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Protein

Cadherin-13

Gene

Cdh13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-13
Alternative name(s):
Heart cadherin
Short name:
H-cadherin
Truncated cadherin
Short name:
T-cad
Short name:
T-cadherin
Gene namesi
Name:Cdh13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:99551. Cdh13.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi152R → E: Strongly inhibits dimerization. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000000379623 – 138By similarityAdd BLAST116
ChainiPRO_0000003797139 – 693Cadherin-13Add BLAST555
PropeptideiPRO_0000003798694 – 714Removed in mature formSequence analysisAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi382N-linked (GlcNAc...)Sequence analysis1
Glycosylationi489N-linked (GlcNAc...)Sequence analysis1
Glycosylationi500N-linked (GlcNAc...)Sequence analysis1
Glycosylationi530N-linked (GlcNAc...)Sequence analysis1
Glycosylationi598N-linked (GlcNAc...)Sequence analysis1
Glycosylationi638N-linked (GlcNAc...)Sequence analysis1
Glycosylationi671N-linked (GlcNAc...)Sequence analysis1
Lipidationi693GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ9WTR5.
PaxDbiQ9WTR5.
PeptideAtlasiQ9WTR5.
PRIDEiQ9WTR5.

PTM databases

iPTMnetiQ9WTR5.
PhosphoSitePlusiQ9WTR5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031841.
CleanExiMM_CDH13.
GenevisibleiQ9WTR5. MM.

Interactioni

Subunit structurei

By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1-EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape.1 Publication

GO - Molecular functioni

  • adiponectin binding Source: BHF-UCL
  • cadherin binding Source: MGI
  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi198633. 2 interactors.
IntActiQ9WTR5. 1 interactor.
STRINGi10090.ENSMUSP00000113527.

Structurei

Secondary structure

1714
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi145 – 148Combined sources4
Beta strandi153 – 155Combined sources3
Beta strandi157 – 161Combined sources5
Beta strandi172 – 178Combined sources7
Turni179 – 181Combined sources3
Beta strandi182 – 184Combined sources3
Beta strandi187 – 190Combined sources4
Turni192 – 194Combined sources3
Beta strandi196 – 199Combined sources4
Turni205 – 207Combined sources3
Beta strandi209 – 218Combined sources10
Beta strandi220 – 222Combined sources3
Beta strandi224 – 236Combined sources13
Beta strandi249 – 255Combined sources7
Beta strandi263 – 266Combined sources4
Beta strandi272 – 275Combined sources4
Helixi277 – 280Combined sources4
Beta strandi282 – 291Combined sources10
Beta strandi298 – 301Combined sources4
Turni303 – 305Combined sources3
Beta strandi307 – 310Combined sources4
Helixi314 – 316Combined sources3
Helixi319 – 321Combined sources3
Beta strandi325 – 335Combined sources11
Turni339 – 342Combined sources4
Beta strandi344 – 354Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3K5RX-ray2.00A/B140-355[»]
3K6FX-ray1.81A/B140-237[»]
ProteinModelPortaliQ9WTR5.
SMRiQ9WTR5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WTR5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini143 – 245Cadherin 1PROSITE-ProRule annotationAdd BLAST103
Domaini246 – 363Cadherin 2PROSITE-ProRule annotationAdd BLAST118
Domaini364 – 477Cadherin 3PROSITE-ProRule annotationAdd BLAST114
Domaini478 – 585Cadherin 4PROSITE-ProRule annotationAdd BLAST108
Domaini586 – 680Cadherin 5PROSITE-ProRule annotationAdd BLAST95

