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Protein

Protein Vpu

Gene

vpu

Organism
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Enhances virion budding by targeting host CD4 and Tetherin/BST2 to proteasome degradation. Degradation of CD4 prevents any unwanted premature interactions between viral Env and its host receptor CD4 in the endoplasmic reticulum. Degradation of antiretroviral protein Tetherin/BST2 is important for virion budding, as BST2 tethers new viral particles to the host cell membrane. Mechanistically, Vpu bridges either CD4 or BST2 to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3 ubiquitin ligase, induces their ubiquitination and subsequent proteasomal degradation. The alteration of the E3 ligase specificity by Vpu seems to promote the degradation of host IKBKB, leading to NF-kappa-B down-regulation and subsequent apoptosis. Ion channel activity has also been suggested, however, formation of cation-selective channel has been reconstituted ex-vivo in lipid bilayers. It is thus unsure that this activity plays a role in vivo.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelUniRule annotation
Biological processApoptosisUniRule annotation, Host-virus interactionUniRule annotation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein VpuUniRule annotation
Alternative name(s):
U ORF proteinUniRule annotation
Viral protein UUniRule annotation
Gene namesi
Name:vpuUniRule annotationImported
OrganismiHuman immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)Imported
Taxonomic identifieri11706 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000105453 Componenti: Genome

Subcellular locationi

  • Host membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 28HelicalUniRule annotationAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Host membraneUniRule annotation, Membrane

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9WB91. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ9WB91.
SMRiQ9WB91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HIV-1 VPU protein family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Family and domain databases

Gene3Di1.10.195.10. 1 hit.
InterProiView protein in InterPro
IPR008187. Vpu.
IPR009032. Vpu_cyt_dom_sf.
PfamiView protein in Pfam
PF00558. Vpu. 1 hit.
SUPFAMiSSF57647. SSF57647. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9WB91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPIPIVAIV ALVVAIIIAI VVWSIVIIEY RKILRQRKID RLIDRLIERA
60 70 80
EDSGNESEGE ISALVEMGVE MGHHAPWDVD DL
Length:82
Mass (Da):9,242
Last modified:November 1, 1999 - v1
Checksum:i53D79E576ACAD7DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033819 Genomic RNA. Translation: AAD20388.1.
RefSeqiNP_057855.1. NC_001802.1.

Genome annotation databases

GeneIDi155945.

Similar proteinsi

Entry informationi

Entry nameiQ9WB91_HV1H2
AccessioniPrimary (citable) accession number: Q9WB91
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: November 22, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported