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Protein

Solute carrier family 22 member 21

Gene

Slc22a21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sodium-ion independent, medium affinity carnitine transporter. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 746.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi218 – 225ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • carnitine metabolic process Source: GO_Central
  • carnitine transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-549127. Organic cation transport.

Protein family/group databases

TCDBi2.A.1.19.41. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 21
Alternative name(s):
Organic cation/carnitine transporter 3
Solute carrier family 22 member 9
Gene namesi
Name:Slc22a21
Synonyms:Octn3, Slc22a9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1929481. Slc22a21.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 41Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini42 – 142ExtracellularSequence analysisAdd BLAST101
Transmembranei143 – 163Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini164 – 172CytoplasmicSequence analysis9
Transmembranei173 – 193Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini194 – 197ExtracellularSequence analysis4
Transmembranei198 – 218Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini219 – 232CytoplasmicSequence analysisAdd BLAST14
Transmembranei233 – 253Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini254 – 257ExtracellularSequence analysis4
Transmembranei258 – 278Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini279 – 344CytoplasmicSequence analysisAdd BLAST66
Transmembranei345 – 365Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini366 – 376ExtracellularSequence analysisAdd BLAST11
Transmembranei377 – 397Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini398 – 409CytoplasmicSequence analysisAdd BLAST12
Transmembranei410 – 430Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini431 – 433ExtracellularSequence analysis3
Transmembranei434 – 454Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini455 – 465CytoplasmicSequence analysisAdd BLAST11
Transmembranei466 – 486Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini487 – 491ExtracellularSequence analysis5
Transmembranei492 – 512Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini513 – 564CytoplasmicSequence analysisAdd BLAST52

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • intrinsic component of peroxisomal membrane Source: UniProtKB
  • peroxisome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2073715.
DrugBankiDB08842. Acetylcarnitine.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002205061 – 564Solute carrier family 22 member 21Add BLAST564

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...)Sequence analysis1
Glycosylationi64N-linked (GlcNAc...)Sequence analysis1
Glycosylationi91N-linked (GlcNAc...)Sequence analysis1
Modified residuei489PhosphotyrosineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9WTN6.
PRIDEiQ9WTN6.

PTM databases

iPTMnetiQ9WTN6.
PhosphoSitePlusiQ9WTN6.

Expressioni

Tissue specificityi

Predominantly expressed in testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000063652.
ExpressionAtlasiQ9WTN6. baseline and differential.
GenevisibleiQ9WTN6. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9WTN6. 1 interactor.
STRINGi10090.ENSMUSP00000075814.

Structurei

3D structure databases

ProteinModelPortaliQ9WTN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRIE. Eukaryota.
ENOG410XSRI. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234570.
HOVERGENiHBG061545.
InParanoidiQ9WTN6.
KOiK08202.
OMAiREDIAYP.
OrthoDBiEOG091G04NR.
PhylomeDBiQ9WTN6.
TreeFamiTF315847.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR004749. Orgcat_transp/SVOP.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WTN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDYDEVTAF LGEWGTFQRL IFFLLSASII PNGFTGLSAV FLTAIPEHRC
60 70 80 90 100
RIPDTVNLSS AWRNHSIPME TKDGPEVPQK CRRYRLATIA NFSELGLEPG
110 120 130 140 150
RDVDLEQLEQ ENCLDGWEYD KDIFLSTIVT EWDLVCKDDW KAPLTTSFFY
160 170 180 190 200
VGVLLGSFIS GQLSDRFGRK NILFLTMAMH TGFSFIQVFS VNFEMFTLLY
210 220 230 240 250
TLVGMGHISN YVAAFVLGTE MLSKSVRIIF ATLGVCIFFA FGFMVLPLFA
260 270 280 290 300
YFIREWRRLL LAITLPGVLC GALWWFIPES PRWLISQGRI KEAEVIIRKA
310 320 330 340 350
AKINGIVAPS TIFDPSETNK LQDDSSKKPQ SHHIYDLVRT PNIRILTIMS
360 370 380 390 400
IILWLTISVG YFGLSLDTPN LNGNIYVNCF LLAAVEVPAY VLAWLLLQHV
410 420 430 440 450
SRRYSMAGSL FLGGSVLLLV QLVPSDLHYL STTLVMVGKF GITSAYSMVY
460 470 480 490 500
VYTAELYPTV VRNMGVGVSS TASRLGSILS PYFVYLGAYD RRLPYILMGS
510 520 530 540 550
LTILTAIITL FFPESSGVSL PETIDEMQKV KKLKQRQSLS KKGSPKESKG
560
NVSRTSRTSE PKGF
Length:564
Mass (Da):63,321
Last modified:November 1, 1999 - v1
Checksum:iC37FDCA6395DAD01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018436 mRNA. Translation: BAA78343.1.
AK133431 mRNA. Translation: BAE21654.1.
AK161508 mRNA. Translation: BAE36432.1.
AL596444 Genomic DNA. Translation: CAI25323.1.
CCDSiCCDS24688.1.
RefSeqiNP_062697.1. NM_019723.2.
UniGeneiMm.154284.

Genome annotation databases

EnsembliENSMUST00000076493; ENSMUSP00000075814; ENSMUSG00000063652.
GeneIDi56517.
KEGGimmu:56517.
UCSCiuc007ixd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018436 mRNA. Translation: BAA78343.1.
AK133431 mRNA. Translation: BAE21654.1.
AK161508 mRNA. Translation: BAE36432.1.
AL596444 Genomic DNA. Translation: CAI25323.1.
CCDSiCCDS24688.1.
RefSeqiNP_062697.1. NM_019723.2.
UniGeneiMm.154284.

3D structure databases

ProteinModelPortaliQ9WTN6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WTN6. 1 interactor.
STRINGi10090.ENSMUSP00000075814.

Chemistry databases

ChEMBLiCHEMBL2073715.
DrugBankiDB08842. Acetylcarnitine.

Protein family/group databases

TCDBi2.A.1.19.41. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ9WTN6.
PhosphoSitePlusiQ9WTN6.

Proteomic databases

PaxDbiQ9WTN6.
PRIDEiQ9WTN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076493; ENSMUSP00000075814; ENSMUSG00000063652.
GeneIDi56517.
KEGGimmu:56517.
UCSCiuc007ixd.1. mouse.

Organism-specific databases

CTDi56517.
MGIiMGI:1929481. Slc22a21.

Phylogenomic databases

eggNOGiENOG410IRIE. Eukaryota.
ENOG410XSRI. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234570.
HOVERGENiHBG061545.
InParanoidiQ9WTN6.
KOiK08202.
OMAiREDIAYP.
OrthoDBiEOG091G04NR.
PhylomeDBiQ9WTN6.
TreeFamiTF315847.

Enzyme and pathway databases

ReactomeiR-MMU-549127. Organic cation transport.

Miscellaneous databases

PROiQ9WTN6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063652.
ExpressionAtlasiQ9WTN6. baseline and differential.
GenevisibleiQ9WTN6. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR004749. Orgcat_transp/SVOP.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS22AL_MOUSE
AccessioniPrimary (citable) accession number: Q9WTN6
Secondary accession number(s): Q5SWV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.