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Protein

Putative transcription factor Ovo-like 1

Gene

Ovol1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri118 – 140C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri146 – 168C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 197C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri213 – 236C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

  • epidermis development Source: MGI
  • germline cell cycle switching, mitotic to meiotic cell cycle Source: MGI
  • kidney development Source: MGI
  • mesoderm development Source: MGI
  • negative regulation of meiotic cell cycle phase transition Source: MGI
  • negative regulation of stem cell proliferation Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • skin development Source: MGI
  • spermatogenesis Source: MGI
  • transcription from RNA polymerase II promoter Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative transcription factor Ovo-like 1
Short name:
mOvo1
Short name:
mOvo1a
Gene namesi
Name:Ovol1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1330290. Ovol1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470121 – 267Putative transcription factor Ovo-like 1Add BLAST267

Proteomic databases

PaxDbiQ9WTJ2.
PRIDEiQ9WTJ2.

PTM databases

iPTMnetiQ9WTJ2.
PhosphoSitePlusiQ9WTJ2.

Expressioni

Tissue specificityi

Expressed in skin, testis, kidney and weakly in lung. Not detected in heart, brain, spleen, liver and skeletal muscle.

Developmental stagei

First expressed at E14.5 day in the suprabasal layers of developing epidermis, at E15.5 expression begins in the inner cells of developing hair germs and restricted to inner root sheath and/or precortical cells of developing hair follicles.

Gene expression databases

BgeeiENSMUSG00000024922.
CleanExiMM_OVOL1.
GenevisibleiQ9WTJ2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025861.

Structurei

3D structure databases

ProteinModelPortaliQ9WTJ2.
SMRiQ9WTJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri118 – 140C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri146 – 168C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 197C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri213 – 236C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG3576. Eukaryota.
ENOG4111H28. LUCA.
GeneTreeiENSGT00860000133786.
HOGENOMiHOG000231694.
HOVERGENiHBG053384.
InParanoidiQ9WTJ2.
KOiK09216.
OMAiQPYQEPE.
OrthoDBiEOG091G0LB1.
PhylomeDBiQ9WTJ2.
TreeFamiTF337552.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR027755. TF_Ovo-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF193. PTHR10032:SF193. 1 hit.
PfamiPF13465. zf-H2C2_2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WTJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRAFLVKKP CVSTCKRNWS ELPDEERGEI YVPVSLGFCP PQPYREPEAS
60 70 80 90 100
VAEPPSCPLA LDMSLRDSSY SVAPGPCVVA QLPSEDVSHL TDPQSRDQGF
110 120 130 140 150
LRTKMKVTLG DSPNGDLFTC HICQKSFTHQ RMLNRHMKCH NDVKRHLCTY
160 170 180 190 200
CGKGFNDTFD LKRHVRTHTG VRPYKCSLCD KAFTQRCSLE SHLKKIHGVQ
210 220 230 240 250
QKYAYKERRA KLYVCEECGC TSESQEGHVL HLKERHPDSP LLRKTSKKVA
260
VALQNTVTSL LQGSPHL
Length:267
Mass (Da):30,222
Last modified:November 1, 1999 - v1
Checksum:iDAD4F51150C21C2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134804 mRNA. Translation: AAD29689.1.
AF134805 mRNA. Translation: AAD29690.1.
AK003801 mRNA. Translation: BAB23003.1.
AK028577 mRNA. Translation: BAC26015.1.
AK132478 mRNA. Translation: BAE21188.1.
AK132505 mRNA. Translation: BAE21208.1.
AK132506 mRNA. Translation: BAE21209.1.
BC021411 mRNA. Translation: AAH21411.1.
CCDSiCCDS29469.1.
RefSeqiNP_064319.1. NM_019935.3.
UniGeneiMm.280225.

Genome annotation databases

EnsembliENSMUST00000025861; ENSMUSP00000025861; ENSMUSG00000024922.
GeneIDi18426.
KEGGimmu:18426.
UCSCiuc008gdu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134804 mRNA. Translation: AAD29689.1.
AF134805 mRNA. Translation: AAD29690.1.
AK003801 mRNA. Translation: BAB23003.1.
AK028577 mRNA. Translation: BAC26015.1.
AK132478 mRNA. Translation: BAE21188.1.
AK132505 mRNA. Translation: BAE21208.1.
AK132506 mRNA. Translation: BAE21209.1.
BC021411 mRNA. Translation: AAH21411.1.
CCDSiCCDS29469.1.
RefSeqiNP_064319.1. NM_019935.3.
UniGeneiMm.280225.

3D structure databases

ProteinModelPortaliQ9WTJ2.
SMRiQ9WTJ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025861.

PTM databases

iPTMnetiQ9WTJ2.
PhosphoSitePlusiQ9WTJ2.

Proteomic databases

PaxDbiQ9WTJ2.
PRIDEiQ9WTJ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025861; ENSMUSP00000025861; ENSMUSG00000024922.
GeneIDi18426.
KEGGimmu:18426.
UCSCiuc008gdu.1. mouse.

Organism-specific databases

CTDi5017.
MGIiMGI:1330290. Ovol1.

Phylogenomic databases

eggNOGiKOG3576. Eukaryota.
ENOG4111H28. LUCA.
GeneTreeiENSGT00860000133786.
HOGENOMiHOG000231694.
HOVERGENiHBG053384.
InParanoidiQ9WTJ2.
KOiK09216.
OMAiQPYQEPE.
OrthoDBiEOG091G0LB1.
PhylomeDBiQ9WTJ2.
TreeFamiTF337552.

Miscellaneous databases

PROiQ9WTJ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024922.
CleanExiMM_OVOL1.
GenevisibleiQ9WTJ2. MM.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR027755. TF_Ovo-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF193. PTHR10032:SF193. 1 hit.
PfamiPF13465. zf-H2C2_2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOVOL1_MOUSE
AccessioniPrimary (citable) accession number: Q9WTJ2
Secondary accession number(s): Q545S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.