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Q9WAB1 (LMBD1_REOVJ) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inner capsid protein lambda-1

Short name=Lambda1
EC=3.6.4.13
Alternative name(s):
ATP-dependent DNA helicase lambda-1
Lambda1(Hel)
OrganismReovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2) [Complete proteome]
Taxonomic identifier10885 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
Virus hostMammalia [TaxID: 40674]

Protein attributes

Sequence length1275 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inner capsid (core) component. Displays NTPase, RNA 5'-triphosphatase (RTPase) and RNA helicase activities and probably participates in transcription of the viral genome. Helicase activity might be involved in unwinding or reannealing dsRNA during RNA synthesis. RTPase enzymatic activity represents the first step in RNA capping, which yields a 5'-diphosphorylated plus-strand RNA By similarity.

Catalytic activity

ATP + H2O = ADP + phosphate.

Cofactor

Magnesium or manganese By similarity.

Subunit structure

Interacts with protein mu-NS; in viral inclusions By similarity.

Subcellular location

Virion Potential. Note: Found in the inner capsid (120 copies) By similarity.

Sequence similarities

Belongs to the orthoreovirus lambda-1 protein family.

Contains 1 C2H2-type zinc finger.

Ontologies

Keywords
   Biological processmRNA capping
mRNA processing
   Cellular componentCapsid protein
Inner capsid protein
Virion
   DomainZinc-finger
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionHelicase
Hydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7-methylguanosine mRNA capping

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentviral inner capsid

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

helicase activity

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12751275Inner capsid protein lambda-1
PRO_0000344997

Regions

Zinc finger181 – 20323C2H2-type

Sequences

Sequence LengthMass (Da)Tools
Q9WAB1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 1238F825C0A27CF2

FASTA1,275142,031
        10         20         30         40         50         60 
MKRIPRKTRG KSSGKGNDST ERADDGSAQL RDKQSSKVTQ NVKEPGTTLK EQYKTRPSLQ 

        70         80         90        100        110        120 
TVQKATENAE LPMQTNDEGA VDKKGNTKGD KTNEHVEAEV NAADATKRQA KDTDKQKAQV 

       130        140        150        160        170        180 
TYNDTGINNA NELSRSGNVD NEGGDNQKPM TTRIAEATSA IISKHPARVG LPPTASSGHG 

       190        200        210        220        230        240 
YQCHVCSAVL FSPLDLDAHV ASHGLHGNMT LTSSEIQRHI TEFISSWQNH PIVQVSADVE 

       250        260        270        280        290        300 
NKKTAQLLHA DTPRLVTWDA GLCTSFKIVP IVPAQVPQDV LAYTFFTSSY AIQSPFPEAA 

       310        320        330        340        350        360 
VSRIVVHTRW ASNVDFDRDS SVIMAPPTEN NIHLFKQLLN NETLSVRGAN PLMFRANVLH 

       370        380        390        400        410        420 
MLLEFVLDNL YINKHTGFSQ DHTPFTEGAN LRSLPGPDAE KWYAIMYPTR MGTPNVSKIC 

       430        440        450        460        470        480 
NFVASCVRNR VGRFDRAQMM NGAMSEWVDV FETSDALTVS IRGRWMARLA RMNINPTEIE 

       490        500        510        520        530        540 
WALTECAHGY VTVTSPYAPS VNRLMPYRVS NAERQISQII RIMNIGNNAT VIQPVLQDIS 

       550        560        570        580        590        600 
VLLQRISPLQ IDPTIISNTM STVSESTTQT LSPASSILGK LRPSNSDFSS FRVALAGWLY 

       610        620        630        640        650        660 
NGVVTTVIDD SSYPKDGGSV TSLENLWDFF ILALALPLTT DPCAPVKAFM TLANMMVGFE 

       670        680        690        700        710        720 
TIPMDNQIYT QSRRASAFST PHTWPRCFMN IQLISPIDAP ILRQWAEIIH RYWPNPSQIR 

       730        740        750        760        770        780 
FGAPNVFGSA NLFTPPEVLL LPIDHQPANV TTPTLDFTNE LTNWRARVCE LMKNLVDNQR 

       790        800        810        820        830        840 
YQPGWTQSLV SSMRGTLDKL KLIKSMTPMY LQQLAPVELA VIAPMLPFPP FQVPYVRLDR 

       850        860        870        880        890        900 
DRVPTMVGVT RQSRDTITQP ALSLSTTNTT VGVPLALDAR AITVALLSGK YPSDLVTNVW 

       910        920        930        940        950        960 
YADAIYPMYA DTEVFSNLQR DMITCEAVQT LITLVAQISE TQYPVDRYLD WIPSLRASAA 

       970        980        990       1000       1010       1020 
TAATFAEWVN TSMKTAFDLS DMLLEPLLSG DPRMSQLAIQ YQQYNGRTFN VIPEMPGSVV 

      1030       1040       1050       1060       1070       1080 
TDCVQLTAEV FNHEYNLFGI ARGDIIIGRV QSTHLWSPLA PPPDLVFDRD TPGVHVFGRD 

      1090       1100       1110       1120       1130       1140 
CRISFGMNGA APMIRDETGM MVPFEGNWIF PLALWQMNTR YFNQQFDAWI KTGELRIRIE 

      1150       1160       1170       1180       1190       1200 
MGAYPYMLHY YDPRQYANAW NLTSAWLEEI SPTSIPSVPF MVPISSDHDI SSAPAVQYII 

      1210       1220       1230       1240       1250       1260 
STEYNDRSLF CTNSSSPQTI AGPDKHIPVE RYNILTNPDA PPTQIQLPEV VDLYNVVTRY 

      1270 
AYETPPITAV VMGVP 

« Hide

References

[1]"Mammalian reovirus L3 gene sequences and evidence for a distinct amino-terminal region of the lambda1 protein."
Harrison S.J., Farsetta D.L., Kim J., Noble S., Broering T.J., Nibert M.L.
Virology 258:54-64(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF129821 mRNA. Translation: AAD42305.1.

3D structure databases

ProteinModelPortalQ9WAB1.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLMBD1_REOVJ
AccessionPrimary (citable) accession number: Q9WAB1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: November 1, 1999
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families