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Q9WTM4

- NF2L3_MOUSE

UniProt

Q9WTM4 - NF2L3_MOUSE

Protein

Nuclear factor erythroid 2-related factor 3

Gene

Nfe2l3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Activates erythroid-specific, globin gene expression.

    GO - Molecular functioni

    1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: NTNU_SB

    GO - Biological processi

    1. negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear factor erythroid 2-related factor 3
    Short name:
    NF-E2-related factor 3
    Short name:
    NFE2-related factor 3
    Alternative name(s):
    Nuclear factor, erythroid derived 2, like 3
    Gene namesi
    Name:Nfe2l3
    Synonyms:Nrf3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1339958. Nfe2l3.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 660660Nuclear factor erythroid 2-related factor 3PRO_0000076453Add
    BLAST

    Proteomic databases

    PRIDEiQ9WTM4.

    Expressioni

    Tissue specificityi

    High level expression in brain, thymus, testis and placenta. Medium level expression in uterus, stomach and lung. Low level expression in kidney. No expression in heart, liver, spleen and ovary.1 Publication

    Gene expression databases

    BgeeiQ9WTM4.
    CleanExiMM_NFE2L3.
    GenevestigatoriQ9WTM4.

    Interactioni

    Subunit structurei

    Heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE).By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WTM4.
    SMRiQ9WTM4. Positions 499-601.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini541 – 60464bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni543 – 56220Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni566 – 5738Leucine-zipperPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the bZIP family. CNC subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG278006.
    GeneTreeiENSGT00550000074399.
    HOGENOMiHOG000234410.
    HOVERGENiHBG052609.
    InParanoidiQ9WTM4.
    KOiK09040.
    OMAiEIVRMPV.
    OrthoDBiEOG715Q3N.
    PhylomeDBiQ9WTM4.
    TreeFamiTF337360.

    Family and domain databases

    Gene3Di1.10.880.10. 1 hit.
    InterProiIPR004827. bZIP.
    IPR004826. bZIP_Maf.
    IPR008917. TF_DNA-bd.
    [Graphical view]
    PfamiPF03131. bZIP_Maf. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF47454. SSF47454. 1 hit.
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9WTM4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLPKPWWAG GGLLQLTILL SLVGLRVDLD LFLPPPAAAL WEELLPLCPT    50
    RPASASNPFS ASEGWERTPL LPAKGRLLHE VRALGVPFIP RTRVDAWLVH 100
    SVATGNADGA HGLLGTAASS AVGDGGQSAS AGGGDPRAAH SSPLAAEEEE 150
    EKAAEPTAQV PDAGGCGSQE NGMLREKSEA VDHSSQQEEN EEGVSAQAKS 200
    RQQSKTEEHK MACASAREAE KITEARNESH LHWSDTSFSL EDLFQLLSSQ 250
    PEHSLEGISV EDIPPFLSSV CESVNSSAQN INLSQAISHD VNLHEAMLLY 300
    PNNTFRRDPS ARSSQAQEPF LQLNPHTNPE QATPAMSLPP FDNQMRNLTS 350
    QDLLYDLDSN IFDGINLMSL ATGFSPLEVS QLFEEPDSGL SLNSSYNSTS 400
    LTNSYRIYDG TVGYNSDLQS LCHDLGAVGG CYPEPHKHCH MDHRTIAGFH 450
    VSLECQQVFH DHTYHLQSGA SEPTSESFAW SEKSQKTSGC LDNPDRNLSR 500
    DEQRAKALHI PFSVDEIVRM PVDSFNSMLS RYYLTDLQVS LIRDIRRRGK 550
    NKVAAQNCRK RKLDIILNLE DDICNLQAKK EALKNEQTQC SKAIDIMRQK 600
    LHGLHQDVFN RLRDDQGRPV NPSQYALQYS HDGTVLIVPK ELISSGHKKE 650
    APKGKRERRN 660
    Length:660
    Mass (Da):72,707
    Last modified:November 1, 1999 - v1
    Checksum:iF5CBEEA77E6F4438
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB013852 mRNA. Translation: BAA76289.1.
    BC005416 mRNA. Translation: AAH05416.1.
    CCDSiCCDS20134.1.
    RefSeqiNP_035033.1. NM_010903.1.
    UniGeneiMm.42138.

    Genome annotation databases

    EnsembliENSMUST00000005103; ENSMUSP00000005103; ENSMUSG00000029832.
    GeneIDi18025.
    KEGGimmu:18025.
    UCSCiuc009bxl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB013852 mRNA. Translation: BAA76289.1 .
    BC005416 mRNA. Translation: AAH05416.1 .
    CCDSi CCDS20134.1.
    RefSeqi NP_035033.1. NM_010903.1.
    UniGenei Mm.42138.

    3D structure databases

    ProteinModelPortali Q9WTM4.
    SMRi Q9WTM4. Positions 499-601.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9WTM4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000005103 ; ENSMUSP00000005103 ; ENSMUSG00000029832 .
    GeneIDi 18025.
    KEGGi mmu:18025.
    UCSCi uc009bxl.1. mouse.

    Organism-specific databases

    CTDi 9603.
    MGIi MGI:1339958. Nfe2l3.

    Phylogenomic databases

    eggNOGi NOG278006.
    GeneTreei ENSGT00550000074399.
    HOGENOMi HOG000234410.
    HOVERGENi HBG052609.
    InParanoidi Q9WTM4.
    KOi K09040.
    OMAi EIVRMPV.
    OrthoDBi EOG715Q3N.
    PhylomeDBi Q9WTM4.
    TreeFami TF337360.

    Miscellaneous databases

    NextBioi 293091.
    PROi Q9WTM4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9WTM4.
    CleanExi MM_NFE2L3.
    Genevestigatori Q9WTM4.

    Family and domain databases

    Gene3Di 1.10.880.10. 1 hit.
    InterProi IPR004827. bZIP.
    IPR004826. bZIP_Maf.
    IPR008917. TF_DNA-bd.
    [Graphical view ]
    Pfami PF03131. bZIP_Maf. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47454. SSF47454. 1 hit.
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3."
      Kobayashi A., Ito E., Toki T., Kogame K., Takahashi S., Igarashi K., Hayashi N., Yamamoto M.
      J. Biol. Chem. 274:6443-6452(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
      Strain: ICR.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    3. "Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus."
      Derjuga A., Gourley T.S., Holm T.M., Heng H.H.Q., Shivdasani R.A., Ahmed R., Andrews N.C., Blank V.
      Mol. Cell. Biol. 24:3286-3294(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiNF2L3_MOUSE
    AccessioniPrimary (citable) accession number: Q9WTM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3