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Protein

V-type proton ATPase subunit G 2

Gene

Atp6v1g2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

  • ATPase activity Source: MGI
  • proton-exporting ATPase activity, phosphorylative mechanism Source: MGI

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1222556 ROS, RNS production in phagocytes
R-MMU-77387 Insulin receptor recycling
R-MMU-917977 Transferrin endocytosis and recycling
R-MMU-983712 Ion channel transport

Protein family/group databases

TCDBi3.A.2.2.6 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit G 2
Short name:
V-ATPase subunit G 2
Alternative name(s):
V-ATPase 13 kDa subunit 2
Vacuolar proton pump subunit G 2
Gene namesi
Name:Atp6v1g2
Synonyms:Atp6g2, Ng38
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1913487 Atp6v1g2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001929021 – 118V-type proton ATPase subunit G 2Add BLAST118

Proteomic databases

MaxQBiQ9WTT4
PaxDbiQ9WTT4
PRIDEiQ9WTT4

PTM databases

iPTMnetiQ9WTT4
PhosphoSitePlusiQ9WTT4

Expressioni

Gene expression databases

BgeeiENSMUSG00000024403
CleanExiMM_ATP6V1G2
ExpressionAtlasiQ9WTT4 baseline and differential
GenevisibleiQ9WTT4 MM

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).By similarity

Protein-protein interaction databases

BioGridi211318, 2 interactors
IntActiQ9WTT4, 2 interactors
MINTiQ9WTT4
STRINGi10090.ENSMUSP00000069482

Structurei

3D structure databases

ProteinModelPortaliQ9WTT4
SMRiQ9WTT4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase G subunit family.Curated

Phylogenomic databases

eggNOGiKOG1772 Eukaryota
ENOG4111XX0 LUCA
GeneTreeiENSGT00390000011172
HOGENOMiHOG000186416
HOVERGENiHBG057827
InParanoidiQ9WTT4
KOiK02152
OMAiEFRTKRV
OrthoDBiEOG091G0XIZ
PhylomeDBiQ9WTT4
TreeFamiTF313777

Family and domain databases

InterProiView protein in InterPro
IPR005124 V-ATPase_G
PANTHERiPTHR12713 PTHR12713, 1 hit
PfamiView protein in Pfam
PF03179 V-ATPase_G, 1 hit
TIGRFAMsiTIGR01147 V_ATP_synt_G, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WTT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQTQGIQQ LLQAEKRAAE KVADARKRKA RRLKQAKEEA QMEVEQYRRE
60 70 80 90 100
REQEFQSKQQ AAMGSQGNLS AEVEQATRRQ VQGMQSSQQR NRERVLAQLL
110
GMVCEVRPQV HPNYRVTV
Length:118
Mass (Da):13,651
Last modified:November 1, 1999 - v1
Checksum:i32479E10DFF11078
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007080 Genomic DNA Translation: AAD30176.1
AK011945 mRNA Translation: BAB27931.1
BC020190 mRNA Translation: AAH20190.1
BC062380 mRNA Translation: AAH62380.1
CCDSiCCDS37597.1
RefSeqiNP_001334280.1, NM_001347351.1
NP_075668.1, NM_023179.3
UniGeneiMm.396107

Genome annotation databases

EnsembliENSMUST00000068261; ENSMUSP00000069482; ENSMUSG00000024403
GeneIDi66237
KEGGimmu:66237
UCSCiuc008cgy.2 mouse

Similar proteinsi

Entry informationi

Entry nameiVATG2_MOUSE
AccessioniPrimary (citable) accession number: Q9WTT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health