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Protein

Triplex capsid protein 1

Gene

TRX1

Organism
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of major capsid protein/MCP, which are linked together by heterotrimers called triplexes. These triplexes are formed by a single molecule of triplex protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally, TRX1 is required for efficient transport of TRX2 to the nucleus, which is the site of capsid assembly.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Triplex capsid protein 1UniRule annotation
Gene namesi
Name:TRX1UniRule annotation
Ordered Locus Names:U29
OrganismiHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus)
Taxonomic identifieri36351 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000006930 Componenti: Genome
  • UP000142685 Componenti: Genome

Subcellular locationi

Q9WT35:
  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004084471 – 299Triplex capsid protein 1Add BLAST299

Interactioni

Subunit structurei

Interacts with TRX2, MCP and capsid vertex component 2/CVC2.UniRule annotation

Structurei

3D structure databases

SMRiQ9WT35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae TRX1 protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090000J1.

Family and domain databases

HAMAPiMF_04018. HSV_TRX1. 1 hit.
InterProiView protein in InterPro
IPR004999. Herpes_1.
PfamiView protein in Pfam
PF03327. Herpes_VP19C. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WT35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSKSSARAA IVDTVEAVKK RKYISIEAGT LNNVVEKERK FLKQFLSGRE
60 70 80 90 100
NLRIAARVFT PCELLAPELE NLGMLMYRFE TDVDNPKILF VGLFFLCSNA
110 120 130 140 150
FNVSACVRTA LTTMYTNSMV DNVLSMINTC KYLEDKVSLF GVTSLVSCGS
160 170 180 190 200
SCLLSCVMQG NVYDANKENI HGLTVLKEIF LEPDWEPRQH STQYVYVVHV
210 220 230 240 250
YKEVLSKLQY GIYVVLTSFQ NEDLVVDILR QYFEKERFLF LNYLINSNTT
260 270 280 290
LSYFGSVQRI GRCATEDIKS GFLQYRGITL PVIKLENIFV DLSEKKVFV
Length:299
Mass (Da):34,127
Last modified:November 1, 1999 - v1
Checksum:iAE9B42EDCDDC2001
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF157706 Genomic DNA. Translation: AAD49643.1.
AB021506 Genomic DNA. Translation: BAA78250.1.
PIRiT43989.
RefSeqiNP_050210.1. NC_000898.1.

Genome annotation databases

GeneIDi1497031.
KEGGivg:1497031.

Similar proteinsi

Entry informationi

Entry nameiTRX1_HHV6Z
AccessioniPrimary (citable) accession number: Q9WT35
Secondary accession number(s): Q77PV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: November 1, 1999
Last modified: October 25, 2017
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families