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Protein

Vasopressin V1a receptor

Gene

Avpr1a

Organism
Microtus ochrogaster (Prairie vole)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Involved in social memory formation.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V1a receptor
Short name:
V1aR
Alternative name(s):
AVPR V1a
Antidiuretic hormone receptor 1a
Vascular/hepatic-type arginine vasopressin receptor
Gene namesi
Name:Avpr1a
OrganismiMicrotus ochrogaster (Prairie vole)
Taxonomic identifieri79684 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeArvicolinaeMicrotus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 54ExtracellularSequence analysisAdd BLAST54
Transmembranei55 – 75Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini76 – 92CytoplasmicSequence analysisAdd BLAST17
Transmembranei93 – 113Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini114 – 125ExtracellularSequence analysisAdd BLAST12
Transmembranei126 – 146Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini147 – 168CytoplasmicSequence analysisAdd BLAST22
Transmembranei169 – 189Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini190 – 225ExtracellularSequence analysisAdd BLAST36
Transmembranei226 – 246Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini247 – 294CytoplasmicSequence analysisAdd BLAST48
Transmembranei295 – 315Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini316 – 331ExtracellularSequence analysisAdd BLAST16
Transmembranei332 – 352Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini353 – 420CytoplasmicSequence analysisAdd BLAST68

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2016428.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701991 – 420Vasopressin V1a receptorAdd BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi124 ↔ 205PROSITE-ProRule annotation
Glycosylationi198N-linked (GlcNAc...)Sequence analysis1
Lipidationi367S-palmitoyl cysteineBy similarity1
Lipidationi368S-palmitoyl cysteineBy similarity1
Modified residuei406PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Interactioni

Chemistry databases

BindingDBiQ9WTV9.

Structurei

3D structure databases

ProteinModelPortaliQ9WTV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG105710.

Family and domain databases

InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
SMARTiSM01164. DUF1856. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WTV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFPRGSYDP AASNSSPWWP LSAEDANSSW EAAGHQKGSD PSGDVRNEEL
60 70 80 90 100
AKLEIAVLAV IFVVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV
110 120 130 140 150
AFFQVLPQLC WDITYRFRGP DWLCRVVKHL QVFAMFASAY MLVVMTADRY
160 170 180 190 200
IAVCHPLKTL QQPTRRSRLM IAASWVLSFL LSTPQYFIFS MIEIEVNNGT
210 220 230 240 250
KTQDCWATFI QPWGTRAYVT WMTSGVFVVP VVILGTCYGF ICYHIWRNVR
260 270 280 290 300
GKTASRQSKG SGEDVAPFHK GLLVTPCVSS VKTISRAKIR TVKMTFVIVT
310 320 330 340 350
AYILCWAPFF IVQMWSVWDD NFIWTDSENP SITITALLAS LNSCCNPWIY
360 370 380 390 400
MFFSGHLLQD CVQSFPCCQR MVQKFTKDDS DNMSRRHTSY SNNRSPTNST
410 420
GTWKDSPKSS RSIRFIPVST
Length:420
Mass (Da):47,560
Last modified:November 1, 1999 - v1
Checksum:i8055B79C351E3DFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069304 Genomic DNA. Translation: AAD02821.2.

Cross-referencesi

Web resourcesi

Protein Spotlight

Nature's philanderers - Issue 52 of November 2004

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069304 Genomic DNA. Translation: AAD02821.2.

3D structure databases

ProteinModelPortaliQ9WTV9.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiQ9WTV9.
ChEMBLiCHEMBL2016428.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG105710.

Family and domain databases

InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
SMARTiSM01164. DUF1856. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiV1AR_MICOH
AccessioniPrimary (citable) accession number: Q9WTV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In prairie and pine voles, the 5' regulatory region of AVPR1A contains a microsatellite region that is virtually absent from montane and meadow voles. This species-specific microsatellite polymorphism modulates gene expression in a cell-type-dependent manner and generates a great individual variability in the brain expression pattern. This polymorphism is correlated with monogamous social organization.
Prairie voles exhibit a monogamous social structure in nature, whereas closely related meadow voles are solitary and polygamous. AVPR1A is expressed at higher levels in the ventral forebrain of monogamous than in promiscuous vole species, whereas dopamine receptor distribution is relatively conserved between species. The partner preference formation in the socially promiscuous meadow vole is increased by AVPR1A gene transfer into the ventral forebrain.

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.