SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9WTM4

- NF2L3_MOUSE

UniProt

Q9WTM4 - NF2L3_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Nuclear factor erythroid 2-related factor 3

Gene
Nfe2l3, Nrf3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Activates erythroid-specific, globin gene expression.

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear factor erythroid 2-related factor 3
Short name:
NF-E2-related factor 3
Short name:
NFE2-related factor 3
Alternative name(s):
Nuclear factor, erythroid derived 2, like 3
Gene namesi
Name:Nfe2l3
Synonyms:Nrf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1339958. Nfe2l3.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 660660Nuclear factor erythroid 2-related factor 3PRO_0000076453Add
BLAST

Proteomic databases

PRIDEiQ9WTM4.

Expressioni

Tissue specificityi

High level expression in brain, thymus, testis and placenta. Medium level expression in uterus, stomach and lung. Low level expression in kidney. No expression in heart, liver, spleen and ovary.1 Publication

Gene expression databases

BgeeiQ9WTM4.
CleanExiMM_NFE2L3.
GenevestigatoriQ9WTM4.

Interactioni

Subunit structurei

Heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE) By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9WTM4.
SMRiQ9WTM4. Positions 499-601.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini541 – 60464bZIPAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni543 – 56220Basic motif By similarityAdd
BLAST
Regioni566 – 5738Leucine-zipper By similarity

Sequence similaritiesi

Belongs to the bZIP family. CNC subfamily.

Phylogenomic databases

eggNOGiNOG278006.
GeneTreeiENSGT00550000074399.
HOGENOMiHOG000234410.
HOVERGENiHBG052609.
InParanoidiQ9WTM4.
KOiK09040.
OMAiEIVRMPV.
OrthoDBiEOG715Q3N.
PhylomeDBiQ9WTM4.
TreeFamiTF337360.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR008917. TF_DNA-bd.
[Graphical view]
PfamiPF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WTM4-1 [UniParc]FASTAAdd to Basket

« Hide

MKLPKPWWAG GGLLQLTILL SLVGLRVDLD LFLPPPAAAL WEELLPLCPT    50
RPASASNPFS ASEGWERTPL LPAKGRLLHE VRALGVPFIP RTRVDAWLVH 100
SVATGNADGA HGLLGTAASS AVGDGGQSAS AGGGDPRAAH SSPLAAEEEE 150
EKAAEPTAQV PDAGGCGSQE NGMLREKSEA VDHSSQQEEN EEGVSAQAKS 200
RQQSKTEEHK MACASAREAE KITEARNESH LHWSDTSFSL EDLFQLLSSQ 250
PEHSLEGISV EDIPPFLSSV CESVNSSAQN INLSQAISHD VNLHEAMLLY 300
PNNTFRRDPS ARSSQAQEPF LQLNPHTNPE QATPAMSLPP FDNQMRNLTS 350
QDLLYDLDSN IFDGINLMSL ATGFSPLEVS QLFEEPDSGL SLNSSYNSTS 400
LTNSYRIYDG TVGYNSDLQS LCHDLGAVGG CYPEPHKHCH MDHRTIAGFH 450
VSLECQQVFH DHTYHLQSGA SEPTSESFAW SEKSQKTSGC LDNPDRNLSR 500
DEQRAKALHI PFSVDEIVRM PVDSFNSMLS RYYLTDLQVS LIRDIRRRGK 550
NKVAAQNCRK RKLDIILNLE DDICNLQAKK EALKNEQTQC SKAIDIMRQK 600
LHGLHQDVFN RLRDDQGRPV NPSQYALQYS HDGTVLIVPK ELISSGHKKE 650
APKGKRERRN 660
Length:660
Mass (Da):72,707
Last modified:November 1, 1999 - v1
Checksum:iF5CBEEA77E6F4438
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB013852 mRNA. Translation: BAA76289.1.
BC005416 mRNA. Translation: AAH05416.1.
CCDSiCCDS20134.1.
RefSeqiNP_035033.1. NM_010903.1.
UniGeneiMm.42138.

Genome annotation databases

EnsembliENSMUST00000005103; ENSMUSP00000005103; ENSMUSG00000029832.
GeneIDi18025.
KEGGimmu:18025.
UCSCiuc009bxl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB013852 mRNA. Translation: BAA76289.1 .
BC005416 mRNA. Translation: AAH05416.1 .
CCDSi CCDS20134.1.
RefSeqi NP_035033.1. NM_010903.1.
UniGenei Mm.42138.

3D structure databases

ProteinModelPortali Q9WTM4.
SMRi Q9WTM4. Positions 499-601.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9WTM4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000005103 ; ENSMUSP00000005103 ; ENSMUSG00000029832 .
GeneIDi 18025.
KEGGi mmu:18025.
UCSCi uc009bxl.1. mouse.

Organism-specific databases

CTDi 9603.
MGIi MGI:1339958. Nfe2l3.

Phylogenomic databases

eggNOGi NOG278006.
GeneTreei ENSGT00550000074399.
HOGENOMi HOG000234410.
HOVERGENi HBG052609.
InParanoidi Q9WTM4.
KOi K09040.
OMAi EIVRMPV.
OrthoDBi EOG715Q3N.
PhylomeDBi Q9WTM4.
TreeFami TF337360.

Miscellaneous databases

NextBioi 293091.
PROi Q9WTM4.
SOURCEi Search...

Gene expression databases

Bgeei Q9WTM4.
CleanExi MM_NFE2L3.
Genevestigatori Q9WTM4.

Family and domain databases

Gene3Di 1.10.880.10. 1 hit.
InterProi IPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR008917. TF_DNA-bd.
[Graphical view ]
Pfami PF03131. bZIP_Maf. 1 hit.
[Graphical view ]
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
SUPFAMi SSF47454. SSF47454. 1 hit.
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3."
    Kobayashi A., Ito E., Toki T., Kogame K., Takahashi S., Igarashi K., Hayashi N., Yamamoto M.
    J. Biol. Chem. 274:6443-6452(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Strain: ICR.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. "Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus."
    Derjuga A., Gourley T.S., Holm T.M., Heng H.H.Q., Shivdasani R.A., Ahmed R., Andrews N.C., Blank V.
    Mol. Cell. Biol. 24:3286-3294(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiNF2L3_MOUSE
AccessioniPrimary (citable) accession number: Q9WTM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi