Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sodium channel protein type 8 subunit alpha

Gene

Scn8a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. In macrophages, isoform 5 may participate in the control of podosome and invadopodia formation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi891 – 898ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • adult locomotory behavior Source: MGI
  • adult walking behavior Source: MGI
  • locomotory behavior Source: MGI
  • membrane depolarization during action potential Source: GO_Central
  • muscle organ development Source: MGI
  • neuromuscular process Source: MGI
  • neuronal action potential Source: GO_Central
  • response to toxic substance Source: MGI
  • sensory perception of sound Source: MGI
  • sodium ion transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel protein type 8 subunit alpha
Alternative name(s):
Sodium channel protein type VIII subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.6
Gene namesi
Name:Scn8a
Synonyms:Nbna1
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:103169. Scn8a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 127CytoplasmicSequence analysisAdd BLAST127
Transmembranei128 – 151Helical; Name=S1 of repeat ISequence analysisAdd BLAST24
Topological domaini152 – 159ExtracellularSequence analysis8
Transmembranei160 – 179Helical; Name=S2 of repeat ISequence analysisAdd BLAST20
Topological domaini180 – 192CytoplasmicSequence analysisAdd BLAST13
Transmembranei193 – 211Helical; Name=S3 of repeat ISequence analysisAdd BLAST19
Topological domaini212 – 217ExtracellularSequence analysis6
Transmembranei218 – 237Helical; Voltage-sensor; Name=S4 of repeat ISequence analysisAdd BLAST20
Topological domaini238 – 252CytoplasmicSequence analysisAdd BLAST15
Transmembranei253 – 277Helical; Name=S5 of repeat ISequence analysisAdd BLAST25
Topological domaini278 – 387ExtracellularSequence analysisAdd BLAST110
Transmembranei388 – 413Helical; Name=S6 of repeat ISequence analysisAdd BLAST26
Topological domaini414 – 745CytoplasmicSequence analysisAdd BLAST332
Transmembranei746 – 770Helical; Name=S1 of repeat IISequence analysisAdd BLAST25
Topological domaini771 – 781ExtracellularSequence analysisAdd BLAST11
Transmembranei782 – 805Helical; Name=S2 of repeat IISequence analysisAdd BLAST24
Topological domaini806 – 813CytoplasmicSequence analysis8
Transmembranei814 – 833Helical; Name=S3 of repeat IISequence analysisAdd BLAST20
Topological domaini834 – 839ExtracellularSequence analysis6
Transmembranei840 – 860Helical; Voltage-sensor; Name=S4 of repeat IISequence analysisAdd BLAST21
Topological domaini861 – 875CytoplasmicSequence analysisAdd BLAST15
Transmembranei876 – 896Helical; Name=S5 of repeat IISequence analysisAdd BLAST21
Topological domaini897 – 949ExtracellularSequence analysisAdd BLAST53
Transmembranei950 – 975Helical; Name=S6 of repeat IISequence analysisAdd BLAST26
Topological domaini976 – 1191CytoplasmicSequence analysisAdd BLAST216
Transmembranei1192 – 1215Helical; Name=S1 of repeat IIISequence analysisAdd BLAST24
Topological domaini1216 – 1228ExtracellularSequence analysisAdd BLAST13
Transmembranei1229 – 1254Helical; Name=S2 of repeat IIISequence analysisAdd BLAST26
Topological domaini1255 – 1260CytoplasmicSequence analysis6
Transmembranei1261 – 1282Helical; Name=S3 of repeat IIISequence analysisAdd BLAST22
Topological domaini1283 – 1286ExtracellularSequence analysis4
Transmembranei1287 – 1308Helical; Voltage-sensor; Name=S4 of repeat IIISequence analysisAdd BLAST22
Topological domaini1309 – 1327CytoplasmicSequence analysisAdd BLAST19
Transmembranei1328 – 1349Helical; Name=S5 of repeat IIISequence analysisAdd BLAST22
Topological domaini1350 – 1435ExtracellularSequence analysisAdd BLAST86
Transmembranei1436 – 1462Helical; Name=S6 of repeat IIISequence analysisAdd BLAST27
Topological domaini1463 – 1515CytoplasmicSequence analysisAdd BLAST53
Transmembranei1516 – 1539Helical; Name=S1 of repeat IVSequence analysisAdd BLAST24
Topological domaini1540 – 1550ExtracellularSequence analysisAdd BLAST11
Transmembranei1551 – 1574Helical; Name=S2 of repeat IVSequence analysisAdd BLAST24
Topological domaini1575 – 1580CytoplasmicSequence analysis6
Transmembranei1581 – 1604Helical; Name=S3 of repeat IVSequence analysisAdd BLAST24
Topological domaini1605 – 1614ExtracellularSequence analysis10
Transmembranei1615 – 1636Helical; Voltage-sensor; Name=S4 of repeat IVSequence analysisAdd BLAST22
Topological domaini1637 – 1651CytoplasmicSequence analysisAdd BLAST15
Transmembranei1652 – 1674Helical; Name=S5 of repeat IVSequence analysisAdd BLAST23
Topological domaini1675 – 1739ExtracellularSequence analysisAdd BLAST65
Transmembranei1740 – 1764Helical; Name=S6 of repeat IVSequence analysisAdd BLAST25
Topological domaini1765 – 1978CytoplasmicSequence analysisAdd BLAST214

