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Q9WTS1

- Q9WTS1_RAT

UniProt

Q9WTS1 - Q9WTS1_RAT

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Protein
Submitted name:

Egfr

Gene

Egfr

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. epidermal growth factor-activated receptor activity Source: RGD
  3. epidermal growth factor binding Source: RGD
  4. glycoprotein binding Source: RGD
  5. integrin binding Source: RGD
  6. nitric-oxide synthase regulator activity Source: Ensembl
  7. protein heterodimerization activity Source: RGD
  8. protein kinase binding Source: RGD
  9. receptor binding Source: RGD

GO - Biological processi

  1. activation of MAPKK activity Source: RGD
  2. alkanesulfonate metabolic process Source: RGD
  3. astrocyte activation Source: RGD
  4. cell proliferation Source: Ensembl
  5. cellular response to amino acid stimulus Source: Ensembl
  6. cellular response to dexamethasone stimulus Source: RGD
  7. cellular response to drug Source: RGD
  8. cellular response to estradiol stimulus Source: Ensembl
  9. cellular response to growth factor stimulus Source: RGD
  10. cellular response to mechanical stimulus Source: RGD
  11. cerebral cortex cell migration Source: Ensembl
  12. circadian rhythm Source: RGD
  13. digestive tract morphogenesis Source: Ensembl
  14. diterpenoid metabolic process Source: RGD
  15. embryonic placenta development Source: Ensembl
  16. epidermal growth factor receptor signaling pathway Source: RGD
  17. hair follicle development Source: Ensembl
  18. hydrogen peroxide metabolic process Source: RGD
  19. intracellular signal transduction Source: RGD
  20. liver development Source: RGD
  21. lung development Source: RGD
  22. magnesium ion homeostasis Source: RGD
  23. morphogenesis of an epithelial fold Source: Ensembl
  24. negative regulation of apoptotic process Source: RGD
  25. negative regulation of mitotic cell cycle Source: RGD
  26. negative regulation of protein catabolic process Source: Ensembl
  27. neuron projection morphogenesis Source: RGD
  28. ovulation cycle Source: RGD
  29. positive regulation of catenin import into nucleus Source: Ensembl
  30. positive regulation of cell migration Source: Ensembl
  31. positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle Source: Ensembl
  32. positive regulation of DNA repair Source: Ensembl
  33. positive regulation of DNA replication Source: Ensembl
  34. positive regulation of epithelial cell proliferation Source: Ensembl
  35. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  36. positive regulation of fibroblast proliferation Source: Ensembl
  37. positive regulation of inflammatory response Source: RGD
  38. positive regulation of MAP kinase activity Source: Ensembl
  39. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  40. positive regulation of protein kinase B signaling Source: Ensembl
  41. positive regulation of smooth muscle cell proliferation Source: RGD
  42. positive regulation of superoxide anion generation Source: RGD
  43. positive regulation of synaptic transmission, glutamatergic Source: RGD
  44. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  45. positive regulation of vasoconstriction Source: RGD
  46. positive regulation of vasodilation Source: RGD
  47. protein autophosphorylation Source: RGD
  48. regulation of nitric-oxide synthase activity Source: Ensembl
  49. regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  50. response to calcium ion Source: RGD
  51. response to cobalamin Source: RGD
  52. response to estradiol Source: RGD
  53. response to hydroxyisoflavone Source: RGD
  54. response to lipid Source: RGD
  55. response to organic cyclic compound Source: RGD
  56. response to osmotic stress Source: RGD
  57. response to oxidative stress Source: RGD
  58. response to UV-A Source: Ensembl
  59. salivary gland morphogenesis Source: Ensembl
  60. signal transduction Source: RGD
  61. single organismal cell-cell adhesion Source: Ensembl
  62. tongue development Source: RGD
  63. translation Source: RGD
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_195027. Signaling by ERBB4.
REACT_195029. SHC1 events in ERBB2 signaling.
REACT_195203. GRB2 events in ERBB2 signaling.
REACT_196848. EGFR Transactivation by Gastrin.
REACT_197527. PI3K events in ERBB2 signaling.
REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
REACT_199249. Signaling by constitutively active EGFR.
REACT_203466. Signaling by ERBB2.
REACT_203692. PLCG1 events in ERBB2 signaling.
REACT_207015. Signaling by EGFR.
REACT_212693. EGFR interacts with phospholipase C-gamma.

Names & Taxonomyi

Protein namesi
Submitted name:
EgfrImported
Gene namesi
Name:EgfrImported
Synonyms:egfrImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2543. Egfr.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: RGD
  2. basolateral plasma membrane Source: RGD
  3. cell surface Source: RGD
  4. endocytic vesicle Source: RGD
  5. endosome Source: RGD
  6. membrane raft Source: Ensembl
  7. nucleus Source: RGD
  8. perinuclear region of cytoplasm Source: Ensembl
  9. plasma membrane Source: RGD
  10. receptor complex Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ9WTS1. baseline and differential.
GenevestigatoriQ9WTS1.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006087.

Sequencei

Sequence statusi: Fragment.

Q9WTS1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20
MRPSGTARTK LLLLLAALCA AGGALEEK
Length:28
Mass (Da):2,855
Last modified:November 1, 1999 - v1
Checksum:iB56EAB41A074D15A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei28 – 281Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB025197 Genomic DNA. Translation: BAA76391.1.
UniGeneiRn.37227.

Genome annotation databases

UCSCiRGD:2543. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB025197 Genomic DNA. Translation: BAA76391.1 .
UniGenei Rn.37227.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000006087.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:2543. rat.

Organism-specific databases

RGDi 2543. Egfr.

Enzyme and pathway databases

Reactomei REACT_195027. Signaling by ERBB4.
REACT_195029. SHC1 events in ERBB2 signaling.
REACT_195203. GRB2 events in ERBB2 signaling.
REACT_196848. EGFR Transactivation by Gastrin.
REACT_197527. PI3K events in ERBB2 signaling.
REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
REACT_199249. Signaling by constitutively active EGFR.
REACT_203466. Signaling by ERBB2.
REACT_203692. PLCG1 events in ERBB2 signaling.
REACT_207015. Signaling by EGFR.
REACT_212693. EGFR interacts with phospholipase C-gamma.

Gene expression databases

ExpressionAtlasi Q9WTS1. baseline and differential.
Genevestigatori Q9WTS1.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Rat EGFR promoter from NRK cells."
    Kondoh S.K., Akiyama N.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9WTS1_RAT
AccessioniPrimary (citable) accession number: Q9WTS1
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)