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Protein

Beta-defensin 3

Gene

Defb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Antimicrobial activity against Gram-negative bacteria E.coli and P.aeruginosa.1 Publication

GO - Biological processi

  • defense response to bacterium Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Protein family/group databases

TCDBi1.C.85.1.8. the pore-forming -defensin (-defensin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 3
Short name:
BD-3
Short name:
mBD-3
Alternative name(s):
Defensin, beta 3
Gene namesi
Name:Defb3
Synonyms:Bd3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1351612. Defb3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Propeptidei21 – 222Sequence analysisPRO_0000006928
Peptidei23 – 6341Beta-defensin 3PRO_0000006929Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 59By similarity
Disulfide bondi38 ↔ 52By similarity
Disulfide bondi42 ↔ 60By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ9WTL0.
PRIDEiQ9WTL0.

Expressioni

Tissue specificityi

Highest expression in salivary glands, epididymis, ovary and pancreas and to a lesser extent in lung, liver and brain. Low or no expression in skeletal muscle and tongue.2 Publications

Inductioni

By bacterial infection.1 Publication

Gene expression databases

BgeeiENSMUSG00000039775.
CleanExiMM_DEFB3.
GenevisibleiQ9WTL0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033852.

Structurei

3D structure databases

ProteinModelPortaliQ9WTL0.
SMRiQ9WTL0. Positions 26-61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family. LAP/TAP subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00830000129362.
HOGENOMiHOG000015465.
HOVERGENiHBG004834.
InParanoidiQ9WTL0.
OMAiRCIGNTR.
OrthoDBiEOG091G1ANZ.
PhylomeDBiQ9WTL0.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WTL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIHYLLFAF LLVLLSPPAA FSKKINNPVS CLRKGGRCWN RCIGNTRQIG
60
SCGVPFLKCC KRK
Length:63
Mass (Da):7,126
Last modified:November 1, 1999 - v1
Checksum:i9D59BC8AD16EA330
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093245 Genomic DNA. Translation: AAD29573.1.
AF092929 mRNA. Translation: AAD29572.1.
BC114344 mRNA. Translation: AAI14345.1.
BC116176 mRNA. Translation: AAI16177.1.
BC116177 mRNA. Translation: AAI16178.1.
BC134358 mRNA. Translation: AAI34359.1.
CCDSiCCDS40258.1.
RefSeqiNP_038784.1. NM_013756.2.
UniGeneiMm.103651.

Genome annotation databases

EnsembliENSMUST00000033852; ENSMUSP00000033852; ENSMUSG00000039775.
GeneIDi27358.
KEGGimmu:27358.
UCSCiuc009lao.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093245 Genomic DNA. Translation: AAD29573.1.
AF092929 mRNA. Translation: AAD29572.1.
BC114344 mRNA. Translation: AAI14345.1.
BC116176 mRNA. Translation: AAI16177.1.
BC116177 mRNA. Translation: AAI16178.1.
BC134358 mRNA. Translation: AAI34359.1.
CCDSiCCDS40258.1.
RefSeqiNP_038784.1. NM_013756.2.
UniGeneiMm.103651.

3D structure databases

ProteinModelPortaliQ9WTL0.
SMRiQ9WTL0. Positions 26-61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033852.

Protein family/group databases

TCDBi1.C.85.1.8. the pore-forming -defensin (-defensin) family.

Proteomic databases

PaxDbiQ9WTL0.
PRIDEiQ9WTL0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033852; ENSMUSP00000033852; ENSMUSG00000039775.
GeneIDi27358.
KEGGimmu:27358.
UCSCiuc009lao.1. mouse.

Organism-specific databases

CTDi27358.
MGIiMGI:1351612. Defb3.

Phylogenomic databases

GeneTreeiENSGT00830000129362.
HOGENOMiHOG000015465.
HOVERGENiHBG004834.
InParanoidiQ9WTL0.
OMAiRCIGNTR.
OrthoDBiEOG091G1ANZ.
PhylomeDBiQ9WTL0.

Miscellaneous databases

PROiQ9WTL0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039775.
CleanExiMM_DEFB3.
GenevisibleiQ9WTL0. MM.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEFB3_MOUSE
AccessioniPrimary (citable) accession number: Q9WTL0
Secondary accession number(s): Q29R78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.