Cadherin-22 precursor - Mus musculus (Mouse)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Cadherin-22

Alternative name(s):
Pituitary and brain cadherin
Short name=PB-cadherin

Gene names

Name:

Cdh22

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	813 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues.
Subcellular location	Cell membrane; Single-pass type I membrane protein.
Tissue specificity	Predominantly expressed in brain. Abundant in olfactory bulb, cerebrum, and cerebellum, less in pons, medulla, and spinal cord. Low expression in heart. No expression in lung, liver, spleen, kidney, testis, stomach, intestine, colon, and placenta.
Developmental stage	Expressed at 9.5 dpc onwards. At 10.5 dpc, in brain (telencephalic vesicles and isthmus), spinal cord and limb buds (in the zone of polarizing activity). At 14.5 dpc, in olfactory bulb and cerebellum. Ref.1
Induction	Down-regulated by thyroid hormone.
Domain	Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.
Sequence similarities	Contains 5 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	homophilic cell adhesion Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 33

33

Potential

Chain

34 – 813

780

Cadherin-22

PRO_0000003822

Regions

Topological domain

34 – 621

588

Extracellular Potential

Transmembrane

622 – 642

21

Helical; Potential

Topological domain

643 – 813

171

Cytoplasmic Potential

Domain

61 – 165

105

Cadherin 1

Domain

166 – 274

109

Cadherin 2

Domain

275 – 391

117

Cadherin 3

Domain

392 – 495

104

Cadherin 4

Domain

496 – 613

118

Cadherin 5

Amino acid modifications

Glycosylation

159

1

N-linked (GlcNAc...) Potential

Glycosylation

463

1

N-linked (GlcNAc...) Potential

Glycosylation

609

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q9WTP5 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 5510F9848D976567
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FASTA

813

88,022

        10         20         30         40         50         60 
MRPRPEGALR AGAALSPVLL FLLLLPLLGH LWAASTPAPS SLSPGAQEDN QLGAGRVKRG 

        70         80         90        100        110        120 
WVWNQFFVVE EYTGTEPLYV GKIHSDSDEG DGTIKYTISG EGAGTIFLID ELTGDIHATE 

       130        140        150        160        170        180 
RLDREQKTFY TLRAQARDRA TNRLLEPESE FIIKVQDIND SEPRFLHGPY IGSVAELSPT 

       190        200        210        220        230        240 
GTSVMQVMAS DADDPTYGRS ARLVYSVLDG EHHFTVDPKT GVIRTAVPDL DRESQERYEV 

       250        260        270        280        290        300 
VIQATDMAGQ LGGLSGSTTV TIVVTDVNDN PPRFPQKMYQ FSIQESAPIG TAVGRVKAED 

       310        320        330        340        350        360 
SDVGENTDMT YHLREESGSG GDAFKVTTDS DTQEAIIVVQ KHLDFESQQV HTVVLEALNK 

       370        380        390        400        410        420 
FVDPRFADLG TFRDQAIVRV AVTDVDEPPE FRPPSGLLEV QEDAQVGSLV GVVTARDPDA 

       430        440        450        460        470        480 
ANRPVRYAID RDSDLEQIFD IDADTGAIVT GKGLDRETAG WHNITVLAME ADNHAQLSRA 

       490        500        510        520        530        540 
SLRIRILDVN DNPPELATPY EAAVCEDAKP GQLIQTISVV DRDEPQGGHR FYFRLVPEAP 

       550        560        570        580        590        600 
SNPHFSLLDI EDNTAAVHTQ HVGFNRQEQD VFLLPILVVD SGPPTLSSTG TLTIRICGCD 

       610        620        630        640        650        660 
SSGTIQSCNT TAFVMAASLS PGALIALLVC VLILVVLALL ILTLRRHHKS HLSSDVDEDM 

       670        680        690        700        710        720 
RDNVIKYNDE GGGEQDTEAY DMSALRSLYD FGELKGGDPG GGAASPPQAA SSSERHSLPR 

       730        740        750        760        770        780 
GPSSPEPDFS VFRDFISRKV ALADADLSVP PYDAFQTYAF EGAGSPAASL SSLHSGSTGS 

       790        800        810 
EQDFAFLRAW GPRFRPLAAL YAGHRGDDEA PAS

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References

[1]	"Expression of a novel type of classic cadherin, PB-cadherin in developing brain and limb buds." Kitajima K., Koshimizu U., Nakamura T. Dev. Dyn. 215:206-214(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE. Strain: ICR. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB019618 mRNA. Translation: BAA34426.1.
IPI	IPI00123678.
UniGene	Mm.151819.
3D structure databases
ProteinModelPortal	Q9WTP5.
SMR	Q9WTP5. Positions 60-597, 734-803.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000066864.
PTM databases
PhosphoSite	Q9WTP5.
Proteomic databases
PRIDE	Q9WTP5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc008nxc.2. mouse.
Organism-specific databases
MGI	MGI:1341843. Cdh22.
Phylogenomic databases
eggNOG	NOG253748.
HOGENOM	HOG000231252.
HOVERGEN	HBG005217.
InParanoid	Q9WTP5.
OrthoDB	EOG49S65V.
Gene expression databases
CleanEx	MM_CDH22.
Genevestigator	Q9WTP5.
GermOnline	ENSMUSG00000053166. Mus musculus.
Family and domain databases
Gene3D	2.60.40.60. 5 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR000233. Cadherin_cytoplasmic-dom. [Graphical view]
Pfam	PF00028. Cadherin. 5 hits. PF01049. Cadherin_C. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 5 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 5 hits.
PROSITE	PS00232. CADHERIN_1. 2 hits. PS50268. CADHERIN_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

CAD22_MOUSE

Accession

Primary (citable) accession number: Q9WTP5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents