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Protein

Solute carrier family 22 member 21

Gene

Slc22a21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sodium-ion independent, medium affinity carnitine transporter. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 746.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi218 – 2258ATPSequence analysis

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • carnitine transmembrane transporter activity Source: MGI

GO - Biological processi

  • carnitine transmembrane transport Source: GOC
  • carnitine transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-549127. Organic cation transport.

Protein family/group databases

TCDBi2.A.1.19.41. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 21
Alternative name(s):
Organic cation/carnitine transporter 3
Solute carrier family 22 member 9
Gene namesi
Name:Slc22a21
Synonyms:Octn3, Slc22a9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1929481. Slc22a21.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020CytoplasmicSequence analysisAdd
BLAST
Transmembranei21 – 4121Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini42 – 142101ExtracellularSequence analysisAdd
BLAST
Transmembranei143 – 16321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini164 – 1729CytoplasmicSequence analysis
Transmembranei173 – 19321Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini194 – 1974ExtracellularSequence analysis
Transmembranei198 – 21821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini219 – 23214CytoplasmicSequence analysisAdd
BLAST
Transmembranei233 – 25321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini254 – 2574ExtracellularSequence analysis
Transmembranei258 – 27821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini279 – 34466CytoplasmicSequence analysisAdd
BLAST
Transmembranei345 – 36521Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini366 – 37611ExtracellularSequence analysisAdd
BLAST
Transmembranei377 – 39721Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini398 – 40912CytoplasmicSequence analysisAdd
BLAST
Transmembranei410 – 43021Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini431 – 4333ExtracellularSequence analysis
Transmembranei434 – 45421Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini455 – 46511CytoplasmicSequence analysisAdd
BLAST
Transmembranei466 – 48621Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini487 – 4915ExtracellularSequence analysis
Transmembranei492 – 51221Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini513 – 56452CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • intrinsic component of peroxisomal membrane Source: UniProtKB
  • peroxisome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2073715.
DrugBankiDB08842. Acetylcarnitine.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 564564Solute carrier family 22 member 21PRO_0000220506Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence analysis
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence analysis
Modified residuei489 – 4891PhosphotyrosineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9WTN6.
PRIDEiQ9WTN6.

PTM databases

iPTMnetiQ9WTN6.

Expressioni

Tissue specificityi

Predominantly expressed in testis.1 Publication

Gene expression databases

BgeeiQ9WTN6.
ExpressionAtlasiQ9WTN6. baseline and differential.
GenevisibleiQ9WTN6. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9WTN6. 1 interaction.
STRINGi10090.ENSMUSP00000075814.

Structurei

3D structure databases

ProteinModelPortaliQ9WTN6.
SMRiQ9WTN6. Positions 144-517.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRIE. Eukaryota.
ENOG410XSRI. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234570.
HOVERGENiHBG061545.
InParanoidiQ9WTN6.
KOiK08202.
OMAiREDIAYP.
OrthoDBiEOG7C8GH9.
PhylomeDBiQ9WTN6.
TreeFamiTF315847.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR004749. Orgcat_transp/SVOP.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WTN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDYDEVTAF LGEWGTFQRL IFFLLSASII PNGFTGLSAV FLTAIPEHRC
60 70 80 90 100
RIPDTVNLSS AWRNHSIPME TKDGPEVPQK CRRYRLATIA NFSELGLEPG
110 120 130 140 150
RDVDLEQLEQ ENCLDGWEYD KDIFLSTIVT EWDLVCKDDW KAPLTTSFFY
160 170 180 190 200
VGVLLGSFIS GQLSDRFGRK NILFLTMAMH TGFSFIQVFS VNFEMFTLLY
210 220 230 240 250
TLVGMGHISN YVAAFVLGTE MLSKSVRIIF ATLGVCIFFA FGFMVLPLFA
260 270 280 290 300
YFIREWRRLL LAITLPGVLC GALWWFIPES PRWLISQGRI KEAEVIIRKA
310 320 330 340 350
AKINGIVAPS TIFDPSETNK LQDDSSKKPQ SHHIYDLVRT PNIRILTIMS
360 370 380 390 400
IILWLTISVG YFGLSLDTPN LNGNIYVNCF LLAAVEVPAY VLAWLLLQHV
410 420 430 440 450
SRRYSMAGSL FLGGSVLLLV QLVPSDLHYL STTLVMVGKF GITSAYSMVY
460 470 480 490 500
VYTAELYPTV VRNMGVGVSS TASRLGSILS PYFVYLGAYD RRLPYILMGS
510 520 530 540 550
LTILTAIITL FFPESSGVSL PETIDEMQKV KKLKQRQSLS KKGSPKESKG
560
NVSRTSRTSE PKGF
Length:564
Mass (Da):63,321
Last modified:November 1, 1999 - v1
Checksum:iC37FDCA6395DAD01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018436 mRNA. Translation: BAA78343.1.
AK133431 mRNA. Translation: BAE21654.1.
AK161508 mRNA. Translation: BAE36432.1.
AL596444 Genomic DNA. Translation: CAI25323.1.
CCDSiCCDS24688.1.
RefSeqiNP_062697.1. NM_019723.2.
UniGeneiMm.154284.

