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Q9WTV9

- V1AR_MICOH

UniProt

Q9WTV9 - V1AR_MICOH

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Protein
Vasopressin V1a receptor
Gene
Avpr1a
Organism
Microtus ochrogaster (Prairie vole)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Involved in social memory formation.1 Publication

GO - Molecular functioni

  1. vasopressin receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V1a receptor
Short name:
V1aR
Alternative name(s):
AVPR V1a
Antidiuretic hormone receptor 1a
Vascular/hepatic-type arginine vasopressin receptor
Gene namesi
Name:Avpr1a
OrganismiMicrotus ochrogaster (Prairie vole)
Taxonomic identifieri79684 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeArvicolinaeMicrotus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5454Extracellular Reviewed prediction
Add
BLAST
Transmembranei55 – 7521Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini76 – 9217Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei93 – 11321Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini114 – 12512Extracellular Reviewed prediction
Add
BLAST
Transmembranei126 – 14621Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini147 – 16822Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei169 – 18921Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini190 – 22536Extracellular Reviewed prediction
Add
BLAST
Transmembranei226 – 24621Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini247 – 29448Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei295 – 31521Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini316 – 33116Extracellular Reviewed prediction
Add
BLAST
Transmembranei332 – 35221Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini353 – 42068Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Vasopressin V1a receptor
PRO_0000070199Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi124 ↔ 205 By similarity
Glycosylationi198 – 1981N-linked (GlcNAc...) Reviewed prediction
Lipidationi367 – 3671S-palmitoyl cysteine By similarity
Lipidationi368 – 3681S-palmitoyl cysteine By similarity
Modified residuei406 – 4061Phosphoserine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ9WTV9.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG105710.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WTV9-1 [UniParc]FASTAAdd to Basket

« Hide

MSFPRGSYDP AASNSSPWWP LSAEDANSSW EAAGHQKGSD PSGDVRNEEL    50
AKLEIAVLAV IFVVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV 100
AFFQVLPQLC WDITYRFRGP DWLCRVVKHL QVFAMFASAY MLVVMTADRY 150
IAVCHPLKTL QQPTRRSRLM IAASWVLSFL LSTPQYFIFS MIEIEVNNGT 200
KTQDCWATFI QPWGTRAYVT WMTSGVFVVP VVILGTCYGF ICYHIWRNVR 250
GKTASRQSKG SGEDVAPFHK GLLVTPCVSS VKTISRAKIR TVKMTFVIVT 300
AYILCWAPFF IVQMWSVWDD NFIWTDSENP SITITALLAS LNSCCNPWIY 350
MFFSGHLLQD CVQSFPCCQR MVQKFTKDDS DNMSRRHTSY SNNRSPTNST 400
GTWKDSPKSS RSIRFIPVST 420
Length:420
Mass (Da):47,560
Last modified:November 1, 1999 - v1
Checksum:i8055B79C351E3DFE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF069304 Genomic DNA. Translation: AAD02821.2.

Cross-referencesi

Web resourcesi

Protein Spotlight

Nature's philanderers - Issue 52 of November 2004

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF069304 Genomic DNA. Translation: AAD02821.2 .

3D structure databases

ProteinModelPortali Q9WTV9.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2016428.

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG105710.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vole."
    Young L.J., Nilsen R., Waymire K.G., MacGregor G.R., Insel T.R.
    Nature 400:766-768(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  2. "Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene."
    Lim M.M., Wang Z., Olazabal D.E., Ren X., Terwilliger E.F., Young L.J.
    Nature 429:754-757(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: ROLE IN SOCIAL BEHAVIOR.

Entry informationi

Entry nameiV1AR_MICOH
AccessioniPrimary (citable) accession number: Q9WTV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In prairie and pine voles, the 5' regulatory region of AVPR1A contains a microsatellite region that is virtually absent from montane and meadow voles. This species-specific microsatellite polymorphism modulates gene expression in a cell-type-dependent manner and generates a great individual variability in the brain expression pattern. This polymorphism is correlated with monogamous social organization.
Prairie voles exhibit a monogamous social structure in nature, whereas closely related meadow voles are solitary and polygamous. AVPR1A is expressed at higher levels in the ventral forebrain of monogamous than in promiscuous vole species, whereas dopamine receptor distribution is relatively conserved between species. The partner preference formation in the socially promiscuous meadow vole is increased by AVPR1A gene transfer into the ventral forebrain.

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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