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Protein

Cadherin-22

Gene

Cdh22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-22
Alternative name(s):
Pituitary and brain cadherin
Short name:
PB-cadherin
Gene namesi
Name:Cdh22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1341843. Cdh22.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 621588ExtracellularSequence analysisAdd
BLAST
Transmembranei622 – 64221HelicalSequence analysisAdd
BLAST
Topological domaini643 – 813171CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Chaini34 – 813780Cadherin-22PRO_0000003822Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence analysis
Glycosylationi463 – 4631N-linked (GlcNAc...)Sequence analysis
Glycosylationi609 – 6091N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9WTP5.
PaxDbiQ9WTP5.
PRIDEiQ9WTP5.

PTM databases

iPTMnetiQ9WTP5.
PhosphoSiteiQ9WTP5.

Expressioni

Tissue specificityi

Predominantly expressed in brain. Abundant in olfactory bulb, cerebrum, and cerebellum, less in pons, medulla, and spinal cord. Low expression in heart. No expression in lung, liver, spleen, kidney, testis, stomach, intestine, colon, and placenta.

Developmental stagei

Expressed at 9.5 dpc onwards. At 10.5 dpc, in brain (telencephalic vesicles and isthmus), spinal cord and limb buds (in the zone of polarizing activity). At 14.5 dpc, in olfactory bulb and cerebellum.1 Publication

Inductioni

Down-regulated by thyroid hormone.

Gene expression databases

BgeeiENSMUSG00000053166.
CleanExiMM_CDH22.
ExpressionAtlasiQ9WTP5. baseline and differential.
GenevisibleiQ9WTP5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066864.

Structurei

3D structure databases

ProteinModelPortaliQ9WTP5.
SMRiQ9WTP5. Positions 60-597, 734-803.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 165105Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini166 – 274109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini275 – 391117Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini392 – 495104Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini496 – 613118Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ9WTP5.
KOiK06812.
OMAiHHKSHLS.
OrthoDBiEOG091G02GU.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WTP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPRPEGALR AGAALSPVLL FLLLLPLLGH LWAASTPAPS SLSPGAQEDN
60 70 80 90 100
QLGAGRVKRG WVWNQFFVVE EYTGTEPLYV GKIHSDSDEG DGTIKYTISG
110 120 130 140 150
EGAGTIFLID ELTGDIHATE RLDREQKTFY TLRAQARDRA TNRLLEPESE
160 170 180 190 200
FIIKVQDIND SEPRFLHGPY IGSVAELSPT GTSVMQVMAS DADDPTYGSS
210 220 230 240 250
ARLVYSVLDG EHHFTVDPKT GVIRTAVPDL DRESQERYEV VIQATDMAGQ
260 270 280 290 300
LGGLSGSTTV TIVVTDVNDN PPRFPQKMYQ FSIQESAPIG TAVGRVKAED
310 320 330 340 350
SDVGENTDMT YHLREESGSG GDAFKVTTDS DTQEAIIVVQ KHLDFESQQV
360 370 380 390 400
HTVVLEALNK FVDPRFADLG TFRDQAIVRV AVTDVDEPPE FRPPSGLLEV
410 420 430 440 450
QEDAQVGSLV GVVTARDPDA ANRPVRYAID RDSDLEQIFD IDADTGAIVT
460 470 480 490 500
GKGLDRETAG WHNITVLAME ADNHAQLSRA SLRIRILDVN DNPPELATPY
510 520 530 540 550
EAAVCEDAKP GQLIQTISVV DRDEPQGGHR FYFRLVPEAP SNPHFSLLDI
560 570 580 590 600
EDNTAAVHTQ HVGFNRQEQD VFLLPILVVD SGPPTLSSTG TLTIRICGCD
610 620 630 640 650
SSGTIQSCNT TAFVMAASLS PGALIALLVC VLILVVLALL ILTLRRHHKS
660 670 680 690 700
HLSSDVDEDM RDNVIKYNDE GGGEQDTEAY DMSALRSLYD FGELKGGDPG
710 720 730 740 750
GGAASPPQAA SSSERHSLPR GPSSPEPDFS VFRDFISRKV ALADADLSVP
760 770 780 790 800
PYDAFQTYAF EGAGSPAASL SSLHSGSTGS EQDFAFLRAW GPRFRPLAAL
810
YAGHRGDDEA PAS
Length:813
Mass (Da):87,953
Last modified:September 18, 2013 - v2
Checksum:iBC0267FD6A6B15D8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti199 – 1991S → R in BAA34426 (PubMed:10398531).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019618 mRNA. Translation: BAA34426.1.
AL591411 Genomic DNA. No translation available.
AL591430 Genomic DNA. No translation available.
CCDSiCCDS17073.1.
RefSeqiNP_778153.2. NM_174988.3.
XP_011237540.1. XM_011239238.1.
UniGeneiMm.151819.

Genome annotation databases

EnsembliENSMUST00000065438; ENSMUSP00000066864; ENSMUSG00000053166.
GeneIDi104010.
KEGGimmu:104010.
UCSCiuc008nxc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019618 mRNA. Translation: BAA34426.1.
AL591411 Genomic DNA. No translation available.
AL591430 Genomic DNA. No translation available.
CCDSiCCDS17073.1.
RefSeqiNP_778153.2. NM_174988.3.
XP_011237540.1. XM_011239238.1.
UniGeneiMm.151819.

3D structure databases

ProteinModelPortaliQ9WTP5.
SMRiQ9WTP5. Positions 60-597, 734-803.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066864.

PTM databases

iPTMnetiQ9WTP5.
PhosphoSiteiQ9WTP5.

Proteomic databases

MaxQBiQ9WTP5.
PaxDbiQ9WTP5.
PRIDEiQ9WTP5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065438; ENSMUSP00000066864; ENSMUSG00000053166.
GeneIDi104010.
KEGGimmu:104010.
UCSCiuc008nxc.2. mouse.

Organism-specific databases

CTDi64405.
MGIiMGI:1341843. Cdh22.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ9WTP5.
KOiK06812.
OMAiHHKSHLS.
OrthoDBiEOG091G02GU.
TreeFamiTF329887.

Miscellaneous databases

PROiQ9WTP5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053166.
CleanExiMM_CDH22.
ExpressionAtlasiQ9WTP5. baseline and differential.
GenevisibleiQ9WTP5. MM.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAD22_MOUSE
AccessioniPrimary (citable) accession number: Q9WTP5
Secondary accession number(s): I7HIP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: September 18, 2013
Last modified: September 7, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.