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Q9WTR6

- XCT_MOUSE

UniProt

Q9WTR6 - XCT_MOUSE

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Protein
Cystine/glutamate transporter
Gene
Slc7a11
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.

GO - Molecular functioni

  1. amino acid transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. brain development Source: Ensembl
  2. lens fiber cell differentiation Source: Ensembl
  3. platelet aggregation Source: MGI
  4. response to nicotine Source: Ensembl
  5. response to oxidative stress Source: Ensembl
  6. response to toxic substance Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

ReactomeiREACT_211508. Basigin interactions.

Protein family/group databases

TCDBi2.A.3.8.5. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystine/glutamate transporter
Alternative name(s):
Amino acid transport system xc-
Solute carrier family 7 member 11
xCT
Gene namesi
Name:Slc7a11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1347355. Slc7a11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei44 – 6421Helical; Reviewed prediction
Add
BLAST
Topological domaini65 – 7410Extracellular Reviewed prediction
Transmembranei75 – 9521Helical; Reviewed prediction
Add
BLAST
Topological domaini96 – 11318Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei114 – 13421Helical; Reviewed prediction
Add
BLAST
Topological domaini135 – 15824Extracellular Reviewed prediction
Add
BLAST
Transmembranei159 – 17921Helical; Reviewed prediction
Add
BLAST
Topological domaini180 – 18910Cytoplasmic Reviewed prediction
Transmembranei190 – 21021Helical; Reviewed prediction
Add
BLAST
Topological domaini211 – 23121Extracellular Reviewed prediction
Add
BLAST
Transmembranei232 – 25221Helical; Reviewed prediction
Add
BLAST
Topological domaini253 – 26513Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei266 – 28621Helical; Reviewed prediction
Add
BLAST
Topological domaini287 – 31731Extracellular Reviewed prediction
Add
BLAST
Transmembranei318 – 33821Helical; Reviewed prediction
Add
BLAST
Topological domaini339 – 36527Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei366 – 38621Helical; Reviewed prediction
Add
BLAST
Topological domaini387 – 3871Extracellular Reviewed prediction
Transmembranei388 – 40821Helical; Reviewed prediction
Add
BLAST
Topological domaini409 – 42214Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei423 – 44321Helical; Reviewed prediction
Add
BLAST
Topological domaini444 – 4496Extracellular Reviewed prediction
Transmembranei450 – 47021Helical; Reviewed prediction
Add
BLAST
Topological domaini471 – 50232Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoskeleton Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: Ensembl
  4. rough endoplasmic reticulum Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Cystine/glutamate transporter
PRO_0000054280Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261Phosphoserine1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ9WTR6.
PRIDEiQ9WTR6.

PTM databases

PhosphoSiteiQ9WTR6.

Expressioni

Gene expression databases

BgeeiQ9WTR6.
GenevestigatoriQ9WTR6.

Interactioni

Subunit structurei

Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.

Structurei

3D structure databases

ProteinModelPortaliQ9WTR6.
SMRiQ9WTR6. Positions 52-382.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00730000110456.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ9WTR6.
KOiK13869.
OMAiTHHFKDA.
OrthoDBiEOG73BVCR.
PhylomeDBiQ9WTR6.
TreeFamiTF313355.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004760. L_AA_transporter.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00911. 2A0308. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WTR6-1 [UniParc]FASTAAdd to Basket

« Hide

MVRKPVVATI SKGGYLQGNM SGRLPSMGDQ EPPGQEKVVL KKKITLLRGV    50
SIIIGTVIGS GIFISPKGIL QNTGSVGMSL VFWSACGVLS LFGALSYAEL 100
GTSIKKSGGH YTYILEVFGP LLAFVRVWVE LLVIRPGATA VISLAFGRYI 150
LEPFFIQCEI PELAIKLVTA VGITVVMVLN STSVSWSARI QIFLTFCKLT 200
AILIIIVPGV IQLIKGQTHH FKDAFSGRDT SLMGLPLAFY YGMYAYAGWF 250
YLNFITEEVD NPEKTIPLAI CISMAIITVG YVLTNVAYFT TISAEELLQS 300
SAVAVTFSER LLGKFSLAVP IFVALSCFGS MNGGVFAVSR LFYVASREGH 350
LPEILSMIHV HKHTPLPAVI VLHPLTMVML FSGDLYSLLN FLSFARWLFM 400
GLAVAGLIYL RYKRPDMHRP FKVPLFIPAL FSFTCLFMVV LSLYSDPFST 450
GVGFLITLTG VPAYYLFIVW DKKPKWFRRL SDRITRTLQI ILEVVPEDSK 500
EL 502
Length:502
Mass (Da):55,456
Last modified:November 1, 1999 - v1
Checksum:iA4A185102D83992A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB022345 mRNA. Translation: BAA77220.1.
AB037661 Genomic DNA. Translation: BAA90522.1.
CCDSiCCDS17335.1.
RefSeqiNP_036120.1. NM_011990.2.
UniGeneiMm.260988.

Genome annotation databases

EnsembliENSMUST00000029297; ENSMUSP00000029297; ENSMUSG00000027737.
GeneIDi26570.
KEGGimmu:26570.
UCSCiuc008pdi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB022345 mRNA. Translation: BAA77220.1 .
AB037661 Genomic DNA. Translation: BAA90522.1 .
CCDSi CCDS17335.1.
RefSeqi NP_036120.1. NM_011990.2.
UniGenei Mm.260988.

3D structure databases

ProteinModelPortali Q9WTR6.
SMRi Q9WTR6. Positions 52-382.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

TCDBi 2.A.3.8.5. the amino acid-polyamine-organocation (apc) family.

PTM databases

PhosphoSitei Q9WTR6.

Proteomic databases

PaxDbi Q9WTR6.
PRIDEi Q9WTR6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029297 ; ENSMUSP00000029297 ; ENSMUSG00000027737 .
GeneIDi 26570.
KEGGi mmu:26570.
UCSCi uc008pdi.1. mouse.

Organism-specific databases

CTDi 23657.
MGIi MGI:1347355. Slc7a11.

Phylogenomic databases

eggNOGi COG0531.
GeneTreei ENSGT00730000110456.
HOGENOMi HOG000098892.
HOVERGENi HBG000476.
InParanoidi Q9WTR6.
KOi K13869.
OMAi THHFKDA.
OrthoDBi EOG73BVCR.
PhylomeDBi Q9WTR6.
TreeFami TF313355.

Enzyme and pathway databases

Reactomei REACT_211508. Basigin interactions.

Miscellaneous databases

ChiTaRSi SLC7A11. mouse.
NextBioi 304655.
PROi Q9WTR6.
SOURCEi Search...

Gene expression databases

Bgeei Q9WTR6.
Genevestigatori Q9WTR6.

Family and domain databases

InterProi IPR002293. AA/rel_permease1.
IPR004760. L_AA_transporter.
[Graphical view ]
PANTHERi PTHR11785. PTHR11785. 1 hit.
Pfami PF13520. AA_permease_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF006060. AA_transporter. 1 hit.
TIGRFAMsi TIGR00911. 2A0308. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins."
    Sato H., Tamba M., Ishii T., Bannai S.
    J. Biol. Chem. 274:11455-11458(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression."
    Sasaki H., Sato H., Kuriyama-Matsumura K., Sato K., Maebara K., Wang H., Tamba M., Itoh K., Yamamoto M., Bannai S.
    J. Biol. Chem. 277:44765-44771(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvJ.
    Tissue: Liver.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiXCT_MOUSE
AccessioniPrimary (citable) accession number: Q9WTR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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