GO - Cellular componenti

  • dendrite Source: MGI
  • membrane Source: MGI
  • neuronal cell body Source: MGI
  • node of Ranvier Source: BHF-UCL
  • plasma membrane Source: GO_Central
  • sodium channel complex Source: MGI
  • voltage-gated sodium channel complex Source: UniProtKB
  • Z disc Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Scn8a are the cause of motor endplate disease (med). Med is a recessive neuromuscular disorder that is characterized by lack of signal transmission at the neuromuscular junction, excess preterminal arborization and degeneration of cerebellar Purkinje cells. It produces early onset progressive paralysis of hind limbs, severe muscle atrophy and juvenile lethality.

Defects in Scn8a are the cause of the jolting mutant (medjo), a mild form of motor endplate disease which is characterized by the absence of spontaneous, regular, simple discharges from Purkinje cells. After 3 weeks of age, jolting mice are unsteady and have wide-based gait and a rhythmical tremor of head and neck induced by attempted movement.

Defects in Scn8a are a cause of degenerating muscle (dmu). Dmu is an autosomal recessive neuromuscular disorder that is characterized by skeletal and cardiac muscle degeneration. It produces early onset progressive loss of mobility of the hind limbs and subsequent lethality in the first month of life.

Keywords - Diseasei

Disease mutation

Chemistry databases

ChEMBLiCHEMBL1914275.
GuidetoPHARMACOLOGYi583.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000485011 – 1978Sodium channel protein type 8 subunit alphaAdd BLAST1978

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi215N-linked (GlcNAc...)Sequence analysis1
Glycosylationi289N-linked (GlcNAc...)Sequence analysis1
Glycosylationi295N-linked (GlcNAc...)Sequence analysis1
Glycosylationi308N-linked (GlcNAc...)Sequence analysis1
Glycosylationi326N-linked (GlcNAc...)Sequence analysis1
Modified residuei477PhosphoserineBy similarity1
Modified residuei504PhosphoserineBy similarity1
Modified residuei518PhosphoserineBy similarity1
Modified residuei520PhosphoserineBy similarity1
Modified residuei546PhosphoserineBy similarity1
Modified residuei579PhosphoserineBy similarity1
Modified residuei613PhosphoserineBy similarity1
Modified residuei697PhosphoserineBy similarity1
Modified residuei700PhosphoserineBy similarity1
Glycosylationi1356N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1370N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1381N-linked (GlcNAc...)Sequence analysis1
Modified residuei1495Phosphoserine; by PKCBy similarity1

Post-translational modificationi

May be ubiquitinated by NEDD4L; which would promote its endocytosis.By similarity
Phosphorylation at Ser-1495 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9WTU3.
PRIDEiQ9WTU3.

PTM databases

iPTMnetiQ9WTU3.
PhosphoSitePlusiQ9WTU3.

Expressioni

Tissue specificityi

Expressed in brain, cerebellum and spinal cord. Isoform 5 may be expressed in non-neuronal tissues, such as peritoneal macrophages.2 Publications

Gene expression databases

CleanExiMM_SCN8A.

Interactioni

Subunit structurei

Interacts with FGF13; may regulate SCN8A activity (By similarity). Interacts with NEDD4 and NEDD4L (PubMed:15123669). Interacts with FGF14, GBG3, GBB2 and SCN1B (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Map1bP148737EBI-6396042,EBI-764653

Protein-protein interaction databases

BioGridi203103. 3 interactors.
IntActiQ9WTU3. 1 interactor.
STRINGi10090.ENSMUSP00000080842.

Chemistry databases

BindingDBiQ9WTU3.

Structurei

Secondary structure

11978
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1893 – 1912Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WFNX-ray1.95B/C/D/E1893-1914[»]
ProteinModelPortaliQ9WTU3.
SMRiQ9WTU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati114 – 442ICuratedAdd BLAST329
Repeati733 – 1005IICuratedAdd BLAST273
Repeati1178 – 1493IIICuratedAdd BLAST316
Repeati1502 – 1799IVCuratedAdd BLAST298
Domaini1893 – 1922IQPROSITE-ProRule annotationCuratedAdd BLAST30

Domaini

The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.Curated

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotationCurated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
HOGENOMiHOG000231755.
HOVERGENiHBG091796.
InParanoidiQ9WTU3.
KOiK04840.
PhylomeDBiQ9WTU3.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR008054. Na_channel_a8su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR024583. Na_trans_cytopl.
[Graphical view]
PfamiPF00520. Ion_trans. 4 hits.
PF00612. IQ. 1 hit.
PF06512. Na_trans_assoc. 1 hit.
PF11933. Na_trans_cytopl. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
PR01667. NACHANNEL8.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]
PROSITEiPS50096. IQ. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 12 Publications (identifier: Q9WTU3-1) [UniParc]FASTAAdd to basket
Also known as: 18A1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAARVLAPPG PDSFKPFTPE SLANIERRIA ESKLKKPPKA DGSHREDDED
60 70 80 90 100
SKPKPNSDLE AGKSLPFIYG DIPQGLVAVP LEDFDPYYLT QKTFVVLNRG
110 120 130 140 150
KTLFRFSATP ALYILSPFNL IRRIAIKILI HSVFSMIIMC TILTNCVFMT
160 170 180 190 200
FSNPPEWSKN VEYTFTGIYT FESLVKIIAR GFCIDGFTFL RDPWNWLDFS
210 220 230 240 250
VIMMAYVTEF VDLGNVSALR TFRVLRALKT ISVIPGLKTI VGALIQSVKK
260 270 280 290 300
LSDVMILTVF CLSVFALIGL QLFMGNLRNK CVVWPINFNE SYLENGTRGF
310 320 330 340 350
DWEEYINNKT NFYMVPGMLE PLLCGNSSDA GQCPEGFQCM KAGRNPNYGY
360 370 380 390 400
TSFDTFSWAF LALFRLMTQD YWENLYQLTL RAAGKTYMIF FVLVIFVGSF
410 420 430 440 450
YLVNLILAVV AMAYEEQNQA TLEEAEQKEA EFKAMLEQLK KQQEEAQAAA
460 470 480 490 500
MATSAGTVSE DAIEEEGEDG VGSPRSSSEL SKLSSKSAKE RRNRRKKRKQ
510 520 530 540 550
KELSEGEEKG DPEKVFKSES EDGMRRKAFR LPDNRIGRKF SIMNQSLLSI
560 570 580 590 600
PGSPFLSRHN SKSSIFSFRG PGRFRDPGSE NEFADDEHST VEESEGRRDS
610 620 630 640 650
LFIPIRARER RSSYSGYSGY SQCSRSSRIF PSLRRSVKRN STVDCNGVVS
