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Q9WTK2

- CDYL_MOUSE

UniProt

Q9WTK2 - CDYL_MOUSE

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Protein

Chromodomain Y-like protein

Gene

Cdyl

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Acts as a RE1-silencing transcription factor (REST) corepressor that facilitates histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Required for chromatin targeting and maximal enzymatic activity of polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (By similarity). Has histone acetyltransferase activity. May play a role in histone hyperacetylation during spermatid maturation.By similarity2 Publications

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC
  2. methylated histone binding Source: UniProtKB
  3. transcription corepressor activity Source: UniProtKB

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Chromodomain Y-like protein (EC:2.3.1.48)
Short name:
CDY-like
Gene namesi
Name:Cdyl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1339956. Cdyl.

Subcellular locationi

Nucleus 2 Publications

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi516 – 5161S → A: Abolishes CoA-binding. No effect on transcriptional repressor activity. 1 Publication
Mutagenesisi588 – 5892RK → AA: Abolishes CoA-binding. No effect on transcriptional repressor activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 593593Chromodomain Y-like proteinPRO_0000080222Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei130 – 1301N6,N6,N6-trimethyllysine; by EHMT2; alternateBy similarity
Modified residuei130 – 1301N6,N6-dimethyllysine; by EHMT2; alternateBy similarity
Modified residuei130 – 1301N6-methyllysine; by EHMT2; alternateBy similarity

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiQ9WTK2.
PaxDbiQ9WTK2.
PRIDEiQ9WTK2.

PTM databases

PhosphoSiteiQ9WTK2.

Expressioni

Tissue specificityi

Highly expressed in testis (at protein level). Expressed as 2 transcripts: a ubiquitous transcript and a highly expressed testis-specific transcript.

Developmental stagei

Highly expressed in elongating spermatids during histone hyperacetylation.2 Publications

Gene expression databases

BgeeiQ9WTK2.
CleanExiMM_CDYL.
ExpressionAtlasiQ9WTK2. baseline and differential.
GenevestigatoriQ9WTK2.

Interactioni

Subunit structurei

Forms multimers and multimerization is required for stable binding to chromatin. Interacts with histone H3K9me3, histone H3K27me2 and histone H3K27me3. Interacts with EZH2, EED, SUZ12, REST, EHMT1 and EHMT2. Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2. Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2 (By similarity). Interacts with HDAC1 and HDAC2 via its C-terminal acetyl-CoA-binding domain.By similarity1 Publication

Protein-protein interaction databases

IntActiQ9WTK2. 1 interaction.
MINTiMINT-4090565.

Structurei

3D structure databases

ProteinModelPortaliQ9WTK2.
SMRiQ9WTK2. Positions 57-114, 336-593.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 11661ChromoPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni56 – 304249Interaction with EZH2By similarityAdd
BLAST

Sequence similaritiesi

Contains 1 chromo domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1024.
GeneTreeiENSGT00760000119100.
HOGENOMiHOG000111507.
HOVERGENiHBG006723.
InParanoidiQ9WTK2.
OMAiIHDFNRR.
OrthoDBiEOG72RN06.
PhylomeDBiQ9WTK2.
TreeFamiTF313375.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9WTK2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGIGNSQPNS QEAQLCTLPE KAEQPTDDNT CQQNNVVPAT VSEPDQASPA
60 70 80 90 100
IQDAETQVES IVDKRKNKKG KTEYLVRWKG YDSEDDTWEP EQHLVNCEEY
110 120 130 140 150
IHDFNRRHNE RQKEGSLARA SRASPSNARK QISRSTHSTL SKTNSKALVV
160 170 180 190 200
GKDHESKSSQ LLAASQKFRK NPAPSLANRK NMDLAKSGIK ILVPKSPVKG
210 220 230 240 250
RTSVDGFQGE SPEKLDPVDQ GAEDTVAPEV TAEKPTGALL GPGAERARMG
260 270 280 290 300
SRPRIHPLVP QVSGPVTAAM ATGLAVNGKG TSPFMDALAA NGTVTIQTSV
310 320 330 340 350
TGVTAGKRKF IDDRRDQPFD KRLRFSVRQT ESAYRYRDIV VRKQDGFTHI
360 370 380 390 400
LLSTKSSENN SLNPEVMKEV QSALSTAAAD DSKLVLLSAV GSVFCCGLDF
410 420 430 440 450
IYFIRRLTDD RKRESTKMAD AIRNFVNTFI QFKKPIIVAV NGPAIGLGAS
460 470 480 490 500
ILPLCDVVWA NEKAWFQTPY TTFGQSPDGC STVMFPKIMG GASANEMLFS
510 520 530 540 550
GRKLTAQEAC GKGLVSQVFW PGTFTQEVMV RIKELASCNP VVLEESKALV
560 570 580 590
RCNMKMELEQ ANERECEVLK KIWGSAQGMD SMLKYLQRKI DEF
Length:593
Mass (Da):65,211
Last modified:November 1, 1999 - v1
Checksum:i470D5B97D7E52CCA
GO
Isoform 2 (identifier: Q9WTK2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.
     50-57: AIQDAETQ → MASEELYE

