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Q9WTW2 (KCNE3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily E member 3
Alternative name(s):
MinK-related peptide 2
Minimum potassium ion channel-related peptide 2
Potassium channel subunit beta MiRP2
Gene names
Name:Kcne3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length103 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion By similarity.

Subunit structure

Associates with KCNC4/Kv3.4. May associate with KCNQ1/KCLQT1 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the potassium channel KCNE family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 103103Potassium voltage-gated channel subfamily E member 3
PRO_0000144290

Regions

Transmembrane58 – 7821Helical; Potential
Topological domain79 – 10325Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation221N-linked (GlcNAc...) Potential
Glycosylation411N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9WTW2 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 92E7C8C2284A8804

FASTA10311,720
        10         20         30         40         50         60 
METSNGTETW YMSLHAVLKA LNTTLHSHLL CRPGPGPGPD NQTEDRRASL PGRNDNSYMY 

        70         80         90        100 
ILFVMFLFAV TVGSLILGYT RSRKVDKRSD PYHVYIKNRV SMI 

« Hide

References

« Hide 'large scale' references
[1]Abbott G.W., Sesti F., Buck M.E., Goldstein S.A.N.
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF076532 mRNA. Translation: AAD28090.1.
BC004629 mRNA. Translation: AAH04629.1.
RefSeqNP_001177798.1. NM_001190869.1.
NP_001177799.1. NM_001190870.1.
NP_001177800.1. NM_001190871.2.
NP_001177879.1. NM_001190950.1.
NP_065599.1. NM_020574.5.
XP_006508121.1. XM_006508058.1.
XP_006508122.1. XM_006508059.1.
XP_006508123.1. XM_006508060.1.
XP_006508124.1. XM_006508061.1.
XP_006508125.1. XM_006508062.1.
XP_006508126.1. XM_006508063.1.
UniGeneMm.282386.

3D structure databases

ProteinModelPortalQ9WTW2.
SMRQ9WTW2. Positions 22-99.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

TCDB8.A.10.3.1. the slow voltage-gated k+) channel accessory protein (mink) family.

Proteomic databases

PRIDEQ9WTW2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000049333; ENSMUSP00000039353; ENSMUSG00000035165.
ENSMUST00000170954; ENSMUSP00000130019; ENSMUSG00000035165.
ENSMUST00000178946; ENSMUSP00000136616; ENSMUSG00000035165.
ENSMUST00000179842; ENSMUSP00000136415; ENSMUSG00000035165.
GeneID57442.
KEGGmmu:57442.
UCSCuc009imm.2. mouse.

Organism-specific databases

CTD10008.
MGIMGI:1891124. Kcne3.

Phylogenomic databases

eggNOGNOG42036.
GeneTreeENSGT00390000008537.
HOGENOMHOG000113209.
HOVERGENHBG052228.
InParanoidQ9WTW2.
KOK04897.
OMAGPGPDNQ.
OrthoDBEOG7KDFD4.
PhylomeDBQ9WTW2.
TreeFamTF335981.

Gene expression databases

ArrayExpressQ9WTW2.
BgeeQ9WTW2.
GenevestigatorQ9WTW2.

Family and domain databases

InterProIPR000369. K_chnl_volt-dep_bsu_KCNE.
IPR005426. K_chnl_volt-dep_bsu_KCNE3.
[Graphical view]
PfamPF02060. ISK_Channel. 1 hit.
[Graphical view]
PRINTSPR01606. KCNE3CHANNEL.
PR00168. KCNECHANNEL.
ProtoNetSearch...

Other

NextBio313841.
PROQ9WTW2.
SOURCESearch...

Entry information

Entry nameKCNE3_MOUSE
AccessionPrimary (citable) accession number: Q9WTW2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot