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Q9WTW2

- KCNE3_MOUSE

UniProt

Q9WTW2 - KCNE3_MOUSE

Protein

Potassium voltage-gated channel subfamily E member 3

Gene

Kcne3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion By similarity.By similarity

    GO - Molecular functioni

    1. potassium channel activity Source: MGI
    2. potassium channel regulator activity Source: Ensembl
    3. voltage-gated potassium channel activity Source: InterPro

    GO - Biological processi

    1. regulation of potassium ion transport Source: Ensembl

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Protein family/group databases

    TCDBi8.A.10.3.1. the slow voltage-gated k+) channel accessory protein (mink) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily E member 3
    Alternative name(s):
    MinK-related peptide 2
    Minimum potassium ion channel-related peptide 2
    Potassium channel subunit beta MiRP2
    Gene namesi
    Name:Kcne3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1891124. Kcne3.

    Subcellular locationi

    GO - Cellular componenti

    1. voltage-gated potassium channel complex Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 103103Potassium voltage-gated channel subfamily E member 3PRO_0000144290Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9WTW2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9WTW2.
    BgeeiQ9WTW2.
    GenevestigatoriQ9WTW2.

    Interactioni

    Subunit structurei

    Associates with KCNC4/Kv3.4. May associate with KCNQ1/KCLQT1 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WTW2.
    SMRiQ9WTW2. Positions 22-99.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini79 – 10325CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei58 – 7821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the potassium channel KCNE family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42036.
    GeneTreeiENSGT00390000008537.
    HOGENOMiHOG000113209.
    HOVERGENiHBG052228.
    InParanoidiQ9WTW2.
    KOiK04897.
    OMAiCSENDYT.
    OrthoDBiEOG7KDFD4.
    PhylomeDBiQ9WTW2.
    TreeFamiTF335981.

    Family and domain databases

    InterProiIPR000369. K_chnl_volt-dep_bsu_KCNE.
    IPR005426. K_chnl_volt-dep_bsu_KCNE3.
    [Graphical view]
    PfamiPF02060. ISK_Channel. 1 hit.
    [Graphical view]
    PRINTSiPR01606. KCNE3CHANNEL.
    PR00168. KCNECHANNEL.

    Sequencei

    Sequence statusi: Complete.

    Q9WTW2-1 [UniParc]FASTAAdd to Basket

    « Hide

    METSNGTETW YMSLHAVLKA LNTTLHSHLL CRPGPGPGPD NQTEDRRASL    50
    PGRNDNSYMY ILFVMFLFAV TVGSLILGYT RSRKVDKRSD PYHVYIKNRV 100
    SMI 103
    Length:103
    Mass (Da):11,720
    Last modified:November 1, 1999 - v1
    Checksum:i92E7C8C2284A8804
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF076532 mRNA. Translation: AAD28090.1.
    BC004629 mRNA. Translation: AAH04629.1.
    CCDSiCCDS21495.1.
    RefSeqiNP_001177798.1. NM_001190869.1.
    NP_001177799.1. NM_001190870.1.
    NP_001177800.1. NM_001190871.2.
    NP_001177879.1. NM_001190950.1.
    NP_065599.1. NM_020574.5.
    XP_006508121.1. XM_006508058.1.
    XP_006508122.1. XM_006508059.1.
    XP_006508123.1. XM_006508060.1.
    XP_006508124.1. XM_006508061.1.
    XP_006508125.1. XM_006508062.1.
    XP_006508126.1. XM_006508063.1.
    UniGeneiMm.282386.

    Genome annotation databases

    EnsembliENSMUST00000049333; ENSMUSP00000039353; ENSMUSG00000035165.
    ENSMUST00000170954; ENSMUSP00000130019; ENSMUSG00000035165.
    ENSMUST00000178946; ENSMUSP00000136616; ENSMUSG00000035165.
    ENSMUST00000179842; ENSMUSP00000136415; ENSMUSG00000035165.
    GeneIDi57442.
    KEGGimmu:57442.
    UCSCiuc009imm.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF076532 mRNA. Translation: AAD28090.1 .
    BC004629 mRNA. Translation: AAH04629.1 .
    CCDSi CCDS21495.1.
    RefSeqi NP_001177798.1. NM_001190869.1.
    NP_001177799.1. NM_001190870.1.
    NP_001177800.1. NM_001190871.2.
    NP_001177879.1. NM_001190950.1.
    NP_065599.1. NM_020574.5.
    XP_006508121.1. XM_006508058.1.
    XP_006508122.1. XM_006508059.1.
    XP_006508123.1. XM_006508060.1.
    XP_006508124.1. XM_006508061.1.
    XP_006508125.1. XM_006508062.1.
    XP_006508126.1. XM_006508063.1.
    UniGenei Mm.282386.

    3D structure databases

    ProteinModelPortali Q9WTW2.
    SMRi Q9WTW2. Positions 22-99.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 8.A.10.3.1. the slow voltage-gated k+) channel accessory protein (mink) family.

    Proteomic databases

    PRIDEi Q9WTW2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000049333 ; ENSMUSP00000039353 ; ENSMUSG00000035165 .
    ENSMUST00000170954 ; ENSMUSP00000130019 ; ENSMUSG00000035165 .
    ENSMUST00000178946 ; ENSMUSP00000136616 ; ENSMUSG00000035165 .
    ENSMUST00000179842 ; ENSMUSP00000136415 ; ENSMUSG00000035165 .
    GeneIDi 57442.
    KEGGi mmu:57442.
    UCSCi uc009imm.2. mouse.

    Organism-specific databases

    CTDi 10008.
    MGIi MGI:1891124. Kcne3.

    Phylogenomic databases

    eggNOGi NOG42036.
    GeneTreei ENSGT00390000008537.
    HOGENOMi HOG000113209.
    HOVERGENi HBG052228.
    InParanoidi Q9WTW2.
    KOi K04897.
    OMAi CSENDYT.
    OrthoDBi EOG7KDFD4.
    PhylomeDBi Q9WTW2.
    TreeFami TF335981.

    Miscellaneous databases

    NextBioi 313841.
    PROi Q9WTW2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9WTW2.
    Bgeei Q9WTW2.
    Genevestigatori Q9WTW2.

    Family and domain databases

    InterProi IPR000369. K_chnl_volt-dep_bsu_KCNE.
    IPR005426. K_chnl_volt-dep_bsu_KCNE3.
    [Graphical view ]
    Pfami PF02060. ISK_Channel. 1 hit.
    [Graphical view ]
    PRINTSi PR01606. KCNE3CHANNEL.
    PR00168. KCNECHANNEL.
    ProtoNeti Search...

    Publicationsi

    1. Abbott G.W., Sesti F., Buck M.E., Goldstein S.A.N.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiKCNE3_MOUSE
    AccessioniPrimary (citable) accession number: Q9WTW2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3