SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9WTL0

- DEFB3_MOUSE

UniProt

Q9WTL0 - DEFB3_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Beta-defensin 3

Gene
Defb3, Bd3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Antimicrobial activity against Gram-negative bacteria E.coli and P.aeruginosa.1 Publication

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 3
Short name:
BD-3
Short name:
mBD-3
Alternative name(s):
Defensin, beta 3
Gene namesi
Name:Defb3
Synonyms:Bd3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1351612. Defb3.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Propeptidei21 – 222 Reviewed predictionPRO_0000006928
Peptidei23 – 6341Beta-defensin 3PRO_0000006929Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 59 By similarity
Disulfide bondi38 ↔ 52 By similarity
Disulfide bondi42 ↔ 60 By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiQ9WTL0.

Expressioni

Tissue specificityi

Highest expression in salivary glands, epididymis, ovary and pancreas and to a lesser extent in lung, liver and brain. Low or no expression in skeletal muscle and tongue.2 Publications

Inductioni

By bacterial infection.1 Publication

Gene expression databases

BgeeiQ9WTL0.
CleanExiMM_DEFB3.
GenevestigatoriQ9WTL0.

Structurei

3D structure databases

ProteinModelPortaliQ9WTL0.
SMRiQ9WTL0. Positions 26-61.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG84369.
GeneTreeiENSGT00730000112127.
HOGENOMiHOG000015465.
HOVERGENiHBG004834.
InParanoidiQ9WTL0.
OMAiRCIGNTR.
OrthoDBiEOG757D1S.
PhylomeDBiQ9WTL0.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
IPR006080. Defensin_beta/neutrophil.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]
SMARTiSM00048. DEFSN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WTL0-1 [UniParc]FASTAAdd to Basket

« Hide

MRIHYLLFAF LLVLLSPPAA FSKKINNPVS CLRKGGRCWN RCIGNTRQIG   50
SCGVPFLKCC KRK 63
Length:63
Mass (Da):7,126
Last modified:November 1, 1999 - v1
Checksum:i9D59BC8AD16EA330
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF093245 Genomic DNA. Translation: AAD29573.1.
AF092929 mRNA. Translation: AAD29572.1.
BC114344 mRNA. Translation: AAI14345.1.
BC116176 mRNA. Translation: AAI16177.1.
BC116177 mRNA. Translation: AAI16178.1.
BC134358 mRNA. Translation: AAI34359.1.
CCDSiCCDS40258.1.
RefSeqiNP_038784.1. NM_013756.2.
UniGeneiMm.103651.

Genome annotation databases

EnsembliENSMUST00000033852; ENSMUSP00000033852; ENSMUSG00000039775.
GeneIDi27358.
KEGGimmu:27358.
UCSCiuc009lao.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF093245 Genomic DNA. Translation: AAD29573.1 .
AF092929 mRNA. Translation: AAD29572.1 .
BC114344 mRNA. Translation: AAI14345.1 .
BC116176 mRNA. Translation: AAI16177.1 .
BC116177 mRNA. Translation: AAI16178.1 .
BC134358 mRNA. Translation: AAI34359.1 .
CCDSi CCDS40258.1.
RefSeqi NP_038784.1. NM_013756.2.
UniGenei Mm.103651.

3D structure databases

ProteinModelPortali Q9WTL0.
SMRi Q9WTL0. Positions 26-61.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9WTL0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033852 ; ENSMUSP00000033852 ; ENSMUSG00000039775 .
GeneIDi 27358.
KEGGi mmu:27358.
UCSCi uc009lao.1. mouse.

Organism-specific databases

CTDi 27358.
MGIi MGI:1351612. Defb3.

Phylogenomic databases

eggNOGi NOG84369.
GeneTreei ENSGT00730000112127.
HOGENOMi HOG000015465.
HOVERGENi HBG004834.
InParanoidi Q9WTL0.
OMAi RCIGNTR.
OrthoDBi EOG757D1S.
PhylomeDBi Q9WTL0.

Miscellaneous databases

NextBioi 305224.
PROi Q9WTL0.
SOURCEi Search...

Gene expression databases

Bgeei Q9WTL0.
CleanExi MM_DEFB3.
Genevestigatori Q9WTL0.

Family and domain databases

InterProi IPR001855. Defensin_beta-typ.
IPR006080. Defensin_beta/neutrophil.
[Graphical view ]
Pfami PF00711. Defensin_beta. 1 hit.
[Graphical view ]
SMARTi SM00048. DEFSN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs."
    Bals R., Wang X., Meegalla R.L., Wattler S., Weiner D.J., Nehls M.C., Wilson J.M.
    Infect. Immun. 67:3542-3547(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "A novel murine beta-defensin expressed in tongue, esophagus, and trachea."
    Jia H.P., Wowk S.A., Schutte B.C., Lee S.K., Vivado A., Tack B.F., Bevins C.L., McCray P.B. Jr.
    J. Biol. Chem. 275:33314-33320(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
    Strain: 129/SvJ, C57BL/6 and FVB.
    Tissue: Lung.

Entry informationi

Entry nameiDEFB3_MOUSE
AccessioniPrimary (citable) accession number: Q9WTL0
Secondary accession number(s): Q29R78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi