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Q9WTR6 (XCT_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cystine/glutamate transporter
Alternative name(s):
Amino acid transport system xc-
Solute carrier family 7 member 11
xCT
Gene names
Name:Slc7a11
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length502 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.

Subunit structure

Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. [View classification]

Ontologies

Keywords
   Biological processAmino-acid transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMDisulfide bond
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionamino acid transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 502502Cystine/glutamate transporter
PRO_0000054280

Regions

Topological domain1 – 4343Cytoplasmic Potential
Transmembrane44 – 6421Helical; Potential
Topological domain65 – 7410Extracellular Potential
Transmembrane75 – 9521Helical; Potential
Topological domain96 – 11318Cytoplasmic Potential
Transmembrane114 – 13421Helical; Potential
Topological domain135 – 15824Extracellular Potential
Transmembrane159 – 17921Helical; Potential
Topological domain180 – 18910Cytoplasmic Potential
Transmembrane190 – 21021Helical; Potential
Topological domain211 – 23121Extracellular Potential
Transmembrane232 – 25221Helical; Potential
Topological domain253 – 26513Cytoplasmic Potential
Transmembrane266 – 28621Helical; Potential
Topological domain287 – 31731Extracellular Potential
Transmembrane318 – 33821Helical; Potential
Topological domain339 – 36527Cytoplasmic Potential
Transmembrane366 – 38621Helical; Potential
Topological domain3871Extracellular Potential
Transmembrane388 – 40821Helical; Potential
Topological domain409 – 42214Cytoplasmic Potential
Transmembrane423 – 44321Helical; Potential
Topological domain444 – 4496Extracellular Potential
Transmembrane450 – 47021Helical; Potential
Topological domain471 – 50232Cytoplasmic Potential

Amino acid modifications

Modified residue261Phosphoserine Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9WTR6 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: A4A185102D83992A

FASTA50255,456
        10         20         30         40         50         60 
MVRKPVVATI SKGGYLQGNM SGRLPSMGDQ EPPGQEKVVL KKKITLLRGV SIIIGTVIGS 

        70         80         90        100        110        120 
GIFISPKGIL QNTGSVGMSL VFWSACGVLS LFGALSYAEL GTSIKKSGGH YTYILEVFGP 

       130        140        150        160        170        180 
LLAFVRVWVE LLVIRPGATA VISLAFGRYI LEPFFIQCEI PELAIKLVTA VGITVVMVLN 

       190        200        210        220        230        240 
STSVSWSARI QIFLTFCKLT AILIIIVPGV IQLIKGQTHH FKDAFSGRDT SLMGLPLAFY 

       250        260        270        280        290        300 
YGMYAYAGWF YLNFITEEVD NPEKTIPLAI CISMAIITVG YVLTNVAYFT TISAEELLQS 

       310        320        330        340        350        360 
SAVAVTFSER LLGKFSLAVP IFVALSCFGS MNGGVFAVSR LFYVASREGH LPEILSMIHV 

       370        380        390        400        410        420 
HKHTPLPAVI VLHPLTMVML FSGDLYSLLN FLSFARWLFM GLAVAGLIYL RYKRPDMHRP 

       430        440        450        460        470        480 
FKVPLFIPAL FSFTCLFMVV LSLYSDPFST GVGFLITLTG VPAYYLFIVW DKKPKWFRRL 

       490        500 
SDRITRTLQI ILEVVPEDSK EL

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins."
Sato H., Tamba M., Ishii T., Bannai S.
J. Biol. Chem. 274:11455-11458(1999) [PubMed: 10206947] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression."
Sasaki H., Sato H., Kuriyama-Matsumura K., Sato K., Maebara K., Wang H., Tamba M., Itoh K., Yamamoto M., Bannai S.
J. Biol. Chem. 277:44765-44771(2002) [PubMed: 12235164] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 129/SvJ.
Tissue: Liver.
[3]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed: 19144319] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, MASS SPECTROMETRY.
Tissue: Macrophage.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB022345 mRNA. Translation: BAA77220.1.
AB037661 Genomic DNA. Translation: BAA90522.1.
IPIIPI00123747.
RefSeqNP_036120.1. NM_011990.2.
UniGeneMm.260988.

3D structure databases

ProteinModelPortalQ9WTR6.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9WTR6.

Protein family/group databases

TCDB2.A.3.8.5. amino acid-polyamine-organocation (APC) family.

PTM databases

PhosphoSiteQ9WTR6.

Proteomic databases

PRIDEQ9WTR6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029297; ENSMUSP00000029297; ENSMUSG00000027737.
GeneID26570.
KEGGmmu:26570.

Organism-specific databases

CTD23657.
MGIMGI:1347355. Slc7a11.

Phylogenomic databases

GeneTreeENSGT00600000084369.
HOGENOMHBG714539.
HOVERGENHBG000476.
InParanoidQ9WTR6.
OMAGQTQHFK.
OrthoDBEOG4F1X35.
PhylomeDBQ9WTR6.

Gene expression databases

ArrayExpressQ9WTR6.
BgeeQ9WTR6.
GenevestigatorQ9WTR6.
GermOnlineENSMUSG00000027737. Mus musculus.

Family and domain databases

InterProIPR004841. AA-permease_dom.
IPR002293. AA/rel_permease1.
IPR004760. L_AA_transporter.
[Graphical view]
KOK13869.
PANTHERPTHR11785. AA/rel_permease1. 1 hit.
PfamPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsTIGR00911. 2A0308. 1 hit.
ProtoNetSearch...

Other

NextBio304655.
SOURCESearch...

Entry information

Entry nameXCT_MOUSE
AccessionPrimary (citable) accession number: Q9WTR6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1999
Last modified: November 16, 2011
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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