Genome annotation databases

EnsembliENSMUST00000076493; ENSMUSP00000075814; ENSMUSG00000063652.
GeneIDi56517.
KEGGimmu:56517.
UCSCiuc007ixd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018436 mRNA. Translation: BAA78343.1.
AK133431 mRNA. Translation: BAE21654.1.
AK161508 mRNA. Translation: BAE36432.1.
AL596444 Genomic DNA. Translation: CAI25323.1.
CCDSiCCDS24688.1.
RefSeqiNP_062697.1. NM_019723.2.
UniGeneiMm.154284.

3D structure databases

ProteinModelPortaliQ9WTN6.
SMRiQ9WTN6. Positions 144-517.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WTN6. 1 interaction.
STRINGi10090.ENSMUSP00000075814.

Chemistry

ChEMBLiCHEMBL2073715.
DrugBankiDB08842. Acetylcarnitine.

Protein family/group databases

TCDBi2.A.1.19.41. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ9WTN6.

Proteomic databases

PaxDbiQ9WTN6.
PRIDEiQ9WTN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076493; ENSMUSP00000075814; ENSMUSG00000063652.
GeneIDi56517.
KEGGimmu:56517.
UCSCiuc007ixd.1. mouse.

Organism-specific databases

CTDi56517.
MGIiMGI:1929481. Slc22a21.

Phylogenomic databases

eggNOGiENOG410IRIE. Eukaryota.
ENOG410XSRI. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234570.
HOVERGENiHBG061545.
InParanoidiQ9WTN6.
KOiK08202.
OMAiREDIAYP.
OrthoDBiEOG7C8GH9.
PhylomeDBiQ9WTN6.
TreeFamiTF315847.

Enzyme and pathway databases

ReactomeiR-MMU-549127. Organic cation transport.

Miscellaneous databases

PROiQ9WTN6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WTN6.
ExpressionAtlasiQ9WTN6. baseline and differential.
GenevisibleiQ9WTN6. MM.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR004749. Orgcat_transp/SVOP.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular and functional characterization of organic cation/carnitine transporter family in mice."
    Tamai I., Ohashi R., Nezu J., Sai Y., Kobayashi D., Oku A., Shimane M., Tsuji A.
    J. Biol. Chem. 275:40064-40072(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "A third human carnitine/organic cation transporter (OCTN3) as a candidate for the 5q31 Crohn's disease locus (IBD5)."
    Lamhonwah A.-M., Skaug J., Scherer S.W., Tein I.
    Biochem. Biophys. Res. Commun. 301:98-101(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  5. Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiS22AL_MOUSE
AccessioniPrimary (citable) accession number: Q9WTN6
Secondary accession number(s): Q5SWV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 1, 1999
Last modified: June 8, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.