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Q9WBI3 (TYSY_IIV6) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP-Rule MF_00008

Pathway

Pyrimidine metabolism; dTTP biosynthesis. HAMAP-Rule MF_00008

Sequence similarities

Belongs to the thymidylate synthase family.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdTMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

dTTP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionthymidylate synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Probable thymidylate synthase 225R HAMAP-Rule MF_00008
PRO_0000377772

Sites

Active site1671 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9WBI3 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 84E3A627EBF7AF02

FASTA29533,961
        10         20         30         40         50         60 
MDINNEEKQY LNLLEKVLFQ GEDRDDRTGI GTKNVFGEQL KFNLRTSFPL LTTKKVFWKG 

        70         80         90        100        110        120 
VVEELLWFIS GSTDVSVLNQ KGVKIWNKNA ESFYTQQNLF KKNDLGPIYG FQWRHYGENY 

       130        140        150        160        170        180 
IGCDNKYGGI DQLKNIITTI QNEPWDRRMI LLAWNPKDNS KMALPPCHCI AHFDVSSKIN 

       190        200        210        220        230        240 
GKRELSCHLF QRSADMGLGV PFNIASYALL THIIAHVSST NTELIVPGDF VHTLSNVHIY 

       250        260        270        280        290 
KNHIKALTEQ ISRIPRKFPT LEIINKNKNI DAFSSKDFVL KDYNPYPALE MEMAL 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the first complete DNA sequence of an invertebrate iridovirus: coding strategy of the genome of Chilo iridescent virus."
Jakob N.J., Mueller K., Bahr U., Darai G.
Virology 286:182-196(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes."
Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R.
Virol. J. 4:11-11(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
[3]"Identification of a thymidylate synthase gene within the genome of Chilo iridescent virus."
Muller K., Tidona C.A., Bahr U., Darai G.
Virus Genes 17:243-258(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF303741 Genomic DNA. Translation: AAD21329.1.
RefSeqNP_149688.1. NC_003038.1.

3D structure databases

ProteinModelPortalQ9WBI3.
SMRQ9WBI3. Positions 4-295.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1733097.

Enzyme and pathway databases

UniPathwayUPA00575.

Family and domain databases

Gene3D3.30.572.10. 1 hit.
HAMAPMF_00008. Thymidy_synth_bact.
InterProIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSPR00108. THYMDSNTHASE.
SUPFAMSSF55831. SSF55831. 1 hit.
TIGRFAMsTIGR03284. thym_sym. 1 hit.
PROSITEPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYSY_IIV6
AccessionPrimary (citable) accession number: Q9WBI3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: November 1, 1999
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways