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Protein

Cystine/glutamate transporter

Gene

Slc7a11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-210991. Basigin interactions.
R-MMU-352230. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.3.8.5. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystine/glutamate transporter
Alternative name(s):
Amino acid transport system xc-
Solute carrier family 7 member 11
xCT
Gene namesi
Name:Slc7a11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1347355. Slc7a11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43CytoplasmicSequence analysisAdd BLAST43
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Topological domaini65 – 74ExtracellularSequence analysis10
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Topological domaini96 – 113CytoplasmicSequence analysisAdd BLAST18
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 158ExtracellularSequence analysisAdd BLAST24
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 189CytoplasmicSequence analysis10
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 231ExtracellularSequence analysisAdd BLAST21
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 265CytoplasmicSequence analysisAdd BLAST13
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Topological domaini287 – 317ExtracellularSequence analysisAdd BLAST31
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Topological domaini339 – 365CytoplasmicSequence analysisAdd BLAST27
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Topological domaini387ExtracellularSequence analysis1
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
Topological domaini409 – 422CytoplasmicSequence analysisAdd BLAST14
Transmembranei423 – 443HelicalSequence analysisAdd BLAST21
Topological domaini444 – 449ExtracellularSequence analysis6
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21
Topological domaini471 – 502CytoplasmicSequence analysisAdd BLAST32

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000542801 – 502Cystine/glutamate transporterAdd BLAST502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ9WTR6.
PRIDEiQ9WTR6.

PTM databases

iPTMnetiQ9WTR6.
PhosphoSitePlusiQ9WTR6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027737.
ExpressionAtlasiQ9WTR6. baseline and differential.
GenevisibleiQ9WTR6. MM.

Interactioni

Subunit structurei

Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029297.

Structurei

3D structure databases

ProteinModelPortaliQ9WTR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1287. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ9WTR6.
KOiK13869.
OMAiMHRPFKX.
OrthoDBiEOG091G07EM.
PhylomeDBiQ9WTR6.
TreeFamiTF313355.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004760. L_AA_transporter.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00911. 2A0308. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WTR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRKPVVATI SKGGYLQGNM SGRLPSMGDQ EPPGQEKVVL KKKITLLRGV
60 70 80 90 100
SIIIGTVIGS GIFISPKGIL QNTGSVGMSL VFWSACGVLS LFGALSYAEL
110 120 130 140 150
GTSIKKSGGH YTYILEVFGP LLAFVRVWVE LLVIRPGATA VISLAFGRYI
160 170 180 190 200
LEPFFIQCEI PELAIKLVTA VGITVVMVLN STSVSWSARI QIFLTFCKLT
210 220 230 240 250
AILIIIVPGV IQLIKGQTHH FKDAFSGRDT SLMGLPLAFY YGMYAYAGWF
260 270 280 290 300
YLNFITEEVD NPEKTIPLAI CISMAIITVG YVLTNVAYFT TISAEELLQS
310 320 330 340 350
SAVAVTFSER LLGKFSLAVP IFVALSCFGS MNGGVFAVSR LFYVASREGH
360 370 380 390 400
LPEILSMIHV HKHTPLPAVI VLHPLTMVML FSGDLYSLLN FLSFARWLFM
410 420 430 440 450
GLAVAGLIYL RYKRPDMHRP FKVPLFIPAL FSFTCLFMVV LSLYSDPFST
460 470 480 490 500
GVGFLITLTG VPAYYLFIVW DKKPKWFRRL SDRITRTLQI ILEVVPEDSK

EL
Length:502
Mass (Da):55,456
Last modified:November 1, 1999 - v1
Checksum:iA4A185102D83992A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022345 mRNA. Translation: BAA77220.1.
AB037661 Genomic DNA. Translation: BAA90522.1.
CCDSiCCDS17335.1.
RefSeqiNP_036120.1. NM_011990.2.
UniGeneiMm.260988.

Genome annotation databases

EnsembliENSMUST00000029297; ENSMUSP00000029297; ENSMUSG00000027737.
GeneIDi26570.
KEGGimmu:26570.
UCSCiuc008pdi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022345 mRNA. Translation: BAA77220.1.
AB037661 Genomic DNA. Translation: BAA90522.1.
CCDSiCCDS17335.1.
RefSeqiNP_036120.1. NM_011990.2.
UniGeneiMm.260988.

3D structure databases

ProteinModelPortaliQ9WTR6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029297.

Protein family/group databases

TCDBi2.A.3.8.5. the amino acid-polyamine-organocation (apc) family.

PTM databases

iPTMnetiQ9WTR6.
PhosphoSitePlusiQ9WTR6.

Proteomic databases

PaxDbiQ9WTR6.
PRIDEiQ9WTR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029297; ENSMUSP00000029297; ENSMUSG00000027737.
GeneIDi26570.
KEGGimmu:26570.
UCSCiuc008pdi.1. mouse.

Organism-specific databases

CTDi23657.
MGIiMGI:1347355. Slc7a11.

Phylogenomic databases

eggNOGiKOG1287. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ9WTR6.
KOiK13869.
OMAiMHRPFKX.
OrthoDBiEOG091G07EM.
PhylomeDBiQ9WTR6.
TreeFamiTF313355.

Enzyme and pathway databases

ReactomeiR-MMU-210991. Basigin interactions.
R-MMU-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

ChiTaRSiSlc7a11. mouse.
PROiQ9WTR6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027737.
ExpressionAtlasiQ9WTR6. baseline and differential.
GenevisibleiQ9WTR6. MM.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004760. L_AA_transporter.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00911. 2A0308. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiXCT_MOUSE
AccessioniPrimary (citable) accession number: Q9WTR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.