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Q9WAB1

- LMBD1_REOVJ

UniProt

Q9WAB1 - LMBD1_REOVJ

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Protein
Inner capsid protein lambda-1
Gene
N/A
Organism
Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Inner capsid (core) component. Displays NTPase, RNA 5'-triphosphatase (RTPase) and RNA helicase activities and probably participates in transcription of the viral genome. Helicase activity might be involved in unwinding or reannealing dsRNA during RNA synthesis. RTPase enzymatic activity represents the first step in RNA capping, which yields a 5'-diphosphorylated plus-strand RNA By similarity.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Cofactori

Magnesium or manganese By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri181 – 20323C2H2-type
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. helicase activity Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. 7-methylguanosine mRNA capping Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

mRNA capping, mRNA processing

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Inner capsid protein lambda-1 (EC:3.6.4.13)
Short name:
Lambda1
Alternative name(s):
ATP-dependent DNA helicase lambda-1
Lambda1(Hel)
OrganismiReovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)
Taxonomic identifieri10885 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
Virus hostiMammalia [TaxID: 40674]
ProteomesiUP000006370: Genome

Subcellular locationi

Virion Reviewed prediction
Note: Found in the inner capsid (120 copies) By similarity.

GO - Cellular componenti

  1. viral inner capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Inner capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12751275Inner capsid protein lambda-1
PRO_0000344997Add
BLAST

Interactioni

Subunit structurei

Interacts with protein mu-NS; in viral inclusions By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9WAB1.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9WAB1-1 [UniParc]FASTAAdd to Basket

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MKRIPRKTRG KSSGKGNDST ERADDGSAQL RDKQSSKVTQ NVKEPGTTLK     50
EQYKTRPSLQ TVQKATENAE LPMQTNDEGA VDKKGNTKGD KTNEHVEAEV 100
NAADATKRQA KDTDKQKAQV TYNDTGINNA NELSRSGNVD NEGGDNQKPM 150
TTRIAEATSA IISKHPARVG LPPTASSGHG YQCHVCSAVL FSPLDLDAHV 200
ASHGLHGNMT LTSSEIQRHI TEFISSWQNH PIVQVSADVE NKKTAQLLHA 250
DTPRLVTWDA GLCTSFKIVP IVPAQVPQDV LAYTFFTSSY AIQSPFPEAA 300
VSRIVVHTRW ASNVDFDRDS SVIMAPPTEN NIHLFKQLLN NETLSVRGAN 350
PLMFRANVLH MLLEFVLDNL YINKHTGFSQ DHTPFTEGAN LRSLPGPDAE 400
KWYAIMYPTR MGTPNVSKIC NFVASCVRNR VGRFDRAQMM NGAMSEWVDV 450
FETSDALTVS IRGRWMARLA RMNINPTEIE WALTECAHGY VTVTSPYAPS 500
VNRLMPYRVS NAERQISQII RIMNIGNNAT VIQPVLQDIS VLLQRISPLQ 550
IDPTIISNTM STVSESTTQT LSPASSILGK LRPSNSDFSS FRVALAGWLY 600
NGVVTTVIDD SSYPKDGGSV TSLENLWDFF ILALALPLTT DPCAPVKAFM 650
TLANMMVGFE TIPMDNQIYT QSRRASAFST PHTWPRCFMN IQLISPIDAP 700
ILRQWAEIIH RYWPNPSQIR FGAPNVFGSA NLFTPPEVLL LPIDHQPANV 750
TTPTLDFTNE LTNWRARVCE LMKNLVDNQR YQPGWTQSLV SSMRGTLDKL 800
KLIKSMTPMY LQQLAPVELA VIAPMLPFPP FQVPYVRLDR DRVPTMVGVT 850
RQSRDTITQP ALSLSTTNTT VGVPLALDAR AITVALLSGK YPSDLVTNVW 900
YADAIYPMYA DTEVFSNLQR DMITCEAVQT LITLVAQISE TQYPVDRYLD 950
WIPSLRASAA TAATFAEWVN TSMKTAFDLS DMLLEPLLSG DPRMSQLAIQ 1000
YQQYNGRTFN VIPEMPGSVV TDCVQLTAEV FNHEYNLFGI ARGDIIIGRV 1050
QSTHLWSPLA PPPDLVFDRD TPGVHVFGRD CRISFGMNGA APMIRDETGM 1100
MVPFEGNWIF PLALWQMNTR YFNQQFDAWI KTGELRIRIE MGAYPYMLHY 1150
YDPRQYANAW NLTSAWLEEI SPTSIPSVPF MVPISSDHDI SSAPAVQYII 1200
STEYNDRSLF CTNSSSPQTI AGPDKHIPVE RYNILTNPDA PPTQIQLPEV 1250
VDLYNVVTRY AYETPPITAV VMGVP 1275
Length:1,275
Mass (Da):142,031
Last modified:November 1, 1999 - v1
Checksum:i1238F825C0A27CF2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF129821 mRNA. Translation: AAD42305.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF129821 mRNA. Translation: AAD42305.1 .

3D structure databases

ProteinModelPortali Q9WAB1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 1 hit.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mammalian reovirus L3 gene sequences and evidence for a distinct amino-terminal region of the lambda1 protein."
    Harrison S.J., Farsetta D.L., Kim J., Noble S., Broering T.J., Nibert M.L.
    Virology 258:54-64(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiLMBD1_REOVJ
AccessioniPrimary (citable) accession number: Q9WAB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: November 1, 1999
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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