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Protein

Growth arrest and DNA damage-inducible protein GADD45 gamma

Gene

Gadd45g

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processApoptosis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest and DNA damage-inducible protein GADD45 gamma
Gene namesi
Name:Gadd45g
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1311796 Gadd45g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001483381 – 159Growth arrest and DNA damage-inducible protein GADD45 gammaAdd BLAST159

Proteomic databases

PaxDbiQ9WTQ7

Expressioni

Gene expression databases

BgeeiENSRNOG00000013090
ExpressionAtlasiQ9WTQ7 baseline and differential
GenevisibleiQ9WTQ7 RN

Interactioni

Subunit structurei

Undergoes concentration-dependent homodimerization, which is required for growth inhibititory activity and enhances interaction with PCNA. Interacts with GADD45GIP1. Interacts with PCNA (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018251

Structurei

3D structure databases

ProteinModelPortaliQ9WTQ7
SMRiQ9WTQ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni43 – 86HomodimerizationBy similarityAdd BLAST44

Domaini

Two central helices mediate homodimerization through parallel packing.By similarity

Sequence similaritiesi

Belongs to the GADD45 family.Curated

Phylogenomic databases

eggNOGiENOG410IW58 Eukaryota
ENOG4111FXB LUCA
GeneTreeiENSGT00390000016506
HOGENOMiHOG000013221
HOVERGENiHBG051684
InParanoidiQ9WTQ7
KOiK04402
OMAiDWVPTIT
OrthoDBiEOG091G0RHU
PhylomeDBiQ9WTQ7
TreeFamiTF300196

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR024824 GADD45
IPR029064 L30e-like
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
PANTHERiPTHR10411 PTHR10411, 1 hit
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
SUPFAMiSSF55315 SSF55315, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WTQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLEEVRGQD TVPESTARMQ GAGKALHELL LSAQRQGCLT AGVYESAKVL
60 70 80 90 100
NVDPDNVTFC VLAADEEDEG DIALQIHFTL IQAFCCENDI DIVRVGDVQR
110 120 130 140 150
LAAIVGADDE GGAPGDLHCI LISNPNEDTW KDPALEKLSL FCEESRSFND

WVPSITLPE
Length:159
Mass (Da):17,287
Last modified:November 1, 1999 - v1
Checksum:i4B598B339E45CD96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020978 mRNA Translation: BAA78094.1
RefSeqiNP_001071108.1, NM_001077640.1
UniGeneiRn.16950

Genome annotation databases

EnsembliENSRNOT00000018252; ENSRNOP00000018251; ENSRNOG00000013090
GeneIDi291005
KEGGirno:291005

Similar proteinsi

Entry informationi

Entry nameiGA45G_RAT
AccessioniPrimary (citable) accession number: Q9WTQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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