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Protein

Transporter

Gene

Slc6a2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • alpha-tubulin binding Source: RGD
  • beta-tubulin binding Source: RGD
  • monoamine transmembrane transporter activity Source: RGD
  • neurotransmitter:sodium symporter activity Source: InterPro
  • norepinephrine transmembrane transporter activity Source: RGD

GO - Biological processi

  • monoamine transport Source: RGD
  • neurotransmitter transport Source: RGD
  • norepinephrine transport Source: RGD
  • response to drug Source: RGD
  • response to pain Source: RGD

Keywordsi

Biological processSymportUniRule annotationSAAS annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
TransporterUniRule annotation
Gene namesi
Name:Slc6a2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi621822. Slc6a2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Transmembranei44 – 66HelicalSequence analysisAdd BLAST23
Transmembranei87 – 114HelicalSequence analysisAdd BLAST28
Transmembranei182 – 200HelicalSequence analysisAdd BLAST19
Transmembranei212 – 237HelicalSequence analysisAdd BLAST26
Transmembranei257 – 282HelicalSequence analysisAdd BLAST26
Transmembranei294 – 319HelicalSequence analysisAdd BLAST26
Transmembranei339 – 365HelicalSequence analysisAdd BLAST27
Transmembranei394 – 419HelicalSequence analysisAdd BLAST26
Transmembranei425 – 448HelicalSequence analysisAdd BLAST24
Transmembranei469 – 488HelicalSequence analysisAdd BLAST20
Transmembranei508 – 528HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL304.

PTM / Processingi

Proteomic databases

PaxDbiQ9WTR4.

Expressioni

Gene expression databases

GenevisibleiQ9WTR4. RN.

Interactioni

GO - Molecular functioni

  • alpha-tubulin binding Source: RGD
  • beta-tubulin binding Source: RGD

Structurei

3D structure databases

ProteinModelPortaliQ9WTR4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
KOiK05035.
PhylomeDBiQ9WTR4.

Family and domain databases

InterProiView protein in InterPro
IPR000175. Na/ntran_symport.
IPR002435. Na/ntran_symport_noradrenaline.
IPR037272. SNS_sf.
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiView protein in Pfam
PF00209. SNF. 1 hit.
PRINTSiPR00176. NANEUSMPORT.
PR01201. NORTRANSPORT.
SUPFAMiSSF161070. SSF161070. 1 hit.
PROSITEiView protein in PROSITE
PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WTR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTRTRETWG KKIDFLLSVV GFAVDLANVW RFPYLCYKNG GGAFLIPYTL
60 70 80 90 100
FLIIAGMPLF YMELALGQFN REGAATVWKI CPFFKGVGYA VILIALYVGF
110 120 130 140 150
YYNVIIAWSL YYLFASFTLN LPWTNCGHAW NSPNCTDPKL LNASVLGDHT
160 170 180 190 200
KYSKYKFTPA AEFYERGVLH LHESSGIHDI GLPQWQLLLC LMVVIVVLYV
210 220 230 240 250
SLWKGVKTSG KVVWITATLP YFVLFVLLVH GVTLPGASNG INAYLHIDFY
260 270 280 290 300
RLKEATVWID AATQIFFSLG AGFGVLIAFA SYNKFDNNCY RDALLTSTIN
310 320 330 340 350
CVTSFISGFA IFSILGYMAH EHKVKIEDVA TEGAGLVFVL YPEAISTLSG
360 370 380 390 400
STFWAVLFFL MLLALGLDSS MGGMEAVITG LADDFQVLKR HRKLFTCAVT
410 420 430 440 450
LGTFLLAMFC ITKGGIYVLT LLDTFAAGTS ILFAVLMEAI GVSWFYGVDR
460 470 480 490 500
FSNDIQQMMG FKPGLYWRLC WKFVSPAFLL FVVVVSIINF KPLTYDDYVY
510 520 530 540 550
PPWANWVGWG IALSSMILVP AYVIYKFFSI RGSLWERVAY GITPENEHHL
560 570 580 590
LALEIELSSL QSFVITSCPI DPLLSSFLFI SCQKTLVFKK SGPAPLI
Length:597
Mass (Da):66,781
Last modified:November 1, 1999 - v1
Checksum:i17C46D0A256A2E06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021971 mRNA. Translation: BAA76942.1.
RefSeqiNP_112633.1. NM_031343.1.
UniGeneiRn.14577.

Genome annotation databases

GeneIDi83511.
KEGGirno:83511.

Similar proteinsi

Entry informationi

Entry nameiQ9WTR4_RAT
AccessioniPrimary (citable) accession number: Q9WTR4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: November 22, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)