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Q9WTN3

- SRBP1_MOUSE

UniProt

Q9WTN3 - SRBP1_MOUSE

Protein

Sterol regulatory element-binding protein 1

Gene

Srebf1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 4 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Isoform SREBP-1A is much more active than isoform SREBP-1C in stimulating transcription from SRE-1-containing promoters.4 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei451 – 4522Cleavage; by caspase-3 and caspase-7By similarity
    Sitei480 – 4812Cleavage; by S2PBy similarity
    Sitei519 – 5202Cleavage; by S1PBy similarity

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. DNA binding Source: UniProtKB
    3. protein binding Source: IntAct
    4. protein kinase binding Source: UniProtKB
    5. sequence-specific DNA binding Source: MGI
    6. sequence-specific DNA binding transcription factor activity Source: HGNC
    7. sterol response element binding Source: HGNC
    8. transcription regulatory region DNA binding Source: MGI

    GO - Biological processi

    1. aging Source: Ensembl
    2. cellular response to fatty acid Source: Ensembl
    3. cellular response to starvation Source: HGNC
    4. cholesterol metabolic process Source: UniProtKB-KW
    5. circadian rhythm Source: UniProtKB
    6. insulin receptor signaling pathway Source: MGI
    7. lipid biosynthetic process Source: UniProtKB
    8. lung development Source: Ensembl
    9. negative regulation of insulin secretion Source: MGI
    10. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    11. positive regulation of cholesterol biosynthetic process Source: MGI
    12. positive regulation of fatty acid biosynthetic process Source: BHF-UCL
    13. positive regulation of histone deacetylation Source: MGI
    14. positive regulation of transcription, DNA-templated Source: BHF-UCL
    15. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    16. positive regulation of triglyceride biosynthetic process Source: UniProtKB
    17. regulation of fatty acid metabolic process Source: MGI
    18. regulation of heart rate by chemical signal Source: MGI
    19. regulation of insulin secretion Source: MGI
    20. regulation of transcription, DNA-templated Source: UniProtKB
    21. response to cAMP Source: Ensembl
    22. response to drug Source: Ensembl
    23. response to food Source: Ensembl
    24. response to glucagon Source: Ensembl
    25. response to glucose Source: MGI
    26. response to progesterone Source: Ensembl
    27. response to retinoic acid Source: Ensembl
    28. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_118837. Rora activates circadian gene expression.
    REACT_198351. RORA activates circadian gene expression.
    REACT_198602. PPARA activates gene expression.
    REACT_198968. Regulation of cholesterol biosynthesis by SREBP (SREBF).
    REACT_198969. Activation of gene expression by SREBF (SREBP).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sterol regulatory element-binding protein 1
    Short name:
    SREBP-1
    Alternative name(s):
    Sterol regulatory element-binding transcription factor 1
    Cleaved into the following chain:
    Gene namesi
    Name:Srebf1
    Synonyms:Srebp1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:107606. Srebf1.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication. Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cytoplasmic vesicleCOPII-coated vesicle membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. ER to Golgi transport vesicle membrane Source: UniProtKB-SubCell
    4. Golgi membrane Source: Reactome
    5. integral component of membrane Source: UniProtKB-KW
    6. membrane Source: BHF-UCL
    7. nucleoplasm Source: Reactome
    8. nucleus Source: UniProtKB
    9. protein complex Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Mice show high embryonic lethality around day 11 dpc. Surviving mice show a 2-3-fold increase in processed Srebpf2 protein in liver nuclei, 3-fold increase in cholesterol synthesis and 50% increase in cholesterol content of the liver. Mice lacking isoform SREBP-1C show a lack of up-regulation of several lipogenic enzymes in response to high insulin or LXR activation. Mice overexpressing processed isoform SREBP-1A in adipocytes show enlarged white and brown adipocytes, increased rate of fatty acid synthesis and secretion leading to a fatty liver. Mice overexpressing processed isoform SREBP-1C in adipocytes show inhibition of adipocyte differentiation leading to a syndrome similar to human lipodystrophy with loss of peripheral white adipose tissue, diabetes and fatty liver.2 Publications

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi331 – 3311S → A: Weakly affects phosphorylation by SIK1. 1 Publication
    Mutagenesisi332 – 3321S → A: Weakly affects phosphorylation by SIK1. 1 Publication
    Mutagenesisi354 – 3541S → A: Does not affect AMPK-mediated phosphorylation. 1 Publication
    Mutagenesisi389 – 3891S → A: Abolishes AMPK-mediated phosphorylation. 1 Publication
    Mutagenesisi395 – 3951S → A: Strongly impairs affects phosphorylation by SIK1. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11341134Sterol regulatory element-binding protein 1PRO_0000127448Add
    BLAST
    Chaini1 – 480480Processed sterol regulatory element-binding protein 1PRO_0000314030Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei115 – 1151PhosphoserineBy similarity
    Modified residuei331 – 3311Phosphoserine; by SIK11 Publication
    Modified residuei332 – 3321Phosphoserine; by SIK11 Publication
    Modified residuei389 – 3891Phosphoserine; by AMPK1 Publication
    Modified residuei395 – 3951Phosphoserine; by SIK11 Publication

