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Q9WTT4

- VATG2_MOUSE

UniProt

Q9WTT4 - VATG2_MOUSE

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Protein

V-type proton ATPase subunit G 2

Gene
Atp6v1g2, Atp6g2, Ng38
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

  1. ATPase activity Source: MGI
  2. hydrogen-exporting ATPase activity, phosphorylative mechanism Source: MGI
  3. protein binding Source: MGI

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. hydrogen ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_198345. Phagosomal maturation (early endosomal stage).
REACT_198515. Transferrin endocytosis and recycling.

Protein family/group databases

TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit G 2
Short name:
V-ATPase subunit G 2
Alternative name(s):
V-ATPase 13 kDa subunit 2
Vacuolar proton pump subunit G 2
Gene namesi
Name:Atp6v1g2
Synonyms:Atp6g2, Ng38
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1913487. Atp6v1g2.

Subcellular locationi

Melanosome By similarity

GO - Cellular componenti

  1. integral component of synaptic vesicle membrane Source: MGI
  2. melanosome Source: UniProtKB-SubCell
  3. vacuolar proton-transporting V-type ATPase complex Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 118118V-type proton ATPase subunit G 2PRO_0000192902Add
BLAST

Proteomic databases

MaxQBiQ9WTT4.
PaxDbiQ9WTT4.
PRIDEiQ9WTT4.

PTM databases

PhosphoSiteiQ9WTT4.

Expressioni

Gene expression databases

ArrayExpressiQ9WTT4.
BgeeiQ9WTT4.
CleanExiMM_ATP6V1G2.
GenevestigatoriQ9WTT4.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d) By similarity.

Protein-protein interaction databases

BioGridi211318. 2 interactions.
IntActiQ9WTT4. 2 interactions.
MINTiMINT-4998475.
STRINGi10090.ENSMUSP00000069482.

Structurei

3D structure databases

ProteinModelPortaliQ9WTT4.
SMRiQ9WTT4. Positions 1-107.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG238684.
GeneTreeiENSGT00390000011172.
HOGENOMiHOG000186416.
HOVERGENiHBG057827.
InParanoidiQ9WTT4.
KOiK02152.
OMAiHPNYRIT.
PhylomeDBiQ9WTT4.
TreeFamiTF313777.

Family and domain databases

InterProiIPR005124. V-ATPase_G.
[Graphical view]
PANTHERiPTHR12713. PTHR12713. 1 hit.
TIGRFAMsiTIGR01147. V_ATP_synt_G. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WTT4-1 [UniParc]FASTAAdd to Basket

« Hide

MASQTQGIQQ LLQAEKRAAE KVADARKRKA RRLKQAKEEA QMEVEQYRRE    50
REQEFQSKQQ AAMGSQGNLS AEVEQATRRQ VQGMQSSQQR NRERVLAQLL 100
GMVCEVRPQV HPNYRVTV 118
Length:118
Mass (Da):13,651
Last modified:November 1, 1999 - v1
Checksum:i32479E10DFF11078
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC007080 Genomic DNA. Translation: AAD30176.1.
AK011945 mRNA. Translation: BAB27931.1.
BC020190 mRNA. Translation: AAH20190.1.
BC062380 mRNA. Translation: AAH62380.1.
CCDSiCCDS37597.1.
RefSeqiNP_075668.1. NM_023179.3.
UniGeneiMm.396107.

Genome annotation databases

EnsembliENSMUST00000068261; ENSMUSP00000069482; ENSMUSG00000024403.
GeneIDi66237.
KEGGimmu:66237.
UCSCiuc008cgy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC007080 Genomic DNA. Translation: AAD30176.1 .
AK011945 mRNA. Translation: BAB27931.1 .
BC020190 mRNA. Translation: AAH20190.1 .
BC062380 mRNA. Translation: AAH62380.1 .
CCDSi CCDS37597.1.
RefSeqi NP_075668.1. NM_023179.3.
UniGenei Mm.396107.

3D structure databases

ProteinModelPortali Q9WTT4.
SMRi Q9WTT4. Positions 1-107.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 211318. 2 interactions.
IntActi Q9WTT4. 2 interactions.
MINTi MINT-4998475.
STRINGi 10090.ENSMUSP00000069482.

Protein family/group databases

TCDBi 3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

PTM databases

PhosphoSitei Q9WTT4.

Proteomic databases

MaxQBi Q9WTT4.
PaxDbi Q9WTT4.
PRIDEi Q9WTT4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000068261 ; ENSMUSP00000069482 ; ENSMUSG00000024403 .
GeneIDi 66237.
KEGGi mmu:66237.
UCSCi uc008cgy.2. mouse.

Organism-specific databases

CTDi 534.
MGIi MGI:1913487. Atp6v1g2.

Phylogenomic databases

eggNOGi NOG238684.
GeneTreei ENSGT00390000011172.
HOGENOMi HOG000186416.
HOVERGENi HBG057827.
InParanoidi Q9WTT4.
KOi K02152.
OMAi HPNYRIT.
PhylomeDBi Q9WTT4.
TreeFami TF313777.

Enzyme and pathway databases

Reactomei REACT_198345. Phagosomal maturation (early endosomal stage).
REACT_198515. Transferrin endocytosis and recycling.

Miscellaneous databases

NextBioi 321055.
PROi Q9WTT4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9WTT4.
Bgeei Q9WTT4.
CleanExi MM_ATP6V1G2.
Genevestigatori Q9WTT4.

Family and domain databases

InterProi IPR005124. V-ATPase_G.
[Graphical view ]
PANTHERi PTHR12713. PTHR12713. 1 hit.
TIGRFAMsi TIGR01147. V_ATP_synt_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 129.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiVATG2_MOUSE
AccessioniPrimary (citable) accession number: Q9WTT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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