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Protein

Receptor activity-modifying protein 1

Gene

Ramp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-419812. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor activity-modifying protein 1
Gene namesi
Name:Ramp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1858418. Ramp1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 11791ExtracellularSequence analysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence analysisAdd
BLAST
Topological domaini139 – 14810CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 148122Receptor activity-modifying protein 1PRO_0000030169Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 82By similarity
Disulfide bondi40 ↔ 72By similarity
Disulfide bondi57 ↔ 104By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ9WTJ5.
MaxQBiQ9WTJ5.
PaxDbiQ9WTJ5.
PRIDEiQ9WTJ5.

PTM databases

iPTMnetiQ9WTJ5.

Expressioni

Tissue specificityi

Expressed predominantly in the thymus, skeletal muscle, embryonic and adult brain, embryonic and adult lung, and colon.3 Publications

Gene expression databases

BgeeiQ9WTJ5.
ExpressionAtlasiQ9WTJ5. baseline and differential.
GenevisibleiQ9WTJ5. MM.

Interactioni

Subunit structurei

Heterodimer of CALCRL and RAMP1.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095253.

Structurei

3D structure databases

ProteinModelPortaliQ9WTJ5.
SMRiQ9WTJ5. Positions 31-110.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RAMP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZHQ. Eukaryota.
ENOG4111NGJ. LUCA.
GeneTreeiENSGT00390000016200.
HOGENOMiHOG000253018.
HOVERGENiHBG061268.
InParanoidiQ9WTJ5.
KOiK08447.
OMAiWRSKRPE.
OrthoDBiEOG7ZKSD3.
PhylomeDBiQ9WTJ5.
TreeFamiTF333286.

Family and domain databases

InterProiIPR006985. RAMP.
[Graphical view]
PANTHERiPTHR14076. PTHR14076. 1 hit.
PfamiPF04901. RAMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WTJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPGLRGLPR CGLWLLLAHH LFMVTACRDP DYGTLIQELC LSRFKENMET
60 70 80 90 100
IGKTLWCDWG KTIQSYGELT YCTKHVAHTI GCFWPNPEVD RFFIAVHHRY
110 120 130 140
FSKCPISGRA LRDPPNSILC PFIALPITVT LLMTALVVWR SKRTEGIV
Length:148
Mass (Da):16,892
Last modified:November 1, 1999 - v1
Checksum:i5EC97385EA11DF97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019046 mRNA. Translation: BAA76617.1.
AF146522 mRNA. Translation: AAD35018.1.
AJ250489 mRNA. Translation: CAB59511.1.
AF209904 mRNA. Translation: AAF21036.1.
BC012644 mRNA. Translation: AAH12644.1.
CCDSiCCDS15158.1.
PIRiJC7261.
RefSeqiNP_058590.1. NM_016894.3.
UniGeneiMm.3272.

Genome annotation databases

EnsembliENSMUST00000097648; ENSMUSP00000095253; ENSMUSG00000034353.
GeneIDi51801.
KEGGimmu:51801.
UCSCiuc007bzx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019046 mRNA. Translation: BAA76617.1.
AF146522 mRNA. Translation: AAD35018.1.
AJ250489 mRNA. Translation: CAB59511.1.
AF209904 mRNA. Translation: AAF21036.1.
BC012644 mRNA. Translation: AAH12644.1.
CCDSiCCDS15158.1.
PIRiJC7261.
RefSeqiNP_058590.1. NM_016894.3.
UniGeneiMm.3272.

3D structure databases

ProteinModelPortaliQ9WTJ5.
SMRiQ9WTJ5. Positions 31-110.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095253.

PTM databases

iPTMnetiQ9WTJ5.

Proteomic databases

EPDiQ9WTJ5.
MaxQBiQ9WTJ5.
PaxDbiQ9WTJ5.
PRIDEiQ9WTJ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097648; ENSMUSP00000095253; ENSMUSG00000034353.
GeneIDi51801.
KEGGimmu:51801.
UCSCiuc007bzx.2. mouse.

Organism-specific databases

CTDi10267.
MGIiMGI:1858418. Ramp1.

Phylogenomic databases

eggNOGiENOG410IZHQ. Eukaryota.
ENOG4111NGJ. LUCA.
GeneTreeiENSGT00390000016200.
HOGENOMiHOG000253018.
HOVERGENiHBG061268.
InParanoidiQ9WTJ5.
KOiK08447.
OMAiWRSKRPE.
OrthoDBiEOG7ZKSD3.
PhylomeDBiQ9WTJ5.
TreeFamiTF333286.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-419812. Calcitonin-like ligand receptors.

Miscellaneous databases

PROiQ9WTJ5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9WTJ5.
ExpressionAtlasiQ9WTJ5. baseline and differential.
GenevisibleiQ9WTJ5. MM.

Family and domain databases

InterProiIPR006985. RAMP.
[Graphical view]
PANTHERiPTHR14076. PTHR14076. 1 hit.
PfamiPF04901. RAMP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of mouse calcitonin gene-related peptide receptor."
    Miyauchi K., Tadotsu N., Hayashi T., Ono Y., Tokoyoda K., Tsujikawa K., Yamamoto H.
    Neuropeptides 36:22-33(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Spleen.
  2. "Cloning and sequencing of mouse CGRP/adrenomedullin receptor subunits."
    Derst C., Preisig-Mueller R., Gerhardus J., Daut J.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid sequence, expression and function."
    Husmann K., Sexton P.M., Fischer J.A., Born W.
    Mol. Cell. Endocrinol. 162:35-43(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  4. "Decreased gene expression of adrenomedullin receptor in mouse lungs during sepsis."
    Ono Y., Okano I., Kojima M., Okada K., Kangawa K.
    Biochem. Biophys. Res. Commun. 271:197-202(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Brain.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiRAMP1_MOUSE
AccessioniPrimary (citable) accession number: Q9WTJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: November 1, 1999
Last modified: June 8, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.