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Q9WLG7

- Q9WLG7_9HIV1

UniProt

Q9WLG7 - Q9WLG7_9HIV1

Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.UniRule annotationSAAS annotation
    The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves.SAAS annotation

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. evasion or tolerance by virus of host immune response Source: UniProtKB-KW
    3. membrane fusion involved in viral entry into host cell Source: UniProtKB-KW
    4. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    ApoptosisSAAS annotation, Fusion of virus membrane with host membraneSAAS annotation, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotation, Viral immunoevasionUniRule annotation, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein gp160UniRule annotation
    Gene namesi
    Name:envImported
    OrganismiHuman immunodeficiency virus 1Imported
    Taxonomic identifieri11676 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

    GO - Cellular componenti

    1. host cell endosome membrane Source: UniProtKB-SubCell
    2. host cell plasma membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. viral envelope Source: UniProtKB-KW
    5. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membraneSAAS annotation, Host endosomeSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotationImported, Virion

    Pathology & Biotechi

    Keywords - Diseasei

    AIDSUniRule annotation

    PTM / Processingi

    Keywords - PTMi

    Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliQ9WLG7.
    SMRiQ9WLG7. Positions 82-479, 494-577.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Family and domain databases

    Gene3Di2.170.40.20. 2 hits.
    InterProiIPR000777. HIV1_GP160.
    IPR000328. Retroviral_envelope_protein.
    [Graphical view]
    PfamiPF00516. GP120. 1 hit.
    PF00517. GP41. 1 hit.
    [Graphical view]
    SUPFAMiSSF56502. SSF56502. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q9WLG7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVKETQMNW PNLWKWGTLI LGLVIICSAS DNLWVTVYYG VPVWRDADTT    50
    LFCASDAKAH KTEVHNVWAT HACVPTDPNP QEIHLENVTE NFNMWKNNMV 100
    EQMQEDVISL WDQSLKPCVK LTPLCVALNC INVNNITDVP NIRGNITDEV 150
    RNCSFNMTTE LRDKKQKVHA LFYKLDIVQI DRNSSEYRLI NCNTSVIKQA 200
    CPKISFDPIP IHYCTPAGYA ILKCNDKNFN GTGPCKNVSS VQCTHGIKPV 250
    VSTQLLLNGS LAEEEIIIRS ENLTNNAKTI IVHLNKSVEI NCTRPSNNTR 300
    TSITIGPGQV FYKTGDIVGD IRKAYCEING TKWNKALEQV TEKLKEHFNN 350
    KTIIFQPPSG GDIEITTHHF NCRGEFFYCN TTKLFNSTCI ENKTMKGCND 400
    TITLPCKIKQ IINMWQGVGQ AMYAPPISGR INCVSNITGI LLTRDGGNNM 450
    TNETFRPGGG NIKDNWRSEL YKYKVVQIEP LGIAPTRAKR RVVERQKRAV 500
    GIGAMIFGFL GAAGSTMGAA SITLTVQARQ LLPGIVQQQS NLLRAIEAQQ 550
    HLLQLTVWGI KQLQARVLAV ERYLKDQKFL GLWGCSGKII CTTAVPWNST 600
    WSNRSFEEIW NNMTWIEWER EISNYTNQIY GILTESQNQQ DRNEKDLLEL 650
    DKWASLWNWF DITKWLWYIK IFIMIVGGLI GLRIIVAVLS IVNRVRQGYS 700
    PLSFQTPTHH QREPDRPERI EEGDGEQSRN RSVRLVSGFL ALAWDDLRSL 750
    CLFSYHRLRD FGLIAARTVE LLGRSSLKGL SRGWEGLKYL GNLLLYWGQE 800
    LKISVISLFN ATAIAVAGWT DRVIEVAQGA WRAVLHIPRR IRQGLERALL 850
    Length:850
    Mass (Da):96,461
    Last modified:November 1, 1999 - v1
    Checksum:iA1E1AB530A838392
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF070705 Genomic DNA. Translation: AAC99349.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF070705 Genomic DNA. Translation: AAC99349.1 .

    3D structure databases

    ProteinModelPortali Q9WLG7.
    SMRi Q9WLG7. Positions 82-479, 494-577.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.170.40.20. 2 hits.
    InterProi IPR000777. HIV1_GP160.
    IPR000328. Retroviral_envelope_protein.
    [Graphical view ]
    Pfami PF00516. GP120. 1 hit.
    PF00517. GP41. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56502. SSF56502. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. McCutchan F.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Diversity of envelope glycoprotein from human immunodeficiency virus type 1 of recent seroconverters in Thailand."
      McCutchan F.E., Viputtigul K., de Souza M.S., Carr J.K., Markowitz L.E., Buapunth P., McNeil J.G., Robb M.L., Nitayaphan S., Birx D.L., Brown A.E.
      AIDS Res. Hum. Retroviruses 16:801-805(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9WLG7_9HIV1
    AccessioniPrimary (citable) accession number: Q9WLG7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1999
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)