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Q9WTM3

- SEM6C_MOUSE

UniProt

Q9WTM3 - SEM6C_MOUSE

Protein

Semaphorin-6C

Gene

Sema6c

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    May be a stop signal for the dorsal root ganglion neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections By similarity.By similarity

    GO - Molecular functioni

    1. receptor activity Source: InterPro
    2. semaphorin receptor binding Source: MGI

    GO - Biological processi

    1. axon guidance Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Semaphorin-6C
    Alternative name(s):
    Semaphorin-Y
    Short name:
    Sema Y
    Gene namesi
    Name:Sema6c
    Synonyms:Semay
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1338032. Sema6c.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 931906Semaphorin-6CPRO_0000032345Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi112 ↔ 122PROSITE-ProRule annotation
    Disulfide bondi140 ↔ 149PROSITE-ProRule annotation
    Disulfide bondi263 ↔ 374PROSITE-ProRule annotation
    Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi288 ↔ 333PROSITE-ProRule annotation
    Glycosylationi438 – 4381N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi480 ↔ 511PROSITE-ProRule annotation
    Disulfide bondi520 ↔ 538PROSITE-ProRule annotation
    Disulfide bondi526 ↔ 571PROSITE-ProRule annotation
    Disulfide bondi530 ↔ 546PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9WTM3.

    PTM databases

    PhosphoSiteiQ9WTM3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9WTM3.
    BgeeiQ9WTM3.
    GenevestigatoriQ9WTM3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WTM3.
    SMRiQ9WTM3. Positions 26-552.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 605580ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini627 – 931305CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei606 – 62621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 517487SemaPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi663 – 6697Poly-Pro
    Compositional biasi754 – 7574Poly-Pro

    Sequence similaritiesi

    Belongs to the semaphorin family.Curated
    Contains 1 PSI domain.Curated
    Contains 1 Sema domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG293968.
    GeneTreeiENSGT00690000101956.
    HOGENOMiHOG000232047.
    HOVERGENiHBG072910.
    KOiK06842.
    OrthoDBiEOG7SV0TJ.
    PhylomeDBiQ9WTM3.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR016201. Plexin-like_fold.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015514. Semaphorin_6C.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PANTHERiPTHR11036. PTHR11036. 1 hit.
    PTHR11036:SF11. PTHR11036:SF11. 1 hit.
    PfamiPF01403. Sema. 1 hit.
    [Graphical view]
    SMARTiSM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view]
    SUPFAMiSSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEiPS51004. SEMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9WTM3-1 [UniParc]FASTAAdd to Basket

