ID   Q9WNA9_HHV8             Unreviewed;       498 AA.
AC   Q9WNA9;
DT   01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1999, sequence version 1.
DT   24-JAN-2024, entry version 48.
DE   SubName: Full=Latent membrane protein {ECO:0000313|EMBL:AAD45296.1};
DE   SubName: Full=Latent signal transducing membrane protein {ECO:0000313|EMBL:AYC62544.1};
GN   Name=K15-M {ECO:0000313|EMBL:AAD45296.1};
GN   Synonyms=ORF-K15-M allele {ECO:0000313|EMBL:AYC62544.1};
OS   Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Orthoherpesviridae; Gammaherpesvirinae; Rhadinovirus;
OC   Rhadinovirus humangamma8.
OX   NCBI_TaxID=37296 {ECO:0000313|EMBL:AAD45296.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:AAD45296.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HBL6 {ECO:0000313|EMBL:AAD45296.1};
RX   PubMed=9709308;
RA   Nicholas J., Zong J.C., Alcendor D.J., Ciufo D.M., Poole L.J.,
RA   Sarisky R.T., Chiou C.J., Zhang X., Wan X., Guo H.G., Reitz M.S.,
RA   Hayward G.S.;
RT   "Novel organizational features, captured cellular genes, and strain
RT   variability within the genome of KSHV/HHV8.";
RL   J. Natl. Cancer Inst. Monogr. 23:79-88(1998).
RN   [2] {ECO:0000313|EMBL:AAD45296.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ASM70-80 {ECO:0000313|EMBL:AYC62544.1}, HBL6
RC   {ECO:0000313|EMBL:AAD45296.1}, and KKS5 {ECO:0000313|EMBL:AYC62549.1};
RX   PubMed=10400762;
RA   Poole L.J., Zong J.C., Ciufo D.M., Alcendor D.J., Cannon J.S., Ambinder R.,
RA   Orenstein J.M., Reitz M.S., Hayward G.S.;
RT   "Comparison of genetic variability at multiple loci across the genomes of
RT   the major subtypes of Kaposi's sarcoma-associated herpesvirus reveals
RT   evidence for recombination and for two distinct types of open reading frame
RT   K15 alleles at the right-hand end.";
RL   J. Virol. 73:6646-6660(1999).
RN   [3] {ECO:0000313|EMBL:AYC62544.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ASM70-80 {ECO:0000313|EMBL:AYC62544.1}, HBL6
RC   {ECO:0000313|EMBL:AYC62545.1}, and KKS5 {ECO:0000313|EMBL:AYC62549.1};
RX   PubMed=17089792;
RA   Hayward G.S., Zong J.C.;
RT   "Modern evolutionary history of the human KSHV genome.";
RL   Curr. Top. Microbiol. Immunol. 312:1-42(2007).
RN   [4] {ECO:0000313|EMBL:AYC62544.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ASM70-80 {ECO:0000313|EMBL:AYC62544.1}, HBL6
RC   {ECO:0000313|EMBL:AYC62545.1}, and KKS5 {ECO:0000313|EMBL:AYC62549.1};
RA   Zong J.-C., Hayward G.S.;
RT   "Sequence comparison of 60 intact ORF-K15(P), ORF-K15(M) and ORF-K15(N)
RT   allele genes and proteins encoded by Kaposi's sarcoma herpesvirus genomes
RT   from KS, PEL and PBMC samples collected worldwide.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- INTERACTION:
CC       Q9WNA9; Q9NZM3: ITSN2; Xeno; NbExp=2; IntAct=EBI-7555439, EBI-308689;
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DR   EMBL; AF156885; AAD45296.1; -; mRNA.
DR   EMBL; MH613961; AYC62544.1; -; Genomic_DNA.
DR   EMBL; MH613962; AYC62545.1; -; Genomic_DNA.
DR   EMBL; MH613966; AYC62549.1; -; Genomic_DNA.
DR   IntAct; Q9WNA9; 12.
DR   MINT; Q9WNA9; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR009304; Herpes_LAMP2.
DR   Pfam; PF06126; Herpes_LAMP2; 1.
PE   1: Evidence at protein level;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        37..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        70..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        93..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        126..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        153..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        178..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        205..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        239..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        274..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        302..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        329..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   498 AA;  54648 MW;  7DF9CA795F39B8AE CRC64;
     MNYKKYLWGT WFAALITCCG CLSIMFCLLT INLQNTIFLL SNISVYYQLF CTITNIYVQS
     KKQRFQASPP IGPSIIVGCI AFASWSFSTQ STLSTVCVCI ISLLSIITAI LSLGGTLRVV
     KCTIDSGLLC IVMVLVLIFS MGLQIYNNWT HCQFFLPLWT LLLVFFIHIF ATDNGPCLKL
     AACVFAICGG ILKATPAFFC VSHSCLSVII AGCISCIHIG MTGLFITMKR HWIGSTKGLM
     SFLLLQGGVL VTLTTTIGIL FIKREQDTNN EGSITLLAGC GFLLYCFFCW QSFHKASLSG
     GFLFLFLAWT CAGCCVKLVL LYTDGWTTGV TSGLICVIVI LSTGQAVLVG YLYRESRLVS
     FNNVTTRLPI YTPHDTPHAH AGRICPDVNH LARRLPPLPS RNVIHSRILS STTDMALSPV
     RVCNTEVTTQ LEMQQLHSER TVTYASILGD NTPPPTRASA CINQSGISNV SNCGVRSLDP
     PPFQPADEVY EEVLFPTD
//