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Q9WTM4 (NF2L3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nuclear factor erythroid 2-related factor 3

Short name=NF-E2-related factor 3
Short name=NFE2-related factor 3
Alternative name(s):
Nuclear factor, erythroid derived 2, like 3
Gene names
Name:Nfe2l3
Synonyms:Nrf3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length660 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Activates erythroid-specific, globin gene expression.

Subunit structure

Heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE) By similarity.

Subcellular location

Nucleus By similarity.

Tissue specificity

High level expression in brain, thymus, testis and placenta. Medium level expression in uterus, stomach and lung. Low level expression in kidney. No expression in heart, liver, spleen and ovary. Ref.3

Sequence similarities

Belongs to the bZIP family. CNC subfamily.

Contains 1 bZIP (basic-leucine zipper) domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 660660Nuclear factor erythroid 2-related factor 3
PRO_0000076453

Regions

Domain541 – 60464bZIP
Region543 – 56220Basic motif By similarity
Region566 – 5738Leucine-zipper By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9WTM4 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: F5CBEEA77E6F4438

FASTA66072,707
        10         20         30         40         50         60 
MKLPKPWWAG GGLLQLTILL SLVGLRVDLD LFLPPPAAAL WEELLPLCPT RPASASNPFS 

        70         80         90        100        110        120 
ASEGWERTPL LPAKGRLLHE VRALGVPFIP RTRVDAWLVH SVATGNADGA HGLLGTAASS 

       130        140        150        160        170        180 
AVGDGGQSAS AGGGDPRAAH SSPLAAEEEE EKAAEPTAQV PDAGGCGSQE NGMLREKSEA 

       190        200        210        220        230        240 
VDHSSQQEEN EEGVSAQAKS RQQSKTEEHK MACASAREAE KITEARNESH LHWSDTSFSL 

       250        260        270        280        290        300 
EDLFQLLSSQ PEHSLEGISV EDIPPFLSSV CESVNSSAQN INLSQAISHD VNLHEAMLLY 

       310        320        330        340        350        360 
PNNTFRRDPS ARSSQAQEPF LQLNPHTNPE QATPAMSLPP FDNQMRNLTS QDLLYDLDSN 

       370        380        390        400        410        420 
IFDGINLMSL ATGFSPLEVS QLFEEPDSGL SLNSSYNSTS LTNSYRIYDG TVGYNSDLQS 

       430        440        450        460        470        480 
LCHDLGAVGG CYPEPHKHCH MDHRTIAGFH VSLECQQVFH DHTYHLQSGA SEPTSESFAW 

       490        500        510        520        530        540 
SEKSQKTSGC LDNPDRNLSR DEQRAKALHI PFSVDEIVRM PVDSFNSMLS RYYLTDLQVS 

       550        560        570        580        590        600 
LIRDIRRRGK NKVAAQNCRK RKLDIILNLE DDICNLQAKK EALKNEQTQC SKAIDIMRQK 

       610        620        630        640        650        660 
LHGLHQDVFN RLRDDQGRPV NPSQYALQYS HDGTVLIVPK ELISSGHKKE APKGKRERRN 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3."
Kobayashi A., Ito E., Toki T., Kogame K., Takahashi S., Igarashi K., Hayashi N., Yamamoto M.
J. Biol. Chem. 274:6443-6452(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
Strain: ICR.
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
[3]"Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus."
Derjuga A., Gourley T.S., Holm T.M., Heng H.H.Q., Shivdasani R.A., Ahmed R., Andrews N.C., Blank V.
Mol. Cell. Biol. 24:3286-3294(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB013852 mRNA. Translation: BAA76289.1.
BC005416 mRNA. Translation: AAH05416.1.
CCDSCCDS20134.1.
RefSeqNP_035033.1. NM_010903.1.
UniGeneMm.42138.

3D structure databases

ProteinModelPortalQ9WTM4.
SMRQ9WTM4. Positions 499-601.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9WTM4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000005103; ENSMUSP00000005103; ENSMUSG00000029832.
GeneID18025.
KEGGmmu:18025.
UCSCuc009bxl.1. mouse.

Organism-specific databases

CTD9603.
MGIMGI:1339958. Nfe2l3.

Phylogenomic databases

eggNOGNOG278006.
GeneTreeENSGT00550000074399.
HOGENOMHOG000234410.
HOVERGENHBG052609.
InParanoidQ9WTM4.
KOK09040.
OMAEIVRMPV.
OrthoDBEOG715Q3N.
PhylomeDBQ9WTM4.
TreeFamTF337360.

Gene expression databases

BgeeQ9WTM4.
CleanExMM_NFE2L3.
GenevestigatorQ9WTM4.

Family and domain databases

Gene3D1.10.880.10. 1 hit.
InterProIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR008917. TF_DNA-bd.
[Graphical view]
PfamPF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMSSF47454. SSF47454. 1 hit.
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio293091.
PROQ9WTM4.
SOURCESearch...

Entry information

Entry nameNF2L3_MOUSE
AccessionPrimary (citable) accession number: Q9WTM4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot