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Q9WC80

- NSP1_ROTRA

UniProt

Q9WC80 - NSP1_ROTRA

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Protein
Non-structural protein 1
Gene
N/A
Organism
Rotavirus A (strain Rabbit/United States/ALA/199? G3-P11[14]-Ix-Rx-Cx-Mx-A9-Nx-Tx-E5-H3) (RV-A) (Rotavirus A (strain Alabama))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Seems to induce the proteasome-dependent degradation of IRF3, IRF5 and IRF7, thereby antagonizing the cellular interferon response and establishment of the antiviral state. Binds and targets IRF3 early post-infection and suppresses IRF3 nuclear translocation By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri42 – 7938 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. suppression by virus of host IRF3 activity Source: UniProtKB-KW
  2. suppression by virus of host IRF7 activity Source: UniProtKB-KW
  3. suppression by virus of host NF-kappaB transcription factor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host IRF7 by virus, Inhibition of host NF-kappa-B by virus, Inhibition of host RLR pathway by virus, Interferon antiviral system evasion, Viral immunoevasion

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 1
Short name:
NSP1
Alternative name(s):
NCVP2
Non-structural RNA-binding protein 53
Short name:
NS53
OrganismiRotavirus A (strain Rabbit/United States/ALA/199? G3-P11[14]-Ix-Rx-Cx-Mx-A9-Nx-Tx-E5-H3) (RV-A) (Rotavirus A (strain Alabama))
Taxonomic identifieri101359 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
Virus hostiOryctolagus cuniculus (Rabbit) [TaxID: 9986]

Subcellular locationi

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-KW
  2. host cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Non-structural protein 1
PRO_0000369093Add
BLAST

Interactioni

Subunit structurei

Interacts (via C-terminus) with host IRF3; this interaction leads to IRF3 degradation. Interacts with host IRF7; this interaction leads to IRF7 degradation By similarity.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 8181RNA-binding By similarity
Add
BLAST
Regioni82 – 17695Important for cytoskeleton localization By similarity
Add
BLAST
Regioni314 – 492179Interaction with IRF3 By similarity
Add
BLAST

Domaini

The zinc-finger domain is important, but not sufficient for binding and degrading IRF3. It is sometimes described as a RING zinc-finger, but it is atypical and it is unclear whether it is related with ubiquitin ligase activity By similarity.

Sequence similaritiesi

Belongs to the rotavirus A NSP1 family.

Keywords - Domaini

Zinc-finger

Family and domain databases

InterProiIPR002148. Rotavirus_NSP1.
[Graphical view]
PfamiPF00981. Rota_NS53. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WC80-1 [UniParc]FASTAAdd to Basket

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MATFKDACFH YRRVTKLNRE LLRIGANSVW TPVSTNKIRG WCVECCQLTE    50
LTFCHGCSLA HVCQWCIQNK RCFLDNEPHL LKLRTFESPI TKEKLQCIID 100
LYNLLFPINS SIVNKFKKTV KQRKCRNEFD KLWYNQLLLP ITLNAAVFKF 150
HSRKVYVFGF YEGSSPCVNL PYKLVNCIDL YDKLLLDQVN FERMSSLPSN 200
LQSIYANKYF KLSRIPSMKL KQIYYSDFSK QNLINKYKFK SRIVLRNFTE 250
FTWDFQLSLH YDLFNNKDKI FAALSTSSLK QFETHDLNLG RVKADVFELG 300
RHCKPNYISS NHWQPASTIS QCKWCNVKYA FRDMDWKMES MYNELLSFIQ 350
SCYKSNVSVG HCSSIERAYP LVKDVLWHSI TKYIDQTIEK LFNVMNPVQV 400
NNQKVISFHW QIDIALYTHI KMILKTERLP FTFTLDQFNS VIKGIVNQWC 450
NVNELDNLPL CTEQTDTLVR LEEEGKLAEE YELLISDSED DD 492
Length:492
Mass (Da):58,020
Last modified:November 1, 1999 - v1
Checksum:iEF878AF133650190
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF084549 Genomic RNA. Translation: AAD33100.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF084549 Genomic RNA. Translation: AAD33100.1 .

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR002148. Rotavirus_NSP1.
[Graphical view ]
Pfami PF00981. Rota_NS53. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Simian rhesus rotavirus is a unique heterologous (non-lapine) rotavirus strain capable of productive replication and horizontal transmission in rabbits."
    Ciarlet M., Estes M.K., Conner M.E.
    J. Gen. Virol. 81:1237-1249(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiNSP1_ROTRA
AccessioniPrimary (citable) accession number: Q9WC80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 1, 1999
Last modified: February 19, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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