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Protein

Transient receptor potential cation channel subfamily V member 2

Gene

Trpv2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.2 Publications

GO - Molecular functioni

  • calcium channel activity Source: MGI
  • cation channel activity Source: MGI

GO - Biological processi

  • positive regulation of axon extension Source: DFLAT
  • positive regulation of calcium ion import Source: DFLAT
  • response to heat Source: InterPro
  • response to temperature stimulus Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-MMU-3295583. TRP channels.

Protein family/group databases

TCDBi1.A.4.2.4. the transient receptor potential ca(2+) channel (trp-cc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily V member 2
Short name:
TrpV2
Alternative name(s):
Growth factor-regulated calcium channel
Short name:
GRC
Osm-9-like TRP channel 2
Short name:
OTRPC2
Gene namesi
Name:Trpv2
Synonyms:Grc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1341836. Trpv2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 387CytoplasmicSequence analysisAdd BLAST387
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
Topological domaini409 – 428ExtracellularSequence analysisAdd BLAST20
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 455CytoplasmicSequence analysis6
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Topological domaini477 – 490ExtracellularSequence analysisAdd BLAST14
Transmembranei491 – 511HelicalSequence analysisAdd BLAST21
Topological domaini512 – 532CytoplasmicSequence analysisAdd BLAST21
Transmembranei533 – 553HelicalSequence analysisAdd BLAST21
Intramembranei568 – 604Pore-formingSequence analysisAdd BLAST37
Transmembranei617 – 637HelicalSequence analysisAdd BLAST21
Topological domaini638 – 756CytoplasmicSequence analysisAdd BLAST119

GO - Cellular componenti

  • axon Source: DFLAT
  • axonal growth cone Source: DFLAT
  • cell body Source: DFLAT
  • cell surface Source: DFLAT
  • growth cone membrane Source: DFLAT
  • integral component of plasma membrane Source: GO_Central
  • intracellular Source: MGI
  • melanosome Source: UniProtKB-SubCell
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi508.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153431 – 756Transient receptor potential cation channel subfamily V member 2Add BLAST756

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineCombined sources1
Modified residuei77PhosphoserineBy similarity1
Glycosylationi567N-linked (GlcNAc...)Sequence analysis1
Modified residuei743PhosphoserineCombined sources1
Modified residuei755PhosphoserineCombined sources1

Post-translational modificationi

N-glycosylated.1 Publication
Phosphorylated by PKA.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9WTR1.
MaxQBiQ9WTR1.
PaxDbiQ9WTR1.
PeptideAtlasiQ9WTR1.
PRIDEiQ9WTR1.

PTM databases

iPTMnetiQ9WTR1.
PhosphoSitePlusiQ9WTR1.
SwissPalmiQ9WTR1.

Expressioni

Tissue specificityi

Abundantly expressed in spleen, placenta, skeleton muscle, lung and brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000018507.
GenevisibleiQ9WTR1. MM.

Interactioni

Subunit structurei

Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with SLC50A1; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation (By similarity).By similarityCurated

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018651.

Structurei

3D structure databases

ProteinModelPortaliQ9WTR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati68 – 110ANK 1Add BLAST43
Repeati111 – 157ANK 2Add BLAST47
Repeati158 – 203ANK 3Add BLAST46
Repeati204 – 239ANK 4Add BLAST36
Repeati240 – 288ANK 5Add BLAST49
Repeati289 – 315ANK 6Add BLAST27

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 385Required for interaction with SLC50A1By similarityAdd BLAST385

