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Q9WTS1 (Q9WTS1_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Egfr RGD 2543
Synonyms:egfr EMBL BAA76391.1
OrganismRattus norvegicus (Rat) EMBL BAA76391.1
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length28 AA.
Sequence statusFragment.
Protein existencePredicted

Ontologies

Gene Ontology (GO)
   Biological_processactivation of MAPKK activity

Inferred from mutant phenotype PubMed 14551192. Source: RGD

alkanesulfonate metabolic process

Inferred from expression pattern PubMed 21251948. Source: RGD

astrocyte activation

Inferred from mutant phenotype PubMed 16837601. Source: RGD

cell proliferation

Inferred from electronic annotation. Source: Ensembl

cellular response to dexamethasone stimulus

Inferred from expression pattern PubMed 17585012. Source: RGD

cellular response to drug

Inferred from expression pattern PubMed 21276422PubMed 21389970. Source: RGD

cellular response to estradiol stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to growth factor stimulus

Inferred from expression pattern PubMed 3495539. Source: RGD

cellular response to mechanical stimulus

Inferred from expression pattern PubMed 20927110. Source: RGD

cerebral cortex cell migration

Inferred from electronic annotation. Source: Ensembl

circadian rhythm

Inferred from expression pattern PubMed 12454858. Source: RGD

digestive tract morphogenesis

Inferred from electronic annotation. Source: Ensembl

diterpenoid metabolic process

Inferred from expression pattern PubMed 21448670. Source: RGD

embryonic placenta development

Inferred from electronic annotation. Source: Ensembl

epidermal growth factor receptor signaling pathway

Inferred from direct assay PubMed 11796513. Source: RGD

hair follicle development

Inferred from electronic annotation. Source: Ensembl

hydrogen peroxide metabolic process

Inferred from expression pattern PubMed 21258655. Source: RGD

intracellular signal transduction

Inferred from direct assay PubMed 12107054. Source: RGD

liver development

Inferred from expression pattern PubMed 12454858. Source: RGD

lung development

Inferred from expression pattern PubMed 20118217. Source: RGD

magnesium ion homeostasis

Inferred from mutant phenotype PubMed 22646904. Source: RGD

morphogenesis of an epithelial fold

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from mutant phenotype PubMed 16466740. Source: RGD

negative regulation of mitotic cell cycle

Inferred from mutant phenotype PubMed 14551192. Source: RGD

negative regulation of protein catabolic process

Inferred from electronic annotation. Source: Ensembl

neuron projection morphogenesis

Inferred from mutant phenotype PubMed 16648628. Source: RGD

ovulation cycle

Inferred from mutant phenotype PubMed 11796513. Source: RGD

positive regulation of DNA repair

Inferred from electronic annotation. Source: Ensembl

positive regulation of DNA replication

Inferred from electronic annotation. Source: Ensembl

positive regulation of ERK1 and ERK2 cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of MAP kinase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of catenin import into nucleus

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of fibroblast proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of inflammatory response

Inferred from mutant phenotype PubMed 22824323. Source: RGD

positive regulation of nitric oxide biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein kinase B signaling

Inferred from electronic annotation. Source: Ensembl

positive regulation of smooth muscle cell proliferation

Inferred from mutant phenotype PubMed 15486316. Source: RGD

positive regulation of superoxide anion generation

Inferred from mutant phenotype PubMed 22966991. Source: RGD

positive regulation of synaptic transmission, glutamatergic

Inferred from mutant phenotype PubMed 16648628. Source: RGD

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of vasoconstriction

Inferred from mutant phenotype PubMed 22966991. Source: RGD

positive regulation of vasodilation

Inferred from mutant phenotype PubMed 23232926. Source: RGD

protein autophosphorylation

Inferred from direct assay PubMed 3015391. Source: RGD

regulation of nitric-oxide synthase activity

Inferred from electronic annotation. Source: Ensembl

regulation of peptidyl-tyrosine phosphorylation

Inferred from electronic annotation. Source: Ensembl

response to UV-A

Inferred from electronic annotation. Source: Ensembl

response to calcium ion

Inferred from mutant phenotype PubMed 15950968. Source: RGD

response to cobalamin

Inferred from expression pattern PubMed 21185268. Source: RGD

response to estradiol

Inferred from expression pattern PubMed 2991264. Source: RGD

response to hydroxyisoflavone

Inferred from expression pattern PubMed 21254785. Source: RGD

response to lipid

Inferred from expression pattern PubMed 15044318. Source: RGD

response to organic cyclic compound

Inferred from expression pattern PubMed 21475988. Source: RGD

response to osmotic stress

Inferred from expression pattern PubMed 11208719. Source: RGD

response to oxidative stress

Inferred from expression pattern PubMed 11208719. Source: RGD

salivary gland morphogenesis

Inferred from electronic annotation. Source: Ensembl

signal transduction

Inferred from direct assay PubMed 12107054. Source: RGD

single organismal cell-cell adhesion

Inferred from electronic annotation. Source: Ensembl

tongue development

Inferred from expression pattern PubMed 10908606. Source: RGD

translation

Inferred from direct assay PubMed 12107054. Source: RGD

   Cellular_componentapical plasma membrane

Inferred from direct assay PubMed 15631999. Source: RGD

basolateral plasma membrane

Inferred from direct assay PubMed 15631999. Source: RGD

cell surface

Inferred from direct assay PubMed 21349584. Source: RGD

endocytic vesicle

Inferred from direct assay PubMed 11071913. Source: RGD

endosome

Inferred from direct assay PubMed 21172338. Source: RGD

membrane raft

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from direct assay PubMed 17553674. Source: RGD

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from direct assay PubMed 11071913. Source: RGD

   Molecular_functionchromatin binding

Inferred from electronic annotation. Source: Ensembl

epidermal growth factor binding

Inferred from mutant phenotype PubMed 15486316. Source: RGD

epidermal growth factor-activated receptor activity

Inferred from direct assay PubMed 11796513. Source: RGD

glycoprotein binding

Inferred from physical interaction PubMed 21349584. Source: RGD

integrin binding

Inferred from physical interaction PubMed 21349584. Source: RGD

nitric-oxide synthase regulator activity

Inferred from electronic annotation. Source: Ensembl

protein binding

Inferred from physical interaction PubMed 21037565PubMed 21258655. Source: RGD

protein heterodimerization activity

Inferred from physical interaction PubMed 16769812. Source: RGD

protein kinase binding

Inferred from physical interaction PubMed 21037565. Source: RGD

receptor binding

Inferred from physical interaction PubMed 21349584. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue281 EMBL BAA76391.1

Sequences

Sequence LengthMass (Da)Tools
Q9WTS1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: B56EAB41A074D15A

FASTA282,855
        10         20 
MRPSGTARTK LLLLLAALCA AGGALEEK 

« Hide

References

[1]"Rat EGFR promoter from NRK cells."
Kondoh S.K., Akiyama N.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB025197 Genomic DNA. Translation: BAA76391.1.
UniGeneRn.37227.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000006087.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:2543. rat.

Organism-specific databases

RGD2543. Egfr.

Phylogenomic databases

InParanoidQ9WTS1.

Gene expression databases

GenevestigatorQ9WTS1.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameQ9WTS1_RAT
AccessionPrimary (citable) accession number: Q9WTS1
Entry history
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)