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Q9WTM3

- SEM6C_MOUSE

UniProt

Q9WTM3 - SEM6C_MOUSE

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Protein
Semaphorin-6C
Gene
Sema6c, Semay
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be a stop signal for the dorsal root ganglion neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections By similarity.

GO - Molecular functioni

  1. receptor activity Source: InterPro
  2. semaphorin receptor binding Source: MGI

GO - Biological processi

  1. axon guidance Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-6C
Alternative name(s):
Semaphorin-Y
Short name:
Sema Y
Gene namesi
Name:Sema6c
Synonyms:Semay
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1338032. Sema6c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 605580Extracellular Reviewed prediction
Add
BLAST
Transmembranei606 – 62621Helical; Reviewed prediction
Add
BLAST
Topological domaini627 – 931305Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 931906Semaphorin-6C
PRO_0000032345Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi112 ↔ 122 By similarity
Disulfide bondi140 ↔ 149 By similarity
Disulfide bondi263 ↔ 374 By similarity
Glycosylationi287 – 2871N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi288 ↔ 333 By similarity
Glycosylationi438 – 4381N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi480 ↔ 511 By similarity
Disulfide bondi520 ↔ 538 By similarity
Disulfide bondi526 ↔ 571 By similarity
Disulfide bondi530 ↔ 546 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9WTM3.

PTM databases

PhosphoSiteiQ9WTM3.

Expressioni

Gene expression databases

ArrayExpressiQ9WTM3.
BgeeiQ9WTM3.
GenevestigatoriQ9WTM3.

Structurei

3D structure databases

ProteinModelPortaliQ9WTM3.
SMRiQ9WTM3. Positions 26-552.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 517487Sema
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi663 – 6697Poly-Pro
Compositional biasi754 – 7574Poly-Pro

Sequence similaritiesi

Belongs to the semaphorin family.
Contains 1 PSI domain.
Contains 1 Sema domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293968.
GeneTreeiENSGT00690000101956.
HOGENOMiHOG000232047.
HOVERGENiHBG072910.
KOiK06842.
OrthoDBiEOG7SV0TJ.
PhylomeDBiQ9WTM3.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015514. Semaphorin_6C.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PTHR11036:SF11. PTHR11036:SF11. 1 hit.
PfamiPF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WTM3-1 [UniParc]FASTAAdd to Basket

« Hide

MPRAPHSMPL LLLLLLLSSL PQAQAAFPQD PTPLLTSDLQ GASPSSWFRG    50
LEDDAVAAEL GLDFQRFLTL NRTLLVAARD HVFSFDLQAQ EEGEGLVPNK 100
FLTWRSQDME NCAVRGKLTD ECYNYIRVLV PWNSQTLLAC GTNSFSPMCR 150
SYGITSLQQE GEELSGQARC PFDATQSTVA IFAEGSLYSA TAADFQASDA 200
VVYRSLGPQP PLRSAKYDSK WLREPHFVYA LEHGEHVYFF FREVSVEDAR 250
LGRVQFSRVA RVCKRDMGGS PRALDRHWTS FLKLRLNCSV PGDSTFYFDV 300
LQSLTGPVNL HGRSALFGVF TTQTNSIPGS AVCAFYLDDI ERGFEGKFKE 350
QRSLDGAWTP VSEDKVPSPR PGSCAGVGAA ASFSSSQDLP DDVLLFIKAH 400
PLLDPAVPPA THQPLLTLTS RALLTQVAVD GMAGPHRNTT VLFLGSNDGT 450
VLKVLPPGGQ SLGSEPIVLE EIDAYSHARC SGKRSPRAAR RIIGLELDTE 500
GHRLFVAFPG CIVYLSLSRC ARHGACQRSC LASLDPYCGW HRSRGCMSIR 550
GPGGTDVDLT GNQESTEHGD CQDGATGSQS GPGDSAYGVR RDLSPASASR 600
SIPIPLLLAC VAAAFALGAS VSGLLVSCAC RRANRRRSKD IETPGLPRPL 650
SLRSLARLHG GGPEPPPPPK DGDAAQTPQL YTTFLPPPDG GSPPELACLP 700
TPETTPELPV KHLRASGGPW EWNQNGNNAS EGPGRPPRGC SGAGGPAPRV 750
LVRPPPPGCP GQAVEVTTLE ELLRYLHGPQ PPRKGSEPLA SAPFTSRPPA 800
SEPGASLFVD SSPMPRDGVP PLRLDVPPEG KRAAPSGRPA LSAPAPRLGV 850
GGSRRLPFPT HRAPPGLLTR VPSGGPARYS GGPGRHLLYL GRPEGHRGRS 900
LKRVDVKSPL SPKPPLASPP QPAPHGGHFN F 931
Length:931
Mass (Da):99,538
Last modified:November 1, 1999 - v1
Checksum:iB0D99D594209F125
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB013729 mRNA. Translation: BAA76294.1.
CCDSiCCDS17604.1.
RefSeqiNP_001258953.1. NM_001272024.1.
NP_035481.1. NM_011351.2.
XP_006501268.1. XM_006501205.1.
UniGeneiMm.23662.

Genome annotation databases

EnsembliENSMUST00000090821; ENSMUSP00000088331; ENSMUSG00000038777.
ENSMUST00000168321; ENSMUSP00000129081; ENSMUSG00000038777.
GeneIDi20360.
KEGGimmu:20360.
UCSCiuc008qij.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB013729 mRNA. Translation: BAA76294.1 .
CCDSi CCDS17604.1.
RefSeqi NP_001258953.1. NM_001272024.1.
NP_035481.1. NM_011351.2.
XP_006501268.1. XM_006501205.1.
UniGenei Mm.23662.

3D structure databases

ProteinModelPortali Q9WTM3.
SMRi Q9WTM3. Positions 26-552.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9WTM3.

Proteomic databases

PRIDEi Q9WTM3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000090821 ; ENSMUSP00000088331 ; ENSMUSG00000038777 .
ENSMUST00000168321 ; ENSMUSP00000129081 ; ENSMUSG00000038777 .
GeneIDi 20360.
KEGGi mmu:20360.
UCSCi uc008qij.1. mouse.

Organism-specific databases

CTDi 10500.
MGIi MGI:1338032. Sema6c.

Phylogenomic databases

eggNOGi NOG293968.
GeneTreei ENSGT00690000101956.
HOGENOMi HOG000232047.
HOVERGENi HBG072910.
KOi K06842.
OrthoDBi EOG7SV0TJ.
PhylomeDBi Q9WTM3.

Miscellaneous databases

NextBioi 298245.
PROi Q9WTM3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9WTM3.
Bgeei Q9WTM3.
Genevestigatori Q9WTM3.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015514. Semaphorin_6C.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
PANTHERi PTHR11036. PTHR11036. 1 hit.
PTHR11036:SF11. PTHR11036:SF11. 1 hit.
Pfami PF01403. Sema. 1 hit.
[Graphical view ]
SMARTi SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEi PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of a novel class VI semaphorin, semaphorin Y."
    Kikuchi K., Chedotal A., Hanafusa H., Ujimasa Y., de Castro F., Goodman C.S., Kimura T.
    Mol. Cell. Neurosci. 13:9-23(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiSEM6C_MOUSE
AccessioniPrimary (citable) accession number: Q9WTM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi