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Q9WTS1

- Q9WTS1_RAT

UniProt

Q9WTS1 - Q9WTS1_RAT

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Protein
Submitted name:

Egfr

Gene

Egfr

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. epidermal growth factor-activated receptor activity Source: RGD
  3. epidermal growth factor binding Source: RGD
  4. glycoprotein binding Source: RGD
  5. integrin binding Source: RGD
  6. nitric-oxide synthase regulator activity Source: Ensembl
  7. protein heterodimerization activity Source: RGD
  8. protein kinase binding Source: RGD
  9. receptor binding Source: RGD

GO - Biological processi

  1. activation of MAPKK activity Source: RGD
  2. alkanesulfonate metabolic process Source: RGD
  3. astrocyte activation Source: RGD
  4. cell proliferation Source: Ensembl
  5. cellular response to amino acid stimulus Source: Ensembl
  6. cellular response to dexamethasone stimulus Source: RGD
  7. cellular response to drug Source: RGD
  8. cellular response to estradiol stimulus Source: Ensembl
  9. cellular response to growth factor stimulus Source: RGD
  10. cellular response to mechanical stimulus Source: RGD
  11. cerebral cortex cell migration Source: Ensembl
  12. circadian rhythm Source: RGD
  13. digestive tract morphogenesis Source: Ensembl
  14. diterpenoid metabolic process Source: RGD
  15. embryonic placenta development Source: Ensembl
  16. epidermal growth factor receptor signaling pathway Source: RGD
  17. hair follicle development Source: Ensembl
  18. hydrogen peroxide metabolic process Source: RGD
  19. intracellular signal transduction Source: RGD
  20. liver development Source: RGD
  21. lung development Source: RGD
  22. magnesium ion homeostasis Source: RGD
  23. morphogenesis of an epithelial fold Source: Ensembl
  24. negative regulation of apoptotic process Source: RGD
  25. negative regulation of mitotic cell cycle Source: RGD
  26. negative regulation of protein catabolic process Source: Ensembl
  27. neuron projection morphogenesis Source: RGD
  28. ovulation cycle Source: RGD
  29. positive regulation of catenin import into nucleus Source: Ensembl
  30. positive regulation of cell migration Source: Ensembl
  31. positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle Source: Ensembl
  32. positive regulation of DNA repair Source: Ensembl
  33. positive regulation of DNA replication Source: Ensembl
  34. positive regulation of epithelial cell proliferation Source: Ensembl
  35. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  36. positive regulation of fibroblast proliferation Source: Ensembl
  37. positive regulation of inflammatory response Source: RGD
  38. positive regulation of MAP kinase activity Source: Ensembl
  39. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  40. positive regulation of protein kinase B signaling Source: Ensembl
  41. positive regulation of smooth muscle cell proliferation Source: RGD
  42. positive regulation of superoxide anion generation Source: RGD
  43. positive regulation of synaptic transmission, glutamatergic Source: RGD
  44. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  45. positive regulation of vasoconstriction Source: RGD
  46. positive regulation of vasodilation Source: RGD
  47. protein autophosphorylation Source: RGD
  48. regulation of nitric-oxide synthase activity Source: Ensembl
  49. regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  50. response to calcium ion Source: RGD
  51. response to cobalamin Source: RGD
  52. response to estradiol Source: RGD
  53. response to hydroxyisoflavone Source: RGD
  54. response to lipid Source: RGD
  55. response to organic cyclic compound Source: RGD
  56. response to osmotic stress Source: RGD
  57. response to oxidative stress Source: RGD
  58. response to UV-A Source: Ensembl
  59. salivary gland morphogenesis Source: Ensembl
  60. signal transduction Source: RGD
  61. single organismal cell-cell adhesion Source: Ensembl
  62. tongue development Source: RGD
  63. translation Source: RGD
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_195027. Signaling by ERBB4.
REACT_195029. SHC1 events in ERBB2 signaling.
REACT_195203. GRB2 events in ERBB2 signaling.
REACT_196848. EGFR Transactivation by Gastrin.
REACT_197527. PI3K events in ERBB2 signaling.
REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
REACT_199249. Signaling by constitutively active EGFR.
REACT_203466. Signaling by ERBB2.
REACT_203692. PLCG1 events in ERBB2 signaling.
REACT_207015. Signaling by EGFR.
REACT_212693. EGFR interacts with phospholipase C-gamma.
REACT_230341. Signal transduction by L1.
REACT_241654. EGFR downregulation.
REACT_243035. GRB2 events in EGFR signaling.
REACT_245188. GAB1 signalosome.
REACT_254614. SHC1 events in EGFR signaling.
REACT_257653. PIP3 activates AKT signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
EgfrImported
Gene namesi
Name:EgfrImported
Synonyms:egfrImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2543. Egfr.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: RGD
  2. basolateral plasma membrane Source: RGD
  3. cell surface Source: RGD
  4. endocytic vesicle Source: RGD
  5. endosome Source: RGD
  6. membrane raft Source: Ensembl
  7. nucleus Source: RGD
  8. perinuclear region of cytoplasm Source: Ensembl
  9. plasma membrane Source: RGD
  10. receptor complex Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ9WTS1. baseline and differential.
GenevestigatoriQ9WTS1.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006087.

Sequencei

Sequence statusi: Fragment.

Q9WTS1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20 
MRPSGTARTK LLLLLAALCA AGGALEEK
Length:28
Mass (Da):2,855
Last modified:November 1, 1999 - v1
Checksum:iB56EAB41A074D15A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei28 – 281Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025197 Genomic DNA. Translation: BAA76391.1.
UniGeneiRn.37227.

Genome annotation databases

UCSCiRGD:2543. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025197 Genomic DNA. Translation: BAA76391.1 .
UniGenei Rn.37227.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000006087.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:2543. rat.

Organism-specific databases

RGDi 2543. Egfr.

Enzyme and pathway databases

Reactomei REACT_195027. Signaling by ERBB4.
REACT_195029. SHC1 events in ERBB2 signaling.
REACT_195203. GRB2 events in ERBB2 signaling.
REACT_196848. EGFR Transactivation by Gastrin.
REACT_197527. PI3K events in ERBB2 signaling.
REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
REACT_199249. Signaling by constitutively active EGFR.
REACT_203466. Signaling by ERBB2.
REACT_203692. PLCG1 events in ERBB2 signaling.
REACT_207015. Signaling by EGFR.
REACT_212693. EGFR interacts with phospholipase C-gamma.
REACT_230341. Signal transduction by L1.
REACT_241654. EGFR downregulation.
REACT_243035. GRB2 events in EGFR signaling.
REACT_245188. GAB1 signalosome.
REACT_254614. SHC1 events in EGFR signaling.
REACT_257653. PIP3 activates AKT signaling.

Gene expression databases

ExpressionAtlasi Q9WTS1. baseline and differential.
Genevestigatori Q9WTS1.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Rat EGFR promoter from NRK cells."
    Kondoh S.K., Akiyama N.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9WTS1_RAT
AccessioniPrimary (citable) accession number: Q9WTS1
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)