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Q9WTR1

- TRPV2_MOUSE

UniProt

Q9WTR1 - TRPV2_MOUSE

Protein

Transient receptor potential cation channel subfamily V member 2

Gene

Trpv2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 2 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.2 Publications

    GO - Molecular functioni

    1. calcium channel activity Source: MGI
    2. cation channel activity Source: MGI

    GO - Biological processi

    1. positive regulation of axon extension Source: DFLAT
    2. positive regulation of calcium ion import Source: DFLAT
    3. response to heat Source: Ensembl
    4. response to temperature stimulus Source: MGI

    Keywords - Molecular functioni

    Calcium channel, Ion channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_227861. TRP channels.

    Protein family/group databases

    TCDBi1.A.4.2.4. the transient receptor potential ca(2+) channel (trp-cc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transient receptor potential cation channel subfamily V member 2
    Short name:
    TrpV2
    Alternative name(s):
    Growth factor-regulated calcium channel
    Short name:
    GRC
    Osm-9-like TRP channel 2
    Short name:
    OTRPC2
    Gene namesi
    Name:Trpv2
    Synonyms:Grc
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1341836. Trpv2.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein. Cytoplasm. Melanosome By similarity
    Note: Translocates from the cytoplasm to the plasma membrane upon ligand stimulation.

    GO - Cellular componenti

    1. axon Source: DFLAT
    2. axonal growth cone Source: DFLAT
    3. cell body Source: DFLAT
    4. cell surface Source: DFLAT
    5. endomembrane system Source: Ensembl
    6. growth cone membrane Source: DFLAT
    7. integral component of membrane Source: UniProtKB-KW
    8. intracellular Source: MGI
    9. melanosome Source: UniProtKB-SubCell
    10. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 756756Transient receptor potential cation channel subfamily V member 2PRO_0000215343Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei15 – 151Phosphoserine1 Publication
    Glycosylationi567 – 5671N-linked (GlcNAc...)Sequence Analysis
    Modified residuei755 – 7551Phosphoserine1 Publication

    Post-translational modificationi

    N-glycosylated.1 Publication
    Phosphorylated by PKA.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ9WTR1.
    PRIDEiQ9WTR1.

    PTM databases

    PhosphoSiteiQ9WTR1.

    Expressioni

    Tissue specificityi

    Abundantly expressed in spleen, placenta, skeleton muscle, lung and brain.1 Publication

    Gene expression databases

    BgeeiQ9WTR1.
    GenevestigatoriQ9WTR1.

    Interactioni

    Subunit structurei

    Homotetramer Probable. Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with SLC50A1; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation By similarity.By similarityCurated

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WTR1.
    SMRiQ9WTR1. Positions 70-676.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 387387CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini409 – 42820ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini450 – 4556CytoplasmicSequence Analysis
    Topological domaini477 – 49014ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini512 – 53221CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini638 – 756119CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei568 – 60437Pore-formingSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei388 – 40821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei429 – 44921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei456 – 47621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei491 – 51121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei533 – 55321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei617 – 63721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati68 – 11043ANK 1Add
    BLAST
    Repeati111 – 15747ANK 2Add
    BLAST
    Repeati158 – 20346ANK 3Add
    BLAST
    Repeati204 – 23936ANK 4Add
    BLAST
    Repeati240 – 28849ANK 5Add
    BLAST
    Repeati289 – 31527ANK 6Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 385385Required for interaction with SLC50A1By similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 6 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG281194.
    GeneTreeiENSGT00550000074425.
    HOGENOMiHOG000234630.
    HOVERGENiHBG054085.
    InParanoidiQ9WTR1.
    KOiK04971.
    OMAiLSQVLCF.
    OrthoDBiEOG7V49XW.
    PhylomeDBiQ9WTR1.
    TreeFamiTF314711.

    Family and domain databases

    Gene3Di1.25.40.20. 2 hits.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    IPR004729. TRP_channel.
    IPR008347. TRPV1-4_channel.
    IPR024865. TRPV2_channel.
    [Graphical view]
    PANTHERiPTHR10582:SF5. PTHR10582:SF5. 1 hit.
    PfamiPF12796. Ank_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR01768. TRPVRECEPTOR.
    SMARTiSM00248. ANK. 4 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    TIGRFAMsiTIGR00870. trp. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9WTR1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSASNPPAF RLETSDGDEE GSAEVNKGKN EPPPMESPFQ GEDRNFSPQI    50
    KVNLNYRKGL GPSQQDPNRF DRDRLFSVVS RGVPEELTGL LEYLRRTSKY 100
    LTDSAYTEGS TGKTCLMKAV LNLQDGVNAC ILPLLQIDRD SGNPQPLVNA 150
    QCTDEFYRGH SALHIAIEKR SLWCVKLLVE NGANVHIRAC GRFFQKHQGT 200
    CFYFGELPLS LAACTKQWDV VTYLLENPHQ PASLEATDSL GNTVLHALVM 250
    IADNSPENSA LVIHMYDSLL QMGARLCPTV QLEDICNHQG LTPLKLAAKE 300
    GKIEIFRHIL QREFSGLYQP LSRKFTEWCY GPVRVSLYDL SSVDSWEKNS 350
    VLEIIAFHCK SPHRHRMVVL EPLNKLLQEK WDRLIPRFFF NFACYLVYMI 400
    IFTIVAYHQP SLEQPAIPSS KATFGDSMLL LGHILILLGG IYLLLGQLWY 450
    FWRRRLFIWI SFMDSYFEIL FLVQALLTVL SQVLRFVETE WYLPLLVSSL 500
    VLGWLNLLYY TRGFQHTGIY SVMIQKVILR DLLRFLLVYL VFLFGFAVAL 550
    VSLSREARSP KAPEDSNTTV TEKPTLGQEE EPVPYGGILD ASLELFKFTI 600
    GMGELAFQEQ LRFRGVVLLL LLAYVLLTYV LLLNMLIALM SETVNSVATD 650
    SWSIWKLQKA ISVLEMENGY WWCRRKRHRA GRLLKVGTKG DGIPDERWCF 700
    RVEEVNWAAW EKTLPTLSED PSGAGITGYK KNPTSKPGKN SASEEDHLPL 750
    QVLQSH 756
    Length:756
    Mass (Da):85,965
    Last modified:April 26, 2005 - v2
    Checksum:iC0E537AB2C86E1A8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti565 – 5651D → N in BAA78478. (PubMed:10559903)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB021665 mRNA. Translation: BAA78478.1.
    AK089004 mRNA. Translation: BAC40695.1.
    AL596181 Genomic DNA. Translation: CAI24670.1.
    BC005415 mRNA. Translation: AAH05415.1.
    CCDSiCCDS24827.1.
    RefSeqiNP_035836.2. NM_011706.2.
    XP_006533228.1. XM_006533165.1.
    UniGeneiMm.288064.

    Genome annotation databases

    EnsembliENSMUST00000018651; ENSMUSP00000018651; ENSMUSG00000018507.
    ENSMUST00000102643; ENSMUSP00000099703; ENSMUSG00000018507.
    GeneIDi22368.
    KEGGimmu:22368.
    UCSCiuc007jjh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB021665 mRNA. Translation: BAA78478.1 .
    AK089004 mRNA. Translation: BAC40695.1 .
    AL596181 Genomic DNA. Translation: CAI24670.1 .
    BC005415 mRNA. Translation: AAH05415.1 .
    CCDSi CCDS24827.1.
    RefSeqi NP_035836.2. NM_011706.2.
    XP_006533228.1. XM_006533165.1.
    UniGenei Mm.288064.

    3D structure databases

    ProteinModelPortali Q9WTR1.
    SMRi Q9WTR1. Positions 70-676.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 508.

    Protein family/group databases

    TCDBi 1.A.4.2.4. the transient receptor potential ca(2+) channel (trp-cc) family.

    PTM databases

    PhosphoSitei Q9WTR1.

    Proteomic databases

    PaxDbi Q9WTR1.
    PRIDEi Q9WTR1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000018651 ; ENSMUSP00000018651 ; ENSMUSG00000018507 .
    ENSMUST00000102643 ; ENSMUSP00000099703 ; ENSMUSG00000018507 .
    GeneIDi 22368.
    KEGGi mmu:22368.
    UCSCi uc007jjh.1. mouse.

    Organism-specific databases

    CTDi 51393.
    MGIi MGI:1341836. Trpv2.

    Phylogenomic databases

    eggNOGi NOG281194.
    GeneTreei ENSGT00550000074425.
    HOGENOMi HOG000234630.
    HOVERGENi HBG054085.
    InParanoidi Q9WTR1.
    KOi K04971.
    OMAi LSQVLCF.
    OrthoDBi EOG7V49XW.
    PhylomeDBi Q9WTR1.
    TreeFami TF314711.

    Enzyme and pathway databases

    Reactomei REACT_227861. TRP channels.

    Miscellaneous databases

    NextBioi 302697.
    PROi Q9WTR1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9WTR1.
    Genevestigatori Q9WTR1.

    Family and domain databases

    Gene3Di 1.25.40.20. 2 hits.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    IPR004729. TRP_channel.
    IPR008347. TRPV1-4_channel.
    IPR024865. TRPV2_channel.
    [Graphical view ]
    PANTHERi PTHR10582:SF5. PTHR10582:SF5. 1 hit.
    Pfami PF12796. Ank_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR01768. TRPVRECEPTOR.
    SMARTi SM00248. ANK. 4 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    TIGRFAMsi TIGR00870. trp. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I."
      Kanzaki M., Zhang Y.-Q., Mashima H., Li L., Shibata H., Kojima I.
      Nat. Cell Biol. 1:165-170(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION.
      Strain: C57BL/6.
      Tissue: Spleen.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.
    5. "The neuropeptide head activator induces activation and translocation of the growth-factor-regulated Ca(2+)-permeable channel GRC."
      Boels K., Glassmeier G., Herrmann D., Riedel I.B., Hampe W., Kojima I., Schwarz J.R., Schaller H.C.
      J. Cell Sci. 114:3599-3606(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    6. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND SER-755, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTRPV2_MOUSE
    AccessioniPrimary (citable) accession number: Q9WTR1
    Secondary accession number(s): Q99K71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3