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Q9WTV9 (V1AR_MICOH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vasopressin V1a receptor

Short name=V1aR
Alternative name(s):
AVPR V1a
Antidiuretic hormone receptor 1a
Vascular/hepatic-type arginine vasopressin receptor
Gene names
Name:Avpr1a
OrganismMicrotus ochrogaster (Prairie vole)
Taxonomic identifier79684 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeArvicolinaeMicrotus

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Involved in social memory formation. Ref.2

Subcellular location

Cell membrane; Multi-pass membrane protein.

Miscellaneous

In prairie and pine voles, the 5' regulatory region of AVPR1A contains a microsatellite region that is virtually absent from montane and meadow voles. This species-specific microsatellite polymorphism modulates gene expression in a cell-type-dependent manner and generates a great individual variability in the brain expression pattern. This polymorphism is correlated with monogamous social organization.

Prairie voles exhibit a monogamous social structure in nature, whereas closely related meadow voles are solitary and polygamous. AVPR1A is expressed at higher levels in the ventral forebrain of monogamous than in promiscuous vole species, whereas dopamine receptor distribution is relatively conserved between species. The partner preference formation in the socially promiscuous meadow vole is increased by AVPR1A gene transfer into the ventral forebrain.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 420420Vasopressin V1a receptor
PRO_0000070199

Regions

Topological domain1 – 5454Extracellular Potential
Transmembrane55 – 7521Helical; Name=1; Potential
Topological domain76 – 9217Cytoplasmic Potential
Transmembrane93 – 11321Helical; Name=2; Potential
Topological domain114 – 12512Extracellular Potential
Transmembrane126 – 14621Helical; Name=3; Potential
Topological domain147 – 16822Cytoplasmic Potential
Transmembrane169 – 18921Helical; Name=4; Potential
Topological domain190 – 22536Extracellular Potential
Transmembrane226 – 24621Helical; Name=5; Potential
Topological domain247 – 29448Cytoplasmic Potential
Transmembrane295 – 31521Helical; Name=6; Potential
Topological domain316 – 33116Extracellular Potential
Transmembrane332 – 35221Helical; Name=7; Potential
Topological domain353 – 42068Cytoplasmic Potential

Amino acid modifications

Modified residue4061Phosphoserine By similarity
Lipidation3671S-palmitoyl cysteine By similarity
Lipidation3681S-palmitoyl cysteine By similarity
Glycosylation271N-linked (GlcNAc...) Potential
Glycosylation1981N-linked (GlcNAc...) Potential
Disulfide bond124 ↔ 205 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9WTV9 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 8055B79C351E3DFE

FASTA42047,560
        10         20         30         40         50         60 
MSFPRGSYDP AASNSSPWWP LSAEDANSSW EAAGHQKGSD PSGDVRNEEL AKLEIAVLAV 

        70         80         90        100        110        120 
IFVVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV AFFQVLPQLC WDITYRFRGP 

       130        140        150        160        170        180 
DWLCRVVKHL QVFAMFASAY MLVVMTADRY IAVCHPLKTL QQPTRRSRLM IAASWVLSFL 

       190        200        210        220        230        240 
LSTPQYFIFS MIEIEVNNGT KTQDCWATFI QPWGTRAYVT WMTSGVFVVP VVILGTCYGF 

       250        260        270        280        290        300 
ICYHIWRNVR GKTASRQSKG SGEDVAPFHK GLLVTPCVSS VKTISRAKIR TVKMTFVIVT 

       310        320        330        340        350        360 
AYILCWAPFF IVQMWSVWDD NFIWTDSENP SITITALLAS LNSCCNPWIY MFFSGHLLQD 

       370        380        390        400        410        420 
CVQSFPCCQR MVQKFTKDDS DNMSRRHTSY SNNRSPTNST GTWKDSPKSS RSIRFIPVST 

« Hide

References

[1]"Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vole."
Young L.J., Nilsen R., Waymire K.G., MacGregor G.R., Insel T.R.
Nature 400:766-768(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Brain.
[2]"Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene."
Lim M.M., Wang Z., Olazabal D.E., Ren X., Terwilliger E.F., Young L.J.
Nature 429:754-757(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: ROLE IN SOCIAL BEHAVIOR.

Web resources

Protein Spotlight

Nature's philanderers - Issue 52 of November 2004

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF069304 Genomic DNA. Translation: AAD02821.2.

3D structure databases

ProteinModelPortalQ9WTV9.
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL2016428.

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG105710.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameV1AR_MICOH
AccessionPrimary (citable) accession number: Q9WTV9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries