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Q9WTL0 (DEFB3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-defensin 3

Short name=BD-3
Short name=mBD-3
Alternative name(s):
Defensin, beta 3
Gene names
Name:Defb3
Synonyms:Bd3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length63 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Antimicrobial activity against Gram-negative bacteria E.coli and P.aeruginosa. Ref.1

Subcellular location

Secreted.

Tissue specificity

Highest expression in salivary glands, epididymis, ovary and pancreas and to a lesser extent in lung, liver and brain. Low or no expression in skeletal muscle and tongue. Ref.1 Ref.3

Induction

By bacterial infection. Ref.1

Sequence similarities

Belongs to the beta-defensin family. LAP/TAP subfamily.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionAntibiotic
Antimicrobial
Defensin
   PTMCleavage on pair of basic residues
Disulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdefense response to bacterium

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Propeptide21 – 222 Potential
PRO_0000006928
Peptide23 – 6341Beta-defensin 3
PRO_0000006929

Amino acid modifications

Disulfide bond31 ↔ 59 By similarity
Disulfide bond38 ↔ 52 By similarity
Disulfide bond42 ↔ 60 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9WTL0 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 9D59BC8AD16EA330

FASTA637,126
        10         20         30         40         50         60 
MRIHYLLFAF LLVLLSPPAA FSKKINNPVS CLRKGGRCWN RCIGNTRQIG SCGVPFLKCC 


KRK 

« Hide

References

« Hide 'large scale' references
[1]"Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs."
Bals R., Wang X., Meegalla R.L., Wattler S., Weiner D.J., Nehls M.C., Wilson J.M.
Infect. Immun. 67:3542-3547(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY.
Strain: C57BL/6.
Tissue: Lung.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"A novel murine beta-defensin expressed in tongue, esophagus, and trachea."
Jia H.P., Wowk S.A., Schutte B.C., Lee S.K., Vivado A., Tack B.F., Bevins C.L., McCray P.B. Jr.
J. Biol. Chem. 275:33314-33320(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
Strain: 129/SvJ, C57BL/6 and FVB.
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF093245 Genomic DNA. Translation: AAD29573.1.
AF092929 mRNA. Translation: AAD29572.1.
BC114344 mRNA. Translation: AAI14345.1.
BC116176 mRNA. Translation: AAI16177.1.
BC116177 mRNA. Translation: AAI16178.1.
BC134358 mRNA. Translation: AAI34359.1.
RefSeqNP_038784.1. NM_013756.2.
UniGeneMm.103651.

3D structure databases

ProteinModelPortalQ9WTL0.
SMRQ9WTL0. Positions 26-61.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9WTL0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033852; ENSMUSP00000033852; ENSMUSG00000039775.
GeneID27358.
KEGGmmu:27358.
UCSCuc009lao.1. mouse.

Organism-specific databases

CTD27358.
MGIMGI:1351612. Defb3.

Phylogenomic databases

eggNOGNOG84369.
GeneTreeENSGT00730000112127.
HOGENOMHOG000015465.
HOVERGENHBG004834.
InParanoidQ9WTL0.
OMAMPLPGVF.
OrthoDBEOG757D1S.
PhylomeDBQ9WTL0.

Gene expression databases

BgeeQ9WTL0.
CleanExMM_DEFB3.
GenevestigatorQ9WTL0.

Family and domain databases

InterProIPR001855. Defensin_beta-typ.
IPR006080. Defensin_beta/neutrophil.
[Graphical view]
PfamPF00711. Defensin_beta. 1 hit.
[Graphical view]
SMARTSM00048. DEFSN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio305224.
PROQ9WTL0.
SOURCESearch...

Entry information

Entry nameDEFB3_MOUSE
AccessionPrimary (citable) accession number: Q9WTL0
Secondary accession number(s): Q29R78
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot