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Q9WTS1

- Q9WTS1_RAT

UniProt

Q9WTS1 - Q9WTS1_RAT

Protein
Submitted name:

Egfr

Gene

Egfr

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. epidermal growth factor-activated receptor activity Source: RGD
    3. epidermal growth factor binding Source: RGD
    4. glycoprotein binding Source: RGD
    5. integrin binding Source: RGD
    6. nitric-oxide synthase regulator activity Source: Ensembl
    7. protein binding Source: RGD
    8. protein heterodimerization activity Source: RGD
    9. protein kinase binding Source: RGD
    10. receptor binding Source: RGD

    GO - Biological processi

    1. activation of MAPKK activity Source: RGD
    2. alkanesulfonate metabolic process Source: RGD
    3. astrocyte activation Source: RGD
    4. cell proliferation Source: Ensembl
    5. cellular response to dexamethasone stimulus Source: RGD
    6. cellular response to drug Source: RGD
    7. cellular response to estradiol stimulus Source: Ensembl
    8. cellular response to growth factor stimulus Source: RGD
    9. cellular response to mechanical stimulus Source: RGD
    10. cerebral cortex cell migration Source: Ensembl
    11. circadian rhythm Source: RGD
    12. digestive tract morphogenesis Source: Ensembl
    13. diterpenoid metabolic process Source: RGD
    14. embryonic placenta development Source: Ensembl
    15. epidermal growth factor receptor signaling pathway Source: RGD
    16. hair follicle development Source: Ensembl
    17. hydrogen peroxide metabolic process Source: RGD
    18. intracellular signal transduction Source: RGD
    19. liver development Source: RGD
    20. lung development Source: RGD
    21. magnesium ion homeostasis Source: RGD
    22. morphogenesis of an epithelial fold Source: Ensembl
    23. negative regulation of apoptotic process Source: RGD
    24. negative regulation of mitotic cell cycle Source: RGD
    25. negative regulation of protein catabolic process Source: Ensembl
    26. neuron projection morphogenesis Source: RGD
    27. ovulation cycle Source: RGD
    28. positive regulation of catenin import into nucleus Source: Ensembl
    29. positive regulation of cell migration Source: Ensembl
    30. positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle Source: Ensembl
    31. positive regulation of DNA repair Source: Ensembl
    32. positive regulation of DNA replication Source: Ensembl
    33. positive regulation of epithelial cell proliferation Source: Ensembl
    34. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    35. positive regulation of fibroblast proliferation Source: Ensembl
    36. positive regulation of inflammatory response Source: RGD
    37. positive regulation of MAP kinase activity Source: Ensembl
    38. positive regulation of nitric oxide biosynthetic process Source: Ensembl
    39. positive regulation of protein kinase B signaling Source: Ensembl
    40. positive regulation of smooth muscle cell proliferation Source: RGD
    41. positive regulation of superoxide anion generation Source: RGD
    42. positive regulation of synaptic transmission, glutamatergic Source: RGD
    43. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    44. positive regulation of vasoconstriction Source: RGD
    45. positive regulation of vasodilation Source: RGD
    46. protein autophosphorylation Source: RGD
    47. regulation of nitric-oxide synthase activity Source: Ensembl
    48. regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    49. response to calcium ion Source: RGD
    50. response to cobalamin Source: RGD
    51. response to estradiol Source: RGD
    52. response to hydroxyisoflavone Source: RGD
    53. response to lipid Source: RGD
    54. response to organic cyclic compound Source: RGD
    55. response to osmotic stress Source: RGD
    56. response to oxidative stress Source: RGD
    57. response to UV-A Source: Ensembl
    58. salivary gland morphogenesis Source: Ensembl
    59. signal transduction Source: RGD
    60. single organismal cell-cell adhesion Source: Ensembl
    61. tongue development Source: RGD
    62. translation Source: RGD

    Enzyme and pathway databases

    ReactomeiREACT_195027. Signaling by ERBB4.
    REACT_195029. SHC1 events in ERBB2 signaling.
    REACT_195203. GRB2 events in ERBB2 signaling.
    REACT_196848. EGFR Transactivation by Gastrin.
    REACT_197527. PI3K events in ERBB2 signaling.
    REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_199249. Signaling by constitutively active EGFR.
    REACT_203466. Signaling by ERBB2.
    REACT_203692. PLCG1 events in ERBB2 signaling.
    REACT_207015. Signaling by EGFR.
    REACT_212693. EGFR interacts with phospholipase C-gamma.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    EgfrImported
    Gene namesi
    Name:EgfrImported
    Synonyms:egfrImported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi2543. Egfr.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: RGD
    2. basolateral plasma membrane Source: RGD
    3. cell surface Source: RGD
    4. endocytic vesicle Source: RGD
    5. endosome Source: RGD
    6. membrane raft Source: Ensembl
    7. nucleus Source: RGD
    8. perinuclear region of cytoplasm Source: Ensembl
    9. plasma membrane Source: RGD

    Expressioni

    Gene expression databases

    GenevestigatoriQ9WTS1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000006087.

    Family & Domainsi

    Phylogenomic databases

    InParanoidiQ9WTS1.

    Sequencei

    Sequence statusi: Fragment.

    Q9WTS1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPSGTARTK LLLLLAALCA AGGALEEK                           28
    Length:28
    Mass (Da):2,855
    Last modified:November 1, 1999 - v1
    Checksum:iB56EAB41A074D15A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei28 – 281Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB025197 Genomic DNA. Translation: BAA76391.1.
    UniGeneiRn.37227.

    Genome annotation databases

    UCSCiRGD:2543. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB025197 Genomic DNA. Translation: BAA76391.1 .
    UniGenei Rn.37227.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000006087.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:2543. rat.

    Organism-specific databases

    RGDi 2543. Egfr.

    Phylogenomic databases

    InParanoidi Q9WTS1.

    Enzyme and pathway databases

    Reactomei REACT_195027. Signaling by ERBB4.
    REACT_195029. SHC1 events in ERBB2 signaling.
    REACT_195203. GRB2 events in ERBB2 signaling.
    REACT_196848. EGFR Transactivation by Gastrin.
    REACT_197527. PI3K events in ERBB2 signaling.
    REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_199249. Signaling by constitutively active EGFR.
    REACT_203466. Signaling by ERBB2.
    REACT_203692. PLCG1 events in ERBB2 signaling.
    REACT_207015. Signaling by EGFR.
    REACT_212693. EGFR interacts with phospholipase C-gamma.

    Gene expression databases

    Genevestigatori Q9WTS1.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Rat EGFR promoter from NRK cells."
      Kondoh S.K., Akiyama N.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9WTS1_RAT
    AccessioniPrimary (citable) accession number: Q9WTS1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1999
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)