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Q9WTP3

- SPDEF_MOUSE

UniProt

Q9WTP3 - SPDEF_MOUSE

Protein

SAM pointed domain-containing Ets transcription factor

Gene

Spdef

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi239 – 32284ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

    GO - Biological processi

    1. intestinal epithelial cell development Source: MGI
    2. lung goblet cell differentiation Source: MGI
    3. negative regulation of cell fate commitment Source: MGI
    4. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    5. positive regulation of apoptotic process Source: Ensembl
    6. positive regulation of cell fate commitment Source: MGI
    7. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    8. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SAM pointed domain-containing Ets transcription factor
    Alternative name(s):
    Prostate epithelium-specific Ets transcription factor
    Short name:
    Prostate-specific Ets
    Prostate-derived Ets factor
    Gene namesi
    Name:Spdef
    Synonyms:Pdef, Pse
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1353422. Spdef.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 325325SAM pointed domain-containing Ets transcription factorPRO_0000223959Add
    BLAST

    Proteomic databases

    PRIDEiQ9WTP3.

    PTM databases

    PhosphoSiteiQ9WTP3.

    Expressioni

    Tissue specificityi

    Expressed in the accessory glands of sex organs including the prostate, seminal vesicle, coagulating gland in males, the oviduct in females, and in intestines. Expression is epithelial-specific.1 Publication

    Gene expression databases

    ArrayExpressiQ9WTP3.
    BgeeiQ9WTP3.
    GenevestigatoriQ9WTP3.

    Interactioni

    Subunit structurei

    Interacts with the DNA-binding domain of the androgen receptor. Interacts with NKX3-1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi205953. 2 interactions.
    STRINGi10090.ENSMUSP00000025054.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WTP3.
    SMRiQ9WTP3. Positions 121-203, 237-324.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini119 – 20385PNTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ETS family.Curated
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG243414.
    GeneTreeiENSGT00750000117271.
    HOGENOMiHOG000237327.
    HOVERGENiHBG080776.
    InParanoidiQ9WTP3.
    KOiK09442.
    OMAiMLYPEDS.
    OrthoDBiEOG76X60D.
    PhylomeDBiQ9WTP3.
    TreeFamiTF318679.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00178. Ets. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view]
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9WTP3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSASPGLSN VSPGCLLLFP DVAPRTGTEK AASGAMGPEK QEWSPSPPAT    50
    PEQGLSAFYL SYFNMYPDDS SWVAKVPEAR AGEDHPEEPE QCPVIDSQAS 100
    GSTLDEHSLE QVQSMVVGEV LKDIETACKL LNITADPGDW SPGNVQKWLL 150
    WTEHQYRLPP AGKAFQELGG KELCAMSEEQ FRQRAPLGGD VLHAHLDIWK 200
    SAAWMKERTS PGTLHYCAST SEEGWTDGEV DSSCSGQPIH LWQFLKELLL 250
    KPHSYGRFIR WLNKEKGIFK IEDSAQVARL WGVRKNRPAM NYDKLSRSIR 300
    QYYKKGIIRK PDISQRLVYQ FVHPV 325
    Length:325
    Mass (Da):36,356
    Last modified:November 1, 1999 - v1
    Checksum:iB55CF6CEC4501125
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB019436 mRNA. Translation: BAA77329.1.
    AK078863 mRNA. Translation: BAC37426.1.
    BC012648 mRNA. Translation: AAH12648.1.
    CCDSiCCDS28568.1.
    RefSeqiNP_038919.1. NM_013891.4.
    XP_006524442.1. XM_006524379.1.
    XP_006524443.1. XM_006524380.1.
    XP_006524444.1. XM_006524381.1.
    XP_006536833.1. XM_006536770.1.
    XP_006536834.1. XM_006536771.1.
    XP_006536835.1. XM_006536772.1.
    UniGeneiMm.26768.

    Genome annotation databases

    EnsembliENSMUST00000025054; ENSMUSP00000025054; ENSMUSG00000024215.
    ENSMUST00000114870; ENSMUSP00000110520; ENSMUSG00000024215.
    ENSMUST00000167489; ENSMUSP00000127056; ENSMUSG00000024215.
    GeneIDi30051.
    KEGGimmu:30051.
    UCSCiuc008bpo.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB019436 mRNA. Translation: BAA77329.1 .
    AK078863 mRNA. Translation: BAC37426.1 .
    BC012648 mRNA. Translation: AAH12648.1 .
    CCDSi CCDS28568.1.
    RefSeqi NP_038919.1. NM_013891.4.
    XP_006524442.1. XM_006524379.1.
    XP_006524443.1. XM_006524380.1.
    XP_006524444.1. XM_006524381.1.
    XP_006536833.1. XM_006536770.1.
    XP_006536834.1. XM_006536771.1.
    XP_006536835.1. XM_006536772.1.
    UniGenei Mm.26768.

    3D structure databases

    ProteinModelPortali Q9WTP3.
    SMRi Q9WTP3. Positions 121-203, 237-324.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 205953. 2 interactions.
    STRINGi 10090.ENSMUSP00000025054.

    PTM databases

    PhosphoSitei Q9WTP3.

    Proteomic databases

    PRIDEi Q9WTP3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025054 ; ENSMUSP00000025054 ; ENSMUSG00000024215 .
    ENSMUST00000114870 ; ENSMUSP00000110520 ; ENSMUSG00000024215 .
    ENSMUST00000167489 ; ENSMUSP00000127056 ; ENSMUSG00000024215 .
    GeneIDi 30051.
    KEGGi mmu:30051.
    UCSCi uc008bpo.2. mouse.

    Organism-specific databases

    CTDi 25803.
    MGIi MGI:1353422. Spdef.

    Phylogenomic databases

    eggNOGi NOG243414.
    GeneTreei ENSGT00750000117271.
    HOGENOMi HOG000237327.
    HOVERGENi HBG080776.
    InParanoidi Q9WTP3.
    KOi K09442.
    OMAi MLYPEDS.
    OrthoDBi EOG76X60D.
    PhylomeDBi Q9WTP3.
    TreeFami TF318679.

    Miscellaneous databases

    NextBioi 307158.
    PROi Q9WTP3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9WTP3.
    Bgeei Q9WTP3.
    Genevestigatori Q9WTP3.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00178. Ets. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view ]
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of the mouse Pse gene encoding a novel Ets family member."
      Yamada N., Tamai Y., Miyamoto H., Nozaki M.
      Gene 241:267-274(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: C57BL/6.
      Tissue: Colon.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Colon.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.

    Entry informationi

    Entry nameiSPDEF_MOUSE
    AccessioniPrimary (citable) accession number: Q9WTP3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2006
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3