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Protein

Basic leucine zipper and W2 domain-containing protein 2

Gene

Bzw2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in neuronal differentiation.1 Publication

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper and W2 domain-containing protein 2
Alternative name(s):
Brain development-related molecule 2
Gene namesi
Name:Bzw2
Synonyms:Bdm2, Hfb2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi621507 Bzw2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002546221 – 419Basic leucine zipper and W2 domain-containing protein 2Add BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei117N6-acetyllysineBy similarity1
Modified residuei412PhosphoserineCombined sources1
Modified residuei414PhosphoserineCombined sources1
Modified residuei419PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9WTT7
PRIDEiQ9WTT7

PTM databases

iPTMnetiQ9WTT7
PhosphoSitePlusiQ9WTT7

Expressioni

Tissue specificityi

Expressed at high levels in heart, and at lower levels in skeletal muscle, spleen and lung. Expressed at low levels in brain regions where nascent and immature neurons are present.1 Publication

Developmental stagei

Expressed at E8. In brain, expression increases between E14 and E16, reaches a plateau at E18, and subsequently decreases.1 Publication

Gene expression databases

BgeeiENSRNOG00000005096
GenevisibleiQ9WTT7 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007414

Structurei

3D structure databases

ProteinModelPortaliQ9WTT7
SMRiQ9WTT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini248 – 415W2PROSITE-ProRule annotationAdd BLAST168

Sequence similaritiesi

Belongs to the BZW family.Curated

Phylogenomic databases

eggNOGiKOG2297 Eukaryota
ENOG410XR08 LUCA
GeneTreeiENSGT00390000012561
HOGENOMiHOG000252932
HOVERGENiHBG080940
InParanoidiQ9WTT7
OMAiFMNKHQK
OrthoDBiEOG091G090E
PhylomeDBiQ9WTT7
TreeFamiTF324313

Family and domain databases

Gene3Di1.25.40.180, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR016021 MIF4-like_sf
IPR003307 W2_domain
PfamiView protein in Pfam
PF02020 W2, 1 hit
SMARTiView protein in SMART
SM00515 eIF5C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51363 W2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WTT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKHQKPVLT GQRFKTRKRD EKEKFEPTVF RDTLVQGLNE AGDDLEAVAK
60 70 80 90 100
FLDSTGSRLD YRRYADTLFD ILVAGSMLAP GGTRIDDGDK TKMTNHCVFS
110 120 130 140 150
ANEDHETIRN YAQVFNKLIR RYKYLEKAFE DEMKKLLLFL KAFSEAEQTK
160 170 180 190 200
LAMLSGILLG NGTLPATILT SLFTDSLVKE GIAASFAVKL FKAWMAEKDA
210 220 230 240 250
NSVTSSLRKA NLDKRLLELF PVNRQSVDHF AKYFTDAGLK ELSDFLRVQQ
260 270 280 290 300
SLGTRKELQK ELQERLSQEC PIKEVVLYVK EEMKRNDLPE TAVIGLLWTC
310 320 330 340 350
VMNAVEWNKK EELVAEQALK HLKQYAPLLA VFSSQGQSEL VLLQKVQEYC
360 370 380 390 400
YDNIHFMKAF QKIVVLFYKA DVLSEEAILK WYKEAHAAKG KSVFLDQMKK
410
FVEWLQNAEE ESESEGEES
Length:419
Mass (Da):48,049
Last modified:November 1, 1999 - v1
Checksum:iC66FC462AA0EA773
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031483 mRNA Translation: AAD20436.1
BC063149 mRNA Translation: AAH63149.1
RefSeqiNP_599229.1, NM_134402.3
UniGeneiRn.13196

Genome annotation databases

EnsembliENSRNOT00000007414; ENSRNOP00000007414; ENSRNOG00000005096
GeneIDi171439
KEGGirno:171439
UCSCiRGD:621507 rat

Similar proteinsi

Entry informationi

Entry nameiBZW2_RAT
AccessioniPrimary (citable) accession number: Q9WTT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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