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    MPRAPHSMPL LLLLLLLSSL PQAQAAFPQD PTPLLTSDLQ GASPSSWFRG    50
    LEDDAVAAEL GLDFQRFLTL NRTLLVAARD HVFSFDLQAQ EEGEGLVPNK 100
    FLTWRSQDME NCAVRGKLTD ECYNYIRVLV PWNSQTLLAC GTNSFSPMCR 150
    SYGITSLQQE GEELSGQARC PFDATQSTVA IFAEGSLYSA TAADFQASDA 200
    VVYRSLGPQP PLRSAKYDSK WLREPHFVYA LEHGEHVYFF FREVSVEDAR 250
    LGRVQFSRVA RVCKRDMGGS PRALDRHWTS FLKLRLNCSV PGDSTFYFDV 300
    LQSLTGPVNL HGRSALFGVF TTQTNSIPGS AVCAFYLDDI ERGFEGKFKE 350
    QRSLDGAWTP VSEDKVPSPR PGSCAGVGAA ASFSSSQDLP DDVLLFIKAH 400
    PLLDPAVPPA THQPLLTLTS RALLTQVAVD GMAGPHRNTT VLFLGSNDGT 450
    VLKVLPPGGQ SLGSEPIVLE EIDAYSHARC SGKRSPRAAR RIIGLELDTE 500
    GHRLFVAFPG CIVYLSLSRC ARHGACQRSC LASLDPYCGW HRSRGCMSIR 550
    GPGGTDVDLT GNQESTEHGD CQDGATGSQS GPGDSAYGVR RDLSPASASR 600
    SIPIPLLLAC VAAAFALGAS VSGLLVSCAC RRANRRRSKD IETPGLPRPL 650
    SLRSLARLHG GGPEPPPPPK DGDAAQTPQL YTTFLPPPDG GSPPELACLP 700
    TPETTPELPV KHLRASGGPW EWNQNGNNAS EGPGRPPRGC SGAGGPAPRV 750
    LVRPPPPGCP GQAVEVTTLE ELLRYLHGPQ PPRKGSEPLA SAPFTSRPPA 800
    SEPGASLFVD SSPMPRDGVP PLRLDVPPEG KRAAPSGRPA LSAPAPRLGV 850
    GGSRRLPFPT HRAPPGLLTR VPSGGPARYS GGPGRHLLYL GRPEGHRGRS 900
    LKRVDVKSPL SPKPPLASPP QPAPHGGHFN F 931
    Length:931
    Mass (Da):99,538
    Last modified:November 1, 1999 - v1
    Checksum:iB0D99D594209F125
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB013729 mRNA. Translation: BAA76294.1.
    CCDSiCCDS17604.1.
    RefSeqiNP_001258953.1. NM_001272024.1.
    NP_035481.1. NM_011351.2.
    XP_006501268.1. XM_006501205.1.
    UniGeneiMm.23662.

    Genome annotation databases

    EnsembliENSMUST00000090821; ENSMUSP00000088331; ENSMUSG00000038777.
    ENSMUST00000168321; ENSMUSP00000129081; ENSMUSG00000038777.
    GeneIDi20360.
    KEGGimmu:20360.
    UCSCiuc008qij.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB013729 mRNA. Translation: BAA76294.1 .
    CCDSi CCDS17604.1.
    RefSeqi NP_001258953.1. NM_001272024.1.
    NP_035481.1. NM_011351.2.
    XP_006501268.1. XM_006501205.1.
    UniGenei Mm.23662.

    3D structure databases

    ProteinModelPortali Q9WTM3.
    SMRi Q9WTM3. Positions 26-552.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9WTM3.

    Proteomic databases

    PRIDEi Q9WTM3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000090821 ; ENSMUSP00000088331 ; ENSMUSG00000038777 .
    ENSMUST00000168321 ; ENSMUSP00000129081 ; ENSMUSG00000038777 .
    GeneIDi 20360.
    KEGGi mmu:20360.
    UCSCi uc008qij.1. mouse.

    Organism-specific databases

    CTDi 10500.
    MGIi MGI:1338032. Sema6c.

    Phylogenomic databases

    eggNOGi NOG293968.
    GeneTreei ENSGT00690000101956.
    HOGENOMi HOG000232047.
    HOVERGENi HBG072910.
    KOi K06842.
    OrthoDBi EOG7SV0TJ.
    PhylomeDBi Q9WTM3.

    Miscellaneous databases

    NextBioi 298245.
    PROi Q9WTM3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9WTM3.
    Bgeei Q9WTM3.
    Genevestigatori Q9WTM3.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR016201. Plexin-like_fold.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015514. Semaphorin_6C.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    PANTHERi PTHR11036. PTHR11036. 1 hit.
    PTHR11036:SF11. PTHR11036:SF11. 1 hit.
    Pfami PF01403. Sema. 1 hit.
    [Graphical view ]
    SMARTi SM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEi PS51004. SEMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel class VI semaphorin, semaphorin Y."
      Kikuchi K., Chedotal A., Hanafusa H., Ujimasa Y., de Castro F., Goodman C.S., Kimura T.
      Mol. Cell. Neurosci. 13:9-23(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiSEM6C_MOUSE
    AccessioniPrimary (citable) accession number: Q9WTM3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3