Q9WTV9 (V1AR_MICOH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vasopressin V1a receptor
Short name=V1aR

Alternative name(s):
AVPR V1a
Antidiuretic hormone receptor 1a
Vascular/hepatic-type arginine vasopressin receptor

Gene names

Name:

Avpr1a

Organism

Microtus ochrogaster (Prairie vole)

Taxonomic identifier

79684 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Cricetidae › Arvicolinae › Microtus

Protein attributes

Sequence length	420 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Involved in social memory formation. Ref.2
Subcellular location	Cell membrane; Multi-pass membrane protein.
Miscellaneous	In prairie and pine voles, the 5' regulatory region of AVPR1A contains a microsatellite region that is virtually absent from montane and meadow voles. This species-specific microsatellite polymorphism modulates gene expression in a cell-type-dependent manner and generates a great individual variability in the brain expression pattern. This polymorphism is correlated with monogamous social organization. Prairie voles exhibit a monogamous social structure in nature, whereas closely related meadow voles are solitary and polygamous. AVPR1A is expressed at higher levels in the ventral forebrain of monogamous than in promiscuous vole species, whereas dopamine receptor distribution is relatively conserved between species. The partner preference formation in the socially promiscuous meadow vole is increased by AVPR1A gene transfer into the ventral forebrain.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate Phosphoprotein
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	vasopressin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 420	420	Vasopressin V1a receptor		PRO_0000070199
Regions
	Topological domain	1 – 54	54	Extracellular Potential
	Transmembrane	55 – 75	21	Helical; Name=1; Potential
	Topological domain	76 – 92	17	Cytoplasmic Potential
	Transmembrane	93 – 113	21	Helical; Name=2; Potential
	Topological domain	114 – 125	12	Extracellular Potential
	Transmembrane	126 – 146	21	Helical; Name=3; Potential
	Topological domain	147 – 168	22	Cytoplasmic Potential
	Transmembrane	169 – 189	21	Helical; Name=4; Potential
	Topological domain	190 – 225	36	Extracellular Potential
	Transmembrane	226 – 246	21	Helical; Name=5; Potential
	Topological domain	247 – 294	48	Cytoplasmic Potential
	Transmembrane	295 – 315	21	Helical; Name=6; Potential
	Topological domain	316 – 331	16	Extracellular Potential
	Transmembrane	332 – 352	21	Helical; Name=7; Potential
	Topological domain	353 – 420	68	Cytoplasmic Potential
Amino acid modifications
	Modified residue	406	1	Phosphoserine By similarity
	Lipidation	367	1	S-palmitoyl cysteine By similarity
	Lipidation	368	1	S-palmitoyl cysteine By similarity
	Glycosylation	27	1	N-linked (GlcNAc...) Potential
	Glycosylation	198	1	N-linked (GlcNAc...) Potential
	Disulfide bond	124 ↔ 205		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9WTV9 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 8055B79C351E3DFE	FASTA	420	47,560
	10 20 30 40 50 60 MSFPRGSYDP AASNSSPWWP LSAEDANSSW EAAGHQKGSD PSGDVRNEEL AKLEIAVLAV 70 80 90 100 110 120 IFVVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV AFFQVLPQLC WDITYRFRGP 130 140 150 160 170 180 DWLCRVVKHL QVFAMFASAY MLVVMTADRY IAVCHPLKTL QQPTRRSRLM IAASWVLSFL 190 200 210 220 230 240 LSTPQYFIFS MIEIEVNNGT KTQDCWATFI QPWGTRAYVT WMTSGVFVVP VVILGTCYGF 250 260 270 280 290 300 ICYHIWRNVR GKTASRQSKG SGEDVAPFHK GLLVTPCVSS VKTISRAKIR TVKMTFVIVT 310 320 330 340 350 360 AYILCWAPFF IVQMWSVWDD NFIWTDSENP SITITALLAS LNSCCNPWIY MFFSGHLLQD 370 380 390 400 410 420 CVQSFPCCQR MVQKFTKDDS DNMSRRHTSY SNNRSPTNST GTWKDSPKSS RSIRFIPVST

References

[1]	"Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vole." Young L.J., Nilsen R., Waymire K.G., MacGregor G.R., Insel T.R. Nature 400:766-768(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Brain.
[2]	"Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene." Lim M.M., Wang Z., Olazabal D.E., Ren X., Terwilliger E.F., Young L.J. Nature 429:754-757(2004) [PubMed] [Europe PMC] [Abstract] Cited for: ROLE IN SOCIAL BEHAVIOR.

Web resources

Protein Spotlight

Nature's philanderers - Issue 52 of November 2004

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF069304 Genomic DNA. Translation: AAD02821.2.
3D structure databases
ProteinModelPortal	Q9WTV9.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG105710.
Family and domain databases
InterPro	IPR015076. DUF1856. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR001817. Vasoprsn_rcpt. IPR001224. Vprs_V1A_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. PF08983. DUF1856. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00896. VASOPRESSINR. PR00752. VASOPRSNV1AR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

V1AR_MICOH

Accession

Primary (citable) accession number: Q9WTV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	November 1, 1999
Last modified:	April 3, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program