    Post-translational modificationi

    At low cholesterol the SCAP/SREBP complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7.
    Phosphorylated by AMPK, leading to suppress protein processing and nuclear translocation, and repress target gene expression. Phosphorylation at Ser-389 by SIK1 represses activity possibly by inhibiting DNA-binding.2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ9WTN3.

    PTM databases

    PhosphoSiteiQ9WTN3.

    Expressioni

    Tissue specificityi

    Isoform SREBP-1C predominates in liver, adrenal gland, brain and adipose tissue, whereas isoform SREBP-1A predominates in spleen. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, thymus, testis, muscle, jejunum, and ileum.

    Inductioni

    Isoform SREBP-1C is expressed in a circadian manner in the liver with a peak at ZT16.1 Publication

    Gene expression databases

    BgeeiQ9WTN3.
    GenevestigatoriQ9WTN3.

    Interactioni

    Subunit structurei

    Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Sirt1Q923E42EBI-5273743,EBI-1802585

    Protein-protein interaction databases

    BioGridi203495. 6 interactions.
    IntActiQ9WTN3. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WTN3.
    SMRiQ9WTN3. Positions 313-393.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 477477CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini499 – 53638LumenalSequence AnalysisAdd
    BLAST
    Topological domaini558 – 1134577CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei478 – 49821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei537 – 55721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini317 – 36751bHLHPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 6060Transcriptional activation (acidic)Add
    BLAST
    Regioni227 – 487261Interaction with LMNAAdd
    BLAST
    Regioni367 – 38822Leucine-zipperAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi61 – 175115Pro/Ser-richAdd
    BLAST
    Compositional biasi420 – 45334Gly/Pro/Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SREBP family.Curated
    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG242942.
    GeneTreeiENSGT00390000017651.
    HOGENOMiHOG000007091.
    HOVERGENiHBG061592.
    InParanoidiQ9WTN3.
    KOiK07197.
    OMAiFDPPYAG.
    PhylomeDBiQ9WTN3.
    TreeFamiTF313894.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform SREBP-1A (identifier: Q9WTN3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDELAFGEAA LEQTLAEMCE LDTAVLNDIE DMLQLINNQD SDFPGLFDAP     50
    YAGGETGDTG PSSPGANSPE SFSSASLASS LEAFLGGPKV TPAPLSPPPS 100
    APAALKMYPS VSPFSPGPGI KEEPVPLTIL QPAAPQPSPG TLLPPSFPAP 150
    PVQLSPAPVL GYSSLPSGFS GTLPGNTQQP PSSLPLAPAP GVLPTPALHT 200
    QVQSLASQQP LPASAAPRTN TVTSQVQQVP VVLQPHFIKA DSLLLTAVKT 250
    DAGATVKTAG ISTLAPGTAV QAGPLQTLVS GGTILATVPL VVDTDKLPIH 300
    RLAAGSKALG SAQSRGEKRT AHNAIEKRYR SSINDKIVEL KDLVVGTEAK 350
    LNKSAVLRKA IDYIRFLQHS NQKLKQENLT LRSAHKSKSL KDLVSACGSG 400
    GGTDVSMEGM KPEVVETLTP PPSDAGSPSQ SSPLSFGSRA SSSGGSDSEP 450
    DSPAFEDSQV KAQRLPSHSR GMLDRSRLAL CVLAFLCLTC NPLASLFGWG 500
    ILTPSDATGT HRSSGRSMLE AESRDGSNWT QWLLPPLVWL ANGLLVLACL 550
    ALLFVYGEPV TRPHSGPAVH FWRHRKQADL DLARGDFPQA AQQLWLALQA 600
    LGRPLPTSNL DLACSLLWNL IRHLLQRLWV GRWLAGQAGG LLRDRGLRKD 650
    ARASARDAAV VYHKLHQLHA MGKYTGGHLA ASNLALSALN LAECAGDAIS 700
    MATLAEIYVA AALRVKTSLP RALHFLTRFF LSSARQACLA QSGSVPLAMQ 750
    WLCHPVGHRF FVDGDWAVHG APPESLYSVA GNPVDPLAQV TRLFREHLLE 800
    RALNCIAQPS PGAADGDREF SDALGYLQLL NSCSDAAGAP ACSFSVSSSM 850
    AATTGPDPVA KWWASLTAVV IHWLRRDEEA AERLYPLVEH IPQVLQDTER 900
    PLPRAALYSF KAARALLDHR KVESSPASLA ICEKASGYLR DSLASTPTGS 950
    SIDKAMQLLL CDLLLVARTS LWQRQQSPAS VQVAHGTSNG PQASALELRG 1000
    FQHDLSSLRR LAQSFRPAMR RVFLHEATAR LMAGASPART HQLLDRSLRR 1050
    RAGSSGKGGT TAELEPRPTW REHTEALLLA SCYLPPAFLS APGQRMSMLA 1100
    EAARTVEKLG DHRLLLDCQQ MLLRLGGGTT VTSS 1134
    Length:1,134
    Mass (Da):120,537
    Last modified:July 24, 2007 - v4
    Checksum:i3D7422406E07A376
    GO
    Isoform SREBP-1A-W42 (identifier: Q9WTN3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         90-131: Missing.

    Show »
    Length:1,092
    Mass (Da):116,275
    Checksum:i7AD020CB6E87C2E6
    GO
    Isoform SREBP-1C (identifier: Q9WTN3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-29: MDELAFGEAALEQTLAEMCELDTAVLNDI → MDCTF

    Show »
    Length:1,110
    Mass (Da):117,996
    Checksum:iFC912A03CE5C785E
    GO
    Isoform SREBP-1C-W42 (identifier: Q9WTN3-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-29: MDELAFGEAALEQTLAEMCELDTAVLNDI → MDCTF
         90-131: Missing.

    Show »
    Length:1,068
    Mass (Da):113,734
    Checksum:i9229327B581AAAD2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti272 – 2765Missing in BAE32576. (PubMed:16141072)Curated
    Sequence conflicti272 – 2765Missing in AAK54762. 1 PublicationCurated
    Sequence conflicti795 – 7951R → P in BAE29268. (PubMed:16141072)Curated
    Sequence conflicti1003 – 10031H → N in AAH06051. (PubMed:15489334)Curated
    Sequence conflicti1061 – 10611T → A in AAH06051. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2929MDELA…VLNDI → MDCTF in isoform SREBP-1C and isoform SREBP-1C-W42. 2 PublicationsVSP_002151Add
    BLAST
    Alternative sequencei90 – 13142Missing in isoform SREBP-1A-W42 and isoform SREBP-1C-W42. 1 PublicationVSP_002152Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK052628 mRNA. Translation: BAC35068.1.
    AK150052 mRNA. Translation: BAE29268.1.
    AK154424 mRNA. Translation: BAE32576.1.
    AK169607 mRNA. Translation: BAE41256.1.
    AL669954 Genomic DNA. Translation: CAI25757.1.
    AL669954 Genomic DNA. Translation: CAI25758.1.
    BC006051 mRNA. Translation: AAH06051.1.
    BC056922 mRNA. Translation: AAH56922.1.
    AB017337 mRNA. Translation: BAA74795.1.
    AF374266 mRNA. Translation: AAK54762.1.
    CCDSiCCDS24785.1. [Q9WTN3-1]
    PIRiPD0035.
    RefSeqiNP_035610.1. NM_011480.3. [Q9WTN3-1]
    XP_006532778.1. XM_006532715.1. [Q9WTN3-3]
    UniGeneiMm.278701.

    Genome annotation databases

    EnsembliENSMUST00000020846; ENSMUSP00000020846; ENSMUSG00000020538. [Q9WTN3-1]
    GeneIDi20787.
    KEGGimmu:20787.
    UCSCiuc007jfn.1. mouse. [Q9WTN3-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK052628 mRNA. Translation: BAC35068.1 .
    AK150052 mRNA. Translation: BAE29268.1 .
    AK154424 mRNA. Translation: BAE32576.1 .
    AK169607 mRNA. Translation: BAE41256.1 .
    AL669954 Genomic DNA. Translation: CAI25757.1 .
    AL669954 Genomic DNA. Translation: CAI25758.1 .
    BC006051 mRNA. Translation: AAH06051.1 .
    BC056922 mRNA. Translation: AAH56922.1 .
    AB017337 mRNA. Translation: BAA74795.1 .
    AF374266 mRNA. Translation: AAK54762.1 .
    CCDSi CCDS24785.1. [Q9WTN3-1 ]
    PIRi PD0035.
    RefSeqi NP_035610.1. NM_011480.3. [Q9WTN3-1 ]
    XP_006532778.1. XM_006532715.1. [Q9WTN3-3 ]
    UniGenei Mm.278701.

