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Protein

Vasopressin V1a receptor

Gene

Avpr1a

Organism
Microtus ochrogaster (Prairie vole)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Involved in social memory formation.1 Publication

GO - Molecular functioni

  1. vasopressin receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V1a receptor
Short name:
V1aR
Alternative name(s):
AVPR V1a
Antidiuretic hormone receptor 1a
Vascular/hepatic-type arginine vasopressin receptor
Gene namesi
Name:Avpr1a
OrganismiMicrotus ochrogaster (Prairie vole)
Taxonomic identifieri79684 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeArvicolinaeMicrotus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5454ExtracellularSequence AnalysisAdd
BLAST
Transmembranei55 – 7521Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini76 – 9217CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei93 – 11321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini114 – 12512ExtracellularSequence AnalysisAdd
BLAST
Transmembranei126 – 14621Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini147 – 16822CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei169 – 18921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini190 – 22536ExtracellularSequence AnalysisAdd
BLAST
Transmembranei226 – 24621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini247 – 29448CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei295 – 31521Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini316 – 33116ExtracellularSequence AnalysisAdd
BLAST
Transmembranei332 – 35221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini353 – 42068CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Vasopressin V1a receptorPRO_0000070199Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi124 ↔ 205PROSITE-ProRule annotation
Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis
Lipidationi367 – 3671S-palmitoyl cysteineBy similarity
Lipidationi368 – 3681S-palmitoyl cysteineBy similarity
Modified residuei406 – 4061PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Interactioni

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG105710.

Family and domain databases

InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WTV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFPRGSYDP AASNSSPWWP LSAEDANSSW EAAGHQKGSD PSGDVRNEEL
60 70 80 90 100
AKLEIAVLAV IFVVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV
110 120 130 140 150
AFFQVLPQLC WDITYRFRGP DWLCRVVKHL QVFAMFASAY MLVVMTADRY
160 170 180 190 200
IAVCHPLKTL QQPTRRSRLM IAASWVLSFL LSTPQYFIFS MIEIEVNNGT
210 220 230 240 250
KTQDCWATFI QPWGTRAYVT WMTSGVFVVP VVILGTCYGF ICYHIWRNVR
260 270 280 290 300
GKTASRQSKG SGEDVAPFHK GLLVTPCVSS VKTISRAKIR TVKMTFVIVT
310 320 330 340 350
AYILCWAPFF IVQMWSVWDD NFIWTDSENP SITITALLAS LNSCCNPWIY
360 370 380 390 400
MFFSGHLLQD CVQSFPCCQR MVQKFTKDDS DNMSRRHTSY SNNRSPTNST
410 420
GTWKDSPKSS RSIRFIPVST
Length:420
Mass (Da):47,560
Last modified:November 1, 1999 - v1
Checksum:i8055B79C351E3DFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069304 Genomic DNA. Translation: AAD02821.2.

Cross-referencesi

Web resourcesi

Protein Spotlight

Nature's philanderers - Issue 52 of November 2004

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069304 Genomic DNA. Translation: AAD02821.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ9WTV9.
ChEMBLiCHEMBL2016428.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG105710.

Family and domain databases

InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vole."
    Young L.J., Nilsen R., Waymire K.G., MacGregor G.R., Insel T.R.
    Nature 400:766-768(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  2. "Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene."
    Lim M.M., Wang Z., Olazabal D.E., Ren X., Terwilliger E.F., Young L.J.
    Nature 429:754-757(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: ROLE IN SOCIAL BEHAVIOR.

Entry informationi

Entry nameiV1AR_MICOH
AccessioniPrimary (citable) accession number: Q9WTV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: November 1, 1999
Last modified: April 1, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In prairie and pine voles, the 5' regulatory region of AVPR1A contains a microsatellite region that is virtually absent from montane and meadow voles. This species-specific microsatellite polymorphism modulates gene expression in a cell-type-dependent manner and generates a great individual variability in the brain expression pattern. This polymorphism is correlated with monogamous social organization.
Prairie voles exhibit a monogamous social structure in nature, whereas closely related meadow voles are solitary and polygamous. AVPR1A is expressed at higher levels in the ventral forebrain of monogamous than in promiscuous vole species, whereas dopamine receptor distribution is relatively conserved between species. The partner preference formation in the socially promiscuous meadow vole is increased by AVPR1A gene transfer into the ventral forebrain.

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.