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Protein

V-type proton ATPase subunit G 2

Gene

Atp6v1g2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

  • ATPase activity Source: MGI
  • hydrogen-exporting ATPase activity, phosphorylative mechanism Source: MGI
Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1222556. ROS, RNS production in response to bacteria.
R-MMU-77387. Insulin receptor recycling.
R-MMU-917977. Transferrin endocytosis and recycling.
R-MMU-983712. Ion channel transport.

Protein family/group databases

TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit G 2
Short name:
V-ATPase subunit G 2
Alternative name(s):
V-ATPase 13 kDa subunit 2
Vacuolar proton pump subunit G 2
Gene namesi
Name:Atp6v1g2
Synonyms:Atp6g2, Ng38
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1913487. Atp6v1g2.

Subcellular locationi

GO - Cellular componenti

  • integral component of synaptic vesicle membrane Source: MGI
  • melanosome Source: UniProtKB-SubCell
  • vacuolar proton-transporting V-type ATPase complex Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001929021 – 118V-type proton ATPase subunit G 2Add BLAST118

Proteomic databases

MaxQBiQ9WTT4.
PaxDbiQ9WTT4.
PRIDEiQ9WTT4.

PTM databases

iPTMnetiQ9WTT4.
PhosphoSitePlusiQ9WTT4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024403.
CleanExiMM_ATP6V1G2.
ExpressionAtlasiQ9WTT4. baseline and differential.
GenevisibleiQ9WTT4. MM.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).By similarity

Protein-protein interaction databases

BioGridi211318. 2 interactors.
IntActiQ9WTT4. 2 interactors.
MINTiMINT-4998475.
STRINGi10090.ENSMUSP00000069482.

Structurei

3D structure databases

ProteinModelPortaliQ9WTT4.
SMRiQ9WTT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase G subunit family.Curated

Phylogenomic databases

eggNOGiKOG1772. Eukaryota.
ENOG4111XX0. LUCA.
GeneTreeiENSGT00390000011172.
HOGENOMiHOG000186416.
HOVERGENiHBG057827.
InParanoidiQ9WTT4.
KOiK02152.
OMAiHPNYRIT.
OrthoDBiEOG091G0XIZ.
PhylomeDBiQ9WTT4.
TreeFamiTF313777.

Family and domain databases

InterProiIPR005124. V-ATPase_G.
[Graphical view]
PANTHERiPTHR12713. PTHR12713. 1 hit.
TIGRFAMsiTIGR01147. V_ATP_synt_G. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WTT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQTQGIQQ LLQAEKRAAE KVADARKRKA RRLKQAKEEA QMEVEQYRRE
60 70 80 90 100
REQEFQSKQQ AAMGSQGNLS AEVEQATRRQ VQGMQSSQQR NRERVLAQLL
110
GMVCEVRPQV HPNYRVTV
Length:118
Mass (Da):13,651
Last modified:November 1, 1999 - v1
Checksum:i32479E10DFF11078
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007080 Genomic DNA. Translation: AAD30176.1.
AK011945 mRNA. Translation: BAB27931.1.
BC020190 mRNA. Translation: AAH20190.1.
BC062380 mRNA. Translation: AAH62380.1.
CCDSiCCDS37597.1.
RefSeqiNP_075668.1. NM_023179.3.
UniGeneiMm.396107.

Genome annotation databases

EnsembliENSMUST00000068261; ENSMUSP00000069482; ENSMUSG00000024403.
GeneIDi66237.
KEGGimmu:66237.
UCSCiuc008cgy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007080 Genomic DNA. Translation: AAD30176.1.
AK011945 mRNA. Translation: BAB27931.1.
BC020190 mRNA. Translation: AAH20190.1.
BC062380 mRNA. Translation: AAH62380.1.
CCDSiCCDS37597.1.
RefSeqiNP_075668.1. NM_023179.3.
UniGeneiMm.396107.

3D structure databases

ProteinModelPortaliQ9WTT4.
SMRiQ9WTT4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211318. 2 interactors.
IntActiQ9WTT4. 2 interactors.
MINTiMINT-4998475.
STRINGi10090.ENSMUSP00000069482.

Protein family/group databases

TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

PTM databases

iPTMnetiQ9WTT4.
PhosphoSitePlusiQ9WTT4.

Proteomic databases

MaxQBiQ9WTT4.
PaxDbiQ9WTT4.
PRIDEiQ9WTT4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068261; ENSMUSP00000069482; ENSMUSG00000024403.
GeneIDi66237.
KEGGimmu:66237.
UCSCiuc008cgy.2. mouse.

Organism-specific databases

CTDi534.
MGIiMGI:1913487. Atp6v1g2.

Phylogenomic databases

eggNOGiKOG1772. Eukaryota.
ENOG4111XX0. LUCA.
GeneTreeiENSGT00390000011172.
HOGENOMiHOG000186416.
HOVERGENiHBG057827.
InParanoidiQ9WTT4.
KOiK02152.
OMAiHPNYRIT.
OrthoDBiEOG091G0XIZ.
PhylomeDBiQ9WTT4.
TreeFamiTF313777.

Enzyme and pathway databases

ReactomeiR-MMU-1222556. ROS, RNS production in response to bacteria.
R-MMU-77387. Insulin receptor recycling.
R-MMU-917977. Transferrin endocytosis and recycling.
R-MMU-983712. Ion channel transport.

Miscellaneous databases

PROiQ9WTT4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024403.
CleanExiMM_ATP6V1G2.
ExpressionAtlasiQ9WTT4. baseline and differential.
GenevisibleiQ9WTT4. MM.

Family and domain databases

InterProiIPR005124. V-ATPase_G.
[Graphical view]
PANTHERiPTHR12713. PTHR12713. 1 hit.
TIGRFAMsiTIGR01147. V_ATP_synt_G. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVATG2_MOUSE
AccessioniPrimary (citable) accession number: Q9WTT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.