    3D structure databases

    ProteinModelPortali Q9WTN3.
    SMRi Q9WTN3. Positions 313-393.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203495. 6 interactions.
    IntActi Q9WTN3. 2 interactions.

    PTM databases

    PhosphoSitei Q9WTN3.

    Proteomic databases

    PRIDEi Q9WTN3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020846 ; ENSMUSP00000020846 ; ENSMUSG00000020538 . [Q9WTN3-1 ]
    GeneIDi 20787.
    KEGGi mmu:20787.
    UCSCi uc007jfn.1. mouse. [Q9WTN3-1 ]

    Organism-specific databases

    CTDi 6720.
    MGIi MGI:107606. Srebf1.

    Phylogenomic databases

    eggNOGi NOG242942.
    GeneTreei ENSGT00390000017651.
    HOGENOMi HOG000007091.
    HOVERGENi HBG061592.
    InParanoidi Q9WTN3.
    KOi K07197.
    OMAi FDPPYAG.
    PhylomeDBi Q9WTN3.
    TreeFami TF313894.

    Enzyme and pathway databases

    Reactomei REACT_118837. Rora activates circadian gene expression.
    REACT_198351. RORA activates circadian gene expression.
    REACT_198602. PPARA activates gene expression.
    REACT_198968. Regulation of cholesterol biosynthesis by SREBP (SREBF).
    REACT_198969. Activation of gene expression by SREBF (SREBP).

    Miscellaneous databases

    ChiTaRSi SREBF1. mouse.
    NextBioi 299515.
    PROi Q9WTN3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9WTN3.
    Genevestigatori Q9WTN3.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SREBP-1A).
      Strain: C57BL/6J and NOD.
      Tissue: Bone marrow, Kidney and Thymus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SREBP-1A).
      Strain: C57BL/6 and Czech II.
      Tissue: Brain and Mammary gland.
    4. "Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells."
      Shimomura I., Shimano H., Horton J.D., Goldstein J.L., Brown M.S.
      J. Clin. Invest. 99:838-845(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-41 (ISOFORMS SREBP-1A AND SREBP-1C).
      Tissue: Liver.
    5. "A novel splicing isoform of mouse sterol regulatory element-binding protein-1 (SREBP-1)."
      Inoue J., Sato R.
      Biosci. Biotechnol. Biochem. 63:243-245(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 42-444 (ISOFORMS SREBP-1A-W42 AND SREBP-1C-W42).
    6. "Mouse Srebp1."
      Lloyd D.J., Shackleton S., Trembath R.C.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 55-1134.
    7. "Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene."
      Shimano H., Shimomura I., Hammer R.E., Herz J., Goldstein J.L., Brown M.S., Horton J.D.
      J. Clin. Invest. 100:2115-2124(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    8. "Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy."
      Shimomura I., Hammer R.E., Richardson J.A., Ikemoto S., Bashmakov Y., Goldstein J.L., Brown M.S.
      Genes Dev. 12:3182-3194(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies."
      Lloyd D.J., Trembath R.C., Shackleton S.
      Hum. Mol. Genet. 11:769-777(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LMNA.
    10. "Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c."
      Liang G., Yang J., Horton J.D., Hammer R.E., Goldstein J.L., Brown M.S.
      J. Biol. Chem. 277:9520-9528(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    11. "Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver."
      Horton J.D., Shimomura I., Ikemoto S., Bashmakov Y., Hammer R.E.
      J. Biol. Chem. 278:36652-36660(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "Salt-inducible kinase regulates hepatic lipogenesis by controlling SREBP-1c phosphorylation."
      Yoon Y.S., Seo W.Y., Lee M.W., Kim S.T., Koo S.H.
      J. Biol. Chem. 284:10446-10452(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-331; SER-332 AND SER-395, MUTAGENESIS OF SER-331; SER-332 AND SER-395.
    13. "The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors."
      Cho Y., Noshiro M., Choi M., Morita K., Kawamoto T., Fujimoto K., Kato Y., Makishima M.
      Mol. Pharmacol. 76:1360-1369(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    14. "AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice."
      Li Y., Xu S., Mihaylova M.M., Zheng B., Hou X., Jiang B., Park O., Luo Z., Lefai E., Shyy J.Y., Gao B., Wierzbicki M., Verbeuren T.J., Shaw R.J., Cohen R.A., Zang M.
      Cell Metab. 13:376-388(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-389, SUBCELLULAR LOCATION, MUTAGENESIS OF SER-354 AND SER-389.

    Entry informationi

    Entry nameiSRBP1_MOUSE
    AccessioniPrimary (citable) accession number: Q9WTN3
    Secondary accession number(s): Q3U458
    , Q3UDJ3, Q5SRX5, Q8C733, Q99JK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 138 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3