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Protein

Signal peptidase complex catalytic subunit SEC11C

Gene

Sec11c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.By similarity

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease

Protein family/group databases

MEROPSiS26.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex catalytic subunit SEC11C (EC:3.4.21.89)
Alternative name(s):
Microsomal signal peptidase 21 kDa subunit
Short name:
SPase 21 kDa subunit
SEC11 homolog C
SEC11-like protein 3
SPC21
Gene namesi
Name:Sec11c
Synonyms:Sec11l3, Spc21
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628665. Sec11c.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28CytoplasmicSequence analysisAdd BLAST28
Transmembranei29 – 48Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini49 – 192LumenalSequence analysisAdd BLAST144

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001095511 – 192Signal peptidase complex catalytic subunit SEC11CAdd BLAST192

Proteomic databases

PaxDbiQ9WTR7.
PRIDEiQ9WTR7.

Interactioni

Subunit structurei

Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022958.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3342. Eukaryota.
COG0681. LUCA.
HOGENOMiHOG000111516.
HOVERGENiHBG057279.
InParanoidiQ9WTR7.
KOiK13280.
PhylomeDBiQ9WTR7.

Family and domain databases

InterProiView protein in InterPro
IPR036286. LexA/Signal_pep-like_sf.
IPR019758. Pept_S26A_signal_pept_1_CS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
PANTHERiPTHR10806. PTHR10806. 1 hit.
PfamiView protein in Pfam
PF00717. Peptidase_S24. 1 hit.
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiView protein in PROSITE
PS00501. SPASE_I_1. 1 hit.
PS00761. SPASE_I_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WTR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRAGAVGTH LPTSSLDIFG DLRKMNKRQL YYQVLNFAMI VSSALMIWKG
60 70 80 90 100
LIVLTGSESP IVVVLSGSME PAFHRGDLLF LTNFREDPIR AGEIVVFKVE
110 120 130 140 150
GRDIPIVHRV IKVHEKDNGD IKFLTKGDNN EVDDRGLYKE GQNWLEKKDV
160 170 180 190
VGRARGFLPY VGMVTIIMND YPKFKYALVA VMGAYVLLKR ES
Length:192
Mass (Da):21,646
Last modified:January 23, 2007 - v3
Checksum:i6D4650314EA9DEF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022714 mRNA. Translation: BAA76439.1.
RefSeqiNP_705892.1. NM_153628.2.
UniGeneiRn.16883.

Genome annotation databases

GeneIDi266758.
KEGGirno:266758.
UCSCiRGD:628665. rat.

Similar proteinsi

Entry informationi

Entry nameiSC11C_RAT
AccessioniPrimary (citable) accession number: Q9WTR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 112 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families