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Protein

Nuclear factor erythroid 2-related factor 3

Gene

Nfe2l3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Activates erythroid-specific, globin gene expression.

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear factor erythroid 2-related factor 3
Short name:
NF-E2-related factor 3
Short name:
NFE2-related factor 3
Alternative name(s):
Nuclear factor, erythroid derived 2, like 3
Gene namesi
Name:Nfe2l3
Synonyms:Nrf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1339958. Nfe2l3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 660660Nuclear factor erythroid 2-related factor 3PRO_0000076453Add
BLAST

Proteomic databases

PRIDEiQ9WTM4.

Expressioni

Tissue specificityi

High level expression in brain, thymus, testis and placenta. Medium level expression in uterus, stomach and lung. Low level expression in kidney. No expression in heart, liver, spleen and ovary.1 Publication

Gene expression databases

BgeeiQ9WTM4.
CleanExiMM_NFE2L3.
ExpressionAtlasiQ9WTM4. baseline and differential.
GenevisibleiQ9WTM4. MM.

Interactioni

Subunit structurei

Heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005103.

Structurei

3D structure databases

ProteinModelPortaliQ9WTM4.
SMRiQ9WTM4. Positions 499-601.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini541 – 60464bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni543 – 56220Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni566 – 5738Leucine-zipperPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the bZIP family. CNC subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG278006.
GeneTreeiENSGT00550000074399.
HOGENOMiHOG000234410.
HOVERGENiHBG052609.
InParanoidiQ9WTM4.
KOiK09040.
OMAiEIVRMPV.
OrthoDBiEOG715Q3N.
PhylomeDBiQ9WTM4.
TreeFamiTF337360.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR029854. NF2L3.
IPR008917. TF_DNA-bd.
[Graphical view]
PANTHERiPTHR24411:SF8. PTHR24411:SF8. 1 hit.
PfamiPF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WTM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLPKPWWAG GGLLQLTILL SLVGLRVDLD LFLPPPAAAL WEELLPLCPT
60 70 80 90 100
RPASASNPFS ASEGWERTPL LPAKGRLLHE VRALGVPFIP RTRVDAWLVH
110 120 130 140 150
SVATGNADGA HGLLGTAASS AVGDGGQSAS AGGGDPRAAH SSPLAAEEEE
160 170 180 190 200
EKAAEPTAQV PDAGGCGSQE NGMLREKSEA VDHSSQQEEN EEGVSAQAKS
210 220 230 240 250
RQQSKTEEHK MACASAREAE KITEARNESH LHWSDTSFSL EDLFQLLSSQ
260 270 280 290 300
PEHSLEGISV EDIPPFLSSV CESVNSSAQN INLSQAISHD VNLHEAMLLY
310 320 330 340 350
PNNTFRRDPS ARSSQAQEPF LQLNPHTNPE QATPAMSLPP FDNQMRNLTS
360 370 380 390 400
QDLLYDLDSN IFDGINLMSL ATGFSPLEVS QLFEEPDSGL SLNSSYNSTS
410 420 430 440 450
LTNSYRIYDG TVGYNSDLQS LCHDLGAVGG CYPEPHKHCH MDHRTIAGFH
460 470 480 490 500
VSLECQQVFH DHTYHLQSGA SEPTSESFAW SEKSQKTSGC LDNPDRNLSR
510 520 530 540 550
DEQRAKALHI PFSVDEIVRM PVDSFNSMLS RYYLTDLQVS LIRDIRRRGK
560 570 580 590 600
NKVAAQNCRK RKLDIILNLE DDICNLQAKK EALKNEQTQC SKAIDIMRQK
610 620 630 640 650
LHGLHQDVFN RLRDDQGRPV NPSQYALQYS HDGTVLIVPK ELISSGHKKE
660
APKGKRERRN
Length:660
Mass (Da):72,707
Last modified:November 1, 1999 - v1
Checksum:iF5CBEEA77E6F4438
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013852 mRNA. Translation: BAA76289.1.
BC005416 mRNA. Translation: AAH05416.1.
CCDSiCCDS20134.1.
RefSeqiNP_035033.1. NM_010903.1.
UniGeneiMm.42138.

Genome annotation databases

EnsembliENSMUST00000005103; ENSMUSP00000005103; ENSMUSG00000029832.
GeneIDi18025.
KEGGimmu:18025.
UCSCiuc009bxl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013852 mRNA. Translation: BAA76289.1.
BC005416 mRNA. Translation: AAH05416.1.
CCDSiCCDS20134.1.
RefSeqiNP_035033.1. NM_010903.1.
UniGeneiMm.42138.

3D structure databases

ProteinModelPortaliQ9WTM4.
SMRiQ9WTM4. Positions 499-601.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005103.

Proteomic databases

PRIDEiQ9WTM4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005103; ENSMUSP00000005103; ENSMUSG00000029832.
GeneIDi18025.
KEGGimmu:18025.
UCSCiuc009bxl.1. mouse.

Organism-specific databases

CTDi9603.
MGIiMGI:1339958. Nfe2l3.

Phylogenomic databases

eggNOGiNOG278006.
GeneTreeiENSGT00550000074399.
HOGENOMiHOG000234410.
HOVERGENiHBG052609.
InParanoidiQ9WTM4.
KOiK09040.
OMAiEIVRMPV.
OrthoDBiEOG715Q3N.
PhylomeDBiQ9WTM4.
TreeFamiTF337360.

Miscellaneous databases

NextBioi293091.
PROiQ9WTM4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WTM4.
CleanExiMM_NFE2L3.
ExpressionAtlasiQ9WTM4. baseline and differential.
GenevisibleiQ9WTM4. MM.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR029854. NF2L3.
IPR008917. TF_DNA-bd.
[Graphical view]
PANTHERiPTHR24411:SF8. PTHR24411:SF8. 1 hit.
PfamiPF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3."
    Kobayashi A., Ito E., Toki T., Kogame K., Takahashi S., Igarashi K., Hayashi N., Yamamoto M.
    J. Biol. Chem. 274:6443-6452(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Strain: ICR.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. "Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus."
    Derjuga A., Gourley T.S., Holm T.M., Heng H.H.Q., Shivdasani R.A., Ahmed R., Andrews N.C., Blank V.
    Mol. Cell. Biol. 24:3286-3294(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiNF2L3_MOUSE
AccessioniPrimary (citable) accession number: Q9WTM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: November 1, 1999
Last modified: June 24, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.