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Q9WTM3 (SEM6C_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Semaphorin-6C
Alternative name(s):
Semaphorin-Y
Short name=Sema Y
Gene names
Name:Sema6c
Synonyms:Semay
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length931 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be a stop signal for the dorsal root ganglion neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the semaphorin family.

Contains 1 PSI domain.

Contains 1 Sema domain.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
   Cellular componentCell membrane
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionDevelopmental protein
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaxon guidance

Inferred from electronic annotation. Source: Compara

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionreceptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 931906Semaphorin-6C
PRO_0000032345

Regions

Topological domain26 – 605580Extracellular Potential
Transmembrane606 – 62621Helical; Potential
Topological domain627 – 931305Cytoplasmic Potential
Domain31 – 517487Sema
Compositional bias663 – 6697Poly-Pro
Compositional bias754 – 7574Poly-Pro

Amino acid modifications

Glycosylation711N-linked (GlcNAc...) Potential
Glycosylation2871N-linked (GlcNAc...) Potential
Glycosylation4381N-linked (GlcNAc...) Potential
Disulfide bond112 ↔ 122 By similarity
Disulfide bond140 ↔ 149 By similarity
Disulfide bond263 ↔ 374 By similarity
Disulfide bond288 ↔ 333 By similarity
Disulfide bond480 ↔ 511 By similarity
Disulfide bond520 ↔ 538 By similarity
Disulfide bond526 ↔ 571 By similarity
Disulfide bond530 ↔ 546 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9WTM3 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: B0D99D594209F125

FASTA93199,538
        10         20         30         40         50         60 
MPRAPHSMPL LLLLLLLSSL PQAQAAFPQD PTPLLTSDLQ GASPSSWFRG LEDDAVAAEL 

        70         80         90        100        110        120 
GLDFQRFLTL NRTLLVAARD HVFSFDLQAQ EEGEGLVPNK FLTWRSQDME NCAVRGKLTD 

       130        140        150        160        170        180 
ECYNYIRVLV PWNSQTLLAC GTNSFSPMCR SYGITSLQQE GEELSGQARC PFDATQSTVA 

       190        200        210        220        230        240 
IFAEGSLYSA TAADFQASDA VVYRSLGPQP PLRSAKYDSK WLREPHFVYA LEHGEHVYFF 

       250        260        270        280        290        300 
FREVSVEDAR LGRVQFSRVA RVCKRDMGGS PRALDRHWTS FLKLRLNCSV PGDSTFYFDV 

       310        320        330        340        350        360 
LQSLTGPVNL HGRSALFGVF TTQTNSIPGS AVCAFYLDDI ERGFEGKFKE QRSLDGAWTP 

       370        380        390        400        410        420 
VSEDKVPSPR PGSCAGVGAA ASFSSSQDLP DDVLLFIKAH PLLDPAVPPA THQPLLTLTS 

       430        440        450        460        470        480 
RALLTQVAVD GMAGPHRNTT VLFLGSNDGT VLKVLPPGGQ SLGSEPIVLE EIDAYSHARC 

       490        500        510        520        530        540 
SGKRSPRAAR RIIGLELDTE GHRLFVAFPG CIVYLSLSRC ARHGACQRSC LASLDPYCGW 

       550        560        570        580        590        600 
HRSRGCMSIR GPGGTDVDLT GNQESTEHGD CQDGATGSQS GPGDSAYGVR RDLSPASASR 

       610        620        630        640        650        660 
SIPIPLLLAC VAAAFALGAS VSGLLVSCAC RRANRRRSKD IETPGLPRPL SLRSLARLHG 

       670        680        690        700        710        720 
GGPEPPPPPK DGDAAQTPQL YTTFLPPPDG GSPPELACLP TPETTPELPV KHLRASGGPW 

       730        740        750        760        770        780 
EWNQNGNNAS EGPGRPPRGC SGAGGPAPRV LVRPPPPGCP GQAVEVTTLE ELLRYLHGPQ 

       790        800        810        820        830        840 
PPRKGSEPLA SAPFTSRPPA SEPGASLFVD SSPMPRDGVP PLRLDVPPEG KRAAPSGRPA 

       850        860        870        880        890        900 
LSAPAPRLGV GGSRRLPFPT HRAPPGLLTR VPSGGPARYS GGPGRHLLYL GRPEGHRGRS 

       910        920        930 
LKRVDVKSPL SPKPPLASPP QPAPHGGHFN F

« Hide

References

[1]"Cloning and characterization of a novel class VI semaphorin, semaphorin Y."
Kikuchi K., Chedotal A., Hanafusa H., Ujimasa Y., de Castro F., Goodman C.S., Kimura T.
Mol. Cell. Neurosci. 13:9-23(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB013729 mRNA. Translation: BAA76294.1.
IPIIPI00123555.
RefSeqNP_001258953.1. NM_001272024.1.
NP_035481.1. NM_011351.2.
UniGeneMm.23662.

3D structure databases

ProteinModelPortalQ9WTM3.
SMRQ9WTM3. Positions 26-552.
ModBaseSearch...

PTM databases

PhosphoSiteQ9WTM3.

Proteomic databases

PRIDEQ9WTM3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000090821; ENSMUSP00000088331; ENSMUSG00000038777.
ENSMUST00000168321; ENSMUSP00000129081; ENSMUSG00000038777.
GeneID20360.
KEGGmmu:20360.
UCSCuc008qij.1. mouse.

Organism-specific databases

CTD10500.
MGIMGI:1338032. Sema6c.

Phylogenomic databases

eggNOGNOG293968.
GeneTreeENSGT00690000101956.
HOGENOMHOG000232047.
HOVERGENHBG072910.
KOK06842.

Gene expression databases

ArrayExpressQ9WTM3.
BgeeQ9WTM3.
GenevestigatorQ9WTM3.
GermOnlineENSMUSG00000038777. Mus musculus.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR003659. Plexin-like.
IPR016201. Plexin-like_fold.
IPR027231. Semaphorin.
IPR001627. Semaphorin/CD100_Ag.
IPR015514. Semaphorin_6C.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERPTHR11036. PTHR11036. 1 hit.
PTHR11036:SF9. PTHR11036:SF9. 1 hit.
PfamPF01403. Sema. 1 hit.
[Graphical view]
SMARTSM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMSSF103575. Plexin-like_fold. 1 hit.
SSF101912. Sema. 1 hit.
PROSITEPS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio298245.
SOURCESearch...

Entry information

Entry nameSEM6C_MOUSE
AccessionPrimary (citable) accession number: Q9WTM3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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