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Protein

Semaphorin-6C

Gene

Sema6c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be a stop signal for the dorsal root ganglion neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections (By similarity).By similarity

GO - Molecular functioni

  1. receptor activity Source: InterPro
  2. semaphorin receptor binding Source: MGI

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. nervous system development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-6C
Alternative name(s):
Semaphorin-Y
Short name:
Sema Y
Gene namesi
Name:Sema6c
Synonyms:Semay
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1338032. Sema6c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 605580ExtracellularSequence AnalysisAdd
BLAST
Transmembranei606 – 62621HelicalSequence AnalysisAdd
BLAST
Topological domaini627 – 931305CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 931906Semaphorin-6CPRO_0000032345Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi112 ↔ 122PROSITE-ProRule annotation
Disulfide bondi140 ↔ 149PROSITE-ProRule annotation
Disulfide bondi263 ↔ 374PROSITE-ProRule annotation
Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi288 ↔ 333PROSITE-ProRule annotation
Glycosylationi438 – 4381N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi480 ↔ 511PROSITE-ProRule annotation
Disulfide bondi520 ↔ 538PROSITE-ProRule annotation
Disulfide bondi526 ↔ 571PROSITE-ProRule annotation
Disulfide bondi530 ↔ 546PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9WTM3.

PTM databases

PhosphoSiteiQ9WTM3.

Expressioni

Gene expression databases

BgeeiQ9WTM3.
ExpressionAtlasiQ9WTM3. baseline and differential.
GenevestigatoriQ9WTM3.

Structurei

3D structure databases

ProteinModelPortaliQ9WTM3.
SMRiQ9WTM3. Positions 26-552.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 517487SemaPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi663 – 6697Poly-Pro
Compositional biasi754 – 7574Poly-Pro

Sequence similaritiesi

Belongs to the semaphorin family.Curated
Contains 1 PSI domain.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293968.
GeneTreeiENSGT00760000119134.
HOGENOMiHOG000232047.
HOVERGENiHBG072910.
InParanoidiQ9WTM3.
KOiK06842.
OrthoDBiEOG7SV0TJ.
PhylomeDBiQ9WTM3.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015514. Semaphorin_6C.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PTHR11036:SF11. PTHR11036:SF11. 1 hit.
PfamiPF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WTM3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRAPHSMPL LLLLLLLSSL PQAQAAFPQD PTPLLTSDLQ GASPSSWFRG
60 70 80 90 100
LEDDAVAAEL GLDFQRFLTL NRTLLVAARD HVFSFDLQAQ EEGEGLVPNK
110 120 130 140 150
FLTWRSQDME NCAVRGKLTD ECYNYIRVLV PWNSQTLLAC GTNSFSPMCR
160 170 180 190 200
SYGITSLQQE GEELSGQARC PFDATQSTVA IFAEGSLYSA TAADFQASDA
210 220 230 240 250
VVYRSLGPQP PLRSAKYDSK WLREPHFVYA LEHGEHVYFF FREVSVEDAR
260 270 280 290 300
LGRVQFSRVA RVCKRDMGGS PRALDRHWTS FLKLRLNCSV PGDSTFYFDV
310 320 330 340 350
LQSLTGPVNL HGRSALFGVF TTQTNSIPGS AVCAFYLDDI ERGFEGKFKE
360 370 380 390 400
QRSLDGAWTP VSEDKVPSPR PGSCAGVGAA ASFSSSQDLP DDVLLFIKAH
410 420 430 440 450
PLLDPAVPPA THQPLLTLTS RALLTQVAVD GMAGPHRNTT VLFLGSNDGT
460 470 480 490 500
VLKVLPPGGQ SLGSEPIVLE EIDAYSHARC SGKRSPRAAR RIIGLELDTE
510 520 530 540 550
GHRLFVAFPG CIVYLSLSRC ARHGACQRSC LASLDPYCGW HRSRGCMSIR
560 570 580 590 600
GPGGTDVDLT GNQESTEHGD CQDGATGSQS GPGDSAYGVR RDLSPASASR
610 620 630 640 650
SIPIPLLLAC VAAAFALGAS VSGLLVSCAC RRANRRRSKD IETPGLPRPL
660 670 680 690 700
SLRSLARLHG GGPEPPPPPK DGDAAQTPQL YTTFLPPPDG GSPPELACLP
710 720 730 740 750
TPETTPELPV KHLRASGGPW EWNQNGNNAS EGPGRPPRGC SGAGGPAPRV
760 770 780 790 800
LVRPPPPGCP GQAVEVTTLE ELLRYLHGPQ PPRKGSEPLA SAPFTSRPPA
810 820 830 840 850
SEPGASLFVD SSPMPRDGVP PLRLDVPPEG KRAAPSGRPA LSAPAPRLGV
860 870 880 890 900
GGSRRLPFPT HRAPPGLLTR VPSGGPARYS GGPGRHLLYL GRPEGHRGRS
910 920 930
LKRVDVKSPL SPKPPLASPP QPAPHGGHFN F
Length:931
Mass (Da):99,538
Last modified:November 1, 1999 - v1
Checksum:iB0D99D594209F125
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013729 mRNA. Translation: BAA76294.1.
CCDSiCCDS17604.1.
RefSeqiNP_001258953.1. NM_001272024.1.
NP_035481.1. NM_011351.2.
XP_006501268.1. XM_006501205.1.
UniGeneiMm.23662.

Genome annotation databases

EnsembliENSMUST00000090821; ENSMUSP00000088331; ENSMUSG00000038777.
ENSMUST00000168321; ENSMUSP00000129081; ENSMUSG00000038777.
GeneIDi20360.
KEGGimmu:20360.
UCSCiuc008qij.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013729 mRNA. Translation: BAA76294.1.
CCDSiCCDS17604.1.
RefSeqiNP_001258953.1. NM_001272024.1.
NP_035481.1. NM_011351.2.
XP_006501268.1. XM_006501205.1.
UniGeneiMm.23662.

3D structure databases

ProteinModelPortaliQ9WTM3.
SMRiQ9WTM3. Positions 26-552.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9WTM3.

Proteomic databases

PRIDEiQ9WTM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090821; ENSMUSP00000088331; ENSMUSG00000038777.
ENSMUST00000168321; ENSMUSP00000129081; ENSMUSG00000038777.
GeneIDi20360.
KEGGimmu:20360.
UCSCiuc008qij.1. mouse.

Organism-specific databases

CTDi10500.
MGIiMGI:1338032. Sema6c.

Phylogenomic databases

eggNOGiNOG293968.
GeneTreeiENSGT00760000119134.
HOGENOMiHOG000232047.
HOVERGENiHBG072910.
InParanoidiQ9WTM3.
KOiK06842.
OrthoDBiEOG7SV0TJ.
PhylomeDBiQ9WTM3.

Miscellaneous databases

NextBioi298245.
PROiQ9WTM3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WTM3.
ExpressionAtlasiQ9WTM3. baseline and differential.
GenevestigatoriQ9WTM3.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015514. Semaphorin_6C.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PTHR11036:SF11. PTHR11036:SF11. 1 hit.
PfamiPF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of a novel class VI semaphorin, semaphorin Y."
    Kikuchi K., Chedotal A., Hanafusa H., Ujimasa Y., de Castro F., Goodman C.S., Kimura T.
    Mol. Cell. Neurosci. 13:9-23(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiSEM6C_MOUSE
AccessioniPrimary (citable) accession number: Q9WTM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: February 4, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.