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Q9WTL2

- RAB25_MOUSE

UniProt

Q9WTL2 - RAB25_MOUSE

Protein

Ras-related protein Rab-25

Gene

Rab25

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (13 Apr 2004)
      Previous versions | rss
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    Functioni

    Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi19 – 279GTPBy similarity
    Nucleotide bindingi67 – 715GTPBy similarity
    Nucleotide bindingi125 – 1284GTPBy similarity
    Nucleotide bindingi155 – 1573GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. protein binding Source: MGI

    GO - Biological processi

    1. positive regulation of cell proliferation Source: UniProtKB
    2. protein transport Source: UniProtKB-KW
    3. pseudopodium organization Source: UniProtKB
    4. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-25
    Gene namesi
    Name:Rab25
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1858203. Rab25.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated. Cell projectionpseudopodium membrane By similarity. Cytoplasmic vesicle By similarity
    Note: Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips.By similarity

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    2. cytoplasmic vesicle Source: UniProtKB
    3. pseudopodium Source: UniProtKB
    4. pseudopodium membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasmic vesicle, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 210210Ras-related protein Rab-25PRO_0000121216Add
    BLAST
    Propeptidei211 – 2133Removed in mature formSequence AnalysisPRO_0000370822

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi209 – 2091S-geranylgeranyl cysteineBy similarity
    Modified residuei210 – 2101Cysteine methyl esterSequence Analysis
    Lipidationi210 – 2101S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    MaxQBiQ9WTL2.
    PaxDbiQ9WTL2.
    PRIDEiQ9WTL2.

    PTM databases

    PhosphoSiteiQ9WTL2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9WTL2.
    BgeeiQ9WTL2.
    CleanExiMM_RAB25.
    GenevestigatoriQ9WTL2.

    Interactioni

    Subunit structurei

    Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. Interacts (via the hypervariable C-terminal region) with ITGB1 (via the cytoplasmic region); the interaction is GTP-dependent. Interacts with ITGAV. Associates with the integrin alpha-V/beta-1 heterodimer By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ9WTL2. 1 interaction.
    MINTiMINT-219202.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WTL2.
    SMRiQ9WTL2. Positions 10-178.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi41 – 499Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00710000106372.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiQ9WTL2.
    KOiK07906.
    OMAiMEEAKMF.
    OrthoDBiEOG7SFHZ2.
    PhylomeDBiQ9WTL2.
    TreeFamiTF300099.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9WTL2-1 [UniParc]FASTAAdd to Basket

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    MGNRTDEDYN FVFKVVLIGE SGVGKTNLLS RFTRNEFSHD SRTTIGVEFS    50
    TRTVMLGTAA VKAQIWDTAG LERYRAITSA YYRGAVGALL VFDLTKHQTY 100
    AVVERWLKEL YDHAEATIVV MLVGNKSDLS QAREVPTEEA CMFAENNGLL 150
    FLETSALDST NVELAFQTVL KEIFAKVSKQ KQNSTRTSAI TLGNAQAGQD 200
    PGPGEKRACC ISL 213
    Length:213
    Mass (Da):23,473
    Last modified:April 13, 2004 - v2
    Checksum:i1359F7B4EA88D070
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti203 – 2031P → L in AAD39911. (PubMed:10708602)Curated
    Sequence conflicti203 – 2031P → L in AAD39912. (PubMed:10708602)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF119675 mRNA. Translation: AAD39911.1.
    AF119676 Genomic DNA. Translation: AAD39912.1.
    AK003260 mRNA. Translation: BAB22676.1.
    BC006624 mRNA. Translation: AAH06624.1.
    CCDSiCCDS17477.1.
    RefSeqiNP_058595.2. NM_016899.4.
    UniGeneiMm.26994.

    Genome annotation databases

    EnsembliENSMUST00000008745; ENSMUSP00000008745; ENSMUSG00000008601.
    GeneIDi53868.
    KEGGimmu:53868.
    UCSCiuc008pvn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF119675 mRNA. Translation: AAD39911.1 .
    AF119676 Genomic DNA. Translation: AAD39912.1 .
    AK003260 mRNA. Translation: BAB22676.1 .
    BC006624 mRNA. Translation: AAH06624.1 .
    CCDSi CCDS17477.1.
    RefSeqi NP_058595.2. NM_016899.4.
    UniGenei Mm.26994.

    3D structure databases

    ProteinModelPortali Q9WTL2.
    SMRi Q9WTL2. Positions 10-178.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9WTL2. 1 interaction.
    MINTi MINT-219202.

    PTM databases

    PhosphoSitei Q9WTL2.

    Proteomic databases

    MaxQBi Q9WTL2.
    PaxDbi Q9WTL2.
    PRIDEi Q9WTL2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000008745 ; ENSMUSP00000008745 ; ENSMUSG00000008601 .
    GeneIDi 53868.
    KEGGi mmu:53868.
    UCSCi uc008pvn.1. mouse.

    Organism-specific databases

    CTDi 57111.
    MGIi MGI:1858203. Rab25.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00710000106372.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi Q9WTL2.
    KOi K07906.
    OMAi MEEAKMF.
    OrthoDBi EOG7SFHZ2.
    PhylomeDBi Q9WTL2.
    TreeFami TF300099.

    Miscellaneous databases

    NextBioi 310713.
    PROi Q9WTL2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9WTL2.
    Bgeei Q9WTL2.
    CleanExi MM_RAB25.
    Genevestigatori Q9WTL2.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 15-25 AND 76-83, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiRAB25_MOUSE
    AccessioniPrimary (citable) accession number: Q9WTL2
    Secondary accession number(s): Q9D1P3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3