Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cell cycle link protein

Gene

DNA-C

Organism
Faba bean necrotic yellows virus (isolate Egyptian EV1-93) (FBNYV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Interacts with and disrupts the function of host retinoblastoma-related proteins RBR, which are key regulators of the cell cycle. Induces transcriptional activation of E2F-regulated S-phase and G2/M-phase-specific genes. Inactivation of the ability of RBR to arrest the cell cycle leads to the stimulation of viral DNA replication.1 Publication

GO - Biological processi

Keywordsi

Biological processHost-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Cell cycle link protein
Short name:
Clink
Gene namesi
Name:DNA-C
Synonyms:C10
OrganismiFaba bean necrotic yellows virus (isolate Egyptian EV1-93) (FBNYV)
Taxonomic identifieri291603 [NCBI]
Taxonomic lineageiVirusesssDNA virusesNanoviridaeNanovirus
Virus hostiCicer arietinum (Chickpea) (Garbanzo) [TaxID: 3827]
Lens culinaris (Lentil) (Cicer lens) [TaxID: 3864]
Phaseolus vulgaris (Kidney bean) (French bean) [TaxID: 3885]
Vicia faba (Broad bean) (Faba vulgaris) [TaxID: 3906]
Proteomesi
  • UP000008665 Componenti: Genome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi10P → L: Loss of binding to host SKP1. No effect on viral replication stimulation. 1 Publication1
Mutagenesisi17I → A: Loss of binding to host SKP1. No effect on viral replication stimulation. 1 Publication1
Mutagenesisi112C → R: Complete loss of viral replication stimulation; when associated with A-114. 1 Publication1
Mutagenesisi114E → A: Complete loss of viral replication stimulation; when associated with R-112. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003386251 – 169Cell cycle link proteinAdd BLAST169

Interactioni

Subunit structurei

Interacts with host SKP1. Interacts (via LXCXE domain) with host retinoblastoma-related protein 1 (RBR1). Interacts (via LXCXE domain) with retinoblastoma-related proteins (RBR) (Probable).1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9WIJ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni9 – 22Binding to host SKP1 proteinSequence analysisAdd BLAST14

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi110 – 114LXCXE motif, interaction with host RBRBy similarity5

Sequence similaritiesi

Belongs to the nanovirus Clink protein family.Curated

Phylogenomic databases

OrthoDBiVOG090000VZ.

Sequencei

Sequence statusi: Complete.

Q9WIJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLKYFSHLP EELREKIVHD HLQQERKKEF LEKAIEDSCR RHVSLLKSDP
60 70 80 90 100
SPSEMYSLSK FLDSLADYVG RQFNTRCLIK WRKDVPANIK FQVMEEQHLR
110 120 130 140 150
LYGFLDMDDL SCRELLPPEE DDDITYEDGM IVNCSELDKL FAALGIRVVY
160
ITVSNNCICT PLNKDIVIS
Length:169
Mass (Da):19,732
Last modified:November 1, 1999 - v1
Checksum:i2A43EDB66575D535
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132179 Genomic DNA. Translation: CAB44019.1.
RefSeqiNP_619566.1. NC_003559.1.

Genome annotation databases

GeneIDi993372.
KEGGivg:993372.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132179 Genomic DNA. Translation: CAB44019.1.
RefSeqiNP_619566.1. NC_003559.1.

3D structure databases

ProteinModelPortaliQ9WIJ4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi993372.
KEGGivg:993372.

Phylogenomic databases

OrthoDBiVOG090000VZ.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCLINK_FBNY1
AccessioniPrimary (citable) accession number: Q9WIJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 1, 1999
Last modified: February 15, 2017
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.