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Q9WTL2

- RAB25_MOUSE

UniProt

Q9WTL2 - RAB25_MOUSE

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Protein

Ras-related protein Rab-25

Gene
Rab25
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 279GTP By similarity
Nucleotide bindingi67 – 715GTP By similarity
Nucleotide bindingi125 – 1284GTP By similarity
Nucleotide bindingi155 – 1573GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. protein binding Source: MGI

GO - Biological processi

  1. positive regulation of cell proliferation Source: UniProtKB
  2. protein transport Source: UniProtKB-KW
  3. pseudopodium organization Source: UniProtKB
  4. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-25
Gene namesi
Name:Rab25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1858203. Rab25.

Subcellular locationi

Cell membrane; Lipid-anchor; Cytoplasmic side Reviewed prediction. Cell projectionpseudopodium membrane By similarity. Cytoplasmic vesicle By similarity
Note: Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips By similarity.

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
  2. cytoplasmic vesicle Source: UniProtKB
  3. pseudopodium Source: UniProtKB
  4. pseudopodium membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Ras-related protein Rab-25PRO_0000121216Add
BLAST
Propeptidei211 – 2133Removed in mature form Reviewed predictionPRO_0000370822

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi209 – 2091S-geranylgeranyl cysteine By similarity
Modified residuei210 – 2101Cysteine methyl ester Reviewed prediction
Lipidationi210 – 2101S-geranylgeranyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ9WTL2.
PaxDbiQ9WTL2.
PRIDEiQ9WTL2.

PTM databases

PhosphoSiteiQ9WTL2.

Expressioni

Gene expression databases

ArrayExpressiQ9WTL2.
BgeeiQ9WTL2.
CleanExiMM_RAB25.
GenevestigatoriQ9WTL2.

Interactioni

Subunit structurei

Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. Interacts (via the hypervariable C-terminal region) with ITGB1 (via the cytoplasmic region); the interaction is GTP-dependent. Interacts with ITGAV. Associates with the integrin alpha-V/beta-1 heterodimer By similarity.

Protein-protein interaction databases

IntActiQ9WTL2. 1 interaction.
MINTiMINT-219202.

Structurei

3D structure databases

ProteinModelPortaliQ9WTL2.
SMRiQ9WTL2. Positions 10-178.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 499Effector region By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00710000106372.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ9WTL2.
KOiK07906.
OMAiMEEAKMF.
OrthoDBiEOG7SFHZ2.
PhylomeDBiQ9WTL2.
TreeFamiTF300099.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WTL2-1 [UniParc]FASTAAdd to Basket

« Hide

MGNRTDEDYN FVFKVVLIGE SGVGKTNLLS RFTRNEFSHD SRTTIGVEFS    50
TRTVMLGTAA VKAQIWDTAG LERYRAITSA YYRGAVGALL VFDLTKHQTY 100
AVVERWLKEL YDHAEATIVV MLVGNKSDLS QAREVPTEEA CMFAENNGLL 150
FLETSALDST NVELAFQTVL KEIFAKVSKQ KQNSTRTSAI TLGNAQAGQD 200
PGPGEKRACC ISL 213
Length:213
Mass (Da):23,473
Last modified:April 13, 2004 - v2
Checksum:i1359F7B4EA88D070
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti203 – 2031P → L in AAD39911. 1 Publication
Sequence conflicti203 – 2031P → L in AAD39912. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF119675 mRNA. Translation: AAD39911.1.
AF119676 Genomic DNA. Translation: AAD39912.1.
AK003260 mRNA. Translation: BAB22676.1.
BC006624 mRNA. Translation: AAH06624.1.
CCDSiCCDS17477.1.
RefSeqiNP_058595.2. NM_016899.4.
UniGeneiMm.26994.

Genome annotation databases

EnsembliENSMUST00000008745; ENSMUSP00000008745; ENSMUSG00000008601.
GeneIDi53868.
KEGGimmu:53868.
UCSCiuc008pvn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF119675 mRNA. Translation: AAD39911.1 .
AF119676 Genomic DNA. Translation: AAD39912.1 .
AK003260 mRNA. Translation: BAB22676.1 .
BC006624 mRNA. Translation: AAH06624.1 .
CCDSi CCDS17477.1.
RefSeqi NP_058595.2. NM_016899.4.
UniGenei Mm.26994.

3D structure databases

ProteinModelPortali Q9WTL2.
SMRi Q9WTL2. Positions 10-178.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9WTL2. 1 interaction.
MINTi MINT-219202.

PTM databases

PhosphoSitei Q9WTL2.

Proteomic databases

MaxQBi Q9WTL2.
PaxDbi Q9WTL2.
PRIDEi Q9WTL2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000008745 ; ENSMUSP00000008745 ; ENSMUSG00000008601 .
GeneIDi 53868.
KEGGi mmu:53868.
UCSCi uc008pvn.1. mouse.

Organism-specific databases

CTDi 57111.
MGIi MGI:1858203. Rab25.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00710000106372.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi Q9WTL2.
KOi K07906.
OMAi MEEAKMF.
OrthoDBi EOG7SFHZ2.
PhylomeDBi Q9WTL2.
TreeFami TF300099.

Miscellaneous databases

NextBioi 310713.
PROi Q9WTL2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9WTL2.
Bgeei Q9WTL2.
CleanExi MM_RAB25.
Genevestigatori Q9WTL2.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 15-25 AND 76-83, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiRAB25_MOUSE
AccessioniPrimary (citable) accession number: Q9WTL2
Secondary accession number(s): Q9D1P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: April 13, 2004
Last modified: July 9, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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