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Protein
Submitted name:

Egfr

Gene

Egfr

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  • actin filament binding Source: RGD
  • cadherin binding Source: RGD
  • calmodulin binding Source: RGD
  • chromatin binding Source: RGD
  • enzyme binding Source: RGD
  • epidermal growth factor-activated receptor activity Source: RGD
  • epidermal growth factor binding Source: RGD
  • identical protein binding Source: RGD
  • integrin binding Source: RGD
  • kinase activity Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein kinase binding Source: RGD
  • protein phosphatase binding Source: RGD
  • protein tyrosine kinase activity Source: RGD
  • receptor binding Source: RGD
  • signal transducer activity Source: RGD
  • transmembrane signaling receptor activity Source: RGD
  • ubiquitin protein ligase binding Source: RGD

GO - Biological processi

  • activation of MAPKK activity Source: RGD
  • astrocyte activation Source: RGD
  • cell-cell adhesion Source: RGD
  • cell morphogenesis Source: RGD
  • cell proliferation Source: RGD
  • cell surface receptor signaling pathway Source: RGD
  • cellular response to amino acid stimulus Source: RGD
  • cellular response to cadmium ion Source: RGD
  • cellular response to dexamethasone stimulus Source: RGD
  • cellular response to drug Source: RGD
  • cellular response to estradiol stimulus Source: RGD
  • cellular response to growth factor stimulus Source: RGD
  • cellular response to mechanical stimulus Source: RGD
  • cellular response to reactive oxygen species Source: RGD
  • cerebral cortex cell migration Source: RGD
  • circadian rhythm Source: RGD
  • digestive tract morphogenesis Source: RGD
  • diterpenoid metabolic process Source: RGD
  • embryonic placenta development Source: RGD
  • epidermal growth factor receptor signaling pathway Source: RGD
  • epidermis development Source: RGD
  • eyelid development in camera-type eye Source: RGD
  • hair follicle development Source: RGD
  • hydrogen peroxide metabolic process Source: RGD
  • intracellular signal transduction Source: RGD
  • liver development Source: RGD
  • liver regeneration Source: RGD
  • lung development Source: RGD
  • magnesium ion homeostasis Source: RGD
  • midgut development Source: RGD
  • morphogenesis of an epithelial fold Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of cardiocyte differentiation Source: RGD
  • negative regulation of mitotic cell cycle Source: RGD
  • negative regulation of protein catabolic process Source: RGD
  • neuron projection morphogenesis Source: RGD
  • ovulation cycle Source: RGD
  • peptidyl-tyrosine autophosphorylation Source: RGD
  • peptidyl-tyrosine phosphorylation Source: RGD
  • positive regulation of blood vessel diameter Source: RGD
  • positive regulation of bone resorption Source: RGD
  • positive regulation of catenin import into nucleus Source: RGD
  • positive regulation of cell growth Source: RGD
  • positive regulation of cell migration Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle Source: RGD
  • positive regulation of DNA repair Source: RGD
  • positive regulation of DNA replication Source: RGD
  • positive regulation of epithelial cell proliferation Source: RGD
  • positive regulation of ERK1 and ERK2 cascade Source: RGD
  • positive regulation of fibroblast proliferation Source: RGD
  • positive regulation of inflammatory response Source: RGD
  • positive regulation of MAP kinase activity Source: RGD
  • positive regulation of NIK/NF-kappaB signaling Source: RGD
  • positive regulation of nitric oxide biosynthetic process Source: RGD
  • positive regulation of peptidyl-serine phosphorylation Source: RGD
  • positive regulation of phosphorylation Source: RGD
  • positive regulation of production of miRNAs involved in gene silencing by miRNA Source: RGD
  • positive regulation of prolactin secretion Source: RGD
  • positive regulation of protein kinase B signaling Source: RGD
  • positive regulation of protein kinase C activity Source: RGD
  • positive regulation of protein localization to plasma membrane Source: RGD
  • positive regulation of protein phosphorylation Source: RGD
  • positive regulation of smooth muscle cell proliferation Source: RGD
  • positive regulation of superoxide anion generation Source: RGD
  • positive regulation of synaptic transmission, glutamatergic Source: RGD
  • positive regulation of transcription, DNA-templated Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter Source: RGD
  • positive regulation of vasoconstriction Source: RGD
  • protein autophosphorylation Source: RGD
  • receptor-mediated endocytosis Source: RGD
  • regulation of cell proliferation Source: RGD
  • regulation of ERK1 and ERK2 cascade Source: RGD
  • regulation of JNK cascade Source: RGD
  • regulation of nitric-oxide synthase activity Source: RGD
  • regulation of peptidyl-tyrosine phosphorylation Source: RGD
  • regulation of phosphatidylinositol 3-kinase signaling Source: RGD
  • response to calcium ion Source: RGD
  • response to cobalamin Source: RGD
  • response to estradiol Source: RGD
  • response to hydroxyisoflavone Source: RGD
  • response to lipid Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to osmotic stress Source: RGD
  • response to oxidative stress Source: RGD
  • response to UV-A Source: RGD
  • salivary gland morphogenesis Source: RGD
  • signal transduction Source: RGD
  • tongue development Source: RGD
  • translation Source: RGD
  • wound healing Source: RGD

Names & Taxonomyi

Protein namesi
Submitted name:
EgfrImported
Gene namesi
Name:EgfrImported
Synonyms:egfrImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2543. Egfr.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiQ9WTS1.

Interactioni

GO - Molecular functioni

  • actin filament binding Source: RGD
  • cadherin binding Source: RGD
  • calmodulin binding Source: RGD
  • enzyme binding Source: RGD
  • epidermal growth factor binding Source: RGD
  • identical protein binding Source: RGD
  • integrin binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein kinase binding Source: RGD
  • protein phosphatase binding Source: RGD
  • receptor binding Source: RGD
  • ubiquitin protein ligase binding Source: RGD

Family & Domainsi

Phylogenomic databases

eggNOGiKOG1025. Eukaryota.
ENOG410XNSR. LUCA.

Sequencei

Sequence statusi: Fragment.

Q9WTS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
MRPSGTARTK LLLLLAALCA AGGALEEK
Length:28
Mass (Da):2,855
Last modified:November 1, 1999 - v1
Checksum:iB56EAB41A074D15A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei28Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025197 Genomic DNA. Translation: BAA76391.1.
UniGeneiRn.154146.
Rn.231255.
Rn.37227.

Genome annotation databases

UCSCiRGD:2543. rat.

Similar proteinsi

Entry informationi

Entry nameiQ9WTS1_RAT
AccessioniPrimary (citable) accession number: Q9WTS1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: November 22, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)