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Protein

Basic leucine zipper and W2 domain-containing protein 2

Gene

Bzw2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in neuronal differentiation.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper and W2 domain-containing protein 2
Alternative name(s):
Brain development-related molecule 2
Gene namesi
Name:Bzw2
Synonyms:Bdm2, Hfb2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi621507. Bzw2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419Basic leucine zipper and W2 domain-containing protein 2PRO_0000254622Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei117 – 1171N6-acetyllysineBy similarity
Modified residuei412 – 4121PhosphoserineCombined sources
Modified residuei414 – 4141PhosphoserineCombined sources
Modified residuei419 – 4191PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9WTT7.
PRIDEiQ9WTT7.

Expressioni

Tissue specificityi

Expressed at high levels in heart, and at lower levels in skeletal muscle, spleen and lung. Expressed at low levels in brain regions where nascent and immature neurons are present.1 Publication

Developmental stagei

Expressed at E8. In brain, expression increases between E14 and E16, reaches a plateau at E18, and subsequently decreases.1 Publication

Gene expression databases

GenevisibleiQ9WTT7. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007414.

Structurei

3D structure databases

ProteinModelPortaliQ9WTT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini248 – 415168W2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the BZW family.Curated
Contains 1 W2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2297. Eukaryota.
ENOG410XR08. LUCA.
GeneTreeiENSGT00390000012561.
HOGENOMiHOG000252932.
HOVERGENiHBG080940.
InParanoidiQ9WTT7.
OMAiFMNKHQK.
OrthoDBiEOG78PV8V.
PhylomeDBiQ9WTT7.
TreeFamiTF324313.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR016021. MIF4-like.
IPR003307. W2_domain.
[Graphical view]
PfamiPF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51363. W2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WTT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKHQKPVLT GQRFKTRKRD EKEKFEPTVF RDTLVQGLNE AGDDLEAVAK
60 70 80 90 100
FLDSTGSRLD YRRYADTLFD ILVAGSMLAP GGTRIDDGDK TKMTNHCVFS
110 120 130 140 150
ANEDHETIRN YAQVFNKLIR RYKYLEKAFE DEMKKLLLFL KAFSEAEQTK
160 170 180 190 200
LAMLSGILLG NGTLPATILT SLFTDSLVKE GIAASFAVKL FKAWMAEKDA
210 220 230 240 250
NSVTSSLRKA NLDKRLLELF PVNRQSVDHF AKYFTDAGLK ELSDFLRVQQ
260 270 280 290 300
SLGTRKELQK ELQERLSQEC PIKEVVLYVK EEMKRNDLPE TAVIGLLWTC
310 320 330 340 350
VMNAVEWNKK EELVAEQALK HLKQYAPLLA VFSSQGQSEL VLLQKVQEYC
360 370 380 390 400
YDNIHFMKAF QKIVVLFYKA DVLSEEAILK WYKEAHAAKG KSVFLDQMKK
410
FVEWLQNAEE ESESEGEES
Length:419
Mass (Da):48,049
Last modified:November 1, 1999 - v1
Checksum:iC66FC462AA0EA773
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031483 mRNA. Translation: AAD20436.1.
BC063149 mRNA. Translation: AAH63149.1.
RefSeqiNP_599229.1. NM_134402.3.
UniGeneiRn.13196.

Genome annotation databases

EnsembliENSRNOT00000007414; ENSRNOP00000007414; ENSRNOG00000005096.
GeneIDi171439.
KEGGirno:171439.
UCSCiRGD:621507. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031483 mRNA. Translation: AAD20436.1.
BC063149 mRNA. Translation: AAH63149.1.
RefSeqiNP_599229.1. NM_134402.3.
UniGeneiRn.13196.

3D structure databases

ProteinModelPortaliQ9WTT7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007414.

Proteomic databases

PaxDbiQ9WTT7.
PRIDEiQ9WTT7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007414; ENSRNOP00000007414; ENSRNOG00000005096.
GeneIDi171439.
KEGGirno:171439.
UCSCiRGD:621507. rat.

Organism-specific databases

CTDi28969.
RGDi621507. Bzw2.

Phylogenomic databases

eggNOGiKOG2297. Eukaryota.
ENOG410XR08. LUCA.
GeneTreeiENSGT00390000012561.
HOGENOMiHOG000252932.
HOVERGENiHBG080940.
InParanoidiQ9WTT7.
OMAiFMNKHQK.
OrthoDBiEOG78PV8V.
PhylomeDBiQ9WTT7.
TreeFamiTF324313.

Miscellaneous databases

NextBioi622348.
PROiQ9WTT7.

Gene expression databases

GenevisibleiQ9WTT7. RN.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR016021. MIF4-like.
IPR003307. W2_domain.
[Graphical view]
PfamiPF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51363. W2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the novel developmentally regulated gene, Bdm2, which is highly expressed in fetal rat brain."
    Nishinaka N., Hongo S., Zhou C.J., Shioda S., Takahashi R., Yamauchi Y., Ohashi T., Ohki T., Nakada N., Takeda F., Takeda M.
    Brain Res. Dev. Brain Res. 120:57-64(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, FUNCTION.
    Strain: Wistar.
    Tissue: Fetal brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-412; SER-414 AND SER-419, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBZW2_RAT
AccessioniPrimary (citable) accession number: Q9WTT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1999
Last modified: November 11, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.