Q9WLG7 (Q9WLG7_9HIV1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Envelope glycoprotein gp160 RuleBase RU004292

Gene names

Name:

env EMBL AAC99349.1

Organism

Human immunodeficiency virus 1 EMBL AAC99349.1

Taxonomic identifier

11676 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Lentivirus › Primate lentivirus group

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	850 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function

The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface By similarity. RuleBase RU004292 SAAS SAAS000328 The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves By similarity. SAAS SAAS000328

Ontologies

Keywords
Biological process	Apoptosis SAAS SAAS000328 Fusion of virus membrane with host membrane SAAS SAAS000328 Host-virus interaction Viral attachment to host cell RuleBase RU004292 SAAS SAAS000328 Viral immunoevasion RuleBase RU004292 Viral penetration into host cytoplasm Virus entry into host cell
Cellular component	Host cell membrane SAAS SAAS000328 Host endosome SAAS SAAS000328 Host membrane Membrane Viral envelope protein RuleBase RU003294 SAAS SAAS000328 EMBL AAC99349.1 Virion
Disease	AIDS RuleBase RU003294
Domain	Transmembrane Transmembrane helix SAAS SAAS000328
PTM	Cleavage on pair of basic residues RuleBase RU004292 Disulfide bond SAAS SAAS000328
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW evasion or tolerance by virus of host immune response Inferred from electronic annotation. Source: UniProtKB-KW viral attachment to host cell Inferred from electronic annotation. Source: UniProtKB-KW viral entry into host cell Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	host cell endosome Inferred from electronic annotation. Source: UniProtKB-KW host cell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW viral envelope Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9WLG7 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: A1E1AB530A838392	FASTA	850	96,461
	10 20 30 40 50 60 MRVKETQMNW PNLWKWGTLI LGLVIICSAS DNLWVTVYYG VPVWRDADTT LFCASDAKAH 70 80 90 100 110 120 KTEVHNVWAT HACVPTDPNP QEIHLENVTE NFNMWKNNMV EQMQEDVISL WDQSLKPCVK 130 140 150 160 170 180 LTPLCVALNC INVNNITDVP NIRGNITDEV RNCSFNMTTE LRDKKQKVHA LFYKLDIVQI 190 200 210 220 230 240 DRNSSEYRLI NCNTSVIKQA CPKISFDPIP IHYCTPAGYA ILKCNDKNFN GTGPCKNVSS 250 260 270 280 290 300 VQCTHGIKPV VSTQLLLNGS LAEEEIIIRS ENLTNNAKTI IVHLNKSVEI NCTRPSNNTR 310 320 330 340 350 360 TSITIGPGQV FYKTGDIVGD IRKAYCEING TKWNKALEQV TEKLKEHFNN KTIIFQPPSG 370 380 390 400 410 420 GDIEITTHHF NCRGEFFYCN TTKLFNSTCI ENKTMKGCND TITLPCKIKQ IINMWQGVGQ 430 440 450 460 470 480 AMYAPPISGR INCVSNITGI LLTRDGGNNM TNETFRPGGG NIKDNWRSEL YKYKVVQIEP 490 500 510 520 530 540 LGIAPTRAKR RVVERQKRAV GIGAMIFGFL GAAGSTMGAA SITLTVQARQ LLPGIVQQQS 550 560 570 580 590 600 NLLRAIEAQQ HLLQLTVWGI KQLQARVLAV ERYLKDQKFL GLWGCSGKII CTTAVPWNST 610 620 630 640 650 660 WSNRSFEEIW NNMTWIEWER EISNYTNQIY GILTESQNQQ DRNEKDLLEL DKWASLWNWF 670 680 690 700 710 720 DITKWLWYIK IFIMIVGGLI GLRIIVAVLS IVNRVRQGYS PLSFQTPTHH QREPDRPERI 730 740 750 760 770 780 EEGDGEQSRN RSVRLVSGFL ALAWDDLRSL CLFSYHRLRD FGLIAARTVE LLGRSSLKGL 790 800 810 820 830 840 SRGWEGLKYL GNLLLYWGQE LKISVISLFN ATAIAVAGWT DRVIEVAQGA WRAVLHIPRR 850 IRQGLERALL

References

[1]	McCutchan F. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Diversity of envelope glycoprotein from human immunodeficiency virus type 1 of recent seroconverters in Thailand." McCutchan F.E., Viputtigul K., de Souza M.S., Carr J.K., Markowitz L.E., Buapunth P., McNeil J.G., Robb M.L., Nitayaphan S., Birx D.L., Brown A.E. AIDS Res. Hum. Retroviruses 16:801-805(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF070705 Genomic DNA. Translation: AAC99349.1.
3D structure databases
ProteinModelPortal	Q9WLG7.
SMR	Q9WLG7. Positions 82-479, 494-577.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.170.40.20. 2 hits.
InterPro	IPR000777. HIV1_GP160. IPR000328. Retroviral_envelope_protein. [Graphical view]
Pfam	PF00516. GP120. 1 hit. PF00517. GP41. 1 hit. [Graphical view]
SUPFAM	SSF56502. GP120. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q9WLG7_9HIV1

Accession

Primary (citable) accession number: Q9WLG7

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 1, 1999
Last modified:	May 29, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)