Q9WBI3 (TYSY_IIV6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable thymidylate synthase 225R
EC=2.1.1.45

Gene names

ORF Names:

IIV6-225R

Organism

Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus) [Reference proteome]

Taxonomic identifier

176652 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Iridoviridae › Iridovirus

Virus host

Acheta domesticus (House cricket) [TaxID: 6997]
Chilo suppressalis (striped riceborer) [TaxID: 168631]
Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999]
Gryllus campestris [TaxID: 58607]
Spodoptera frugiperda (Fall armyworm) [TaxID: 7108]

Protein attributes

Sequence length	295 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
Pathway	Pyrimidine metabolism; dTTP biosynthesis.
Sequence similarities	Belongs to the thymidylate synthase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dTMP biosynthetic process Inferred from electronic annotation. Source: InterPro dTTP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	thymidylate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 295	295	Probable thymidylate synthase 225R		PRO_0000377772
Sites
	Active site	167	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9WBI3 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 84E3A627EBF7AF02	FASTA	295	33,961
	10 20 30 40 50 60 MDINNEEKQY LNLLEKVLFQ GEDRDDRTGI GTKNVFGEQL KFNLRTSFPL LTTKKVFWKG 70 80 90 100 110 120 VVEELLWFIS GSTDVSVLNQ KGVKIWNKNA ESFYTQQNLF KKNDLGPIYG FQWRHYGENY 130 140 150 160 170 180 IGCDNKYGGI DQLKNIITTI QNEPWDRRMI LLAWNPKDNS KMALPPCHCI AHFDVSSKIN 190 200 210 220 230 240 GKRELSCHLF QRSADMGLGV PFNIASYALL THIIAHVSST NTELIVPGDF VHTLSNVHIY 250 260 270 280 290 KNHIKALTEQ ISRIPRKFPT LEIINKNKNI DAFSSKDFVL KDYNPYPALE MEMAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the first complete DNA sequence of an invertebrate iridovirus: coding strategy of the genome of Chilo iridescent virus." Jakob N.J., Mueller K., Bahr U., Darai G. Virology 286:182-196(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes." Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R. Virol. J. 4:11-11(2007) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION.
[3]	"Identification of a thymidylate synthase gene within the genome of Chilo iridescent virus." Muller K., Tidona C.A., Bahr U., Darai G. Virus Genes 17:243-258(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF303741 Genomic DNA. Translation: AAD21329.1.
RefSeq	NP_149688.1. NC_003038.1.
3D structure databases
HSSP	HSSP built from PDB template 1CI7 based on UniProtKB P13100.
ProteinModelPortal	Q9WBI3.
SMR	Q9WBI3. Positions 4-295.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1733097.
Enzyme and pathway databases
UniPathway	UPA00575.
Family and domain databases
Gene3D	3.30.572.10. 1 hit.
InterPro	IPR023451. Thymidate_synth/dCMP_Mease. IPR000398. Thymidylate_synthase. IPR020940. Thymidylate_synthase_AS. [Graphical view]
Pfam	PF00303. Thymidylat_synt. 1 hit. [Graphical view]
PRINTS	PR00108. THYMDSNTHASE.
SUPFAM	SSF55831. Thymidylat_synth_C. 1 hit.
TIGRFAMs	TIGR03284. thym_sym. 1 hit.
PROSITE	PS00091. THYMIDYLATE_SYNTHASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYSY_IIV6

Accession

Primary (citable) accession number: Q9WBI3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2009
Last sequence update:	November 1, 1999
Last modified:	April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program