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Q9WTV9

- V1AR_MICOH

UniProt

Q9WTV9 - V1AR_MICOH

Protein

Vasopressin V1a receptor

Gene

Avpr1a

Organism
Microtus ochrogaster (Prairie vole)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Involved in social memory formation.1 Publication

    GO - Molecular functioni

    1. vasopressin receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vasopressin V1a receptor
    Short name:
    V1aR
    Alternative name(s):
    AVPR V1a
    Antidiuretic hormone receptor 1a
    Vascular/hepatic-type arginine vasopressin receptor
    Gene namesi
    Name:Avpr1a
    OrganismiMicrotus ochrogaster (Prairie vole)
    Taxonomic identifieri79684 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeArvicolinaeMicrotus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 420420Vasopressin V1a receptorPRO_0000070199Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi124 ↔ 205PROSITE-ProRule annotation
    Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis
    Lipidationi367 – 3671S-palmitoyl cysteineBy similarity
    Lipidationi368 – 3681S-palmitoyl cysteineBy similarity
    Modified residuei406 – 4061PhosphoserineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WTV9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5454ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini76 – 9217CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini114 – 12512ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini147 – 16822CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini190 – 22536ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini247 – 29448CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini316 – 33116ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini353 – 42068CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei55 – 7521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei93 – 11321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei126 – 14621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei169 – 18921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei226 – 24621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei295 – 31521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei332 – 35221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG105710.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR015076. DUF1856.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001817. Vasoprsn_rcpt.
    IPR001224. Vprs_V1A_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    PF08983. DUF1856. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00896. VASOPRESSINR.
    PR00752. VASOPRSNV1AR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9WTV9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFPRGSYDP AASNSSPWWP LSAEDANSSW EAAGHQKGSD PSGDVRNEEL    50
    AKLEIAVLAV IFVVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV 100
    AFFQVLPQLC WDITYRFRGP DWLCRVVKHL QVFAMFASAY MLVVMTADRY 150
    IAVCHPLKTL QQPTRRSRLM IAASWVLSFL LSTPQYFIFS MIEIEVNNGT 200
    KTQDCWATFI QPWGTRAYVT WMTSGVFVVP VVILGTCYGF ICYHIWRNVR 250
    GKTASRQSKG SGEDVAPFHK GLLVTPCVSS VKTISRAKIR TVKMTFVIVT 300
    AYILCWAPFF IVQMWSVWDD NFIWTDSENP SITITALLAS LNSCCNPWIY 350
    MFFSGHLLQD CVQSFPCCQR MVQKFTKDDS DNMSRRHTSY SNNRSPTNST 400
    GTWKDSPKSS RSIRFIPVST 420
    Length:420
    Mass (Da):47,560
    Last modified:November 1, 1999 - v1
    Checksum:i8055B79C351E3DFE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF069304 Genomic DNA. Translation: AAD02821.2.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Nature's philanderers - Issue 52 of November 2004

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF069304 Genomic DNA. Translation: AAD02821.2 .

    3D structure databases

    ProteinModelPortali Q9WTV9.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL2016428.

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG105710.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR015076. DUF1856.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001817. Vasoprsn_rcpt.
    IPR001224. Vprs_V1A_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    PF08983. DUF1856. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00896. VASOPRESSINR.
    PR00752. VASOPRSNV1AR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vole."
      Young L.J., Nilsen R., Waymire K.G., MacGregor G.R., Insel T.R.
      Nature 400:766-768(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Brain.
    2. "Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene."
      Lim M.M., Wang Z., Olazabal D.E., Ren X., Terwilliger E.F., Young L.J.
      Nature 429:754-757(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: ROLE IN SOCIAL BEHAVIOR.

    Entry informationi

    Entry nameiV1AR_MICOH
    AccessioniPrimary (citable) accession number: Q9WTV9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    In prairie and pine voles, the 5' regulatory region of AVPR1A contains a microsatellite region that is virtually absent from montane and meadow voles. This species-specific microsatellite polymorphism modulates gene expression in a cell-type-dependent manner and generates a great individual variability in the brain expression pattern. This polymorphism is correlated with monogamous social organization.
    Prairie voles exhibit a monogamous social structure in nature, whereas closely related meadow voles are solitary and polygamous. AVPR1A is expressed at higher levels in the ventral forebrain of monogamous than in promiscuous vole species, whereas dopamine receptor distribution is relatively conserved between species. The partner preference formation in the socially promiscuous meadow vole is increased by AVPR1A gene transfer into the ventral forebrain.

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3