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Protein
Submitted name:

Egfr

Gene

Egfr

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  • calmodulin binding Source: RGD
  • epidermal growth factor-activated receptor activity Source: RGD
  • epidermal growth factor binding Source: RGD
  • glycoprotein binding Source: RGD
  • integrin binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein kinase binding Source: RGD
  • protein tyrosine kinase activity Source: RGD
  • receptor binding Source: RGD

GO - Biological processi

  • activation of MAPKK activity Source: RGD
  • astrocyte activation Source: RGD
  • cellular response to dexamethasone stimulus Source: RGD
  • cellular response to drug Source: RGD
  • cellular response to growth factor stimulus Source: RGD
  • cellular response to mechanical stimulus Source: RGD
  • circadian rhythm Source: RGD
  • diterpenoid metabolic process Source: RGD
  • epidermal growth factor receptor signaling pathway Source: RGD
  • hair follicle development Source: RGD
  • hydrogen peroxide metabolic process Source: RGD
  • intracellular signal transduction Source: RGD
  • liver development Source: RGD
  • liver regeneration Source: RGD
  • lung development Source: RGD
  • magnesium ion homeostasis Source: RGD
  • midgut development Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of mitotic cell cycle Source: RGD
  • neuron projection morphogenesis Source: RGD
  • ovulation cycle Source: RGD
  • peptidyl-tyrosine phosphorylation Source: RGD
  • positive regulation of bone resorption Source: RGD
  • positive regulation of inflammatory response Source: RGD
  • positive regulation of prolactin secretion Source: RGD
  • positive regulation of smooth muscle cell proliferation Source: RGD
  • positive regulation of superoxide anion generation Source: RGD
  • positive regulation of synaptic transmission, glutamatergic Source: RGD
  • positive regulation of vasoconstriction Source: RGD
  • positive regulation of vasodilation Source: RGD
  • protein autophosphorylation Source: RGD
  • response to calcium ion Source: RGD
  • response to cobalamin Source: RGD
  • response to estradiol Source: RGD
  • response to hydroxyisoflavone Source: RGD
  • response to lipid Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to osmotic stress Source: RGD
  • response to oxidative stress Source: RGD
  • signal transduction Source: RGD
  • tongue development Source: RGD
  • translation Source: RGD
  • wound healing Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
EgfrImported
Gene namesi
Name:EgfrImported
Synonyms:egfrImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2543. Egfr.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: RGD
  • basolateral plasma membrane Source: RGD
  • cell surface Source: RGD
  • endocytic vesicle Source: RGD
  • endosome Source: RGD
  • membrane raft Source: RGD
  • nucleus Source: RGD
  • plasma membrane Source: RGD
  • synapse Source: RGD
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ9WTS1.

Interactioni

GO - Molecular functioni

  • calmodulin binding Source: RGD
  • epidermal growth factor binding Source: RGD
  • glycoprotein binding Source: RGD
  • integrin binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein kinase binding Source: RGD
  • receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006087.

Family & Domainsi

Phylogenomic databases

eggNOGiKOG1025. Eukaryota.
ENOG410XNSR. LUCA.

Sequencei

Sequence statusi: Fragment.

Q9WTS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
MRPSGTARTK LLLLLAALCA AGGALEEK
Length:28
Mass (Da):2,855
Last modified:November 1, 1999 - v1
Checksum:iB56EAB41A074D15A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei28 – 281Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025197 Genomic DNA. Translation: BAA76391.1.
UniGeneiRn.37227.

Genome annotation databases

UCSCiRGD:2543. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025197 Genomic DNA. Translation: BAA76391.1.
UniGeneiRn.37227.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006087.

Proteomic databases

PaxDbiQ9WTS1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:2543. rat.

Organism-specific databases

RGDi2543. Egfr.

Phylogenomic databases

eggNOGiKOG1025. Eukaryota.
ENOG410XNSR. LUCA.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Rat EGFR promoter from NRK cells."
    Kondoh S.K., Akiyama N.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9WTS1_RAT
AccessioniPrimary (citable) accession number: Q9WTS1
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: March 16, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.