660 670 680 690 700
LIGPGSHIGR LLPEATTEVE IKKKGPGSLL VSMEQLASYG RKDRINSIMS
710 720 730 740 750
VVTNTLVEEL EESQRKCPPC WYKFANTFLI WECHPYWIKL KEIVNLIVMD
760 770 780 790 800
PFVDLAITIC IVLNTLFMAM EHHPMTPQFE HVLAVGNLVF TGIFTAEMFL
810 820 830 840 850
KLIAMDPYYY FQEGWNIFDG FIVSLSLMEL GLADVEGLSV LRSFRLLRVF
860 870 880 890 900
KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV GMQLFGKSYK
910 920 930 940 950
ECVCKISQEC KLPRWHMNDF FHSFLIVFRV LCGEWIETMW DCMEVAGQAM
960 970 980 990 1000
CLIVFMMVMV IGNLVVLNLF LALLLSSFSA DNLAATDDDG EMNNLQISVI
1010 1020 1030 1040 1050
RIKKGVAWAK VKVHAFMQAH FKQREADEVK PLDELYEKKA NCIANHTGVD
1060 1070 1080 1090 1100
IHRNGDFQKN GNGTTSGIGS SVEKYIIDED HMSFINNPNL TVRVPIAVGE
1110 1120 1130 1140 1150
SDFENLNTED VSSESDPEGS KDKLDDTSSS EGSTIDIKPE VEEVPVEQPE
1160 1170 1180 1190 1200
EYLDPDACFT EGCVQRFKCC QVNIEEGLGK SWWILRKTCF LIVEHNWFET
1210 1220 1230 1240 1250
FIIFMILLSS GALAFEDIYI EQRKTIRTIL EYADKVFTYI FILEMLLKWT
1260 1270 1280 1290 1300
AYGFVKFFTN AWCWLDFLIV AVSLVSLIAN ALGYSELGAI KSLRTLRALR
1310 1320 1330 1340 1350
PLRALSRFEG MRVVVNALVG AIPSIMNVLL VCLIFWLIFS IMGVNLFAGK
1360 1370 1380 1390 1400
YHYCFNETSE IRFEIDEVNN KTDCEKLMEG NNTEIRWKNV KINFDNVGAG
1410 1420 1430 1440 1450
YLALLQVATF KGWMDIMYAA VDSRKPDEQP DYEGNIYMYI YFVIFIIFGS
1460 1470 1480 1490 1500
FFTLNLFIGV IIDNFNQQKK KFGGQDIFMT EEQKKYYNAM KKLGSKKPQK
1510 1520 1530 1540 1550
PIPRPLNKIQ GIVFDFVTQQ AFDIVIMMLI CLNMVTMMVE TDTQSKQMEN
1560 1570 1580 1590 1600
ILYWINLVFV IFFTCECVLK MFALRHYYFT IGWNIFDFVV VILSIVGMFL
1610 1620 1630 1640 1650
ADIIEKYFVS PTLFRVIRLA RIGRILRLIK GAKGIRTLLF ALMMSLPALF
1660 1670 1680 1690 1700
NIGLLLFLVM FIFSIFGMSN FAYVKHEAGI DDMFNFETFG NSMICLFQIT
1710 1720 1730 1740 1750
TSAGWDGLLL PILNRPPDCS LDKEHPGSGF KGDCGNPSVG IFFFVSYIII
1760 1770 1780 1790 1800
SFLIVVNMYI AIILENFSVA TEESADPLSE DDFETFYEIW EKFDPDATQF
1810 1820 1830 1840 1850
IEYCKLADFA DALEHPLRVP KPNTIELIAM DLPMVSGDRI HCLDILFAFT
1860 1870 1880 1890 1900
KRVLGDSGEL DILRQQMEER FVASNPSKVS YEPITTTLRR KQEEVSAVVL
1910 1920 1930 1940 1950
QRAYRGHLAR RGFICRKITS NKLENGGTHR EKKESTPSTA SLPSYDSVTK
1960 1970
PDKEKQQRAE EGRRERAKRQ KEVRESKC
Length:1,978
Mass (Da):225,141
Last modified:November 1, 1999 - v1
Checksum:i9EA4A8E610707220
GO
Isoform 21 Publication (identifier: Q9WTU3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     428-673: Missing.

Note: Due to aberrant splicing.
Show »
Length:1,732
Mass (Da):197,648
Checksum:i7A7CF0DB544EBCF6
GO
Isoform 31 Publication (identifier: Q9WTU3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     664-664: E → EVKIDKAATDS

Show »
Length:1,988
Mass (Da):226,170
Checksum:i4DF697091BEFF58B
GO
Isoform 41 Publication (identifier: Q9WTU3-4) [UniParc]FASTAAdd to basket
Also known as: 18N1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1273-1280: SLVSLIAN → PLSLSGLI
     1281-1978: Missing.

