Reviewed, UniProtKB/Swiss-Prot Q9WTP7 (KAD3_MOUSE)

Names and origin

Protein names

Recommended name:
    GTP:AMP phosphotransferase mitochondrial
    EC=2.7.4.10
Alternative name(s):
    Adenylate kinase 3
      Short name=AK 3
    Adenylate kinase 3 alpha-like 1

Gene names

Name:	Ak3
Synonyms:	Ak3l, Ak3l1, Akl3l

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	NTP + AMP = NDP + ADP.
Subunit structure	Monomer By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the adenylate kinase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Ligand	GTP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Acetylation
Gene Ontology (GO)
Biological process	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro GTP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: InterPro nucleoside triphosphate adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 227	226	GTP:AMP phosphotransferase mitochondrial		PRO_0000158923
Regions
	Nucleotide binding	14 – 22	9	GTP By similarity
	Nucleotide binding	91 – 98	8	AMP By similarity
Sites
	Binding site	38	1	AMP By similarity
Amino acid modifications
	Modified residue	34	1	N6-acetyllysine Ref.4
Experimental info
	Sequence conflict	171	1	K → E in BAB23625. Ref.1
	Sequence conflict	202	1	N → D in BAB23876. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9WTP7-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 6601DF10971DE5AC	FASTA	227	25,426
	10 20 30 40 50 60 MGASGRLLRA VIMGAPGSGK GTVSSRITKH FELKHLSSGD LLRQNMLQGT EIGVLAKTFI 70 80 90 100 110 120 DQGKLIPDDV MTRLALHELK TLTQCSWLLD GFPRTLPQAE ALDKVYQIDT VINLNVPFEV 130 140 150 160 170 180 IKQRLTARWI HPASGRVYNI EFNPPKTVGI DDLTGEPLIQ REDDKPETVI KRLKAYEAQT 190 200 210 220 EPVLQYYQKK GVLETFSGTE TNKIWPHVYS FLQTKVPETT QKASVTP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J and NOD. Tissue: Amnion, Bone marrow, Cerebellum, Eye, Liver, Stomach, Testis and Thymus.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon and Mammary gland.
[3]	Noma T. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-227.
[4]	"Substrate and functional diversity of lysine acetylation revealed by a proteomics survey." Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y. Mol. Cell 23:607-618(2006) [PubMed: 16916647] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-34, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK004864 mRNA. Translation: BAB23625.1. AK005194 mRNA. Translation: BAB23876.1. AK008681 mRNA. Translation: BAB25829.1. AK031631 mRNA. Translation: BAC27488.1. AK053644 mRNA. Translation: BAC35459.1. AK089027 mRNA. Translation: BAC40707.1. AK147060 mRNA. Translation: BAE27644.1. AK149996 mRNA. Translation: BAE29224.1. BC016432 mRNA. Translation: AAH16432.1. BC019174 mRNA. Translation: AAH19174.1. BC024871 mRNA. Translation: AAH24871.1. BC058191 mRNA. Translation: AAH58191.1. AB020203 mRNA. Translation: BAA77360.1.
IPI	IPI00221769.
RefSeq	NP_067274.1.
UniGene	Mm.196067
3D structure databases
HSSP	HSSP built from PDB template 2AK3 based on UniProtKB P08760.
SMR	Q9WTP7. Positions 2-227.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9WTP7.
PTM databases
PhosphoSite	Q9WTP7.
Proteomic databases
PRIDE	Q9WTP7.
Genome annotation databases
Ensembl	ENSMUST00000025696; ENSMUSP00000025696; ENSMUSG00000024782; Mus musculus. [Genome view]
GeneID	56248.
KEGG	mmu:56248.
NMPDR	fig|10090.3.peg.4905.
UCSC	uc008hcx.1. mouse.
Organism-specific databases
CTD	56248.
MGI	MGI:1860835. Ak3.
Phylogenomic databases
HOGENOM	Q9WTP7.
HOVERGEN	Q9WTP7.
OMA	NPPKTVG.
Enzyme and pathway databases
BRENDA	2.7.4.10. 244.
Gene expression databases
ArrayExpress	Q9WTP7.
Bgee	Q9WTP7.
CleanEx	MM_AK3. MM_AK3L1.
Genevestigator	Q9WTP7.
GermOnline	ENSMUSG00000024782. Mus musculus.
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_Znf_lid. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
ProDom	PD000657. Adenylate_kin. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01351. adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	312140.
SOURCE	Search...

Entry information

Entry name

KAD3_MOUSE

Accession

Primary (citable) accession number: Q9WTP7
Secondary accession number(s): Q3UDN7 , Q8BGX5, Q9D7Z1, Q9DB57, Q9DBM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 23, 2007
Last modified:	November 3, 2009
This is version 85 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)