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Protein

Flt3-interacting zinc finger protein 1

Gene

Fiz1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri29 – 51C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri57 – 79C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri85 – 107C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri113 – 136C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri204 – 226C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 357C2H2-type 7PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri363 – 386C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri418 – 440C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • nucleic acid binding Source: InterPro
  • receptor tyrosine kinase binding Source: UniProtKB

GO - Biological processi

  • positive regulation of protein phosphorylation Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Flt3-interacting zinc finger protein 1
Gene namesi
Name:Fiz1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1344336. Fiz1.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000469381 – 500Flt3-interacting zinc finger protein 1Add BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9WTJ4.
MaxQBiQ9WTJ4.
PaxDbiQ9WTJ4.
PRIDEiQ9WTJ4.

PTM databases

iPTMnetiQ9WTJ4.
PhosphoSitePlusiQ9WTJ4.

Expressioni

Tissue specificityi

Widely expressed. In the retina, highest expression in the ganglion cell layer.2 Publications

Developmental stagei

Expressed in the retina at 14.5 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000061374.
CleanExiMM_FIZ1.
ExpressionAtlasiQ9WTJ4. baseline and differential.
GenevisibleiQ9WTJ4. MM.

Interactioni

Subunit structurei

Interacts with FLT3 cytoplasmic catalytic domain, following receptor stimulation, in a kinase-independent manner. Does not interact with other structurally related receptor tyrosine kinases, including KIT, CSF1R and PDGFR. Interacts with NRL (By similarity).By similarity

GO - Molecular functioni

  • receptor tyrosine kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi204770. 4 interactors.
IntActiQ9WTJ4. 2 interactors.
MINTiMINT-1728667.
STRINGi10090.ENSMUSP00000076603.

Structurei

3D structure databases

ProteinModelPortaliQ9WTJ4.
SMRiQ9WTJ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri29 – 51C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri57 – 79C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri85 – 107C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri113 – 136C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri204 – 226C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 357C2H2-type 7PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri363 – 386C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri418 – 440C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132444.
HOVERGENiHBG018163.
InParanoidiQ9WTJ4.
OMAiQPAWDGG.
OrthoDBiEOG091G0I07.
PhylomeDBiQ9WTJ4.
TreeFamiTF337381.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WTJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDSSLPVVP APIAAPGPAP SATAPRVPFH CSECGKSFRY RSDLRRHFAR
60 70 80 90 100
HTALKPHACP RCGKGFKHSF NLANHLRSHT GERPYRCSAC PKGFRDSTGL
110 120 130 140 150
LHHQVVHTGE KPYCCLVCEL RFSSRSSLGR HLKRQHRGTL PSPLQPSPGL
160 170 180 190 200
PPLSSPCSVC CNVGPCSVCG GGGSSGGEGL EGAGATSWGL AEAAAAAAAS
210 220 230 240 250
LPPFACGACA RRFDHGRELA AHWAAHTDVK PFKCPRCERD FNAPALLERH
260 270 280 290 300
KLTHDLQGSN APPTQVWASG GGPEVAGEGD ASEVGAAPQT WDAGLLLSPT
310 320 330 340 350
GAGVPKLEAL LPGDEGSGND QAPAAAAEAS SEDTLYQCDC GTFFASAPAL
360 370 380 390 400
ASHLEAHSGP ATYGCGHCGA LYAALAALEE HRRASHGEGS GEAAPDGEGN
410 420 430 440 450
QAAGGPGPGS SSRSKKIFGC SECEKLFRSP RDLERHVLVH TGEKPFPCLE
460 470 480 490 500
CGKFFRHECY LKRHRLLHGT ERPFPCHICG KGFITLSNLS RHLKLHRGMD
Length:500
Mass (Da):52,685
Last modified:November 1, 1999 - v1
Checksum:i9F0F553ABD7F7F45
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti404G → D in AAH06633 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126747 mRNA. Translation: AAD45499.1.
AF126746 mRNA. Translation: AAD45498.1.
BC006633 mRNA. Translation: AAH06633.1.
AK003641 mRNA. Translation: BAB22907.1.
CCDSiCCDS20751.1.
RefSeqiNP_001103798.1. NM_001110328.1.
NP_001103799.1. NM_001110329.1.
NP_001103800.1. NM_001110330.1.
NP_035943.3. NM_011813.3.
XP_006539970.1. XM_006539907.3.
UniGeneiMm.38911.

Genome annotation databases

EnsembliENSMUST00000077385; ENSMUSP00000076603; ENSMUSG00000061374.
ENSMUST00000165320; ENSMUSP00000128105; ENSMUSG00000061374.
ENSMUST00000167804; ENSMUSP00000126765; ENSMUSG00000061374.
ENSMUST00000207030; ENSMUSP00000147082; ENSMUSG00000061374.
ENSMUST00000208944; ENSMUSP00000147011; ENSMUSG00000061374.
GeneIDi23877.
KEGGimmu:23877.
UCSCiuc009eze.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126747 mRNA. Translation: AAD45499.1.
AF126746 mRNA. Translation: AAD45498.1.
BC006633 mRNA. Translation: AAH06633.1.
AK003641 mRNA. Translation: BAB22907.1.
CCDSiCCDS20751.1.
RefSeqiNP_001103798.1. NM_001110328.1.
NP_001103799.1. NM_001110329.1.
NP_001103800.1. NM_001110330.1.
NP_035943.3. NM_011813.3.
XP_006539970.1. XM_006539907.3.
UniGeneiMm.38911.

3D structure databases

ProteinModelPortaliQ9WTJ4.
SMRiQ9WTJ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204770. 4 interactors.
IntActiQ9WTJ4. 2 interactors.
MINTiMINT-1728667.
STRINGi10090.ENSMUSP00000076603.

PTM databases

iPTMnetiQ9WTJ4.
PhosphoSitePlusiQ9WTJ4.

Proteomic databases

EPDiQ9WTJ4.
MaxQBiQ9WTJ4.
PaxDbiQ9WTJ4.
PRIDEiQ9WTJ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077385; ENSMUSP00000076603; ENSMUSG00000061374.
ENSMUST00000165320; ENSMUSP00000128105; ENSMUSG00000061374.
ENSMUST00000167804; ENSMUSP00000126765; ENSMUSG00000061374.
ENSMUST00000207030; ENSMUSP00000147082; ENSMUSG00000061374.
ENSMUST00000208944; ENSMUSP00000147011; ENSMUSG00000061374.
GeneIDi23877.
KEGGimmu:23877.
UCSCiuc009eze.2. mouse.

Organism-specific databases

CTDi84922.
MGIiMGI:1344336. Fiz1.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132444.
HOVERGENiHBG018163.
InParanoidiQ9WTJ4.
OMAiQPAWDGG.
OrthoDBiEOG091G0I07.
PhylomeDBiQ9WTJ4.
TreeFamiTF337381.

Miscellaneous databases

PROiQ9WTJ4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061374.
CleanExiMM_FIZ1.
ExpressionAtlasiQ9WTJ4. baseline and differential.
GenevisibleiQ9WTJ4. MM.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFIZ1_MOUSE
AccessioniPrimary (citable) accession number: Q9WTJ4
Secondary accession number(s): Q91W14, Q9CTG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.