Q9WTL0 (DEFB3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-defensin 3
Short name=BD-3
Short name=mBD-3

Alternative name(s):
Defensin, beta 3

Gene names

Name:	Defb3
Synonyms:	Bd3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	63 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Antimicrobial activity against Gram-negative bacteria E.coli and P.aeruginosa. Ref.1
Subcellular location	Secreted.
Tissue specificity	Highest expression in salivary glands, epididymis, ovary and pancreas and to a lesser extent in lung, liver and brain. Low or no expression in skeletal muscle and tongue. Ref.1 Ref.3
Induction	By bacterial infection. Ref.1
Sequence similarities	Belongs to the beta-defensin family. LAP/TAP subfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial Defensin
PTM	Cleavage on pair of basic residues Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Propeptide	21 – 22	2	Potential		PRO_0000006928
	Peptide	23 – 63	41	Beta-defensin 3		PRO_0000006929
Amino acid modifications
	Disulfide bond	31 ↔ 59		By similarity
	Disulfide bond	38 ↔ 52		By similarity
	Disulfide bond	42 ↔ 60		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9WTL0 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 9D59BC8AD16EA330	FASTA	63	7,126
	10 20 30 40 50 60 MRIHYLLFAF LLVLLSPPAA FSKKINNPVS CLRKGGRCWN RCIGNTRQIG SCGVPFLKCC KRK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs." Bals R., Wang X., Meegalla R.L., Wattler S., Weiner D.J., Nehls M.C., Wilson J.M. Infect. Immun. 67:3542-3547(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY. Strain: C57BL/6. Tissue: Lung.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"A novel murine beta-defensin expressed in tongue, esophagus, and trachea." Jia H.P., Wowk S.A., Schutte B.C., Lee S.K., Vivado A., Tack B.F., Bevins C.L., McCray P.B. Jr. J. Biol. Chem. 275:33314-33320(2000) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY. Strain: 129/SvJ, C57BL/6 and FVB. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF093245 Genomic DNA. Translation: AAD29573.1. AF092929 mRNA. Translation: AAD29572.1. BC114344 mRNA. Translation: AAI14345.1. BC116176 mRNA. Translation: AAI16177.1. BC116177 mRNA. Translation: AAI16178.1. BC134358 mRNA. Translation: AAI34359.1.
IPI	IPI00123512.
RefSeq	NP_038784.1. NM_013756.2.
UniGene	Mm.103651.
3D structure databases
ProteinModelPortal	Q9WTL0.
SMR	Q9WTL0. Positions 26-61.
ModBase	Search...
Proteomic databases
PRIDE	Q9WTL0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000033852; ENSMUSP00000033852; ENSMUSG00000039775.
GeneID	27358.
KEGG	mmu:27358.
UCSC	uc009lao.1. mouse.
Organism-specific databases
CTD	27358.
MGI	MGI:1351612. Defb3.
Phylogenomic databases
eggNOG	NOG84369.
GeneTree	ENSGT00530000064490.
HOGENOM	HOG000015465.
HOVERGEN	HBG004834.
InParanoid	Q9WTL0.
OMA	RCIGNTR.
OrthoDB	EOG4WM4WG.
Gene expression databases
Bgee	Q9WTL0.
CleanEx	MM_DEFB3.
Genevestigator	Q9WTL0.
GermOnline	ENSMUSG00000039775. Mus musculus.
Family and domain databases
InterPro	IPR001855. Defensin_beta-typ. IPR006080. Defensin_beta/neutrophil. [Graphical view]
Pfam	PF00711. Defensin_beta. 1 hit. [Graphical view]
SMART	SM00048. DEFSN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	305224.
SOURCE	Search...

Entry information

Entry name

DEFB3_MOUSE

Accession

Primary (citable) accession number: Q9WTL0
Secondary accession number(s): Q29R78

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	November 1, 1999
Last modified:	April 3, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program