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Q9WTT4

- VATG2_MOUSE

UniProt

Q9WTT4 - VATG2_MOUSE

Protein

V-type proton ATPase subunit G 2

Gene

Atp6v1g2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

    GO - Molecular functioni

    1. ATPase activity Source: MGI
    2. hydrogen-exporting ATPase activity, phosphorylative mechanism Source: MGI
    3. protein binding Source: MGI

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. hydrogen ion transmembrane transport Source: GOC

    Keywords - Biological processi

    Hydrogen ion transport, Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_198345. Phagosomal maturation (early endosomal stage).
    REACT_198515. Transferrin endocytosis and recycling.

    Protein family/group databases

    TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    V-type proton ATPase subunit G 2
    Short name:
    V-ATPase subunit G 2
    Alternative name(s):
    V-ATPase 13 kDa subunit 2
    Vacuolar proton pump subunit G 2
    Gene namesi
    Name:Atp6v1g2
    Synonyms:Atp6g2, Ng38
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1913487. Atp6v1g2.

    Subcellular locationi

    Melanosome By similarity

    GO - Cellular componenti

    1. integral component of synaptic vesicle membrane Source: MGI
    2. melanosome Source: UniProtKB-SubCell
    3. vacuolar proton-transporting V-type ATPase complex Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 118118V-type proton ATPase subunit G 2PRO_0000192902Add
    BLAST

    Proteomic databases

    MaxQBiQ9WTT4.
    PaxDbiQ9WTT4.
    PRIDEiQ9WTT4.

    PTM databases

    PhosphoSiteiQ9WTT4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9WTT4.
    BgeeiQ9WTT4.
    CleanExiMM_ATP6V1G2.
    GenevestigatoriQ9WTT4.

    Interactioni

    Subunit structurei

    V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).By similarity

    Protein-protein interaction databases

    BioGridi211318. 2 interactions.
    IntActiQ9WTT4. 2 interactions.
    MINTiMINT-4998475.
    STRINGi10090.ENSMUSP00000069482.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WTT4.
    SMRiQ9WTT4. Positions 1-107.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the V-ATPase G subunit family.Curated

    Phylogenomic databases

    eggNOGiNOG238684.
    GeneTreeiENSGT00390000011172.
    HOGENOMiHOG000186416.
    HOVERGENiHBG057827.
    InParanoidiQ9WTT4.
    KOiK02152.
    OMAiHPNYRIT.
    PhylomeDBiQ9WTT4.
    TreeFamiTF313777.

    Family and domain databases

    InterProiIPR005124. V-ATPase_G.
    [Graphical view]
    PANTHERiPTHR12713. PTHR12713. 1 hit.
    TIGRFAMsiTIGR01147. V_ATP_synt_G. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9WTT4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASQTQGIQQ LLQAEKRAAE KVADARKRKA RRLKQAKEEA QMEVEQYRRE    50
    REQEFQSKQQ AAMGSQGNLS AEVEQATRRQ VQGMQSSQQR NRERVLAQLL 100
    GMVCEVRPQV HPNYRVTV 118
    Length:118
    Mass (Da):13,651
    Last modified:November 1, 1999 - v1
    Checksum:i32479E10DFF11078
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007080 Genomic DNA. Translation: AAD30176.1.
    AK011945 mRNA. Translation: BAB27931.1.
    BC020190 mRNA. Translation: AAH20190.1.
    BC062380 mRNA. Translation: AAH62380.1.
    CCDSiCCDS37597.1.
    RefSeqiNP_075668.1. NM_023179.3.
    UniGeneiMm.396107.

    Genome annotation databases

    EnsembliENSMUST00000068261; ENSMUSP00000069482; ENSMUSG00000024403.
    GeneIDi66237.
    KEGGimmu:66237.
    UCSCiuc008cgy.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007080 Genomic DNA. Translation: AAD30176.1 .
    AK011945 mRNA. Translation: BAB27931.1 .
    BC020190 mRNA. Translation: AAH20190.1 .
    BC062380 mRNA. Translation: AAH62380.1 .
    CCDSi CCDS37597.1.
    RefSeqi NP_075668.1. NM_023179.3.
    UniGenei Mm.396107.

    3D structure databases

    ProteinModelPortali Q9WTT4.
    SMRi Q9WTT4. Positions 1-107.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 211318. 2 interactions.
    IntActi Q9WTT4. 2 interactions.
    MINTi MINT-4998475.
    STRINGi 10090.ENSMUSP00000069482.

    Protein family/group databases

    TCDBi 3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    PTM databases

    PhosphoSitei Q9WTT4.

    Proteomic databases

    MaxQBi Q9WTT4.
    PaxDbi Q9WTT4.
    PRIDEi Q9WTT4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000068261 ; ENSMUSP00000069482 ; ENSMUSG00000024403 .
    GeneIDi 66237.
    KEGGi mmu:66237.
    UCSCi uc008cgy.2. mouse.

    Organism-specific databases

    CTDi 534.
    MGIi MGI:1913487. Atp6v1g2.

    Phylogenomic databases

    eggNOGi NOG238684.
    GeneTreei ENSGT00390000011172.
    HOGENOMi HOG000186416.
    HOVERGENi HBG057827.
    InParanoidi Q9WTT4.
    KOi K02152.
    OMAi HPNYRIT.
    PhylomeDBi Q9WTT4.
    TreeFami TF313777.

    Enzyme and pathway databases

    Reactomei REACT_198345. Phagosomal maturation (early endosomal stage).
    REACT_198515. Transferrin endocytosis and recycling.

    Miscellaneous databases

    NextBioi 321055.
    PROi Q9WTT4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9WTT4.
    Bgeei Q9WTT4.
    CleanExi MM_ATP6V1G2.
    Genevestigatori Q9WTT4.

    Family and domain databases

    InterProi IPR005124. V-ATPase_G.
    [Graphical view ]
    PANTHERi PTHR12713. PTHR12713. 1 hit.
    TIGRFAMsi TIGR01147. V_ATP_synt_G. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
      Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 129.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiVATG2_MOUSE
    AccessioniPrimary (citable) accession number: Q9WTT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3