Reviewed, UniProtKB/Swiss-Prot Q9WTN0 (GGPPS_MOUSE)

Names and origin

Protein names

Recommended name:
    Geranylgeranyl pyrophosphate synthetase
      Short name=GGPP synthetase
      Short name=GGPPSase
Alternative name(s):
    Geranylgeranyl diphosphate synthase
Including the following 3 domains:
    1- Recommended name:
            Dimethylallyltranstransferase
              EC=2.5.1.1
    2- Recommended name:
            Geranyltranstransferase
              EC=2.5.1.10
    3- Recommended name:
            Farnesyltranstransferase
              EC=2.5.1.29

Gene names

Name:

Ggps1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.
Catalytic activity	Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate. Trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
Pathway	Isoprenoid biosynthesis; farnesyl-PP biosynthesis; farnesyl-PP from geranyl-PP and isopentenyl-PP: step 1/1. Isoprenoid biosynthesis; geranyl-PP biosynthesis; geranyl-PP from dimethylallyl-PP and isopentenyl-PP: step 1/1. Isoprenoid biosynthesis; geranylgeranyl-PP biosynthesis; geranylgeranyl-PP from farnesyl-PP and isopentenyl-PP: step 1/1.
Subunit structure	Homooctamer By similarity.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the FPP/GGPP synthetase family.

Ontologies

Keywords
Biological process	Isoprene biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Multifunctional enzyme
Gene Ontology (GO)
Biological process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell soluble fraction Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	dimethylallyltranstransferase activity Inferred from electronic annotation. Source: EC farnesyltranstransferase activity Inferred from sequence or structural similarity. Source: UniProtKB geranyltranstransferase activity Ref.1 Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 300	300	Geranylgeranyl pyrophosphate synthetase		PRO_0000123963

Sequences

	Sequence		Length	Mass (Da)
	Q9WTN0-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 13ECB67EA17EEE63	FASTA	300	34,707
	10 20 30 40 50 60 MEKTKEKAER ILLEPYRYLL QLPGKQVRSK LSQAFNHWLK VPEDKLQIII EVTEMLHNAS 70 80 90 100 110 120 LLIDDIEDSS KLRRGFPVAH SIYGVPSVIN SANYVYFLGL EKVLTLDHPD AVKLFTRQLL 130 140 150 160 170 180 ELHQGQGLDI YWRDTYTCPT EEEYKAMVLQ KTGGLFGLAV GLMQLFSDYK EDLKPLLDTL 190 200 210 220 230 240 GLFFQIRDDY ANLHSKEYSE NKSFCEDLTE GKFSFPTIHA IWSRPESTQV QNILRQRTEN 250 260 270 280 290 300 IDIKKYCVQY LEDVGSFAYT RHTLRELEAK AYKQIEACGG NPSLVALVKH LSKMFTEENK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human." Kainou T., Kawamura K., Tanaka K., Matsuda H., Kawamukai M. Biochim. Biophys. Acta 1437:333-340(1999) [PubMed: 10101267] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J. Tissue: Lymph node.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB016044 mRNA. Translation: BAA76512.1. BC069913 mRNA. Translation: AAH69913.1.
IPI	IPI00123594.
RefSeq	NP_034412.1.
UniGene	Mm.465375 Mm.473704
3D structure databases
SMR	Q9WTN0. Positions 6-295.
ModBase	Search...
PTM databases
PhosphoSite	Q9WTN0.
Proteomic databases
PRIDE	Q9WTN0.
Genome annotation databases
Ensembl	ENSMUSG00000021302. Mus musculus. [Contig view]
GeneID	14593.
KEGG	mmu:14593.
Organism-specific databases
MGI	MGI:1341724. Ggps1.
Phylogenomic databases
HOGENOM	Q9WTN0.
HOVERGEN	Q9WTN0.
OMA	Q9WTN0. HTINCAN.
Enzyme and pathway databases
BRENDA	2.5.1.1. 244. 2.5.1.10. 244. 2.5.1.29. 244.
Gene expression databases
ArrayExpress	Q9WTN0.
Bgee	Q9WTN0.
CleanEx	MM_GGPS1.
GermOnline	ENSMUSG00000021302. Mus musculus.
Family and domain databases
InterPro	IPR000092. Polyprenyl_synt. IPR017446. Polyprenyl_synth-rel. IPR008949. Terpenoid_synth. [Graphical view]
Gene3D	G3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
PANTHER	PTHR12001. Polyprenyl_synt. 1 hit.
Pfam	PF00348. polyprenyl_synt. 1 hit. [Graphical view]
PROSITE	PS00723. POLYPRENYL_SYNTHET_1. 1 hit. PS00444. POLYPRENYL_SYNTHET_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	286348.
SOURCE	Search...

Entry information

Entry name

GGPPS_MOUSE

Accession

Primary (citable) accession number: Q9WTN0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	June 16, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)