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Protein

26S proteasome non-ATPase regulatory subunit 9

Gene

Psmd9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process (By similarity).By similarity

GO - Molecular functioni

  • bHLH transcription factor binding Source: BHF-UCL
  • protein C-terminus binding Source: RGD
  • transcription coactivator activity Source: BHF-UCL

GO - Biological processi

  • negative regulation of insulin secretion Source: BHF-UCL
  • positive regulation of insulin secretion Source: BHF-UCL
  • positive regulation of transcription, DNA-templated Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: RGD
  • proteasome regulatory particle assembly Source: UniProtKB
  • type B pancreatic cell apoptotic process Source: BHF-UCL

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 9
Alternative name(s):
26S proteasome regulatory subunit p27
Transactivating protein Bridge-1
Gene namesi
Name:Psmd9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621110. Psmd9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001738541 – 22226S proteasome non-ATPase regulatory subunit 9Add BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei128PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9WTV5.
PRIDEiQ9WTV5.

PTM databases

iPTMnetiQ9WTV5.
PhosphoSitePlusiQ9WTV5.

Interactioni

Subunit structurei

Interacts with PSMC3. Part of a transient complex (modulator) containing PSMD9, PSMC6 and PSMC3 formed during the assembly of the 26S proteasome (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Pdx1P529473EBI-7626072,EBI-7626093

GO - Molecular functioni

  • bHLH transcription factor binding Source: BHF-UCL
  • protein C-terminus binding Source: RGD

Protein-protein interaction databases

BioGridi250907. 2 interactors.
IntActiQ9WTV5. 1 interactor.
MINTiMINT-1894545.
STRINGi10116.ENSRNOP00000054528.

Structurei

3D structure databases

ProteinModelPortaliQ9WTV5.
SMRiQ9WTV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 194PDZAdd BLAST87

Sequence similaritiesi

Belongs to the proteasome subunit p27 family.Curated

Phylogenomic databases

eggNOGiKOG3129. Eukaryota.
COG0265. LUCA.
HOGENOMiHOG000216665.
HOVERGENiHBG001851.
InParanoidiQ9WTV5.
KOiK06693.
PhylomeDBiQ9WTV5.

Family and domain databases

InterProiView protein in InterPro
IPR001478. PDZ.
IPR036034. PDZ_sf.
IPR035269. PSMD9.
PANTHERiPTHR12651. PTHR12651. 1 hit.
PfamiView protein in Pfam
PF13180. PDZ_2. 1 hit.
SMARTiView protein in SMART
SM00228. PDZ. 1 hit.
SUPFAMiSSF50156. SSF50156. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WTV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEEVRHRA ESSEARAAAV SDIQELMRRK EEIEAQIKAN YDVLESQKGI
60 70 80 90 100
GMNEPLVDCE GYPRADVDLY QVRTARHNII CLQNDHKALM KQVEEALHQL
110 120 130 140 150
HARDKEKQAR DMAEAREEAM NRRLASDSPA LPKAFARVNS ISPGSPASIA
160 170 180 190 200
GLQVDDEIVE FGSVNTQNFQ SLQNVGTVVQ HSEGKPLNVM VIRRGEKHQL
210 220
RLTPTRWAGK GLLGCNITPL QR
Length:222
Mass (Da):24,829
Last modified:November 1, 1999 - v1
Checksum:i731BC90C3226B88B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067728 mRNA. Translation: AAD32925.1.
RefSeqiNP_569114.1. NM_130430.1.
UniGeneiRn.24127.

Genome annotation databases

GeneIDi161475.
KEGGirno:161475.
UCSCiRGD:621110. rat.

Similar proteinsi

Entry informationi

Entry nameiPSMD9_RAT
AccessioniPrimary (citable) accession number: Q9WTV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: October 25, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families