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Protein

Ventral anterior homeobox 2

Gene

Vax2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle. May be a regulator of axial polarization in the retina.4 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi102 – 16160HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • axonogenesis Source: MGI
  • camera-type eye development Source: MGI
  • dorsal/ventral axis specification Source: MGI
  • embryonic eye morphogenesis Source: MGI
  • forebrain development Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • retina development in camera-type eye Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
  • visual perception Source: InterPro
  • Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation, Wnt signaling pathway

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ventral anterior homeobox 2
Alternative name(s):
Ventral retina homeodomain protein
Gene namesi
Name:Vax2
Synonyms:Vex
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1346018. Vax2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Ventral anterior homeobox 2PRO_0000049352Add
BLAST

Proteomic databases

MaxQBiQ9WTP9.
PaxDbiQ9WTP9.
PRIDEiQ9WTP9.

PTM databases

iPTMnetiQ9WTP9.
PhosphoSiteiQ9WTP9.

Expressioni

Tissue specificityi

Expressed in the developing and mature retina.2 Publications

Developmental stagei

At 9.5 dpc, expressed solely in the ventral halves of the optic stalks and vesicles without proximo-distal restriction. Expression in the optic stalk diminishes after 11.5 dpc and becomes restricted to the inner layer of optic cup in its ventral half. Expression persists in the ventral halves of all neural retina layers (inner and outer nuclear layer) at 14.5 dpc and 16.5 dpc, and the ganglion cell layer, inner nuclear layer and photoreceptor layer in the adult.2 Publications

Gene expression databases

BgeeiQ9WTP9.
CleanExiMM_VAX2.
ExpressionAtlasiQ9WTP9. baseline and differential.
GenevisibleiQ9WTP9. MM.

Interactioni

Protein-protein interaction databases

BioGridi204905. 5 interactions.
STRINGi10090.ENSMUSP00000035976.

Structurei

3D structure databases

ProteinModelPortaliQ9WTP9.
SMRiQ9WTP9. Positions 104-159.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EMX homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0843. Eukaryota.
ENOG4111SRW. LUCA.
GeneTreeiENSGT00840000129733.
HOGENOMiHOG000049217.
HOVERGENiHBG007558.
InParanoidiQ9WTP9.
KOiK09318.
OMAiCGPNPLC.
OrthoDBiEOG71ZP35.
PhylomeDBiQ9WTP9.
TreeFamiTF319504.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
IPR033021. Vax2.
[Graphical view]
PANTHERiPTHR24339:SF34. PTHR24339:SF34. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WTP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDGGAERDR GPKRREEPGG RSGRHGEHRG AEDLRADTGS ASPREIAGTS
60 70 80 90 100
ASSPAGSRES GGDSDGQQAL GETDHCRRIL VRDAKGTIRE IVLPKGLDLD
110 120 130 140 150
RPKRTRTSFT AEQLYRLEME FQRCQYVVGR ERTELARQLN LSETQVKVWF
160 170 180 190 200
QNRRTKQKKD QSRDLEKRAS SSASEAFATS NVLRLLEQGR LLSVPRAPSL
210 220 230 240 250
LALTPGLPGL PASHRGTSLV DPRNSSPRLN PMPSASASSP LPPPLPAICF
260 270 280 290
SSAPLLDLPA GYKLGSSAFE PYSRLEQQKV GSPGQSDKKA DI
Length:292
Mass (Da):31,701
Last modified:November 1, 1999 - v1
Checksum:iC6A76B7BB799445D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020498 Genomic DNA. Translation: BAA76867.1.
Y17792 mRNA. Translation: CAB56169.1.
AF028715 mRNA. Translation: AAF21632.1.
CCDSiCCDS20282.1.
RefSeqiNP_036042.1. NM_011912.3.
UniGeneiMm.307165.

Genome annotation databases

EnsembliENSMUST00000037807; ENSMUSP00000035976; ENSMUSG00000034777.
GeneIDi24113.
KEGGimmu:24113.
UCSCiuc009cob.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020498 Genomic DNA. Translation: BAA76867.1.
Y17792 mRNA. Translation: CAB56169.1.
AF028715 mRNA. Translation: AAF21632.1.
CCDSiCCDS20282.1.
RefSeqiNP_036042.1. NM_011912.3.
UniGeneiMm.307165.

3D structure databases

ProteinModelPortaliQ9WTP9.
SMRiQ9WTP9. Positions 104-159.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204905. 5 interactions.
STRINGi10090.ENSMUSP00000035976.

PTM databases

iPTMnetiQ9WTP9.
PhosphoSiteiQ9WTP9.

Proteomic databases

MaxQBiQ9WTP9.
PaxDbiQ9WTP9.
PRIDEiQ9WTP9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037807; ENSMUSP00000035976; ENSMUSG00000034777.
GeneIDi24113.
KEGGimmu:24113.
UCSCiuc009cob.1. mouse.

Organism-specific databases

CTDi25806.
MGIiMGI:1346018. Vax2.

Phylogenomic databases

eggNOGiKOG0843. Eukaryota.
ENOG4111SRW. LUCA.
GeneTreeiENSGT00840000129733.
HOGENOMiHOG000049217.
HOVERGENiHBG007558.
InParanoidiQ9WTP9.
KOiK09318.
OMAiCGPNPLC.
OrthoDBiEOG71ZP35.
PhylomeDBiQ9WTP9.
TreeFamiTF319504.

Miscellaneous databases

NextBioi304143.
PROiQ9WTP9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WTP9.
CleanExiMM_VAX2.
ExpressionAtlasiQ9WTP9. baseline and differential.
GenevisibleiQ9WTP9. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
IPR033021. Vax2.
[Graphical view]
PANTHERiPTHR24339:SF34. PTHR24339:SF34. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of the Vax family homeobox genes suggests multiple roles in eye development."
    Ohsaki K., Morimitsu T., Ishida Y., Kominami R., Takahashi N.
    Genes Cells 4:267-276(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: BALB/cJ.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Tissue: Embryo.
  3. "Misexpression of the Emx-related homeobox genes cVax and mVax2 ventralizes the retina and perturbs the retinotectal map."
    Schulte D., Furukawa T., Peters M.A., Kozak C.A., Cepko C.L.
    Neuron 24:541-553(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Retina.
  4. "The homeodomain protein Vax2 patterns the dorsoventral and nasotemporal axes of the eye."
    Mui S.H., Hindges R., O'Leary D.D., Lemke G., Bertuzzi S.
    Development 129:797-804(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN EYE DEVELOPMENT.
  5. "A novel mechanism for the transcriptional regulation of Wnt signaling in development."
    Vacik T., Stubbs J.L., Lemke G.
    Genes Dev. 25:1783-1795(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiVAX2_MOUSE
AccessioniPrimary (citable) accession number: Q9WTP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.