ID   V1AR_MICOH              Reviewed;         420 AA.
AC   Q9WTV9;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   27-MAR-2024, entry version 88.
DE   RecName: Full=Vasopressin V1a receptor;
DE            Short=V1aR;
DE   AltName: Full=AVPR V1a;
DE   AltName: Full=Antidiuretic hormone receptor 1a;
DE   AltName: Full=Vascular/hepatic-type arginine vasopressin receptor;
GN   Name=Avpr1a;
OS   Microtus ochrogaster (Prairie vole).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Arvicolinae; Microtus.
OX   NCBI_TaxID=79684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Brain;
RX   PubMed=10466725; DOI=10.1038/23475;
RA   Young L.J., Nilsen R., Waymire K.G., MacGregor G.R., Insel T.R.;
RT   "Increased affiliative response to vasopressin in mice expressing the V1a
RT   receptor from a monogamous vole.";
RL   Nature 400:766-768(1999).
RN   [2]
RP   ROLE IN SOCIAL BEHAVIOR.
RX   PubMed=15201909; DOI=10.1038/nature02539;
RA   Lim M.M., Wang Z., Olazabal D.E., Ren X., Terwilliger E.F., Young L.J.;
RT   "Enhanced partner preference in a promiscuous species by manipulating the
RT   expression of a single gene.";
RL   Nature 429:754-757(2004).
CC   -!- FUNCTION: Receptor for arginine vasopressin. The activity of this
CC       receptor is mediated by G proteins which activate a phosphatidyl-
CC       inositol-calcium second messenger system. Involved in social memory
CC       formation. {ECO:0000269|PubMed:15201909}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- MISCELLANEOUS: In prairie and pine voles, the 5' regulatory region of
CC       AVPR1A contains a microsatellite region that is virtually absent from
CC       montane and meadow voles. This species-specific microsatellite
CC       polymorphism modulates gene expression in a cell-type-dependent manner
CC       and generates a great individual variability in the brain expression
CC       pattern. This polymorphism is correlated with monogamous social
CC       organization.
CC   -!- MISCELLANEOUS: Prairie voles exhibit a monogamous social structure in
CC       nature, whereas closely related meadow voles are solitary and
CC       polygamous. AVPR1A is expressed at higher levels in the ventral
CC       forebrain of monogamous than in promiscuous vole species, whereas
CC       dopamine receptor distribution is relatively conserved between species.
CC       The partner preference formation in the socially promiscuous meadow
CC       vole is increased by AVPR1A gene transfer into the ventral forebrain.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Protein Spotlight; Note=Nature's philanderers
CC       - Issue 52 of November 2004;
CC       URL="https://web.expasy.org/spotlight/back_issues/052";
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DR   EMBL; AF069304; AAD02821.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q9WTV9; -.
DR   SMR; Q9WTV9; -.
DR   BindingDB; Q9WTV9; -.
DR   ChEMBL; CHEMBL2016428; -.
DR   GlyCosmos; Q9WTV9; 2 sites, No reported glycans.
DR   Proteomes; UP000694915; Genome assembly.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005000; F:vasopressin receptor activity; IEA:InterPro.
DR   CDD; cd15385; 7tmA_V1aR; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR015076; V1R_C.
DR   InterPro; IPR001817; Vasoprsn_rcpt.
DR   InterPro; IPR001224; Vprs_V1A_rcpt.
DR   PANTHER; PTHR24241; NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR24241:SF17; VASOPRESSIN V1A RECEPTOR; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   Pfam; PF08983; V1R_C; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00896; VASOPRESSINR.
DR   PRINTS; PR00752; VASOPRSNV1AR.
DR   SMART; SM01164; DUF1856; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Lipoprotein; Membrane; Palmitate; Phosphoprotein; Receptor; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..420
FT                   /note="Vasopressin V1a receptor"
FT                   /id="PRO_0000070199"
FT   TOPO_DOM        1..54
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..92
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        114..125
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        147..168
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        190..225
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        247..294
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        295..315
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        316..331
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        332..352
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        353..420
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          379..411
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        386..411
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         406
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q62463"
FT   LIPID           367
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           368
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        27
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        198
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        124..205
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   420 AA;  47560 MW;  8055B79C351E3DFE CRC64;
     MSFPRGSYDP AASNSSPWWP LSAEDANSSW EAAGHQKGSD PSGDVRNEEL AKLEIAVLAV
     IFVVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV AFFQVLPQLC WDITYRFRGP
     DWLCRVVKHL QVFAMFASAY MLVVMTADRY IAVCHPLKTL QQPTRRSRLM IAASWVLSFL
     LSTPQYFIFS MIEIEVNNGT KTQDCWATFI QPWGTRAYVT WMTSGVFVVP VVILGTCYGF
     ICYHIWRNVR GKTASRQSKG SGEDVAPFHK GLLVTPCVSS VKTISRAKIR TVKMTFVIVT
     AYILCWAPFF IVQMWSVWDD NFIWTDSENP SITITALLAS LNSCCNPWIY MFFSGHLLQD
     CVQSFPCCQR MVQKFTKDDS DNMSRRHTSY SNNRSPTNST GTWKDSPKSS RSIRFIPVST
//