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000231254.
HOVERGENiHBG106438.
InParanoidiQ9WTR5.
KOiK06808.
OMAiTIATYQL.
OrthoDBiEOG091G02OG.
TreeFamiTF316817.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR014868. Cadherin_pro_dom.
IPR033216. CDH13.
[Graphical view]
PANTHERiPTHR24027:SF80. PTHR24027:SF80. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WTR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPRTPLTLC VLLSQVLLVT SADDLECTPG FQRKVLHIHQ PAEFIEDQPV
60 70 80 90 100
LNLTFNDCKG NEKLHYEVSS PHFKVNSDGT LVALRNITAV GRTLFVHART
110 120 130 140 150
PHAEDMAELV IVGGKDIQGS LQDIFKFART SPVPRQKRSI VVSPILIPEN
160 170 180 190 200
QRQPFPRDVG KVVDSDRPEG SKFRLTGKGV DQDPKGTFRI NENTGSVSVT
210 220 230 240 250
RTLDRETIAT YQLYVETTDA SGKTLEGPVP LEVIVIDQND NRPIFREGPY
260 270 280 290 300
IGHVMEGSPT GTTVMRMTAF DADDPATDNA LLRYNIRQQT PDKPSPNMFY
310 320 330 340 350
IDPEKGDIVT VVSPALLDRE TLENPKYELI IEAQDMAGLD VGLTGTATAT
360 370 380 390 400
IVIDDKNDHS PKFTKKEFQA TVEEGAVGVI VNLTVEDKDD PTTGAWRAAY
410 420 430 440 450
TIINGNPGQS FEIHTNPQTN EGMLSVVKPL DYEISAFHTL LIKVENEDPL
460 470 480 490 500
VPDVSYGPSS TATVHITVLD VNEGPVFYPD PMMVTKQENI SVGSVLLTVN
510 520 530 540 550
ATDPDSLQHQ TIRYSIYKDP AGWLSINPIN GTVDTTAVLD RESPFVHNSV
560 570 580 590 600
YTALFLAIDS GNPPATGTGT LLITLEDIND NAPVIYPTVA EVCDDARNLS
610 620 630 640 650
VVILGASDKD LHPNTDPFKF EIHKQTVPDK VWKISKINNT HALVSLLQNL
660 670 680 690 700
NKANYNLPIM VTDSGKPPMT NITDLRVQVC SCKNSKVDCN GAGALHLSLS
710
LLLLFSLLSL LSGL
Length:714
Mass (Da):78,186
Last modified:July 27, 2011 - v2
Checksum:iD6EE6573B2B23204
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti282L → W in BAA76677 (PubMed:10737605).Curated1
Sequence conflicti371T → R in BAA76677 (PubMed:10737605).Curated1
Sequence conflicti676R → K in BAA76677 (PubMed:10737605).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022100 mRNA. Translation: BAA76677.1.
AK039438 mRNA. Translation: BAC30347.1.
AK048724 mRNA. Translation: BAC33435.1.
AK134649 mRNA. Translation: BAE22225.1.
CH466525 Genomic DNA. Translation: EDL11590.1.
CCDSiCCDS52682.1.
RefSeqiNP_062681.2. NM_019707.5.
UniGeneiMm.334841.

Genome annotation databases

EnsembliENSMUST00000117160; ENSMUSP00000113527; ENSMUSG00000031841.
GeneIDi12554.
KEGGimmu:12554.
UCSCiuc009npl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022100 mRNA. Translation: BAA76677.1.
AK039438 mRNA. Translation: BAC30347.1.
AK048724 mRNA. Translation: BAC33435.1.
AK134649 mRNA. Translation: BAE22225.1.
CH466525 Genomic DNA. Translation: EDL11590.1.
CCDSiCCDS52682.1.
RefSeqiNP_062681.2. NM_019707.5.
UniGeneiMm.334841.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3K5RX-ray2.00A/B140-355[»]
3K6FX-ray1.81A/B140-237[»]
ProteinModelPortaliQ9WTR5.
SMRiQ9WTR5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198633. 2 interactors.
IntActiQ9WTR5. 1 interactor.
STRINGi10090.ENSMUSP00000113527.

PTM databases

iPTMnetiQ9WTR5.
PhosphoSitePlusiQ9WTR5.

Proteomic databases

MaxQBiQ9WTR5.
PaxDbiQ9WTR5.
PeptideAtlasiQ9WTR5.
PRIDEiQ9WTR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000117160; ENSMUSP00000113527; ENSMUSG00000031841.
GeneIDi12554.
KEGGimmu:12554.
UCSCiuc009npl.1. mouse.

Organism-specific databases

CTDi1012.
MGIiMGI:99551. Cdh13.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000231254.
HOVERGENiHBG106438.
InParanoidiQ9WTR5.
KOiK06808.
OMAiTIATYQL.
OrthoDBiEOG091G02OG.
TreeFamiTF316817.

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.

Miscellaneous databases

EvolutionaryTraceiQ9WTR5.
PROiQ9WTR5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031841.
CleanExiMM_CDH13.
GenevisibleiQ9WTR5. MM.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR014868. Cadherin_pro_dom.
IPR033216. CDH13.
[Graphical view]
PANTHERiPTHR24027:SF80. PTHR24027:SF80. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAD13_MOUSE
AccessioniPrimary (citable) accession number: Q9WTR5
Secondary accession number(s): Q8BG11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.