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Protein

Acyl-protein thioesterase 2

Gene

Lypla2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Deacylates GAP43 (By similarity). Has lysophospholipase activity.By similarity1 Publication

Catalytic activityi

Palmitoyl-protein + H2O = palmitate + protein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei122 – 1221Charge relay systemBy similarity
Active sitei176 – 1761Charge relay systemBy similarity
Active sitei210 – 2101Charge relay systemBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

BRENDAi3.1.1.5. 3474.

Protein family/group databases

ESTHERimouse-lypla2. LYsophospholipase_carboxylesterase.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-protein thioesterase 2 (EC:3.1.2.-)
Short name:
APT-2
Alternative name(s):
Lysophospholipase 2
Lysophospholipase II
Short name:
LPL-II
Short name:
LysoPLA II
Short name:
mLyso II
Gene namesi
Name:Lypla2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1347000. Lypla2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3259480.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231Acyl-protein thioesterase 2PRO_0000102272Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei82 – 821PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9WTL7.
MaxQBiQ9WTL7.
PaxDbiQ9WTL7.
PeptideAtlasiQ9WTL7.
PRIDEiQ9WTL7.

2D gel databases

REPRODUCTION-2DPAGEIPI00123518.
Q9WTL7.

PTM databases

iPTMnetiQ9WTL7.
PhosphoSiteiQ9WTL7.

Expressioni

Tissue specificityi

Ubiquitous; detected at low levels.1 Publication

Gene expression databases

BgeeiQ9WTL7.
CleanExiMM_LYPLA2.
GenevisibleiQ9WTL7. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9WTL7. 1 interaction.
MINTiMINT-4100820.
STRINGi10090.ENSMUSP00000064204.

Structurei

3D structure databases

ProteinModelPortaliQ9WTL7.
SMRiQ9WTL7. Positions 6-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2112. Eukaryota.
COG0400. LUCA.
GeneTreeiENSGT00390000009648.
HOGENOMiHOG000260139.
HOVERGENiHBG052378.
InParanoidiQ9WTL7.
KOiK06130.
OMAiWLPLHRN.
OrthoDBiEOG7M0NSQ.
PhylomeDBiQ9WTL7.
TreeFamiTF314619.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR003140. PLipase/COase/thioEstase.
[Graphical view]
PfamiPF02230. Abhydrolase_2. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WTL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGNTMSVPL LTDAATVSGA ERETAAVIFL HGLGDTGHSW ADALSTIRLP
60 70 80 90 100
HVKYICPHAP RIPVTLNMKM VMPSWFDLMG LSPDAPEDEA GIKKAAENIK
110 120 130 140 150
ALIEHEMKNG IPANRIVLGG FSQGGALSLY TALTCPHPLA GIVALSCWLP
160 170 180 190 200
LHRNFPQAAN GSAKDLAILQ CHGELDPMVP VRFGALTAEK LRTVVTPARV
210 220 230
QFKTYPGVMH SSCPQEMAAV KEFLEKLLPP V
Length:231
Mass (Da):24,794
Last modified:November 1, 1999 - v1
Checksum:iE18797A17570AA97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009653 mRNA. Translation: BAA76751.1.
AK003689 mRNA. Translation: BAB22940.1.
AK075590 mRNA. Translation: BAC35841.1.
AK089112 mRNA. Translation: BAC40757.1.
AK167478 mRNA. Translation: BAE39559.1.
BC068120 mRNA. Translation: AAH68120.1.
CCDSiCCDS18797.1.
RefSeqiNP_036072.1. NM_011942.1.
XP_011248560.1. XM_011250258.1.
UniGeneiMm.34302.

Genome annotation databases

EnsembliENSMUST00000067567; ENSMUSP00000064204; ENSMUSG00000028670.
ENSMUST00000105852; ENSMUSP00000101478; ENSMUSG00000028670.
GeneIDi26394.
KEGGimmu:26394.
UCSCiuc008vhm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009653 mRNA. Translation: BAA76751.1.
AK003689 mRNA. Translation: BAB22940.1.
AK075590 mRNA. Translation: BAC35841.1.
AK089112 mRNA. Translation: BAC40757.1.
AK167478 mRNA. Translation: BAE39559.1.
BC068120 mRNA. Translation: AAH68120.1.
CCDSiCCDS18797.1.
RefSeqiNP_036072.1. NM_011942.1.
XP_011248560.1. XM_011250258.1.
UniGeneiMm.34302.

3D structure databases

ProteinModelPortaliQ9WTL7.
SMRiQ9WTL7. Positions 6-231.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WTL7. 1 interaction.
MINTiMINT-4100820.
STRINGi10090.ENSMUSP00000064204.

Chemistry

ChEMBLiCHEMBL3259480.

Protein family/group databases

ESTHERimouse-lypla2. LYsophospholipase_carboxylesterase.

PTM databases

iPTMnetiQ9WTL7.
PhosphoSiteiQ9WTL7.

2D gel databases

REPRODUCTION-2DPAGEIPI00123518.
Q9WTL7.

Proteomic databases

EPDiQ9WTL7.
MaxQBiQ9WTL7.
PaxDbiQ9WTL7.
PeptideAtlasiQ9WTL7.
PRIDEiQ9WTL7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067567; ENSMUSP00000064204; ENSMUSG00000028670.
ENSMUST00000105852; ENSMUSP00000101478; ENSMUSG00000028670.
GeneIDi26394.
KEGGimmu:26394.
UCSCiuc008vhm.2. mouse.

Organism-specific databases

CTDi11313.
MGIiMGI:1347000. Lypla2.

Phylogenomic databases

eggNOGiKOG2112. Eukaryota.
COG0400. LUCA.
GeneTreeiENSGT00390000009648.
HOGENOMiHOG000260139.
HOVERGENiHBG052378.
InParanoidiQ9WTL7.
KOiK06130.
OMAiWLPLHRN.
OrthoDBiEOG7M0NSQ.
PhylomeDBiQ9WTL7.
TreeFamiTF314619.

Enzyme and pathway databases

BRENDAi3.1.1.5. 3474.

Miscellaneous databases

PROiQ9WTL7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WTL7.
CleanExiMM_LYPLA2.
GenevisibleiQ9WTL7. MM.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR003140. PLipase/COase/thioEstase.
[Graphical view]
PfamiPF02230. Abhydrolase_2. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence, expression in Escherichia coli, and characterization of lysophospholipase II."
    Toyoda T., Sugimoto H., Yamashita S.
    Biochim. Biophys. Acta 1437:182-193(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Embryo, Kidney, Placenta and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 154-164, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiLYPA2_MOUSE
AccessioniPrimary (citable) accession number: Q9WTL7
Secondary accession number(s): Q3TJD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 1, 1999
Last modified: July 6, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.