Q9WTW2 (KCNE3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel subfamily E member 3

Alternative name(s):
MinK-related peptide 2
Minimum potassium ion channel-related peptide 2
Potassium channel subunit beta MiRP2

Gene names

Name:

Kcne3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	103 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion By similarity.
Subunit structure	Associates with KCNC4/Kv3.4. May associate with KCNQ1/KCLQT1 By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the potassium channel KCNE family.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of potassium ion transport Inferred from electronic annotation. Source: Compara
Cellular_component	voltage-gated potassium channel complex Inferred from sequence or structural similarity PubMed 10219239. Source: MGI
Molecular_function	potassium channel activity Inferred from sequence or structural similarity PubMed 10219239. Source: MGI potassium channel regulator activity Inferred from electronic annotation. Source: Compara voltage-gated potassium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 103	103	Potassium voltage-gated channel subfamily E member 3		PRO_0000144290
Regions
	Transmembrane	58 – 78	21	Helical; Potential
	Topological domain	79 – 103	25	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Glycosylation	22	1	N-linked (GlcNAc...) Potential
	Glycosylation	41	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9WTW2 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 92E7C8C2284A8804	FASTA	103	11,720
	10 20 30 40 50 60 METSNGTETW YMSLHAVLKA LNTTLHSHLL CRPGPGPGPD NQTEDRRASL PGRNDNSYMY 70 80 90 100 ILFVMFLFAV TVGSLILGYT RSRKVDKRSD PYHVYIKNRV SMI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Abbott G.W., Sesti F., Buck M.E., Goldstein S.A.N. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF076532 mRNA. Translation: AAD28090.1. BC004629 mRNA. Translation: AAH04629.1.
IPI	IPI00123966.
RefSeq	NP_001177798.1. NM_001190869.1. NP_001177799.1. NM_001190870.1. NP_001177800.1. NM_001190871.2. NP_001177879.1. NM_001190950.1. NP_065599.1. NM_020574.5.
UniGene	Mm.282386.
3D structure databases
ProteinModelPortal	Q9WTW2.
SMR	Q9WTW2. Positions 19-99.
ModBase	Search...
Protein family/group databases
TCDB	8.A.10.3.1. slow voltage-gated K+ channel accessory protein (MinK) family.
Proteomic databases
PRIDE	Q9WTW2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000049333; ENSMUSP00000039353; ENSMUSG00000035165. ENSMUST00000170954; ENSMUSP00000130019; ENSMUSG00000035165. ENSMUST00000178946; ENSMUSP00000136616; ENSMUSG00000035165. ENSMUST00000179842; ENSMUSP00000136415; ENSMUSG00000035165.
GeneID	57442.
KEGG	mmu:57442.
Organism-specific databases
CTD	10008.
MGI	MGI:1891124. Kcne3.
Phylogenomic databases
eggNOG	NOG42036.
GeneTree	ENSGT00390000008537.
HOGENOM	HOG000113209.
HOVERGEN	HBG052228.
InParanoid	Q9WTW2.
KO	K04897.
OMA	GPGPDNQ.
OrthoDB	EOG4B5P6P.
Gene expression databases
ArrayExpress	Q9WTW2.
Bgee	Q9WTW2.
Genevestigator	Q9WTW2.
GermOnline	ENSMUSG00000035165. Mus musculus.
Family and domain databases
InterPro	IPR000369. K_chnl_volt-dep_bsu_KCNE. IPR005426. K_chnl_volt-dep_bsu_KCNE3. [Graphical view]
Pfam	PF02060. ISK_Channel. 1 hit. [Graphical view]
PRINTS	PR01606. KCNE3CHANNEL. PR00168. KCNECHANNEL.
ProtoNet	Search...
Other
NextBio	313841.
SOURCE	Search...

Entry information

Entry name

KCNE3_MOUSE

Accession

Primary (citable) accession number: Q9WTW2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	April 3, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program