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Protein

Growth arrest and DNA damage-inducible protein GADD45 gamma

Gene

Gadd45g

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Apoptosis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest and DNA damage-inducible protein GADD45 gamma
Gene namesi
Name:Gadd45g
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1311796. Gadd45g.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159Growth arrest and DNA damage-inducible protein GADD45 gammaPRO_0000148338Add
BLAST

Proteomic databases

PaxDbiQ9WTQ7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000013090.
ExpressionAtlasiQ9WTQ7. baseline and differential.
GenevisibleiQ9WTQ7. RN.

Interactioni

Subunit structurei

Undergoes concentration-dependent homodimerization, which is required for growth inhibititory activity and enhances interaction with PCNA. Interacts with GADD45GIP1. Interacts with PCNA (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018251.

Structurei

3D structure databases

ProteinModelPortaliQ9WTQ7.
SMRiQ9WTQ7. Positions 16-159.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni43 – 8644HomodimerizationBy similarityAdd
BLAST

Domaini

Two central helices mediate homodimerization through parallel packing.By similarity

Sequence similaritiesi

Belongs to the GADD45 family.Curated

Phylogenomic databases

eggNOGiENOG410IW58. Eukaryota.
ENOG4111FXB. LUCA.
GeneTreeiENSGT00390000016506.
HOGENOMiHOG000013221.
HOVERGENiHBG051684.
InParanoidiQ9WTQ7.
KOiK04402.
OMAiDWVPTIT.
OrthoDBiEOG091G0RHU.
PhylomeDBiQ9WTQ7.
TreeFamiTF300196.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR024824. GADD45.
IPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
[Graphical view]
PANTHERiPTHR10411. PTHR10411. 1 hit.
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WTQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLEEVRGQD TVPESTARMQ GAGKALHELL LSAQRQGCLT AGVYESAKVL
60 70 80 90 100
NVDPDNVTFC VLAADEEDEG DIALQIHFTL IQAFCCENDI DIVRVGDVQR
110 120 130 140 150
LAAIVGADDE GGAPGDLHCI LISNPNEDTW KDPALEKLSL FCEESRSFND

WVPSITLPE
Length:159
Mass (Da):17,287
Last modified:November 1, 1999 - v1
Checksum:i4B598B339E45CD96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020978 mRNA. Translation: BAA78094.1.
RefSeqiNP_001071108.1. NM_001077640.1.
UniGeneiRn.16950.

Genome annotation databases

EnsembliENSRNOT00000018252; ENSRNOP00000018251; ENSRNOG00000013090.
GeneIDi291005.
KEGGirno:291005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020978 mRNA. Translation: BAA78094.1.
RefSeqiNP_001071108.1. NM_001077640.1.
UniGeneiRn.16950.

3D structure databases

ProteinModelPortaliQ9WTQ7.
SMRiQ9WTQ7. Positions 16-159.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018251.

Proteomic databases

PaxDbiQ9WTQ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018252; ENSRNOP00000018251; ENSRNOG00000013090.
GeneIDi291005.
KEGGirno:291005.

Organism-specific databases

CTDi10912.
RGDi1311796. Gadd45g.

Phylogenomic databases

eggNOGiENOG410IW58. Eukaryota.
ENOG4111FXB. LUCA.
GeneTreeiENSGT00390000016506.
HOGENOMiHOG000013221.
HOVERGENiHBG051684.
InParanoidiQ9WTQ7.
KOiK04402.
OMAiDWVPTIT.
OrthoDBiEOG091G0RHU.
PhylomeDBiQ9WTQ7.
TreeFamiTF300196.

Miscellaneous databases

PROiQ9WTQ7.

Gene expression databases

BgeeiENSRNOG00000013090.
ExpressionAtlasiQ9WTQ7. baseline and differential.
GenevisibleiQ9WTQ7. RN.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR024824. GADD45.
IPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
[Graphical view]
PANTHERiPTHR10411. PTHR10411. 1 hit.
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGA45G_RAT
AccessioniPrimary (citable) accession number: Q9WTQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.