9WTW2.
KOiK04897.
OMAiYKSLHAV.
OrthoDBiEOG091G0Z41.
PhylomeDBiQ9WTW2.
TreeFamiTF335981.

Family and domain databases

InterProiView protein in InterPro
IPR000369. K_chnl_KCNE.
IPR005426. K_chnl_volt-dep_bsu_KCNE3.
PANTHERiPTHR15282:SF6. PTHR15282:SF6. 1 hit.
PfamiView protein in Pfam
PF02060. ISK_Channel. 1 hit.
PRINTSiPR01606. KCNE3CHANNEL.
PR00168. KCNECHANNEL.

Sequencei

Sequence statusi: Complete.

Q9WTW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METSNGTETW YMSLHAVLKA LNTTLHSHLL CRPGPGPGPD NQTEDRRASL
60 70 80 90 100
PGRNDNSYMY ILFVMFLFAV TVGSLILGYT RSRKVDKRSD PYHVYIKNRV

SMI
Length:103
Mass (Da):11,720
Last modified:November 1, 1999 - v1
Checksum:i92E7C8C2284A8804
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076532 mRNA. Translation: AAD28090.1.
BC004629 mRNA. Translation: AAH04629.1.
CCDSiCCDS21495.1.
RefSeqiNP_001177798.1. NM_001190869.1.
NP_001177799.1. NM_001190870.1.
NP_001177800.1. NM_001190871.2.
NP_001177879.1. NM_001190950.1.
NP_065599.1. NM_020574.5.
XP_006508121.1. XM_006508058.2.
XP_006508122.1. XM_006508059.2.
XP_006508125.1. XM_006508062.1.
XP_017177877.1. XM_017322388.1.
UniGeneiMm.282386.

Genome annotation databases

EnsembliENSMUST00000049333; ENSMUSP00000039353; ENSMUSG00000035165.
ENSMUST00000170954; ENSMUSP00000130019; ENSMUSG00000035165.
ENSMUST00000178946; ENSMUSP00000136616; ENSMUSG00000035165.
ENSMUST00000179842; ENSMUSP00000136415; ENSMUSG00000035165.
ENSMUST00000207358; ENSMUSP00000146583; ENSMUSG00000035165.
ENSMUST00000207995; ENSMUSP00000147151; ENSMUSG00000035165.
ENSMUST00000208260; ENSMUSP00000147047; ENSMUSG00000035165.
GeneIDi57442.
KEGGimmu:57442.
UCSCiuc009imm.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiKCNE3_MOUSE
AccessioniPrimary (citable) accession number: Q9WTW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: October 25, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families