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Q9WTR6

- XCT_MOUSE

UniProt

Q9WTR6 - XCT_MOUSE

Protein

Cystine/glutamate transporter

Gene

Slc7a11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.

    GO - Molecular functioni

    1. amino acid transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. brain development Source: Ensembl
    2. lens fiber cell differentiation Source: Ensembl
    3. platelet aggregation Source: MGI
    4. response to nicotine Source: Ensembl
    5. response to oxidative stress Source: Ensembl
    6. response to toxic substance Source: Ensembl

    Keywords - Biological processi

    Amino-acid transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_211508. Basigin interactions.

    Protein family/group databases

    TCDBi2.A.3.8.5. the amino acid-polyamine-organocation (apc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cystine/glutamate transporter
    Alternative name(s):
    Amino acid transport system xc-
    Solute carrier family 7 member 11
    xCT
    Gene namesi
    Name:Slc7a11
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1347355. Slc7a11.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoskeleton Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Ensembl
    4. rough endoplasmic reticulum Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 502502Cystine/glutamate transporterPRO_0000054280Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei26 – 261Phosphoserine1 Publication

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    PaxDbiQ9WTR6.
    PRIDEiQ9WTR6.

    PTM databases

    PhosphoSiteiQ9WTR6.

    Expressioni

    Gene expression databases

    BgeeiQ9WTR6.
    GenevestigatoriQ9WTR6.

    Interactioni

    Subunit structurei

    Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WTR6.
    SMRiQ9WTR6. Positions 52-382.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4343CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini65 – 7410ExtracellularSequence Analysis
    Topological domaini96 – 11318CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini135 – 15824ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini180 – 18910CytoplasmicSequence Analysis
    Topological domaini211 – 23121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini253 – 26513CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini287 – 31731ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini339 – 36527CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini387 – 3871ExtracellularSequence Analysis
    Topological domaini409 – 42214CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini444 – 4496ExtracellularSequence Analysis
    Topological domaini471 – 50232CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei44 – 6421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei75 – 9521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei190 – 21021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei232 – 25221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei266 – 28621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei318 – 33821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei366 – 38621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei388 – 40821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei423 – 44321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei450 – 47021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0531.
    GeneTreeiENSGT00730000110456.
    HOGENOMiHOG000098892.
    HOVERGENiHBG000476.
    InParanoidiQ9WTR6.
    KOiK13869.
    OMAiTHHFKDA.
    OrthoDBiEOG73BVCR.
    PhylomeDBiQ9WTR6.
    TreeFamiTF313355.

    Family and domain databases

    InterProiIPR002293. AA/rel_permease1.
    IPR004760. L_AA_transporter.
    [Graphical view]
    PANTHERiPTHR11785. PTHR11785. 1 hit.
    PfamiPF13520. AA_permease_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006060. AA_transporter. 1 hit.
    TIGRFAMsiTIGR00911. 2A0308. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9WTR6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRKPVVATI SKGGYLQGNM SGRLPSMGDQ EPPGQEKVVL KKKITLLRGV    50
    SIIIGTVIGS GIFISPKGIL QNTGSVGMSL VFWSACGVLS LFGALSYAEL 100
    GTSIKKSGGH YTYILEVFGP LLAFVRVWVE LLVIRPGATA VISLAFGRYI 150
    LEPFFIQCEI PELAIKLVTA VGITVVMVLN STSVSWSARI QIFLTFCKLT 200
    AILIIIVPGV IQLIKGQTHH FKDAFSGRDT SLMGLPLAFY YGMYAYAGWF 250
    YLNFITEEVD NPEKTIPLAI CISMAIITVG YVLTNVAYFT TISAEELLQS 300
    SAVAVTFSER LLGKFSLAVP IFVALSCFGS MNGGVFAVSR LFYVASREGH 350
    LPEILSMIHV HKHTPLPAVI VLHPLTMVML FSGDLYSLLN FLSFARWLFM 400
    GLAVAGLIYL RYKRPDMHRP FKVPLFIPAL FSFTCLFMVV LSLYSDPFST 450
    GVGFLITLTG VPAYYLFIVW DKKPKWFRRL SDRITRTLQI ILEVVPEDSK 500
    EL 502
    Length:502
    Mass (Da):55,456
    Last modified:November 1, 1999 - v1
    Checksum:iA4A185102D83992A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB022345 mRNA. Translation: BAA77220.1.
    AB037661 Genomic DNA. Translation: BAA90522.1.
    CCDSiCCDS17335.1.
    RefSeqiNP_036120.1. NM_011990.2.
    UniGeneiMm.260988.

    Genome annotation databases

    EnsembliENSMUST00000029297; ENSMUSP00000029297; ENSMUSG00000027737.
    GeneIDi26570.
    KEGGimmu:26570.
    UCSCiuc008pdi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB022345 mRNA. Translation: BAA77220.1 .
    AB037661 Genomic DNA. Translation: BAA90522.1 .
    CCDSi CCDS17335.1.
    RefSeqi NP_036120.1. NM_011990.2.
    UniGenei Mm.260988.

    3D structure databases

    ProteinModelPortali Q9WTR6.
    SMRi Q9WTR6. Positions 52-382.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 2.A.3.8.5. the amino acid-polyamine-organocation (apc) family.

    PTM databases

    PhosphoSitei Q9WTR6.

    Proteomic databases

    PaxDbi Q9WTR6.
    PRIDEi Q9WTR6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029297 ; ENSMUSP00000029297 ; ENSMUSG00000027737 .
    GeneIDi 26570.
    KEGGi mmu:26570.
    UCSCi uc008pdi.1. mouse.

    Organism-specific databases

    CTDi 23657.
    MGIi MGI:1347355. Slc7a11.

    Phylogenomic databases

    eggNOGi COG0531.
    GeneTreei ENSGT00730000110456.
    HOGENOMi HOG000098892.
    HOVERGENi HBG000476.
    InParanoidi Q9WTR6.
    KOi K13869.
    OMAi THHFKDA.
    OrthoDBi EOG73BVCR.
    PhylomeDBi Q9WTR6.
    TreeFami TF313355.

    Enzyme and pathway databases

    Reactomei REACT_211508. Basigin interactions.

    Miscellaneous databases

    ChiTaRSi SLC7A11. mouse.
    NextBioi 304655.
    PROi Q9WTR6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9WTR6.
    Genevestigatori Q9WTR6.

    Family and domain databases

    InterProi IPR002293. AA/rel_permease1.
    IPR004760. L_AA_transporter.
    [Graphical view ]
    PANTHERi PTHR11785. PTHR11785. 1 hit.
    Pfami PF13520. AA_permease_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006060. AA_transporter. 1 hit.
    TIGRFAMsi TIGR00911. 2A0308. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins."
      Sato H., Tamba M., Ishii T., Bannai S.
      J. Biol. Chem. 274:11455-11458(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression."
      Sasaki H., Sato H., Kuriyama-Matsumura K., Sato K., Maebara K., Wang H., Tamba M., Itoh K., Yamamoto M., Bannai S.
      J. Biol. Chem. 277:44765-44771(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/SvJ.
      Tissue: Liver.
    3. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiXCT_MOUSE
    AccessioniPrimary (citable) accession number: Q9WTR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3