Show »
Length:544
Mass (Da):60,142
Checksum:iB8E3B85969ED9103
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti489 – 4891M → I in BAE33739. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4949Missing in isoform 2. 2 PublicationsVSP_026385Add
BLAST
Alternative sequencei50 – 578AIQDAETQ → MASEELYE in isoform 2. 2 PublicationsVSP_026386

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081260 mRNA. Translation: AAD22736.1.
AF081261 mRNA. Translation: AAD22737.1.
AK156509 mRNA. Translation: BAE33739.1.
BC055103 mRNA. Translation: AAH55103.1.
BC062123 mRNA. Translation: AAH62123.1.
CCDSiCCDS49235.1. [Q9WTK2-1]
CCDS49236.1. [Q9WTK2-2]
RefSeqiNP_001116858.1. NM_001123386.1. [Q9WTK2-2]
NP_034011.1. NM_009881.3. [Q9WTK2-1]
UniGeneiMm.29002.

Genome annotation databases

EnsembliENSMUST00000075220; ENSMUSP00000074707; ENSMUSG00000059288. [Q9WTK2-1]
ENSMUST00000163595; ENSMUSP00000131784; ENSMUSG00000059288. [Q9WTK2-2]
GeneIDi12593.
KEGGimmu:12593.
UCSCiuc007qce.2. mouse. [Q9WTK2-1]
uc007qcg.2. mouse. [Q9WTK2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081260 mRNA. Translation: AAD22736.1 .
AF081261 mRNA. Translation: AAD22737.1 .
AK156509 mRNA. Translation: BAE33739.1 .
BC055103 mRNA. Translation: AAH55103.1 .
BC062123 mRNA. Translation: AAH62123.1 .
CCDSi CCDS49235.1. [Q9WTK2-1 ]
CCDS49236.1. [Q9WTK2-2 ]
RefSeqi NP_001116858.1. NM_001123386.1. [Q9WTK2-2 ]
NP_034011.1. NM_009881.3. [Q9WTK2-1 ]
UniGenei Mm.29002.

3D structure databases

ProteinModelPortali Q9WTK2.
SMRi Q9WTK2. Positions 57-114, 336-593.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9WTK2. 1 interaction.
MINTi MINT-4090565.

PTM databases

PhosphoSitei Q9WTK2.

Proteomic databases

MaxQBi Q9WTK2.
PaxDbi Q9WTK2.
PRIDEi Q9WTK2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000075220 ; ENSMUSP00000074707 ; ENSMUSG00000059288 . [Q9WTK2-1 ]
ENSMUST00000163595 ; ENSMUSP00000131784 ; ENSMUSG00000059288 . [Q9WTK2-2 ]
GeneIDi 12593.
KEGGi mmu:12593.
UCSCi uc007qce.2. mouse. [Q9WTK2-1 ]
uc007qcg.2. mouse. [Q9WTK2-2 ]

Organism-specific databases

CTDi 9425.
MGIi MGI:1339956. Cdyl.

Phylogenomic databases

eggNOGi COG1024.
GeneTreei ENSGT00760000119100.
HOGENOMi HOG000111507.
HOVERGENi HBG006723.
InParanoidi Q9WTK2.
OMAi IHDFNRR.
OrthoDBi EOG72RN06.
PhylomeDBi Q9WTK2.
TreeFami TF313375.

Miscellaneous databases

NextBioi 281746.
PROi Q9WTK2.
SOURCEi Search...

Gene expression databases

Bgeei Q9WTK2.
CleanExi MM_CDYL.
ExpressionAtlasi Q9WTK2. baseline and differential.
Genevestigatori Q9WTK2.

Family and domain databases

Gene3Di 3.90.226.10. 1 hit.
InterProi IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
[Graphical view ]
Pfami PF00385. Chromo. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view ]
SMARTi SM00298. CHROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF52096. SSF52096. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEi PS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome."
    Lahn B.T., Page D.C.
    Nat. Genet. 21:429-433(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: NOD.
    Tissue: Spleen.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis.
  4. "Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis."
    Lahn B.T., Tang Z.L., Zhou J., Barndt R.J., Parvinen M., Allis C.D., Page D.C.
    Proc. Natl. Acad. Sci. U.S.A. 99:8707-8712(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, ALTERNATIVE SPLICING.
  5. Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, INTERACTION WITH HDAC1 AND HDAC2, MUTAGENESIS OF SER-516 AND 588-ARG-LYS-589.

Entry informationi

Entry nameiCDYL_MOUSE
AccessioniPrimary (citable) accession number: Q9WTK2
Secondary accession number(s): Q3U0W2, Q6P6N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Interaction with HDAC1 or HDAC2 prevents coenzyme A binding.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3