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Q9WTL0

- DEFB3_MOUSE

UniProt

Q9WTL0 - DEFB3_MOUSE

Protein

Beta-defensin 3

Gene

Defb3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Antimicrobial activity against Gram-negative bacteria E.coli and P.aeruginosa.1 Publication

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Defensin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-defensin 3
    Short name:
    BD-3
    Short name:
    mBD-3
    Alternative name(s):
    Defensin, beta 3
    Gene namesi
    Name:Defb3
    Synonyms:Bd3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1351612. Defb3.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Propeptidei21 – 222Sequence AnalysisPRO_0000006928
    Peptidei23 – 6341Beta-defensin 3PRO_0000006929Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 59By similarity
    Disulfide bondi38 ↔ 52By similarity
    Disulfide bondi42 ↔ 60By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PRIDEiQ9WTL0.

    Expressioni

    Tissue specificityi

    Highest expression in salivary glands, epididymis, ovary and pancreas and to a lesser extent in lung, liver and brain. Low or no expression in skeletal muscle and tongue.2 Publications

    Inductioni

    By bacterial infection.1 Publication

    Gene expression databases

    BgeeiQ9WTL0.
    CleanExiMM_DEFB3.
    GenevestigatoriQ9WTL0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WTL0.
    SMRiQ9WTL0. Positions 26-61.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-defensin family. LAP/TAP subfamily.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG84369.
    GeneTreeiENSGT00730000112127.
    HOGENOMiHOG000015465.
    HOVERGENiHBG004834.
    InParanoidiQ9WTL0.
    OMAiRCIGNTR.
    OrthoDBiEOG757D1S.
    PhylomeDBiQ9WTL0.

    Family and domain databases

    InterProiIPR001855. Defensin_beta-typ.
    IPR006080. Defensin_beta/neutrophil.
    [Graphical view]
    PfamiPF00711. Defensin_beta. 1 hit.
    [Graphical view]
    SMARTiSM00048. DEFSN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9WTL0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRIHYLLFAF LLVLLSPPAA FSKKINNPVS CLRKGGRCWN RCIGNTRQIG   50
    SCGVPFLKCC KRK 63
    Length:63
    Mass (Da):7,126
    Last modified:November 1, 1999 - v1
    Checksum:i9D59BC8AD16EA330
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF093245 Genomic DNA. Translation: AAD29573.1.
    AF092929 mRNA. Translation: AAD29572.1.
    BC114344 mRNA. Translation: AAI14345.1.
    BC116176 mRNA. Translation: AAI16177.1.
    BC116177 mRNA. Translation: AAI16178.1.
    BC134358 mRNA. Translation: AAI34359.1.
    CCDSiCCDS40258.1.
    RefSeqiNP_038784.1. NM_013756.2.
    UniGeneiMm.103651.

    Genome annotation databases

    EnsembliENSMUST00000033852; ENSMUSP00000033852; ENSMUSG00000039775.
    GeneIDi27358.
    KEGGimmu:27358.
    UCSCiuc009lao.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF093245 Genomic DNA. Translation: AAD29573.1 .
    AF092929 mRNA. Translation: AAD29572.1 .
    BC114344 mRNA. Translation: AAI14345.1 .
    BC116176 mRNA. Translation: AAI16177.1 .
    BC116177 mRNA. Translation: AAI16178.1 .
    BC134358 mRNA. Translation: AAI34359.1 .
    CCDSi CCDS40258.1.
    RefSeqi NP_038784.1. NM_013756.2.
    UniGenei Mm.103651.

    3D structure databases

    ProteinModelPortali Q9WTL0.
    SMRi Q9WTL0. Positions 26-61.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9WTL0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033852 ; ENSMUSP00000033852 ; ENSMUSG00000039775 .
    GeneIDi 27358.
    KEGGi mmu:27358.
    UCSCi uc009lao.1. mouse.

    Organism-specific databases

    CTDi 27358.
    MGIi MGI:1351612. Defb3.

    Phylogenomic databases

    eggNOGi NOG84369.
    GeneTreei ENSGT00730000112127.
    HOGENOMi HOG000015465.
    HOVERGENi HBG004834.
    InParanoidi Q9WTL0.
    OMAi RCIGNTR.
    OrthoDBi EOG757D1S.
    PhylomeDBi Q9WTL0.

    Miscellaneous databases

    NextBioi 305224.
    PROi Q9WTL0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9WTL0.
    CleanExi MM_DEFB3.
    Genevestigatori Q9WTL0.

    Family and domain databases

    InterProi IPR001855. Defensin_beta-typ.
    IPR006080. Defensin_beta/neutrophil.
    [Graphical view ]
    Pfami PF00711. Defensin_beta. 1 hit.
    [Graphical view ]
    SMARTi SM00048. DEFSN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs."
      Bals R., Wang X., Meegalla R.L., Wattler S., Weiner D.J., Nehls M.C., Wilson J.M.
      Infect. Immun. 67:3542-3547(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY.
      Strain: C57BL/6.
      Tissue: Lung.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "A novel murine beta-defensin expressed in tongue, esophagus, and trachea."
      Jia H.P., Wowk S.A., Schutte B.C., Lee S.K., Vivado A., Tack B.F., Bevins C.L., McCray P.B. Jr.
      J. Biol. Chem. 275:33314-33320(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
      Strain: 129/SvJ, C57BL/6 and FVB.
      Tissue: Lung.

    Entry informationi

    Entry nameiDEFB3_MOUSE
    AccessioniPrimary (citable) accession number: Q9WTL0
    Secondary accession number(s): Q29R78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3