Sequence similaritiesi

Contains 6 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3676. Eukaryota.
ENOG4110DG4. LUCA.
GeneTreeiENSGT00550000074425.
HOGENOMiHOG000234630.
HOVERGENiHBG054085.
InParanoidiQ9WTR1.
KOiK04971.
OMAiICVLEME.
OrthoDBiEOG091G02AF.
PhylomeDBiQ9WTR1.
TreeFamiTF314711.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR008347. TRPV1-4_channel.
IPR024865. TRPV2_channel.
[Graphical view]
PANTHERiPTHR10582:SF5. PTHR10582:SF5. 2 hits.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01768. TRPVRECEPTOR.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WTR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSASNPPAF RLETSDGDEE GSAEVNKGKN EPPPMESPFQ GEDRNFSPQI
60 70 80 90 100
KVNLNYRKGL GPSQQDPNRF DRDRLFSVVS RGVPEELTGL LEYLRRTSKY
110 120 130 140 150
LTDSAYTEGS TGKTCLMKAV LNLQDGVNAC ILPLLQIDRD SGNPQPLVNA
160 170 180 190 200
QCTDEFYRGH SALHIAIEKR SLWCVKLLVE NGANVHIRAC GRFFQKHQGT
210 220 230 240 250
CFYFGELPLS LAACTKQWDV VTYLLENPHQ PASLEATDSL GNTVLHALVM
260 270 280 290 300
IADNSPENSA LVIHMYDSLL QMGARLCPTV QLEDICNHQG LTPLKLAAKE
310 320 330 340 350
GKIEIFRHIL QREFSGLYQP LSRKFTEWCY GPVRVSLYDL SSVDSWEKNS
360 370 380 390 400
VLEIIAFHCK SPHRHRMVVL EPLNKLLQEK WDRLIPRFFF NFACYLVYMI
410 420 430 440 450
IFTIVAYHQP SLEQPAIPSS KATFGDSMLL LGHILILLGG IYLLLGQLWY
460 470 480 490 500
FWRRRLFIWI SFMDSYFEIL FLVQALLTVL SQVLRFVETE WYLPLLVSSL
510 520 530 540 550
VLGWLNLLYY TRGFQHTGIY SVMIQKVILR DLLRFLLVYL VFLFGFAVAL
560 570 580 590 600
VSLSREARSP KAPEDSNTTV TEKPTLGQEE EPVPYGGILD ASLELFKFTI
610 620 630 640 650
GMGELAFQEQ LRFRGVVLLL LLAYVLLTYV LLLNMLIALM SETVNSVATD
660 670 680 690 700
SWSIWKLQKA ISVLEMENGY WWCRRKRHRA GRLLKVGTKG DGIPDERWCF
710 720 730 740 750
RVEEVNWAAW EKTLPTLSED PSGAGITGYK KNPTSKPGKN SASEEDHLPL

QVLQSH
Length:756
Mass (Da):85,965
Last modified:April 26, 2005 - v2
Checksum:iC0E537AB2C86E1A8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti565D → N in BAA78478 (PubMed:10559903).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021665 mRNA. Translation: BAA78478.1.
AK089004 mRNA. Translation: BAC40695.1.
AL596181 Genomic DNA. Translation: CAI24670.1.
BC005415 mRNA. Translation: AAH05415.1.
CCDSiCCDS24827.1.
RefSeqiNP_035836.2. NM_011706.2.
XP_006533228.1. XM_006533165.2.
XP_011247273.1. XM_011248971.1.
UniGeneiMm.288064.

Genome annotation databases

EnsembliENSMUST00000018651; ENSMUSP00000018651; ENSMUSG00000018507.
ENSMUST00000102643; ENSMUSP00000099703; ENSMUSG00000018507.
GeneIDi22368.
KEGGimmu:22368.
UCSCiuc007jjh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021665 mRNA. Translation: BAA78478.1.
AK089004 mRNA. Translation: BAC40695.1.
AL596181 Genomic DNA. Translation: CAI24670.1.
BC005415 mRNA. Translation: AAH05415.1.
CCDSiCCDS24827.1.
RefSeqiNP_035836.2. NM_011706.2.
XP_006533228.1. XM_006533165.2.
XP_011247273.1. XM_011248971.1.
UniGeneiMm.288064.

3D structure databases

ProteinModelPortaliQ9WTR1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018651.

Chemistry databases

GuidetoPHARMACOLOGYi508.

Protein family/group databases

TCDBi1.A.4.2.4. the transient receptor potential ca(2+) channel (trp-cc) family.

PTM databases

iPTMnetiQ9WTR1.
PhosphoSitePlusiQ9WTR1.
SwissPalmiQ9WTR1.

Proteomic databases

EPDiQ9WTR1.
MaxQBiQ9WTR1.
PaxDbiQ9WTR1.
PeptideAtlasiQ9WTR1.
PRIDEiQ9WTR1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018651; ENSMUSP00000018651; ENSMUSG00000018507.
ENSMUST00000102643; ENSMUSP00000099703; ENSMUSG00000018507.
GeneIDi22368.
KEGGimmu:22368.
UCSCiuc007jjh.1. mouse.

Organism-specific databases

CTDi51393.
MGIiMGI:1341836. Trpv2.

Phylogenomic databases

eggNOGiKOG3676. Eukaryota.
ENOG4110DG4. LUCA.
GeneTreeiENSGT00550000074425.
HOGENOMiHOG000234630.
HOVERGENiHBG054085.
InParanoidiQ9WTR1.
KOiK04971.
OMAiICVLEME.
OrthoDBiEOG091G02AF.
PhylomeDBiQ9WTR1.
TreeFamiTF314711.

Enzyme and pathway databases

ReactomeiR-MMU-3295583. TRP channels.

Miscellaneous databases

PROiQ9WTR1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018507.
GenevisibleiQ9WTR1. MM.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR008347. TRPV1-4_channel.
IPR024865. TRPV2_channel.
[Graphical view]
PANTHERiPTHR10582:SF5. PTHR10582:SF5. 2 hits.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01768. TRPVRECEPTOR.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRPV2_MOUSE
AccessioniPrimary (citable) accession number: Q9WTR1
Secondary accession number(s): Q99K71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: November 2, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.