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Protein

Receptor activity-modifying protein 1

Gene

Ramp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-419812. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor activity-modifying protein 1
Gene namesi
Name:Ramp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1858418. Ramp1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 117ExtracellularSequence analysisAdd BLAST91
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 148CytoplasmicSequence analysis10

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000003016927 – 148Receptor activity-modifying protein 1Add BLAST122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 82By similarity
Disulfide bondi40 ↔ 72By similarity
Disulfide bondi57 ↔ 104By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9WTJ5.
PRIDEiQ9WTJ5.

PTM databases

iPTMnetiQ9WTJ5.
PhosphoSitePlusiQ9WTJ5.

Expressioni

Tissue specificityi

Expressed predominantly in the thymus, skeletal muscle, embryonic and adult brain, embryonic and adult lung, and colon.3 Publications

Gene expression databases

BgeeiENSMUSG00000034353.
ExpressionAtlasiQ9WTJ5. baseline and differential.
GenevisibleiQ9WTJ5. MM.

Interactioni

Subunit structurei

Heterodimer of CALCRL and RAMP1.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095253.

Structurei

3D structure databases

ProteinModelPortaliQ9WTJ5.
SMRiQ9WTJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RAMP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZHQ. Eukaryota.
ENOG4111NGJ. LUCA.
GeneTreeiENSGT00390000016200.
HOGENOMiHOG000253018.
HOVERGENiHBG061268.
InParanoidiQ9WTJ5.
KOiK08447.
OMAiWRSKRPE.
OrthoDBiEOG091G0KY6.
PhylomeDBiQ9WTJ5.
TreeFamiTF333286.

Family and domain databases

InterProiIPR006985. RAMP.
[Graphical view]
PANTHERiPTHR14076. PTHR14076. 1 hit.
PfamiPF04901. RAMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WTJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPGLRGLPR CGLWLLLAHH LFMVTACRDP DYGTLIQELC LSRFKENMET
60 70 80 90 100
IGKTLWCDWG KTIQSYGELT YCTKHVAHTI GCFWPNPEVD RFFIAVHHRY
110 120 130 140
FSKCPISGRA LRDPPNSILC PFIALPITVT LLMTALVVWR SKRTEGIV
Length:148
Mass (Da):16,892
Last modified:November 1, 1999 - v1
Checksum:i5EC97385EA11DF97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019046 mRNA. Translation: BAA76617.1.
AF146522 mRNA. Translation: AAD35018.1.
AJ250489 mRNA. Translation: CAB59511.1.
AF209904 mRNA. Translation: AAF21036.1.
BC012644 mRNA. Translation: AAH12644.1.
CCDSiCCDS15158.1.
PIRiJC7261.
RefSeqiNP_058590.1. NM_016894.3.
UniGeneiMm.3272.

Genome annotation databases

EnsembliENSMUST00000097648; ENSMUSP00000095253; ENSMUSG00000034353.
GeneIDi51801.
KEGGimmu:51801.
UCSCiuc007bzx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019046 mRNA. Translation: BAA76617.1.
AF146522 mRNA. Translation: AAD35018.1.
AJ250489 mRNA. Translation: CAB59511.1.
AF209904 mRNA. Translation: AAF21036.1.
BC012644 mRNA. Translation: AAH12644.1.
CCDSiCCDS15158.1.
PIRiJC7261.
RefSeqiNP_058590.1. NM_016894.3.
UniGeneiMm.3272.

3D structure databases

ProteinModelPortaliQ9WTJ5.
SMRiQ9WTJ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095253.

PTM databases

iPTMnetiQ9WTJ5.
PhosphoSitePlusiQ9WTJ5.

Proteomic databases

PaxDbiQ9WTJ5.
PRIDEiQ9WTJ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097648; ENSMUSP00000095253; ENSMUSG00000034353.
GeneIDi51801.
KEGGimmu:51801.
UCSCiuc007bzx.2. mouse.

Organism-specific databases

CTDi10267.
MGIiMGI:1858418. Ramp1.

Phylogenomic databases

eggNOGiENOG410IZHQ. Eukaryota.
ENOG4111NGJ. LUCA.
GeneTreeiENSGT00390000016200.
HOGENOMiHOG000253018.
HOVERGENiHBG061268.
InParanoidiQ9WTJ5.
KOiK08447.
OMAiWRSKRPE.
OrthoDBiEOG091G0KY6.
PhylomeDBiQ9WTJ5.
TreeFamiTF333286.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-419812. Calcitonin-like ligand receptors.

Miscellaneous databases

PROiQ9WTJ5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034353.
ExpressionAtlasiQ9WTJ5. baseline and differential.
GenevisibleiQ9WTJ5. MM.

Family and domain databases

InterProiIPR006985. RAMP.
[Graphical view]
PANTHERiPTHR14076. PTHR14076. 1 hit.
PfamiPF04901. RAMP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAMP1_MOUSE
AccessioniPrimary (citable) accession number: Q9WTJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.