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Q9WTL2 (RAB25_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras-related protein Rab-25
Gene names
Name:Rab25
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis By similarity.

Subunit structure

Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. Interacts (via the hypervariable C-terminal region) with ITGB1 (via the cytoplasmic region); the interaction is GTP-dependent. Interacts with ITGAV. Associates with the integrin alpha-V/beta-1 heterodimer By similarity.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential. Cell projectionpseudopodium membrane By similarity. Cytoplasmic vesicle By similarity. Note: Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips By similarity.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 210210Ras-related protein Rab-25
PRO_0000121216
Propeptide211 – 2133Removed in mature form Potential
PRO_0000370822

Regions

Nucleotide binding19 – 279GTP By similarity
Nucleotide binding67 – 715GTP By similarity
Nucleotide binding125 – 1284GTP By similarity
Nucleotide binding155 – 1573GTP By similarity
Motif41 – 499Effector region By similarity

Amino acid modifications

Modified residue2101Cysteine methyl ester Potential
Lipidation2091S-geranylgeranyl cysteine By similarity
Lipidation2101S-geranylgeranyl cysteine By similarity

Experimental info

Sequence conflict2031P → L in AAD39911. Ref.1
Sequence conflict2031P → L in AAD39912. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9WTL2 [UniParc].

Last modified April 13, 2004. Version 2.
Checksum: 1359F7B4EA88D070

FASTA21323,473
        10         20         30         40         50         60 
MGNRTDEDYN FVFKVVLIGE SGVGKTNLLS RFTRNEFSHD SRTTIGVEFS TRTVMLGTAA 

        70         80         90        100        110        120 
VKAQIWDTAG LERYRAITSA YYRGAVGALL VFDLTKHQTY AVVERWLKEL YDHAEATIVV 

       130        140        150        160        170        180 
MLVGNKSDLS QAREVPTEEA CMFAENNGLL FLETSALDST NVELAFQTVL KEIFAKVSKQ 

       190        200        210 
KQNSTRTSAI TLGNAQAGQD PGPGEKRACC ISL 

« Hide

References

« Hide 'large scale' references
[1]"Genomic structure of murine rab11 family members."
Bhartur S.G., Calhoun B.C., Woodrum J., Kurkjian J., Iyer S., Lai F., Goldenring J.R.
Biochem. Biophys. Res. Commun. 269:611-617(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 15-25 AND 76-83, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF119675 mRNA. Translation: AAD39911.1.
AF119676 Genomic DNA. Translation: AAD39912.1.
AK003260 mRNA. Translation: BAB22676.1.
BC006624 mRNA. Translation: AAH06624.1.
RefSeqNP_058595.2. NM_016899.4.
UniGeneMm.26994.

3D structure databases

ProteinModelPortalQ9WTL2.
SMRQ9WTL2. Positions 10-178.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9WTL2. 1 interaction.
MINTMINT-219202.

PTM databases

PhosphoSiteQ9WTL2.

Proteomic databases

PaxDbQ9WTL2.
PRIDEQ9WTL2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000008745; ENSMUSP00000008745; ENSMUSG00000008601.
GeneID53868.
KEGGmmu:53868.
UCSCuc008pvn.1. mouse.

Organism-specific databases

CTD57111.
MGIMGI:1858203. Rab25.

Phylogenomic databases

eggNOGCOG1100.
GeneTreeENSGT00710000106372.
HOGENOMHOG000233968.
HOVERGENHBG009351.
InParanoidQ9WTL2.
KOK07906.
OMARTDEDYN.
OrthoDBEOG7SFHZ2.
PhylomeDBQ9WTL2.
TreeFamTF300099.

Gene expression databases

ArrayExpressQ9WTL2.
BgeeQ9WTL2.
CleanExMM_RAB25.
GenevestigatorQ9WTL2.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio310713.
PROQ9WTL2.
SOURCESearch...

Entry information

Entry nameRAB25_MOUSE
AccessionPrimary (citable) accession number: Q9WTL2
Secondary accession number(s): Q9D1P3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: April 13, 2004
Last modified: April 16, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot