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Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ApoptosisSAAS annotation, Fusion of virus membrane with host membraneSAAS annotation, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotation, Viral immunoevasionUniRule annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160UniRule annotationSAAS annotation
Alternative name(s):
Endogenous retrovirus group K member 113 Env polyproteinSAAS annotation
Endogenous retrovirus group K member 13-1 Env polyproteinSAAS annotation
Endogenous retrovirus group K member 18 Env polyproteinSAAS annotation
Endogenous retrovirus group K member 19 Env polyproteinSAAS annotation
Endogenous retrovirus group K member 21 Env polyproteinSAAS annotation
Endogenous retrovirus group K member 24 Env polyproteinSAAS annotation
Endogenous retrovirus group K member 25 Env polyproteinSAAS annotation
Endogenous retrovirus group K member 6 Env polyproteinSAAS annotation
Endogenous retrovirus group K member 7 Env polyproteinSAAS annotation
Endogenous retrovirus group K member 9 Env polyproteinSAAS annotation
Envelope glycoprotein gp160
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotation, Host endosomeSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotation, Virion

Pathology & Biotechi

Keywords - Diseasei

AIDSUniRule annotation

PTM / Processingi

Keywords - PTMi

Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ9WLG7.
SMRiQ9WLG7. Positions 82-479, 494-577.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Family and domain databases

Gene3Di2.170.40.20. 2 hits.
InterProiIPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]
PfamiPF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9WLG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVKETQMNW PNLWKWGTLI LGLVIICSAS DNLWVTVYYG VPVWRDADTT
60 70 80 90 100
LFCASDAKAH KTEVHNVWAT HACVPTDPNP QEIHLENVTE NFNMWKNNMV
110 120 130 140 150
EQMQEDVISL WDQSLKPCVK LTPLCVALNC INVNNITDVP NIRGNITDEV
160 170 180 190 200
RNCSFNMTTE LRDKKQKVHA LFYKLDIVQI DRNSSEYRLI NCNTSVIKQA
210 220 230 240 250
CPKISFDPIP IHYCTPAGYA ILKCNDKNFN GTGPCKNVSS VQCTHGIKPV
260 270 280 290 300
VSTQLLLNGS LAEEEIIIRS ENLTNNAKTI IVHLNKSVEI NCTRPSNNTR
310 320 330 340 350
TSITIGPGQV FYKTGDIVGD IRKAYCEING TKWNKALEQV TEKLKEHFNN
360 370 380 390 400
KTIIFQPPSG GDIEITTHHF NCRGEFFYCN TTKLFNSTCI ENKTMKGCND
410 420 430 440 450
TITLPCKIKQ IINMWQGVGQ AMYAPPISGR INCVSNITGI LLTRDGGNNM
460 470 480 490 500
TNETFRPGGG NIKDNWRSEL YKYKVVQIEP LGIAPTRAKR RVVERQKRAV
510 520 530 540 550
GIGAMIFGFL GAAGSTMGAA SITLTVQARQ LLPGIVQQQS NLLRAIEAQQ
560 570 580 590 600
HLLQLTVWGI KQLQARVLAV ERYLKDQKFL GLWGCSGKII CTTAVPWNST
610 620 630 640 650
WSNRSFEEIW NNMTWIEWER EISNYTNQIY GILTESQNQQ DRNEKDLLEL
660 670 680 690 700
DKWASLWNWF DITKWLWYIK IFIMIVGGLI GLRIIVAVLS IVNRVRQGYS
710 720 730 740 750
PLSFQTPTHH QREPDRPERI EEGDGEQSRN RSVRLVSGFL ALAWDDLRSL
760 770 780 790 800
CLFSYHRLRD FGLIAARTVE LLGRSSLKGL SRGWEGLKYL GNLLLYWGQE
810 820 830 840 850
LKISVISLFN ATAIAVAGWT DRVIEVAQGA WRAVLHIPRR IRQGLERALL
Length:850
Mass (Da):96,461
Last modified:November 1, 1999 - v1
Checksum:iA1E1AB530A838392
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070705 Genomic DNA. Translation: AAC99349.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070705 Genomic DNA. Translation: AAC99349.1.

3D structure databases

ProteinModelPortaliQ9WLG7.
SMRiQ9WLG7. Positions 82-479, 494-577.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.170.40.20. 2 hits.
InterProiIPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]
PfamiPF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. McCutchan F.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Diversity of envelope glycoprotein from human immunodeficiency virus type 1 of recent seroconverters in Thailand."
    McCutchan F.E., Viputtigul K., de Souza M.S., Carr J.K., Markowitz L.E., Buapunth P., McNeil J.G., Robb M.L., Nitayaphan S., Birx D.L., Brown A.E.
    AIDS Res. Hum. Retroviruses 16:801-805(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9WLG7_9HIV1
AccessioniPrimary (citable) accession number: Q9WLG7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: June 24, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.