Show »
Length:1,280
Mass (Da):145,012
Checksum:i829683D208A54355
GO
Isoform 51 Publication (identifier: Q9WTU3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1272-1312: Missing.

Show »
Length:1,937
Mass (Da):220,659
Checksum:i12C51774C21ADF5E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti207V → I in BAE34580 (PubMed:16141072).Curated1
Sequence conflicti212D → N in BAE34580 (PubMed:16141072).Curated1
Sequence conflicti554P → T in BAE34580 (PubMed:16141072).Curated1
Sequence conflicti596G → D in BAE34580 (PubMed:16141072).Curated1
Sequence conflicti1498P → A in AAA65599 (Ref. 5) Curated1
Sequence conflicti1504R → E in AAA65599 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti5V → L.2 Publications1
Natural varianti1317A → T in medjo. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_050594428 – 673Missing in isoform 2. 1 PublicationAdd BLAST246
Alternative sequenceiVSP_050595664E → EVKIDKAATDS in isoform 3. 1 Publication1
Alternative sequenceiVSP_0505981272 – 1312Missing in isoform 5. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_0505961273 – 1280SLVSLIAN → PLSLSGLI in isoform 4. 1 Publication8
Alternative sequenceiVSP_0505971281 – 1978Missing in isoform 4. 1 PublicationAdd BLAST698

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049617 mRNA. Translation: AAD20438.1.
U26707 mRNA. Translation: AAC52242.1.
AK158609 mRNA. Translation: BAE34580.1.
U59964, U59963 Genomic DNA. Translation: AAC52708.1.
U23158 mRNA. Translation: AAA65599.1.
CCDSiCCDS57011.1. [Q9WTU3-1]
RefSeqiNP_001070967.1. NM_001077499.2.
NP_035453.2. NM_011323.3.
UniGeneiMm.385012.

Genome annotation databases

GeneIDi20273.
KEGGimmu:20273.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049617 mRNA. Translation: AAD20438.1.
U26707 mRNA. Translation: AAC52242.1.
AK158609 mRNA. Translation: BAE34580.1.
U59964, U59963 Genomic DNA. Translation: AAC52708.1.
U23158 mRNA. Translation: AAA65599.1.
CCDSiCCDS57011.1. [Q9WTU3-1]
RefSeqiNP_001070967.1. NM_001077499.2.
NP_035453.2. NM_011323.3.
UniGeneiMm.385012.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WFNX-ray1.95B/C/D/E1893-1914[»]
ProteinModelPortaliQ9WTU3.
SMRiQ9WTU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203103. 3 interactors.
IntActiQ9WTU3. 1 interactor.
STRINGi10090.ENSMUSP00000080842.

Chemistry databases

BindingDBiQ9WTU3.
ChEMBLiCHEMBL1914275.
GuidetoPHARMACOLOGYi583.

PTM databases

iPTMnetiQ9WTU3.
PhosphoSitePlusiQ9WTU3.

Proteomic databases

PaxDbiQ9WTU3.
PRIDEiQ9WTU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20273.
KEGGimmu:20273.

Organism-specific databases

CTDi6334.
MGIiMGI:103169. Scn8a.

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
HOGENOMiHOG000231755.
HOVERGENiHBG091796.
InParanoidiQ9WTU3.
KOiK04840.
PhylomeDBiQ9WTU3.

Miscellaneous databases

ChiTaRSiScn8a. mouse.
PROiQ9WTU3.
SOURCEiSearch...

Gene expression databases

CleanExiMM_SCN8A.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR008054. Na_channel_a8su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR024583. Na_trans_cytopl.
[Graphical view]
PfamiPF00520. Ion_trans. 4 hits.
PF00612. IQ. 1 hit.
PF06512. Na_trans_assoc. 1 hit.
PF11933. Na_trans_cytopl. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
PR01667. NACHANNEL8.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]
PROSITEiPS50096. IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCN8A_MOUSE
AccessioniPrimary (citable) accession number: Q9WTU3
Secondary accession number(s): Q3TYI3
, Q60828, Q60858, Q62449
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.