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Protein

Potassium voltage-gated channel subfamily E member 3

Gene

Kcne3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion (By similarity).By similarity

GO - Molecular functioni

  1. potassium channel activity Source: MGI
  2. potassium channel regulator activity Source: GO_Central
  3. voltage-gated potassium channel activity Source: InterPro

GO - Biological processi

  1. regulation of membrane repolarization Source: GO_Central
  2. regulation of potassium ion transmembrane transport Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Protein family/group databases

TCDBi8.A.10.3.1. the slow voltage-gated k+) channel accessory protein (mink) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily E member 3
Alternative name(s):
MinK-related peptide 2
Minimum potassium ion channel-related peptide 2
Potassium channel subunit beta MiRP2
Gene namesi
Name:Kcne3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1891124. Kcne3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei58 – 7821HelicalSequence AnalysisAdd
BLAST
Topological domaini79 – 10325CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. voltage-gated potassium channel complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 103103Potassium voltage-gated channel subfamily E member 3PRO_0000144290Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9WTW2.

Expressioni

Gene expression databases

BgeeiQ9WTW2.
ExpressionAtlasiQ9WTW2. baseline and differential.
GenevestigatoriQ9WTW2.

Interactioni

Subunit structurei

Associates with KCNC4/Kv3.4. May associate with KCNQ1/KCLQT1 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9WTW2.
SMRiQ9WTW2. Positions 59-99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the potassium channel KCNE family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42036.
GeneTreeiENSGT00390000008537.
HOGENOMiHOG000113209.
HOVERGENiHBG052228.
InParanoidiQ9WTW2.
KOiK04897.
OMAiGPGPDNQ.
OrthoDBiEOG7KDFD4.
PhylomeDBiQ9WTW2.
TreeFamiTF335981.

Family and domain databases

InterProiIPR000369. K_chnl_volt-dep_bsu_KCNE.
IPR005426. K_chnl_volt-dep_bsu_KCNE3.
[Graphical view]
PfamiPF02060. ISK_Channel. 1 hit.
[Graphical view]
PRINTSiPR01606. KCNE3CHANNEL.
PR00168. KCNECHANNEL.

Sequencei

Sequence statusi: Complete.

Q9WTW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METSNGTETW YMSLHAVLKA LNTTLHSHLL CRPGPGPGPD NQTEDRRASL
60 70 80 90 100
PGRNDNSYMY ILFVMFLFAV TVGSLILGYT RSRKVDKRSD PYHVYIKNRV

SMI
Length:103
Mass (Da):11,720
Last modified:November 1, 1999 - v1
Checksum:i92E7C8C2284A8804
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076532 mRNA. Translation: AAD28090.1.
BC004629 mRNA. Translation: AAH04629.1.
CCDSiCCDS21495.1.
RefSeqiNP_001177798.1. NM_001190869.1.
NP_001177799.1. NM_001190870.1.
NP_001177800.1. NM_001190871.2.
NP_001177879.1. NM_001190950.1.
NP_065599.1. NM_020574.5.
XP_006508121.1. XM_006508058.1.
XP_006508122.1. XM_006508059.1.
XP_006508123.1. XM_006508060.1.
XP_006508124.1. XM_006508061.1.
XP_006508125.1. XM_006508062.1.
XP_006508126.1. XM_006508063.1.
UniGeneiMm.282386.

Genome annotation databases

EnsembliENSMUST00000049333; ENSMUSP00000039353; ENSMUSG00000035165.
ENSMUST00000170954; ENSMUSP00000130019; ENSMUSG00000035165.
ENSMUST00000178946; ENSMUSP00000136616; ENSMUSG00000035165.
ENSMUST00000179842; ENSMUSP00000136415; ENSMUSG00000035165.
GeneIDi57442.
KEGGimmu:57442.
UCSCiuc009imm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076532 mRNA. Translation: AAD28090.1.
BC004629 mRNA. Translation: AAH04629.1.
CCDSiCCDS21495.1.
RefSeqiNP_001177798.1. NM_001190869.1.
NP_001177799.1. NM_001190870.1.
NP_001177800.1. NM_001190871.2.
NP_001177879.1. NM_001190950.1.
NP_065599.1. NM_020574.5.
XP_006508121.1. XM_006508058.1.
XP_006508122.1. XM_006508059.1.
XP_006508123.1. XM_006508060.1.
XP_006508124.1. XM_006508061.1.
XP_006508125.1. XM_006508062.1.
XP_006508126.1. XM_006508063.1.
UniGeneiMm.282386.

3D structure databases

ProteinModelPortaliQ9WTW2.
SMRiQ9WTW2. Positions 59-99.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi8.A.10.3.1. the slow voltage-gated k+) channel accessory protein (mink) family.

Proteomic databases

PRIDEiQ9WTW2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049333; ENSMUSP00000039353; ENSMUSG00000035165.
ENSMUST00000170954; ENSMUSP00000130019; ENSMUSG00000035165.
ENSMUST00000178946; ENSMUSP00000136616; ENSMUSG00000035165.
ENSMUST00000179842; ENSMUSP00000136415; ENSMUSG00000035165.
GeneIDi57442.
KEGGimmu:57442.
UCSCiuc009imm.2. mouse.

Organism-specific databases

CTDi10008.
MGIiMGI:1891124. Kcne3.

Phylogenomic databases

eggNOGiNOG42036.
GeneTreeiENSGT00390000008537.
HOGENOMiHOG000113209.
HOVERGENiHBG052228.
InParanoidiQ9WTW2.
KOiK04897.
OMAiGPGPDNQ.
OrthoDBiEOG7KDFD4.
PhylomeDBiQ9WTW2.
TreeFamiTF335981.

Miscellaneous databases

NextBioi313841.
PROiQ9WTW2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WTW2.
ExpressionAtlasiQ9WTW2. baseline and differential.
GenevestigatoriQ9WTW2.

Family and domain databases

InterProiIPR000369. K_chnl_volt-dep_bsu_KCNE.
IPR005426. K_chnl_volt-dep_bsu_KCNE3.
[Graphical view]
PfamiPF02060. ISK_Channel. 1 hit.
[Graphical view]
PRINTSiPR01606. KCNE3CHANNEL.
PR00168. KCNECHANNEL.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Abbott G.W., Sesti F., Buck M.E., Goldstein S.A.N.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiKCNE3_MOUSE
AccessioniPrimary (citable) accession number: Q9WTW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: February 4, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.