ID   DEFB3_MOUSE             Reviewed;          63 AA.
AC   Q9WTL0; Q29R78;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   24-JAN-2024, entry version 136.
DE   RecName: Full=Beta-defensin 3;
DE            Short=BD-3;
DE            Short=mBD-3;
DE   AltName: Full=Defensin, beta 3;
DE   Flags: Precursor;
GN   Name=Defb3; Synonyms=Bd3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, INDUCTION, AND TISSUE
RP   SPECIFICITY.
RC   STRAIN=C57BL/6J; TISSUE=Lung;
RX   PubMed=10377137; DOI=10.1128/iai.67.7.3542-3547.1999;
RA   Bals R., Wang X., Meegalla R.L., Wattler S., Weiner D.J., Nehls M.C.,
RA   Wilson J.M.;
RT   "Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in
RT   the epithelia of multiple organs.";
RL   Infect. Immun. 67:3542-3547(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   TISSUE SPECIFICITY.
RC   STRAIN=129/SvJ, C57BL/6J, and FVB/NJ; TISSUE=Lung;
RX   PubMed=10922379; DOI=10.1074/jbc.m006603200;
RA   Jia H.P., Wowk S.A., Schutte B.C., Lee S.K., Vivado A., Tack B.F.,
RA   Bevins C.L., McCray P.B. Jr.;
RT   "A novel murine beta-defensin expressed in tongue, esophagus, and
RT   trachea.";
RL   J. Biol. Chem. 275:33314-33320(2000).
CC   -!- FUNCTION: Antimicrobial activity against Gram-negative bacteria E.coli
CC       and P.aeruginosa. {ECO:0000269|PubMed:10377137}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Highest expression in salivary glands, epididymis,
CC       ovary and pancreas and to a lesser extent in lung, liver and brain. Low
CC       or no expression in skeletal muscle and tongue.
CC       {ECO:0000269|PubMed:10377137, ECO:0000269|PubMed:10922379}.
CC   -!- INDUCTION: By bacterial infection. {ECO:0000269|PubMed:10377137}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. LAP/TAP subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF093245; AAD29573.1; -; Genomic_DNA.
DR   EMBL; AF092929; AAD29572.1; -; mRNA.
DR   EMBL; BC114344; AAI14345.1; -; mRNA.
DR   EMBL; BC116176; AAI16177.1; -; mRNA.
DR   EMBL; BC116177; AAI16178.1; -; mRNA.
DR   EMBL; BC134358; AAI34359.1; -; mRNA.
DR   CCDS; CCDS40258.1; -.
DR   RefSeq; NP_038784.1; NM_013756.2.
DR   AlphaFoldDB; Q9WTL0; -.
DR   SMR; Q9WTL0; -.
DR   STRING; 10090.ENSMUSP00000033852; -.
DR   TCDB; 1.C.85.1.8; the pore-forming Beta-defensin (Beta-defensin) family.
DR   PaxDb; 10090-ENSMUSP00000033852; -.
DR   ProteomicsDB; 279191; -.
DR   DNASU; 27358; -.
DR   Ensembl; ENSMUST00000033852.8; ENSMUSP00000033852.8; ENSMUSG00000039775.8.
DR   GeneID; 27358; -.
DR   KEGG; mmu:27358; -.
DR   UCSC; uc009lao.1; mouse.
DR   AGR; MGI:1351612; -.
DR   CTD; 27358; -.
DR   MGI; MGI:1351612; Defb3.
DR   VEuPathDB; HostDB:ENSMUSG00000039775; -.
DR   eggNOG; ENOG502T3P6; Eukaryota.
DR   GeneTree; ENSGT00940000160995; -.
DR   HOGENOM; CLU_189296_4_1_1; -.
DR   InParanoid; Q9WTL0; -.
DR   OMA; PGTKCCR; -.
DR   OrthoDB; 4840034at2759; -.
DR   PhylomeDB; Q9WTL0; -.
DR   BioGRID-ORCS; 27358; 2 hits in 76 CRISPR screens.
DR   PRO; PR:Q9WTL0; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q9WTL0; Protein.
DR   Bgee; ENSMUSG00000039775; Expressed in lip and 9 other cell types or tissues.
DR   GO; GO:0005615; C:extracellular space; ISO:MGI.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; ISO:MGI.
DR   GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR   GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; ISO:MGI.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IMP:MGI.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   PANTHER; PTHR20515; BETA-DEFENSIN; 1.
DR   PANTHER; PTHR20515:SF12; BETA-DEFENSIN 3-RELATED; 1.
DR   Pfam; PF00711; Defensin_beta; 1.
DR   SUPFAM; SSF57392; Defensin-like; 1.
DR   Genevisible; Q9WTL0; MM.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Cleavage on pair of basic residues; Defensin;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..22
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000006928"
FT   PEPTIDE         23..63
FT                   /note="Beta-defensin 3"
FT                   /id="PRO_0000006929"
FT   DISULFID        31..59
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..52
FT                   /evidence="ECO:0000250"
FT   DISULFID        42..60
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   63 AA;  7126 MW;  9D59BC8AD16EA330 CRC64;
     MRIHYLLFAF LLVLLSPPAA FSKKINNPVS CLRKGGRCWN RCIGNTRQIG SCGVPFLKCC
     KRK
//