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Protein

Beta-defensin 3

Gene

Defb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Antimicrobial activity against Gram-negative bacteria E.coli and P.aeruginosa.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 3
Short name:
BD-3
Short name:
mBD-3
Alternative name(s):
Defensin, beta 3
Gene namesi
Name:Defb3
Synonyms:Bd3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1351612. Defb3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Propeptidei21 – 222Sequence AnalysisPRO_0000006928
Peptidei23 – 6341Beta-defensin 3PRO_0000006929Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 59By similarity
Disulfide bondi38 ↔ 52By similarity
Disulfide bondi42 ↔ 60By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiQ9WTL0.

Expressioni

Tissue specificityi

Highest expression in salivary glands, epididymis, ovary and pancreas and to a lesser extent in lung, liver and brain. Low or no expression in skeletal muscle and tongue.2 Publications

Inductioni

By bacterial infection.1 Publication

Gene expression databases

BgeeiQ9WTL0.
CleanExiMM_DEFB3.
GenevisibleiQ9WTL0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033852.

Structurei

3D structure databases

ProteinModelPortaliQ9WTL0.
SMRiQ9WTL0. Positions 26-61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family. LAP/TAP subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG84369.
GeneTreeiENSGT00730000112127.
HOGENOMiHOG000015465.
HOVERGENiHBG004834.
InParanoidiQ9WTL0.
OMAiRCIGNTR.
OrthoDBiEOG757D1S.
PhylomeDBiQ9WTL0.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
IPR006080. Defensin_beta/neutrophil.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]
SMARTiSM00048. DEFSN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WTL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIHYLLFAF LLVLLSPPAA FSKKINNPVS CLRKGGRCWN RCIGNTRQIG
60
SCGVPFLKCC KRK
Length:63
Mass (Da):7,126
Last modified:November 1, 1999 - v1
Checksum:i9D59BC8AD16EA330
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093245 Genomic DNA. Translation: AAD29573.1.
AF092929 mRNA. Translation: AAD29572.1.
BC114344 mRNA. Translation: AAI14345.1.
BC116176 mRNA. Translation: AAI16177.1.
BC116177 mRNA. Translation: AAI16178.1.
BC134358 mRNA. Translation: AAI34359.1.
CCDSiCCDS40258.1.
RefSeqiNP_038784.1. NM_013756.2.
UniGeneiMm.103651.

Genome annotation databases

EnsembliENSMUST00000033852; ENSMUSP00000033852; ENSMUSG00000039775.
GeneIDi27358.
KEGGimmu:27358.
UCSCiuc009lao.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093245 Genomic DNA. Translation: AAD29573.1.
AF092929 mRNA. Translation: AAD29572.1.
BC114344 mRNA. Translation: AAI14345.1.
BC116176 mRNA. Translation: AAI16177.1.
BC116177 mRNA. Translation: AAI16178.1.
BC134358 mRNA. Translation: AAI34359.1.
CCDSiCCDS40258.1.
RefSeqiNP_038784.1. NM_013756.2.
UniGeneiMm.103651.

3D structure databases

ProteinModelPortaliQ9WTL0.
SMRiQ9WTL0. Positions 26-61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033852.

Proteomic databases

PRIDEiQ9WTL0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033852; ENSMUSP00000033852; ENSMUSG00000039775.
GeneIDi27358.
KEGGimmu:27358.
UCSCiuc009lao.1. mouse.

Organism-specific databases

CTDi27358.
MGIiMGI:1351612. Defb3.

Phylogenomic databases

eggNOGiNOG84369.
GeneTreeiENSGT00730000112127.
HOGENOMiHOG000015465.
HOVERGENiHBG004834.
InParanoidiQ9WTL0.
OMAiRCIGNTR.
OrthoDBiEOG757D1S.
PhylomeDBiQ9WTL0.

Miscellaneous databases

NextBioi305224.
PROiQ9WTL0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WTL0.
CleanExiMM_DEFB3.
GenevisibleiQ9WTL0. MM.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
IPR006080. Defensin_beta/neutrophil.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]
SMARTiSM00048. DEFSN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs."
    Bals R., Wang X., Meegalla R.L., Wattler S., Weiner D.J., Nehls M.C., Wilson J.M.
    Infect. Immun. 67:3542-3547(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "A novel murine beta-defensin expressed in tongue, esophagus, and trachea."
    Jia H.P., Wowk S.A., Schutte B.C., Lee S.K., Vivado A., Tack B.F., Bevins C.L., McCray P.B. Jr.
    J. Biol. Chem. 275:33314-33320(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
    Strain: 129/SvJ, C57BL/6 and FVB.
    Tissue: Lung.

Entry informationi

Entry nameiDEFB3_MOUSE
AccessioniPrimary (citable) accession number: Q9WTL0
Secondary accession number(s): Q29R78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1999
Last modified: June 24, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.